Health economic analysis of five nucleic acid detection systems based on electrochemical biosensors_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Menghe ,  MING Desong

Department of Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, P.R.China;

Corresponding?author：

MING Desong, Email: mds6430@126.com

Keywords：

Cost-effectiveness analysis; Cost-utility analysis; Incremental cost-effectiveness ration; Gold electrode; Glassy carbon electrode; Carbon paste electrode; Screen-printed electrode; ITO glass electrode

DOI：

10.7507/1672-2531.201805071

Video：

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Objectives This study aimed to study the economic effect of five kinds of detection systems for nucleic acid, which were based on five kinds of working electrodes: gold electrode, glassy carbon electrode, carbon paste electrode, screen printing electrode, and indium-tin-oxide (ITO) glass electrode.Methods The cost of completing a single test was taken as the cost of economic analysis. The Youden index was used to represent the effect of cost-effectiveness analysis (CEA). Meanwhile, the cost-utility analysis (CUA) and incremental cost-effectiveness ratio (ICER) were used for the economic analysis of the corresponding system.Results The cost of five detection systems based on gold electrode, glass carbon electrode, carbon paste electrode, screen printing electrode, and ITO glass electrode was 3.70 yuan/unit, 4.20 yuan/unit, 5.25 yuan/unit, 33.98 yuan/unit and 5.01 yuan/unit, respectively. The Youden indexes of all five systems were 1. The cost effectiveness (C/E) were 3.70, 4.20, 5.25, 33.98, and 5.01, respectively. The cost utility (C/U) were 6.61, 6.89, 9.91, 62.93, and 9.45, respectively. The C'/E and C'/U of the gold electrode detection system were the minimum (2.96 and 5.29). Compared with the system applying the gold electrode, the system using the glassy carbon electrode had ΔC >0 and ?E₀ >0; When carbon paste electrode, screen printing electrode, and ITO glass electrode system were used, ?C was >0 and ?E₀ was <0.Conclusions From the perspective of CEA and CUA, the system using the gold electrode has the best economic effect. The sensitivity analysis proved the reliability of CEA and CUA results. According to the ICER, gold electrode or glassy carbon electrode can be used in clinical practice with the choice depending on the user.

Citation： WANG Menghe, MING Desong. Health economic analysis of five nucleic acid detection systems based on electrochemical biosensors. Chinese Journal of Evidence-Based Medicine, 2019, 19(10): 1244-1249. doi: 10.7507/1672-2531.201805071 Copy

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7.	Zhai S, Fang C, Yan J, et al. A label-free genetic biosensor for diabetes based on AuNPs decorated ITO with electroche miluminescent signaling. Anal Chim Acta, 2017, 982: 62-71.
8.	孟奎奎, 郭珈玲, 云陽方, 等. 鄰苯二酚和對苯二酚在金納米修飾玻碳電極(GNP/GCE)上的同時靈敏檢測. 化學研究與應用, 2018, 30(3): 432-436.
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10.	李雪迎. 診斷能力評價的統計學方法—準確度與約登指數. 中國介入心臟病學雜志, 2011, 19(4): 213.
11.	明德松. 乙型肝炎病毒表面抗原三種檢測方法的檢驗經濟學分析. 世界感染雜志, 2005, 5(2): 158-160.
12.	王友基, 陳慧丹. 福建省優生健康檢查乙肝血清學五項不同廠家試劑盒的經濟學分析. 中國藥物經濟學, 2013, (S2): 12-13.
13.	羅霞, 彭六保, 萬小敏, 等. 運用Markov模型進行藥物經濟學評價的概率敏感度分析. 中國新藥與臨床雜志, 2009, 28(3): 175-178.
14.	Black WC. The CE plane: a graphic representation of cost-effectiveness. Med Decis Making, 1990, 10(3): 212-214.
15.	張楠, 石學峰, 吳晶. 增量成本效果比在衛生技術評估中的應用. 中國衛生政策研究, 2012, 5(2): 64-68.
16.	白雪, 金君, 司豆豆, 等. 介孔硅吸附亞甲基藍修飾碳糊電極對苯酚的測定. 山東化工, 2018, 47(1): 58-60.
17.	Le BH, Seo YJ. Direct incorporation and extension of a fluorescent nucleotide through rolling circle DNA amplification for the detection of microRNA 24-3P. Bioorg Med Chem Lett, 2018, 28(11): 2035-2038.
18.	Jian Y, Wang H, Lan F, et al. Electrochemiluminescence based detection of microRNA by applying an amplification strategy and Hg(II)-triggered disassembly of a metal organic frameworks functionalized with ruthenium(II)tris(bipyridine). Mikrochim Acta, 2018, 185(2): 133.

