Association between periodontal disease and gastric cancer risk: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Binghui ^1,2,3 , MENG Jiming ^1,2,3 , WANG Chaoyang ^1,2,3 , ZHENG Zhongli ^1,2,3 , ZI Hao ^2,3,4 , CHEN Shaohua ^2,3 , ZENG Xiantao ^2,3,5,6,7,8 ,  REN Xuequn ^1,2,3

1. Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
2. Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
3. Center for Evidence-Based Medicine, Henan University, Kaifeng, 475000, P.R.China;
4. Department of Urology, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
5. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China;
6. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan, 430071, P.R.China;
7. Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College, Wuhan University, Wuhan, 430071, P.R.China;
8. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, P.R.China;

Corresponding?author：

REN Xuequn, Email: renxuequn001@163.com

Keywords：

Gastric cancer; Periodontal disease; Periodontitis; Case-control studies; Cohort studies; Meta-analysis

DOI：

10.7507/1672-2531.201703145

Video：

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Objective To systematically review the relationship between periodontal disease and gastric cancer risk. Methods We retrieved PubMed, EMbase, CNKI, WanFang Data, VIP, and CBM databases to collect studies about the correlation between periodontal disease and gastric cancer from inception to January 31^st, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results Five studies were included. The results of meta-analysis showed that there was no significant correlation between periodontal disease and gastric cancer (RR=0.99, 95%CI 0.83 to 1.19, P=0.93). Sensitivity analysis showed good stability. Subgroup analysis showed that the type of study, race and type of effect size have no statistically impact on the outcome, there was no significant correlation between periodontal disease and gastric cancer. Conclusion According to the current evidence, periodontal disease probably is not a risk factor of gastric cancer. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.

Citation： LI Binghui, MENG Jiming, WANG Chaoyang, ZHENG Zhongli, ZI Hao, CHEN Shaohua, ZENG Xiantao, REN Xuequn. Association between periodontal disease and gastric cancer risk: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(10): 1183-1187. doi: 10.7507/1672-2531.201703145 Copy

1.	陳萬青, 鄭榮壽, 張思維, 等. 2012 年中國惡性腫瘤發病和死亡分析. 中國腫瘤, 2016, 25(1): 1-8.0.
2.	張惠珍, 王佩英. 牙周病與幽門螺桿菌相關性的觀察研究. 浙江臨床醫學, 2005, 7(8): 808.0.
3.	Watabe K, Nishi M, Miyake H, et al. Lifestyle and gastric cancer: a case-control study. Oncol Rep, 1998, 5(5): 1191-1194.
4.	Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol, 2008, 9(6): 550-558.
5.	Hujoel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003, 13(5): 312-316.
6.	Arora M, Weuve J, Fall K, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010, 171(2): 253-259.
7.	Wen BW, Tsai CS, Lin CL, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM, 2014, 107(4): 283-290.
8.	曾憲濤, 李勝, 馬鉆, 等. Meta 分析系列之八: Meta 分析的報告規范. 中國循證心血管醫學雜志, 2012, 4(6): 500-503.0.
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10.	文進, 李幼平. Meta 分析中效應尺度指標的選擇. 中國循證醫學雜志, 2007, 7(8): 606-613.0.
11.	羅杰, 冷衛東, 主編. 系統評價/Meta 分析理論與實踐. 第一版. 北京: 軍事醫學科學出版社, 2013: 106-108.
12.	Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
13.	Linden GJ, Herzberg MC. Periodontitis and systemic diseases: a record of discussions of working group 4 of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol, 2013, 40(S14): 20-23.
14.	劉文斌, 曹廣文. 癌癥進化發育學: 基于炎-癌轉化研究的新學說. 中國腫瘤生物治療雜志, 2017, 24(2): 103-111.0.
15.	Adler I, Muino A, Aguas S, et al. Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol, 2014, 20(29): 9922-9935.
16.	Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol, 2006, 12(1): 17-20.
17.	田文靜, 王濱有, 張建中, 等. 中國幽門螺桿菌感染與胃癌關系的 Meta 分析. 中國循證醫學雜志, 2006, 6(11): 833-838.0.
18.	Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci, 2005, 96(1): 1-6.
19.	鮑萍萍, 陶夢華, 劉大可, 等. 吸煙、飲酒與胃癌關系的病例對照研究. 腫瘤, 2001, 21(5): 334-338.0.
20.	Duell EJ, Travier N, Lujan-Barroso L, et al. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 2011, 94(5): 1266-1275.
21.	Krajden S, Fuksa M, Anderson J, et al. Examination of human stomach biopsies, saliva, and dental plaque for campylobacter pylori. J Clin Microbiol, 1989, 27(6): 1397-1398.
22.	張和平, 曹紅勇, 袁愛華. 抗炎癥治療胃癌的原理和進展. 現代醫學, 2013, 41(8): 605-609.0.

