Correlation between plasma fibrinogen level and renal cell carcinoma risk: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

XU Yunyun ¹ , ZHAI Zhenxing ² ,  LI Guixiang ¹

1. Department of Gamma Knife Treatment, Lanzhou University Second Hospital, Lanzhou, 730030, P.R.China;
2. Institute of Urology, Lanzhou University Second Hospital, Lanzhou, 730030, P.R.China;

Corresponding?author：

LI Guixiang, Email: lgx.doctor007@163.com

Keywords：

Plasma fibrinogen; Renal cell carcinoma; Meta-analysis; Cohort study

DOI：

10.7507/1672-2531.201606076

Video：

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Objective To systematically review the prognostic and clinicopathological value of plasma fibrinogen in renal cell carcinoma (RCC). Methods An electronic search of the PubMed, EMbase, The Cochrane Library (Issue 5, 2016), CNKI, CBM and WanFang Data databases was performed to collect cohort studies about the prognostic value of plasma fibrinogen in RCC from inception to May 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using RevMan 5.3 software. Results A total of 3 744 RCC patients from 7 cohort studies were included. The results of meta-analysis showed that the lower plasma fibrinogen expression group was superior to the higher expression group in overall survival (HR=2.13, 95%CI 1.74 to 2.61,P<0.00 001) and cancer-specific survival (HR=3.12, 95%CI 2.19 to 4.44,P<0.00 001). Subgroup analysis showed that plasma fibrinogen expression was higher in stage Ⅲ to Ⅳ than stage ⅠtoⅡ (OR=0.27, 95%CI 0.13 to 0.55,P=0.000 3) and was higher in Fuhrman grading G3+G4 than grading G1+G2 (OR=0.49, 95%CI 0.40 to 0.59,P<0.000 01). However, the level of plasma fibrinogen was not found to be associated with gender (OR=0.85, 95%CI 0.69 to 1.05,P=0.14). Conclusion Current evidence shows plasma fibrinogen expression is associated with the prognostic and clinicopathological value of RCC. Due to limited quantity and quality of included studies, the above conclusions are still needed to be verified by more high quality studies.

Citation： XU Yunyun, ZHAI Zhenxing, LI Guixiang. Correlation between plasma fibrinogen level and renal cell carcinoma risk: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(5): 529-535. doi: 10.7507/1672-2531.201606076 Copy