1. Diener HC. CGRP as a new target in prevention and treatment of migraine. Lancet Neurol, 2014, 13(11): 1065-1067.
2. Cobb SJ, Ayres ZJ, Macpherson JV. Boron doped diamond: a designer electrode material for the twenty-first century. Annu Rev Anal Chem (Palo Alto Calif), 2018, 11(1): 463-484.
3. 黃艷麗. 基于聚鳥嘌呤納米線信號放大技術構建識別汞離子, DNA, microRNA的電化學生物傳感器. 重慶: 西南大學, 2017.
4. Pan HZ, Yu H, Wang N, et al. A highly sensitive oligonucleotide hybridization assay for klebsiella pneumoniae carbapenemase with the probes on a gold nanoparticles modified glassy carbon electrode. J Aoac Int, 2015, 98(6): 1728-1732.
5. Gao H, Qi X, Chen Y, et al. Electrochemical deoxyribonucleic acid biosensor based on the self-assembly film with nanogold decorated on ionic liquid modified carbon paste electrode. Anal Chim Acta, 2011, 704(1-2): 133-138.
6. He C, Tang Y, Wang S, et al. An electrochemical DNA biosensor based on au-reduced graphene oxide nanocomposite for transgenic event BT63 detection. Anal Sci, 2017, 33(10): 1155-1160.
7. Zhai S, Fang C, Yan J, et al. A label-free genetic biosensor for diabetes based on AuNPs decorated ITO with electroche miluminescent signaling. Anal Chim Acta, 2017, 982: 62-71.
8. 孟奎奎, 郭珈玲, 云陽方, 等. 鄰苯二酚和對苯二酚在金納米修飾玻碳電極(GNP/GCE)上的同時靈敏檢測. 化學研究與應用, 2018, 30(3): 432-436.
9. 于樂成, 侯金林. 2017年歐洲肝病學會臨床實踐指南: HBV感染的管理(精粹). 臨床肝膽病雜志, 2017, (6): 1017-1032.
10. 李雪迎. 診斷能力評價的統計學方法—準確度與約登指數. 中國介入心臟病學雜志, 2011, 19(4): 213.
11. 明德松. 乙型肝炎病毒表面抗原三種檢測方法的檢驗經濟學分析. 世界感染雜志, 2005, 5(2): 158-160.
12. 王友基, 陳慧丹. 福建省優生健康檢查乙肝血清學五項不同廠家試劑盒的經濟學分析. 中國藥物經濟學, 2013, (S2): 12-13.
13. 羅霞, 彭六保, 萬小敏, 等. 運用Markov模型進行藥物經濟學評價的概率敏感度分析. 中國新藥與臨床雜志, 2009, 28(3): 175-178.
14. Black WC. The CE plane: a graphic representation of cost-effectiveness. Med Decis Making, 1990, 10(3): 212-214.
15. 張楠, 石學峰, 吳晶. 增量成本效果比在衛生技術評估中的應用. 中國衛生政策研究, 2012, 5(2): 64-68.
16. 白雪, 金君, 司豆豆, 等. 介孔硅吸附亞甲基藍修飾碳糊電極對苯酚的測定. 山東化工, 2018, 47(1): 58-60.
17. Le BH, Seo YJ. Direct incorporation and extension of a fluorescent nucleotide through rolling circle DNA amplification for the detection of microRNA 24-3P. Bioorg Med Chem Lett, 2018, 28(11): 2035-2038.
18. Jian Y, Wang H, Lan F, et al. Electrochemiluminescence based detection of microRNA by applying an amplification strategy and Hg(II)-triggered disassembly of a metal organic frameworks functionalized with ruthenium(II)tris(bipyridine). Mikrochim Acta, 2018, 185(2): 133.

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