Risk factors associated with prediabetes in Chinese: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

REN Ming ¹ , SUN Xiao ¹ , WANG Meina ¹ , HUO Da ² , LI Yan ¹ ,  GUO Liping ²

1. Baokang Hospital, Tianjin University of TCM, Tianjin, 300193, P.R.China;
2. Tianjin University of TCM, Tianjin, 300000, P.R.China;

Corresponding?author：

GUO Liping, Email: lpgtjn@163.com

Keywords：

Prediabetes; Risk factor; meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.201805159

Video：

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Objectives To systematically review the risk factors associated with prediabetes, and to provide reference for prevention and treatment of diabetes mellitus and health education.Methods PubMed, EMbase, SinoMed, CNKI, WanFang Data and VIP databases were electronically searched to collect case-control studies on the risk factors associated with prediabetes from inception to February 20^th, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.Results A total of 13 studies involving 49 168 patients were included. The results of meta-analysis showed that: drinking (OR=1.31, 95%CI 1.04 to 1.65, P=0.02), hypertension (OR=1.75, 95%CI 1.11 to 2.76, P=0.02), abdominal obesity (OR=1.26, 95%CI 1.12 to 1.42, P=0.000 1), and waist to hip ratio (OR=1.77, 95%CI 1.27 to 2.45, P=0.000 6) might be the risk factors for prediabetes. However, dyslipidemia, smoking, physical activity, family history of diabetes, body mass index and waist circumference might not be risk factors for prediabetes.Conclusions Current evidence shows that drinking, hypertension, abdominal obesity and waist-hip ratio may be the influencing factors of pre-diabetes, while other related risk factors are required to be further studied. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

Citation： REN Ming, SUN Xiao, WANG Meina, HUO Da, LI Yan, GUO Liping. Risk factors associated with prediabetes in Chinese: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2019, 19(2): 140-146. doi: 10.7507/1672-2531.201805159 Copy

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2.	Bagheri F, Siassi F, Koohdani F, et al. Healthy and unhealthy dietary patterns are related to pre-diabetes: a case-control study. Br J Nutr, 2016, 116(5): 874-881.
3.	Zheng S, Shi S, Ren X, et al. Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study. J Transl Med, 2016, 14: 260.
4.	Kowall B, Lehnich AT, Strucksberg KH, et al. Associations among sleep disturbances, nocturnal sleep duration, daytime napping, and incident prediabetes and type 2 diabetes: the Heinz Nixdorf Recall study. Sleep Med, 2016, 21: 35-41.
5.	Ho CH, Yu HJ, Wang CY, et al. Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome. PLoS One, 2013, 8(9): e74173.
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13.	王冰, 劉明川, 李欣宇, 等. 大連市 40 歲以上城市人群 2 型糖尿病及糖尿病前期患病情況及其影響因素分析. 天津醫科大學學報, 2016, 38(4): 334-338.
14.	王丹, 鄭代坤, 鄭勝. 重慶市萬州區 2 型糖尿病前期流行現狀及其危險因素分析. 現代預防醫學, 2016, 43(10): 1735-1738, 1765.
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16.	王瑞, 周衛, 謝奎, 等. 深圳市羅湖區居民糖尿病及其前期患病情況及影響因素. 中國慢性病預防與控制, 2015, 23(4): 252-255.
17.	蘇齊, 侯進. 上海城郊中老年人群糖尿病前期影響因素分析. 實用預防醫學, 2015, 22(5): 559-562.
18.	陳曉英, 王叢昀, 蘇美芳, 等. 社區居民糖調節受損和 2 型糖尿病相關因素的病例對照研究. 上海預防醫學, 2015, 27(11): 669-672, 677.
19.	徐忠良. 天津市 20-79 歲居民空腹血糖受損患病率及相關因素研究. 天津: 天津醫科大學, 2012.
20.	丁紅, 邵潔, 者煒, 等. 維吾爾族糖調節受損影響因素 Logistic 回歸分析. 中國民族民間醫藥, 2009, 18(18): 7-8.
21.	劉立亞, 陳立章, 戴進雄, 等. 湘西地區侗族 2 型糖尿病危險因素的病例對照研究. 中南大學學報(醫學版), 2013, 38(10): 1057-1064.
22.	陳瑞芳, 常少瓊. 糖尿病前期危險因素分析及八段錦的運用. 光明中醫, 2013, 28(12): 2531-2533.
23.	中華醫學會糖尿病學分會. 中國 2 型糖尿病防治指南(2013 年版). 中國醫學前沿雜志(電子版), 2015, 7(3): 26-89.
24.	Tao LX, Yang K, Huang FF, et al. Association of waist circumference gain and incident prediabetes defined by fasting glucose: a seven-year longitudinal study in Beijing, China. Int J Environ Res Public Health, 2017, 14(10): E1208.
25.	汪秋實, 閆麗, 呂淑榮, 等. 糖尿病前期人群血脂異常及其危險因素分析. 東南大學學報(醫學版), 2015, 34(5): 749-754.
26.	張揚, 王明杰, 劉鑫, 等. 吉林省成年居民糖尿病前期患病情況及其危險因素分析. 中國公共衛生, 2018, 34(7): 977-981.
27.	張輝映, 袁旻健, 婁靈芝, 等. 糖尿病前期人群血糖水平的影響因素分析. 上海預防醫學, 2011, 23(5): 207-209.
28.	薛安紅. 腹型肥胖 2 型糖尿病的治療體會. 中國醫療前沿, 2010, 5(1): 36.

