Efficacy of multimodal nonpharmacological interventions in mild cognitive impairment: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

MEI Xiaofeng ¹ , ZHAO Xue ¹ , WANG Yunyun ² , WANG Li ³ ,  CAO Hong ⁴

1. Graduate College, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P.R.China;
2. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China;
3. Department of Nursing, Tianjin Hospital, Tianjin, 300211, P.R.China;
4. Department of Osteoporosis Internal Medicine, Tianjin Hospital, Tianjin, 300211, P.R.China;

Corresponding?author：

CAO Hong, Email: caohong1968@yeah.net

Keywords：

Multimodal nonpharmacological interventions; Mild cognitive impairment; meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.201803015

Video：

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Objectives To systematically review the efficacy of multimodal nonpharmacological interventions in mild cognitive impairment (MCI). Methods An electronically search was conducted in PubMed, EMbase, The Cochrane Library, PsycINFO, Web of Science, CINAHL, VIP, CBM, WanFang Data and CNKI databases from inception to November 2017 to collect randomized controlled trials (RCTs) on multimodal nonpharmacological interventions for MCI. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by RevMan 5.3 software. Results A total of 12 RCTs involving 1 359 patients were included. The results of meta-analysis showed that there were no statistical differences between two groups in MMSE scores (SMD=0.33, 95%CI–0.13 to 0.78, P=0.16). However, the MoCA scores (SMD=0.52, 95%CI 0.38 to 0.67, P<0.000 01) and ADAS-Cog scores (SMD=1.13, 95%CI 0.75 to 1.51, P<0.000 01) in the multimodal nonpharmacological interventions group were better than those in the control group. Additionally, multimodal nonpharmacological interventions produced significant effects on ADL (SMD=–0.64, 95%CI –0.83 to–0.45, P<0.000 01), QOL-AD (MD=3.65, 95%CI 1.03 to 6.27, P=0.006) and depression (SMD=–0.83, 95%CI –1.41 to–0.26, P=0.005). There were no statistical differences between two groups on conversion rate to Alzheimer's disease (RR=0.27, 95%CI 0.06 to 1.26, P=0.10). Conclusions The current evidence shows that multimodal nonpharmacological interventions are feasible for patients with MCI as they have positive effects on overall cognitive abilities, daily living skills, and quality of life and depression. Nevertheless, due to the limited quantity and quality of included studies, more high quality studies are required to verify the conclusion.

Citation： MEI Xiaofeng, ZHAO Xue, WANG Yunyun, WANG Li, CAO Hong. Efficacy of multimodal nonpharmacological interventions in mild cognitive impairment: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2019, 19(2): 180-188. doi: 10.7507/1672-2531.201803015 Copy