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3.	Custodio S, Joaquim A, Peixoto V, et al. Metastatic renal cell carcinoma: the importance of immunohistochemistry in differential diagnosis. Case Rep Oncol, 2012, 5(1): 30-34.
4.	Eisengart LJ, MacVicar GR, Yang XJ. Predictors of response to targeted therapy in renal cell carcinoma. Arch Pathol Lab Med, 2012, 136(5): 490-495.
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6.	Mei Y, Zhao S, Lu X, et al. Clinical and Prognostic Significance of Preoperative Plasma Fibrinogen Levels in Patients with Operable Breast Cancer. PLoS One, 2016, 11(1): e0146233.
7.	Troppan KT, Melchardt T, Wenzl K, et al. The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma. J Clin Pathol, 2016, 69(4): 326-330.
8.	Zhu LR, Li J, Chen P, et al. Clinical significance of plasma fibrinogen and D-dimer in predicting the chemotherapy efficacy and prognosis for small cell lung cancer patients. Clin Transl Oncol, 2016, 18(2): 178-188.
9.	Zhang D, Zhou X, Bao W, et al. Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma. Oncotarget, 2015, 6(35): 38410-38420.
10.	Du J, Zheng JH, Chen XS, et al. High preoperative plasma fibrinogen is an independent predictor of distant metastasis and poor prognosis in renal cell carcinoma. Int J Clin Oncol, 2013, 18(3): 517-523.
11.	Pichler M, Hutterer GC, Stojakovic T, et al. High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients. Br J Cancer, 2013, 109(5): 1123-1129.
12.	Erdem S, Amasyali AS, Aytac O, et al. Increased preoperative levels of plasma fibrinogen and D dimer in patients with renal cell carcinoma is associated with poor survival and adverse tumor characteristics. Urol Oncol, 2014, 32(7): 1031-1040.
13.	Niedworok C, Dorrenhaus B, Vom Dorp F, et al. Renal cell carcinoma and tumour thrombus in the inferior vena cava: clinical outcome of 98 consecutive patients and the prognostic value of preoperative parameters. World J Urol, 2015, 33(10): 1541-1552.
14.	Sasaki T, Onishi T. Pretherapeutic Plasma Fibrinogen Level is an Independent Survival Predictor in Renal Cell Carcinoma. Oncol Res Treat, 2015, 38(7-8): 374-378.
15.	Obata J, Tanaka N, Mizuno R, et al. Plasma fibrinogen level: An independent prognostic factor for disease-free survival and cancer-specific survival in patients with localized renal cell carcinoma. BJU Int, 2016, 118(4):598-603.
16.	Lee H, Lee SE, Byun SS, et al. Preoperative Plasma Fibrinogen Level as a Significant Prognostic Factor in Patients With Localized Renal Cell Carcinoma After Surgical Treatment. Medicine (Baltimore), 2016, 95(4): e2626.
17.	Lip GY, Chin BS, Blann AD. Cancer and the prothrombotic state. Lancet Oncol, 2002, 3(1): 27-34.
18.	Son HJ, Park JW, Chang HJ, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol, 2013, 20(9): 2908-2913.
19.	Simpson-Haidaris PJ, Rybarczyk B. Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein. Ann N Y Acad Sci, 2001, 936: 406-425.
20.	Sahni A, Francis CW. Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Blood, 2000, 96(12): 3772-3778.
21.	Sahni A, Simpson-Haidaris PJ, Sahni SK, et al. Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J Thromb Haemost, 2008, 6(1): 176-183.
22.	Witsch E, Sela M, Yarden Y. Roles for growth factors in cancer progression. Physiology (Bethesda), 2010, 25(2): 85-101.
23.	Zheng S, Shen J, Jiao Y, et al. Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity. Cancer Sci, 2009, 100(5): 859-865.
24.	Shu YJ, Weng H, Bao RF, et al. Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study. BMC Cancer, 2014, 566(14): 1-12.
25.	Tsimafeyeu IV, Demidov LV, Madzhuga AV, et al. Hypercoagulability as a prognostic factor for survival in patients with metastatic renal cell carcinoma. J Exp Clin Cancer Res, 2009, 30(28): 1-8.
26.	王燕, 趙玉玲, 曾紅春, 等. 超聲造影對腎臟良惡性腫瘤診斷價值的 Meta 分析. 中國循證醫學雜志, 2014, 14(10): 1206-1209.

