Association of Arterial Stiffness with Cardiovascular Risk Factors: the Northern Shanghai Study_Chinese Journal of Evidence-Based Medicine

Authors：

 XUJin , QINYan-li , WANGKai , LVYu-yan , XIONGJing , BAIBin , YUShi-kai , ZHOUYi-wu , CHIChen ,  ZHANGYi , XUYa-wei

Department of Cardiology, No. 10 Hospital, Tongji University, Shanghai 200072, China;

Corresponding?author：

ZHANGYi, Email: yizshcn@gmail.com

Keywords：

Elderly; Arteriosclerosis; Cardiovascular risk factors; Pulse wave velocity; Population study

DOI：

10.7507/1672-2531.20160206

Video：

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Objective To investigate the association of arterial stiffness with cardiovascular risk factors. Methods From July 2014 to August 2015, 1 599 participants aged over 65 years old were recruited from 10 communities located in the northern Shanghai. Carotid-femoral pulse wave velocity (cf-PWV) was measured by SphygmoCor device. Cardiovascular risk factors were assessed by questionnaire, anthropometry or conventional biochemical measurements. SPSS 20.0 was applied for data management and statistical analysis. Results Cf-PWV was significantly associated with cardiovascular risk factors (P<0.001). Moreover, with the accumulating cardiovascular risk factors, cf-PWV increased gradually and significantly (P<0.001). The increasing trend remained significant in all participants, in men and in women, respectively. Conclusion Arterial stiffness is significantly associated with cardiovascular risk factors and their accumulation.

Citation： XUJin, QINYan-li, WANGKai, LVYu-yan, XIONGJing, BAIBin, YUShi-kai, ZHOUYi-wu, CHIChen, ZHANGYi, XUYa-wei. Association of Arterial Stiffness with Cardiovascular Risk Factors: the Northern Shanghai Study. Chinese Journal of Evidence-Based Medicine, 2016, 16(12): 1365-1369. doi: 10.7507/1672-2531.20160206 Copy

1.	Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension, 2001, 37(5):1236-1241.
2.	Laurent S, Cockcroft J, Van BL, et al. Expert consensus document on arterial stiffness:methodological issues and clinical applications. Eur Heart J, 2006, 27(21):2588-2605.
3.	Tanaka H, Munakata M, Kawano Y, et al. Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness. J Hypertens, 2009, 27(10):2022-2027.
4.	王宏宇. 血管病變早期評價技術系統的臨床應用. 心血管病學進展, 2009, 30(2):194-196.
5.	Mitchell GF, Hwang SJ, Vasan RS, et al. Arteral stiffness and cardiovascular events:the Framingham Heart Study. Circulation, 2010, 122(19):505-511.
6.	Terai M, Ohishi M, Ito N, et al. Comparison of arterial functional evaluations as a predictor of cardiovascular events in hypertensive patients:the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study. Hypertens Res, 2008, 31(6):1135-1145.
7.	李玲, 金曉峰, 徐瑞燚, 等. 脈搏波傳導速度與冠狀動脈介入治療患者的臨床預后關系. 中國循環雜志, 2009, 24(1):17-19.
8.	Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the Management of arterial hypertension:the Task Force for the management of arterial Hypertension of the European Society of Hypertension(ESH)and of the European Society of Cardiology (ESC). J Hypertens, 2013, 31(7):1281-1357.
9.	朱淑賢, 錢菊英, 葛均波, 等. 大動脈僵硬度與冠心病相關性研究. 中華老年醫學雜志, 2007, 26(1):9-12.
10.	Scuteri A, Orru M, Morrell CH, et al. Associations of large artery structure and function with adiposity:effects of age, gender, and hypertension:the SardiNIA study. Atherosclerosis, 2012, 221(1):189-197.
11.	Liu XN, Gao HQ, Li BY, et al. Pulse wave velocity as a marker of arteriosclerosis and its comorbiditier in Chinese patients. Hypertens Res, 2007, 30(3):237-242.
12.	李小玲, 李穎, 王瑞濤. 不同水平的低密度脂蛋白膽固醇人群踝肱脈搏波傳導速度的研究. 中西醫結合心腦血管病雜志, 2012, 10(5):532-534.
13.	Khoshdel AR, Thakkinstian, Carney SL, et al. Estimation of an age-specific reference interval for pulse wave velocity:a meta-analysis. J Hypertens, 2006, 24(7):1231-1237.
14.	Dengo AL, Dennis EA, Orr JS, et al. Arterial destiffening with weight loss in overweight and obese middle-aged and older adults. Hypertension, 2010, 55(4):855-861.
15.	張明華, 葉平, 駱雷鳴, 等. 健康人不同部位脈搏波傳導速度、反射波增強指數之間的相關性及影響因素. 中華心血管病雜志, 2010, 38(11):998-1005.
16.	譚靜, 華琦, 聞靜, 等. 高血壓病患者脈搏波速度與心血管疾病危險因素. 中華高血壓雜志, 2007, 15(10):807-811.
17.	Wilkinson IB, Prasad K, Hall IR, et al. Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol, 2002, 39(6):1005-1011.
18.	張曉東, 李易, 李健美, 等. 臂踝脈搏波傳播速度與急性冠脈綜合征患者冠脈病變的關系研究. 中國臨床新醫學, 2008, 1(S1):31-33.
19.	Kim JW, Park CG, Hong SJ, et al. Acute and chronic effects of cigarette smoking on arterial stiffness. Blood Press, 2005, 14(2):80-85.
20.	趙桂琴, 布艾加爾·哈斯木. 吸煙對老年人脈搏波傳導速度、頸動脈內中膜厚度以及踝臂指數影響的研究. 實用臨床醫藥雜志, 2012, 16(13):13-15.
21.	陳桂英, 郭來敬, 廖燕華, 等. 吸煙與脈搏波傳導速度、踝臂指數以及頸動脈硬化改變的相關性研究. 現代中西醫結合雜志, 2013, 22(35):3883-3885.
22.	Rehill N, Beck CR, Yeo KR, et al. The effect of chronic tobacco smoking on arterial stiffness. Brit J Clin Pharmaco, 2006, 61(6):767-773.

1. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension, 2001, 37(5):1236-1241.
2. Laurent S, Cockcroft J, Van BL, et al. Expert consensus document on arterial stiffness:methodological issues and clinical applications. Eur Heart J, 2006, 27(21):2588-2605.
3. Tanaka H, Munakata M, Kawano Y, et al. Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness. J Hypertens, 2009, 27(10):2022-2027.
4. 王宏宇. 血管病變早期評價技術系統的臨床應用. 心血管病學進展, 2009, 30(2):194-196.
5. Mitchell GF, Hwang SJ, Vasan RS, et al. Arteral stiffness and cardiovascular events:the Framingham Heart Study. Circulation, 2010, 122(19):505-511.
6. Terai M, Ohishi M, Ito N, et al. Comparison of arterial functional evaluations as a predictor of cardiovascular events in hypertensive patients:the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study. Hypertens Res, 2008, 31(6):1135-1145.
7. 李玲, 金曉峰, 徐瑞燚, 等. 脈搏波傳導速度與冠狀動脈介入治療患者的臨床預后關系. 中國循環雜志, 2009, 24(1):17-19.
8. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the Management of arterial hypertension:the Task Force for the management of arterial Hypertension of the European Society of Hypertension(ESH)and of the European Society of Cardiology (ESC). J Hypertens, 2013, 31(7):1281-1357.
9. 朱淑賢, 錢菊英, 葛均波, 等. 大動脈僵硬度與冠心病相關性研究. 中華老年醫學雜志, 2007, 26(1):9-12.
10. Scuteri A, Orru M, Morrell CH, et al. Associations of large artery structure and function with adiposity:effects of age, gender, and hypertension:the SardiNIA study. Atherosclerosis, 2012, 221(1):189-197.
11. Liu XN, Gao HQ, Li BY, et al. Pulse wave velocity as a marker of arteriosclerosis and its comorbiditier in Chinese patients. Hypertens Res, 2007, 30(3):237-242.
12. 李小玲, 李穎, 王瑞濤. 不同水平的低密度脂蛋白膽固醇人群踝肱脈搏波傳導速度的研究. 中西醫結合心腦血管病雜志, 2012, 10(5):532-534.
13. Khoshdel AR, Thakkinstian, Carney SL, et al. Estimation of an age-specific reference interval for pulse wave velocity:a meta-analysis. J Hypertens, 2006, 24(7):1231-1237.
14. Dengo AL, Dennis EA, Orr JS, et al. Arterial destiffening with weight loss in overweight and obese middle-aged and older adults. Hypertension, 2010, 55(4):855-861.
15. 張明華, 葉平, 駱雷鳴, 等. 健康人不同部位脈搏波傳導速度、反射波增強指數之間的相關性及影響因素. 中華心血管病雜志, 2010, 38(11):998-1005.
16. 譚靜, 華琦, 聞靜, 等. 高血壓病患者脈搏波速度與心血管疾病危險因素. 中華高血壓雜志, 2007, 15(10):807-811.
17. Wilkinson IB, Prasad K, Hall IR, et al. Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol, 2002, 39(6):1005-1011.
18. 張曉東, 李易, 李健美, 等. 臂踝脈搏波傳播速度與急性冠脈綜合征患者冠脈病變的關系研究. 中國臨床新醫學, 2008, 1(S1):31-33.
19. Kim JW, Park CG, Hong SJ, et al. Acute and chronic effects of cigarette smoking on arterial stiffness. Blood Press, 2005, 14(2):80-85.
20. 趙桂琴, 布艾加爾·哈斯木. 吸煙對老年人脈搏波傳導速度、頸動脈內中膜厚度以及踝臂指數影響的研究. 實用臨床醫藥雜志, 2012, 16(13):13-15.
21. 陳桂英, 郭來敬, 廖燕華, 等. 吸煙與脈搏波傳導速度、踝臂指數以及頸動脈硬化改變的相關性研究. 現代中西醫結合雜志, 2013, 22(35):3883-3885.
22. Rehill N, Beck CR, Yeo KR, et al. The effect of chronic tobacco smoking on arterial stiffness. Brit J Clin Pharmaco, 2006, 61(6):767-773.

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