Prevalence of mycoplasma pneumonia in pediatric outpatient department of Shanghai Pudong New District Zhoupu Hospital and its relationship with PM 2.5_Chinese Journal of Evidence-Based Medicine

Authors：

FU Peihua ¹ ,  WANG Chaoxin ² , TAN Chunyu ¹

1. Pediatric Department, Shanghai Pudong New District Zhoupu Hospital, Shanghai, 201318, P.R.China;
2. Pediatric Department, the Tenth People's Hospital of Tongji University, Shanghai, 200072, P.R.China;

Corresponding?author：

WANG Chaoxin, Email: supercell002@sina.com

Keywords：

Mycoplasma pneumonia(MP); Epidemic characteristics; Children; Fine particulate matter (PM 2.5)

DOI：

10.7507/1672-2531.201705112

Video：

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ObjectivesTo investigate the prevalence of mycoplasma pneumonia (MP) in the pediatric outpatient department of Shanghai Pudong New District Zhoupu Hospital and its relationship with the concentration of fine particulate matter (PM 2.5) in the air.MethodsPatients with respiratory tract infection, from one month to 15 years old, diagnosed in the pediatric department of Shanghai Pudong New District Zhoupu Hospital from May 2016 to April 2017 were enrolled. Mycoplasma pneumonia antibody was detected by colloidal gold assay, and mycoplasma antibody was detected after 1 week of negative test. PM 2.5 index of the same period was also collected. SAS 9.1.3 software was used for statistical analysis.ResultsA total of 3 862 children were enrolled, of which 947 were positive for MP, with a positive rate of 24.52%. The positive rates of each age group were 10.02% for the one month to one year old group, 23.51% for the 1 to 4 years old group, 31.70% for the 4 to 7 years old group, and 22.81% for the 7 to 15 years old group. The positive rate of each age group had statistically significant difference (χ²=86.120 0, P<0.000 1). The positive rates of spring, summer, autumn, and winter were 25.06%, 20.43%, 19.52 and 33.61%, respectively. The difference was statistically significant (χ²=67.1446, P<0.000 1). Combining the PM 2.5 index in Shanghai Pudong area from May 2016 to April 2017, the positive correlation between PM 2.5 and positive rate of MP was found (r=0.9007, P<0.001).ConclusionsThe positive rate of MP in Shanghai Pudong area is 24.52%, and reach its highest level in the preschool children and in winter. It is positively correlated with the PM 2.5 index as well.

Citation： FU Peihua, WANG Chaoxin, TAN Chunyu. Prevalence of mycoplasma pneumonia in pediatric outpatient department of Shanghai Pudong New District Zhoupu Hospital and its relationship with PM 2.5. Chinese Journal of Evidence-Based Medicine, 2018, 18(2): 130-133. doi: 10.7507/1672-2531.201705112 Copy