1. ?Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
2. 田躍軍, 郭琦, 陳朝暉, 等. 缺氧誘導因子-1α 蛋白表達與腎細胞癌風險相關性的 Meta 分析. 中國循證醫學雜志, 2015, 15(9): 1035-1041.
3. Custodio S, Joaquim A, Peixoto V, et al. Metastatic renal cell carcinoma: the importance of immunohistochemistry in differential diagnosis. Case Rep Oncol, 2012, 5(1): 30-34.
4. Eisengart LJ, MacVicar GR, Yang XJ. Predictors of response to targeted therapy in renal cell carcinoma. Arch Pathol Lab Med, 2012, 136(5): 490-495.
5. Palumbo JS, Degen JL. Mechanisms coupling the hemostatic system to colitis-associated cancer. Thromb Res, 2010, 125(Suppl 2): S39-43.
6. Mei Y, Zhao S, Lu X, et al. Clinical and Prognostic Significance of Preoperative Plasma Fibrinogen Levels in Patients with Operable Breast Cancer. PLoS One, 2016, 11(1): e0146233.
7. Troppan KT, Melchardt T, Wenzl K, et al. The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma. J Clin Pathol, 2016, 69(4): 326-330.
8. Zhu LR, Li J, Chen P, et al. Clinical significance of plasma fibrinogen and D-dimer in predicting the chemotherapy efficacy and prognosis for small cell lung cancer patients. Clin Transl Oncol, 2016, 18(2): 178-188.
9. Zhang D, Zhou X, Bao W, et al. Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma. Oncotarget, 2015, 6(35): 38410-38420.
10. Du J, Zheng JH, Chen XS, et al. High preoperative plasma fibrinogen is an independent predictor of distant metastasis and poor prognosis in renal cell carcinoma. Int J Clin Oncol, 2013, 18(3): 517-523.
11. Pichler M, Hutterer GC, Stojakovic T, et al. High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients. Br J Cancer, 2013, 109(5): 1123-1129.
12. Erdem S, Amasyali AS, Aytac O, et al. Increased preoperative levels of plasma fibrinogen and D dimer in patients with renal cell carcinoma is associated with poor survival and adverse tumor characteristics. Urol Oncol, 2014, 32(7): 1031-1040.
13. Niedworok C, Dorrenhaus B, Vom Dorp F, et al. Renal cell carcinoma and tumour thrombus in the inferior vena cava: clinical outcome of 98 consecutive patients and the prognostic value of preoperative parameters. World J Urol, 2015, 33(10): 1541-1552.
14. Sasaki T, Onishi T. Pretherapeutic Plasma Fibrinogen Level is an Independent Survival Predictor in Renal Cell Carcinoma. Oncol Res Treat, 2015, 38(7-8): 374-378.
15. Obata J, Tanaka N, Mizuno R, et al. Plasma fibrinogen level: An independent prognostic factor for disease-free survival and cancer-specific survival in patients with localized renal cell carcinoma. BJU Int, 2016, 118(4):598-603.
16. Lee H, Lee SE, Byun SS, et al. Preoperative Plasma Fibrinogen Level as a Significant Prognostic Factor in Patients With Localized Renal Cell Carcinoma After Surgical Treatment. Medicine (Baltimore), 2016, 95(4): e2626.
17. Lip GY, Chin BS, Blann AD. Cancer and the prothrombotic state. Lancet Oncol, 2002, 3(1): 27-34.
18. Son HJ, Park JW, Chang HJ, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol, 2013, 20(9): 2908-2913.
19. Simpson-Haidaris PJ, Rybarczyk B. Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein. Ann N Y Acad Sci, 2001, 936: 406-425.
20. Sahni A, Francis CW. Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Blood, 2000, 96(12): 3772-3778.
21. Sahni A, Simpson-Haidaris PJ, Sahni SK, et al. Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J Thromb Haemost, 2008, 6(1): 176-183.
22. Witsch E, Sela M, Yarden Y. Roles for growth factors in cancer progression. Physiology (Bethesda), 2010, 25(2): 85-101.
23. Zheng S, Shen J, Jiao Y, et al. Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity. Cancer Sci, 2009, 100(5): 859-865.
24. Shu YJ, Weng H, Bao RF, et al. Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study. BMC Cancer, 2014, 566(14): 1-12.
25. Tsimafeyeu IV, Demidov LV, Madzhuga AV, et al. Hypercoagulability as a prognostic factor for survival in patients with metastatic renal cell carcinoma. J Exp Clin Cancer Res, 2009, 30(28): 1-8.
26. 王燕, 趙玉玲, 曾紅春, 等. 超聲造影對腎臟良惡性腫瘤診斷價值的 Meta 分析. 中國循證醫學雜志, 2014, 14(10): 1206-1209.

Chinese Journal of Evidence-Based Medicine

Correlation between plasma fibrinogen level and renal cell carcinoma risk: a meta-analysis

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