1. Unwin N, Shaw J, Zimmet P, et al. Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabet Med, 2002, 19(9): 708-723.
2. Bagheri F, Siassi F, Koohdani F, et al. Healthy and unhealthy dietary patterns are related to pre-diabetes: a case-control study. Br J Nutr, 2016, 116(5): 874-881.
3. Zheng S, Shi S, Ren X, et al. Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study. J Transl Med, 2016, 14: 260.
4. Kowall B, Lehnich AT, Strucksberg KH, et al. Associations among sleep disturbances, nocturnal sleep duration, daytime napping, and incident prediabetes and type 2 diabetes: the Heinz Nixdorf Recall study. Sleep Med, 2016, 21: 35-41.
5. Ho CH, Yu HJ, Wang CY, et al. Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome. PLoS One, 2013, 8(9): e74173.
6. Wells G, Shea B, Oconnell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses, 2000. Available at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
7. 劉鳴. 系統評價、Meta 分析設計和實施辦法. 北京: 人民衛生出版社, 2010: 72-73.
8. 何瓊, 黃淵秀, 康文婧, 等. 2001-2010 年我國傷害預防病例對照研究及隊列研究文獻質量評價. 中華疾病控制雜志, 2014, 18(10): 913-916.
9. 王麗瓊, 陳建華, 劉春榮, 等. 武漢市楊園社區居民糖調節受損人群危險因素分析. 中國社會醫學雜志, 2017, 34(3): 274-276.
10. 賈會春, 孫玉玲. 糖尿病前期的患病情況及相關因素分析. 影像研究與醫學應用, 2017, 1(11): 22-23.
11. 王培, 韋麗婭, 李奇觀, 等. 廣州地區糖尿病前期的患病情況及相關因素分析. 廣東醫學, 2017, 38(7): 1089-1091.
12. 黃晶晶, 尹蓮花, 許藝惠, 等. 肥胖、體脂率、血脂水平異常與糖尿病前期的關系探討. 湖南中醫雜志, 2016, 32(6): 4-6.
13. 王冰, 劉明川, 李欣宇, 等. 大連市 40 歲以上城市人群 2 型糖尿病及糖尿病前期患病情況及其影響因素分析. 天津醫科大學學報, 2016, 38(4): 334-338.
14. 王丹, 鄭代坤, 鄭勝. 重慶市萬州區 2 型糖尿病前期流行現狀及其危險因素分析. 現代預防醫學, 2016, 43(10): 1735-1738, 1765.
15. 林漢英, 謝乃強, 李曉莉, 等. 肇慶市區 40 歲以上人群糖尿病、糖尿病前期流行病學調查. 廣東醫學, 2016, 37(2): 285-287.
16. 王瑞, 周衛, 謝奎, 等. 深圳市羅湖區居民糖尿病及其前期患病情況及影響因素. 中國慢性病預防與控制, 2015, 23(4): 252-255.
17. 蘇齊, 侯進. 上海城郊中老年人群糖尿病前期影響因素分析. 實用預防醫學, 2015, 22(5): 559-562.
18. 陳曉英, 王叢昀, 蘇美芳, 等. 社區居民糖調節受損和 2 型糖尿病相關因素的病例對照研究. 上海預防醫學, 2015, 27(11): 669-672, 677.
19. 徐忠良. 天津市 20-79 歲居民空腹血糖受損患病率及相關因素研究. 天津: 天津醫科大學, 2012.
20. 丁紅, 邵潔, 者煒, 等. 維吾爾族糖調節受損影響因素 Logistic 回歸分析. 中國民族民間醫藥, 2009, 18(18): 7-8.
21. 劉立亞, 陳立章, 戴進雄, 等. 湘西地區侗族 2 型糖尿病危險因素的病例對照研究. 中南大學學報(醫學版), 2013, 38(10): 1057-1064.
22. 陳瑞芳, 常少瓊. 糖尿病前期危險因素分析及八段錦的運用. 光明中醫, 2013, 28(12): 2531-2533.
23. 中華醫學會糖尿病學分會. 中國 2 型糖尿病防治指南(2013 年版). 中國醫學前沿雜志(電子版), 2015, 7(3): 26-89.
24. Tao LX, Yang K, Huang FF, et al. Association of waist circumference gain and incident prediabetes defined by fasting glucose: a seven-year longitudinal study in Beijing, China. Int J Environ Res Public Health, 2017, 14(10): E1208.
25. 汪秋實, 閆麗, 呂淑榮, 等. 糖尿病前期人群血脂異常及其危險因素分析. 東南大學學報(醫學版), 2015, 34(5): 749-754.
26. 張揚, 王明杰, 劉鑫, 等. 吉林省成年居民糖尿病前期患病情況及其危險因素分析. 中國公共衛生, 2018, 34(7): 977-981.
27. 張輝映, 袁旻健, 婁靈芝, 等. 糖尿病前期人群血糖水平的影響因素分析. 上海預防醫學, 2011, 23(5): 207-209.
28. 薛安紅. 腹型肥胖 2 型糖尿病的治療體會. 中國醫療前沿, 2010, 5(1): 36.

Chinese Journal of Evidence-Based Medicine

Risk factors associated with prediabetes in Chinese: a meta-analysis

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