1.	許秋艷, 范麗萍, 陶會, 等. 蘇州地區嬰幼兒肺炎支原體肺炎住院患兒流行病學及臨床特點分析. 中國小兒急救醫學, 2017, 24(3): 215-219.
2.	王軍華, 范承武, 劉勝, 等. 桂林市兒童肺炎支原體感染流行特點及與氣候因素相關性研究. 臨床兒科雜志, 2013, 31(11): 1038-1041.
3.	倪慧萍, 季偉, 陳正榮. 氣候因素對于兒童肺炎支原體肺炎的作用研究. 中國醫藥導刊, 2014, 16(11): 1385-1386.
4.	徐迎春. 杭州地區兒童支原體肺炎流行特征與氣象因素的相關分析. 杭州: 浙江大學, 2010.
5.	郭紅波. 蘇州地區兒童急性呼吸道感染病原學與氣候相關性探討. 蘇州: 蘇州大學, 2010.
6.	劉文淵. 醫院就診兒童肺炎支原體感染的流行特征及與氣象因素的相關性研究. 杭州: 浙江大學, 2015.
7.	吳邵芳, 裴立紅, 蘭巖菊, 等. 肺炎與急性蕁麻疹相關性的病例對照研究. 中國循證醫學雜志, 2014, 14(6): 659-661.
8.	Hou W, Xu XJ, Lei YG, et al. The role of the PM 2.5-associated metals in pathogenesis of child mycoplasma pneumoniae infections: a systematic review. Environ Sci Pollut Res, 2016, 23(4): 10604-10614.
9.	Sarnat SE, Winquist A, Schauer JJ, et al. Fine particulate matter components and emergency department visits for cardiovascular and respiratory diseases in the St. Louis, Missouri-Illinois, metropolitan area. Environ Health Perspect, 2015, 123(9): 437-444.
10.	Traversi D, Cervella P, Gilli G. Evaluating the genotoxicity of urban PM 2.5 using PCR-based methods in human lung cells and the salmonella TA98 reverse test. Environ Sci Pollut Res Int, 2015, 22(6): 1279-1289.
11.	胡雨生. 鹽城市 2007–2010 年住院患兒肺炎支原體感染的流行病學特征分析. 蘇州: 蘇州大學, 2012.
12.	Zeng X, Xu X, Zheng X, et al. Heavy metals in PM 2.5 and in blood, and children’s respiratory symptoms and asthma from an e-waste recycling area. Environ Pollut, 2016, 210(11): 346-353.

1. 許秋艷, 范麗萍, 陶會, 等. 蘇州地區嬰幼兒肺炎支原體肺炎住院患兒流行病學及臨床特點分析. 中國小兒急救醫學, 2017, 24(3): 215-219.
2. 王軍華, 范承武, 劉勝, 等. 桂林市兒童肺炎支原體感染流行特點及與氣候因素相關性研究. 臨床兒科雜志, 2013, 31(11): 1038-1041.
3. 倪慧萍, 季偉, 陳正榮. 氣候因素對于兒童肺炎支原體肺炎的作用研究. 中國醫藥導刊, 2014, 16(11): 1385-1386.
4. 徐迎春. 杭州地區兒童支原體肺炎流行特征與氣象因素的相關分析. 杭州: 浙江大學, 2010.
5. 郭紅波. 蘇州地區兒童急性呼吸道感染病原學與氣候相關性探討. 蘇州: 蘇州大學, 2010.
6. 劉文淵. 醫院就診兒童肺炎支原體感染的流行特征及與氣象因素的相關性研究. 杭州: 浙江大學, 2015.
7. 吳邵芳, 裴立紅, 蘭巖菊, 等. 肺炎與急性蕁麻疹相關性的病例對照研究. 中國循證醫學雜志, 2014, 14(6): 659-661.
8. Hou W, Xu XJ, Lei YG, et al. The role of the PM 2.5-associated metals in pathogenesis of child mycoplasma pneumoniae infections: a systematic review. Environ Sci Pollut Res, 2016, 23(4): 10604-10614.
9. Sarnat SE, Winquist A, Schauer JJ, et al. Fine particulate matter components and emergency department visits for cardiovascular and respiratory diseases in the St. Louis, Missouri-Illinois, metropolitan area. Environ Health Perspect, 2015, 123(9): 437-444.
10. Traversi D, Cervella P, Gilli G. Evaluating the genotoxicity of urban PM 2.5 using PCR-based methods in human lung cells and the salmonella TA98 reverse test. Environ Sci Pollut Res Int, 2015, 22(6): 1279-1289.
11. 胡雨生. 鹽城市 2007–2010 年住院患兒肺炎支原體感染的流行病學特征分析. 蘇州: 蘇州大學, 2012.
12. Zeng X, Xu X, Zheng X, et al. Heavy metals in PM 2.5 and in blood, and children’s respiratory symptoms and asthma from an e-waste recycling area. Environ Pollut, 2016, 210(11): 346-353.

Chinese Journal of Evidence-Based Medicine

Prevalence of mycoplasma pneumonia in pediatric outpatient department of Shanghai Pudong New District Zhoupu Hospital and its relationship with PM 2.5

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