1.	Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol, 1999, 56(3): 303-308.
2.	Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment-beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med, 2004, 256(3): 240-246.
3.	Ward A, Tardiff S, Dye C, et al. Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature. Dement Geriatr Cogn Dis Extra, 2013, 3(1): 320-332.
4.	Clare L, Woods RT, Moniz CE, et al. Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev, 2003, (4): CD003260.
5.	Erickson KI, Prakash RS, Voss MW, et al. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus, 2009, 19(10): 1030-1039.
6.	Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA, 2011, 108(7): 3017-3022.
7.	Voss MW, Prakash RS, Erickson KI, et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci, 2010, 2(1): 1-16.
8.	Anderson JG, Lopez RP, Rose KM, et al. Nonpharmacological strategies for patients with early-stage dementia or mild cognitive impairment: a 10-year update. Res Gerontol Nurs, 2017, 10(1): 5-11.
9.	Simon SS, Yokomizo JE, Bottino CM. Cognitive intervention in amnestic mild cognitive impairment: a systematic review. Neurosci Biobehav Rev, 2012, 36(4): 1163-1178.
10.	Kurz A, Pohl C, Ramsenthaler M, et al. Cognitive rehabilitation in patients with mild cognitive impairment. Int J Geriatr Psychiatry, 2009, 24(2): 163-168.
11.	李志武, 黃悅勤, 劉杰, 等. 南苑地區老年輕度認知損害社區干預效果評價研究. 中國醫藥導報, 2012, 9(34): 50-51.
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14.	Tsolaki M, Kounti F, Agogiatou C, et al. Effectiveness of nonpharmacological approaches in patients with mild cognitive impairment. Neurodegener Dis, 2011, 8(3): 138-145.
15.	Buschert VC, Friese U, Teipel SJ, et al. Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study. J Alzheimers Dis, 2011, 25(4): 679-694.
16.	Buschert VC, Giegling I, Teipel SJ, et al. Long-term observation of a multicomponent cognitive intervention in mild cognitive impairment. J Clin Psychiatry, 2012, 73(12): e1492-e1498.
17.	黃鑫, 張耀東, 徐勇, 等. 老年輕度認知障礙綜合干預效果初步研究. 中外醫療, 2012, 31(14): 102-103.
18.	Rojas GJ, Villar V, Iturry M, et al. Efficacy of a cognitive intervention program in patients with mild cognitive impairment. Int Psychogeriatr, 2013, 25(5): 825-831.
19.	殷淑琴, 宋瑜, 徐勇, 等. 湖州市老年人輕度認知功能障礙早期干預研究. 中國現代醫生, 2013, 51(3): 67-68.
20.	Maffei L, Picano E, Andreassi MG, et al. Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study. Sci Rep, 2017, 7: 39471.
21.	沈紅仙, 殷淑琴, 方玉紅. 老年輕度認知功能障礙患者社區護理的干預效果. 解放軍護理雜志, 2013, 30(16): 23-25.
22.	何璐. 江西省社區老年人輕度認知功能障礙的評估和干預研究. 南昌: 南昌大學, 2015.
23.	陳慶友, 張艷蕉, 姜敏, 等. 齊齊哈爾市社區老年人輕度認知功能障礙的現況調查和干預性研究. 中國實用神經疾病雜志, 2015, 18(19): 37-38.
24.	潘惠英. 金華市社區老年人輕度認知功能障礙的現況調查和干預性研究. 上海: 復旦大學, 2012.
25.	聶曉璐, 呂曉珍, 卓琳, 等. 2001–2015 年中國輕度認知功能障礙患病率的 Meta 分析. 中華精神科雜志, 2016, 49(5): 298-306.
26.	Karp A, Paillard-Borg S, Wang HX, et al. Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord, 2006, 21(2): 65-73.
27.	Zanetti O, Vallotti B, Frisoni GB, et al. Insight in dementia: when does it occur? Evidence for a nonlinear relationship between insight and cognitive status. J Gerontol B Psychol Sci Soc Sci, 1999, 54(2): 100-106.
28.	Francomarina F, Garcíagonzález JJ, Wagnerecheagaray F, et al. The mini-mental state examination revisited: ceiling and floor effects after score adjustment for educational level in an aging Mexican population. Int Psychogeriatr, 2010, 22(1): 72-81.
29.	葛芳芳. 北京社區老人的神經心理標記物研究和顳葉變異型語義性癡呆的臨床神經心理特征分析. 北京: 北京協和醫學院, 2014.
30.	Olazarán J, Clare L. Non-pharmacological therapies in Alzheimer’s disease: a systematic review of efficacy. Dement Geriatr Cogn Disord, 2010, 30(2): 161-178.
31.	Chan SS, Lam LC, Tam CW, et al. Prevalence of clinically significant depressive symptoms in an epidemiologic sample of community-dwelling elders with milder forms of cognitive impairment in Hong Kong SAR. Int J Geriatr Psychiatry, 2010, 23(6): 611-617.
32.	Rosenberg PB, Mielke MM, Appleby BS, et al. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry, 2013, 21(7): 685-695.
33.	李杭霏, 蘇向妮, 徐莎莎, 等. 社區認知障礙老年人生活質量調查及影響因素分析. 護理學報, 2016, 23(4): 41-43.
34.	史亞楠, 方柳絮, 孫秋華. 抑郁對老年輕度認知障礙病人生活質量的影響. 護理研究, 2017, 31(33): 4288-4291.

1. Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol, 1999, 56(3): 303-308.
2. Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment-beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med, 2004, 256(3): 240-246.
3. Ward A, Tardiff S, Dye C, et al. Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature. Dement Geriatr Cogn Dis Extra, 2013, 3(1): 320-332.
4. Clare L, Woods RT, Moniz CE, et al. Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev, 2003, (4): CD003260.
5. Erickson KI, Prakash RS, Voss MW, et al. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus, 2009, 19(10): 1030-1039.
6. Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA, 2011, 108(7): 3017-3022.
7. Voss MW, Prakash RS, Erickson KI, et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci, 2010, 2(1): 1-16.
8. Anderson JG, Lopez RP, Rose KM, et al. Nonpharmacological strategies for patients with early-stage dementia or mild cognitive impairment: a 10-year update. Res Gerontol Nurs, 2017, 10(1): 5-11.
9. Simon SS, Yokomizo JE, Bottino CM. Cognitive intervention in amnestic mild cognitive impairment: a systematic review. Neurosci Biobehav Rev, 2012, 36(4): 1163-1178.
10. Kurz A, Pohl C, Ramsenthaler M, et al. Cognitive rehabilitation in patients with mild cognitive impairment. Int J Geriatr Psychiatry, 2009, 24(2): 163-168.
11. 李志武, 黃悅勤, 劉杰, 等. 南苑地區老年輕度認知損害社區干預效果評價研究. 中國醫藥導報, 2012, 9(34): 50-51.
12. Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions (version 5.1.0) Available at: http://handbook.cochrane.org.
13. Follmann D, Elliott P, Suh I, et al. Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol, 1992, 45(7): 769-773.
14. Tsolaki M, Kounti F, Agogiatou C, et al. Effectiveness of nonpharmacological approaches in patients with mild cognitive impairment. Neurodegener Dis, 2011, 8(3): 138-145.
15. Buschert VC, Friese U, Teipel SJ, et al. Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study. J Alzheimers Dis, 2011, 25(4): 679-694.
16. Buschert VC, Giegling I, Teipel SJ, et al. Long-term observation of a multicomponent cognitive intervention in mild cognitive impairment. J Clin Psychiatry, 2012, 73(12): e1492-e1498.
17. 黃鑫, 張耀東, 徐勇, 等. 老年輕度認知障礙綜合干預效果初步研究. 中外醫療, 2012, 31(14): 102-103.
18. Rojas GJ, Villar V, Iturry M, et al. Efficacy of a cognitive intervention program in patients with mild cognitive impairment. Int Psychogeriatr, 2013, 25(5): 825-831.
19. 殷淑琴, 宋瑜, 徐勇, 等. 湖州市老年人輕度認知功能障礙早期干預研究. 中國現代醫生, 2013, 51(3): 67-68.
20. Maffei L, Picano E, Andreassi MG, et al. Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study. Sci Rep, 2017, 7: 39471.
21. 沈紅仙, 殷淑琴, 方玉紅. 老年輕度認知功能障礙患者社區護理的干預效果. 解放軍護理雜志, 2013, 30(16): 23-25.
22. 何璐. 江西省社區老年人輕度認知功能障礙的評估和干預研究. 南昌: 南昌大學, 2015.
23. 陳慶友, 張艷蕉, 姜敏, 等. 齊齊哈爾市社區老年人輕度認知功能障礙的現況調查和干預性研究. 中國實用神經疾病雜志, 2015, 18(19): 37-38.
24. 潘惠英. 金華市社區老年人輕度認知功能障礙的現況調查和干預性研究. 上海: 復旦大學, 2012.
25. 聶曉璐, 呂曉珍, 卓琳, 等. 2001–2015 年中國輕度認知功能障礙患病率的 Meta 分析. 中華精神科雜志, 2016, 49(5): 298-306.
26. Karp A, Paillard-Borg S, Wang HX, et al. Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord, 2006, 21(2): 65-73.
27. Zanetti O, Vallotti B, Frisoni GB, et al. Insight in dementia: when does it occur? Evidence for a nonlinear relationship between insight and cognitive status. J Gerontol B Psychol Sci Soc Sci, 1999, 54(2): 100-106.
28. Francomarina F, Garcíagonzález JJ, Wagnerecheagaray F, et al. The mini-mental state examination revisited: ceiling and floor effects after score adjustment for educational level in an aging Mexican population. Int Psychogeriatr, 2010, 22(1): 72-81.
29. 葛芳芳. 北京社區老人的神經心理標記物研究和顳葉變異型語義性癡呆的臨床神經心理特征分析. 北京: 北京協和醫學院, 2014.
30. Olazarán J, Clare L. Non-pharmacological therapies in Alzheimer’s disease: a systematic review of efficacy. Dement Geriatr Cogn Disord, 2010, 30(2): 161-178.
31. Chan SS, Lam LC, Tam CW, et al. Prevalence of clinically significant depressive symptoms in an epidemiologic sample of community-dwelling elders with milder forms of cognitive impairment in Hong Kong SAR. Int J Geriatr Psychiatry, 2010, 23(6): 611-617.
32. Rosenberg PB, Mielke MM, Appleby BS, et al. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry, 2013, 21(7): 685-695.
33. 李杭霏, 蘇向妮, 徐莎莎, 等. 社區認知障礙老年人生活質量調查及影響因素分析. 護理學報, 2016, 23(4): 41-43.
34. 史亞楠, 方柳絮, 孫秋華. 抑郁對老年輕度認知障礙病人生活質量的影響. 護理研究, 2017, 31(33): 4288-4291.

Chinese Journal of Evidence-Based Medicine

Efficacy of multimodal nonpharmacological interventions in mild cognitive impairment: a meta-analysis

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