1. 陳萬青, 鄭榮壽, 張思維, 等. 2012 年中國惡性腫瘤發病和死亡分析. 中國腫瘤, 2016, 25(1): 1-8.0.
2. 張惠珍, 王佩英. 牙周病與幽門螺桿菌相關性的觀察研究. 浙江臨床醫學, 2005, 7(8): 808.0.
3. Watabe K, Nishi M, Miyake H, et al. Lifestyle and gastric cancer: a case-control study. Oncol Rep, 1998, 5(5): 1191-1194.
4. Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol, 2008, 9(6): 550-558.
5. Hujoel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003, 13(5): 312-316.
6. Arora M, Weuve J, Fall K, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010, 171(2): 253-259.
7. Wen BW, Tsai CS, Lin CL, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM, 2014, 107(4): 283-290.
8. 曾憲濤, 李勝, 馬鉆, 等. Meta 分析系列之八: Meta 分析的報告規范. 中國循證心血管醫學雜志, 2012, 4(6): 500-503.0.
9. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
10. 文進, 李幼平. Meta 分析中效應尺度指標的選擇. 中國循證醫學雜志, 2007, 7(8): 606-613.0.
11. 羅杰, 冷衛東, 主編. 系統評價/Meta 分析理論與實踐. 第一版. 北京: 軍事醫學科學出版社, 2013: 106-108.
12. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
13. Linden GJ, Herzberg MC. Periodontitis and systemic diseases: a record of discussions of working group 4 of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol, 2013, 40(S14): 20-23.
14. 劉文斌, 曹廣文. 癌癥進化發育學: 基于炎-癌轉化研究的新學說. 中國腫瘤生物治療雜志, 2017, 24(2): 103-111.0.
15. Adler I, Muino A, Aguas S, et al. Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol, 2014, 20(29): 9922-9935.
16. Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol, 2006, 12(1): 17-20.
17. 田文靜, 王濱有, 張建中, 等. 中國幽門螺桿菌感染與胃癌關系的 Meta 分析. 中國循證醫學雜志, 2006, 6(11): 833-838.0.
18. Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci, 2005, 96(1): 1-6.
19. 鮑萍萍, 陶夢華, 劉大可, 等. 吸煙、飲酒與胃癌關系的病例對照研究. 腫瘤, 2001, 21(5): 334-338.0.
20. Duell EJ, Travier N, Lujan-Barroso L, et al. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 2011, 94(5): 1266-1275.
21. Krajden S, Fuksa M, Anderson J, et al. Examination of human stomach biopsies, saliva, and dental plaque for campylobacter pylori. J Clin Microbiol, 1989, 27(6): 1397-1398.
22. 張和平, 曹紅勇, 袁愛華. 抗炎癥治療胃癌的原理和進展. 現代醫學, 2013, 41(8): 605-609.0.

Chinese Journal of Evidence-Based Medicine

Association between periodontal disease and gastric cancer risk: a meta-analysis

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