Correlation between Metabolic Syndrome and Arterial Stiffness in Elderly People: A Population-based Study in Communities of Northern Shanghai_Chinese Journal of Evidence-Based Medicine

Authors：

 QINYan-li , WANGKai , LVYu-yan , XIONGJing , BAIBin , YUShi-kai , ZHOUYi-wu , CHIChen ,  ZHANGYi , XUYa-wei

Department of Cardiology, No. 10 Hospital, Tongji University, Shanghai 200072, China;

Corresponding?author：

ZHANGYi, Email: yizshcn@gmail.com

Keywords：

Elderly; Arteriosclerosis; Metabolic syndrome; Pulse wave velocity; Population study

DOI：

10.7507/1672-2531.20160172

Video：

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Objective To investigate the association between metabolic syndrome and arterial stiffness in elderly people. Methods 1 599 participants aged over 65 years old were recruited from 10 communities located in the northern Shanghai. Carotid-femoral pulse wave velocity (cf-PWV) of each participant was measured by SphygmoCor device. Measurements for the diagnosis of metabolic syndrome were all investigated for each participant. SPSS 20.0 was used for data management and statistical analysis. Results Cf-PWV was significantly associated with metabolic syndrome and its diagnostic measurements (P<0.001). Moreover, with the accumulating diagnostic measurements, cf-PWV increased gradually and significantly. The increasing trend remained significant in all participants, in men and in women (P<0.001). Conclusion Arterial stiffness is significantly associated with metabolic syndrome and the accumulation of its diagnostic measurements.

Citation： QINYan-li, WANGKai, LVYu-yan, XIONGJing, BAIBin, YUShi-kai, ZHOUYi-wu, CHIChen, ZHANGYi, XUYa-wei. Correlation between Metabolic Syndrome and Arterial Stiffness in Elderly People: A Population-based Study in Communities of Northern Shanghai. Chinese Journal of Evidence-Based Medicine, 2016, 16(10): 1127-1130. doi: 10.7507/1672-2531.20160172 Copy

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14.	陳民, 李玉曉, 李莉, 等. 中年代謝綜合征?糖尿病及糖尿病合并冠心病脈搏波傳導速度?踝肱指數對比分析. 中國醫藥指南, 2012, 10(10): 98-100.
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16.	Antonino Tuttolomondo, Domenico Di Raimondo, Riccardo Di Sciacca, et al. Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome. Atherosclerosis, 2012, 225: 216-219.
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18.	Shin JY, Lee HR, Lee DC. Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes. Cardiovasc Diabetol, 2011, 10: 1-5.
19.	Kawamoto R, Tabara Y, Kusunoki T, et al. A slightly high-normal glucose level is associated with increased arterial stiffness in Japanese community-dwelling persons with pre-diabetes. Vasc Med, 2013, 18(5): 251-256.
20.	張艷芬, 佟偉軍, 劉洋, 等. 代謝綜合征與心腦血管病及死亡前瞻性隊列研究. 中國公共衛生, 2013, 29(10): 1405-1409.
21.	王宏宇, 龔蘭生, 張維中. 脈搏波傳導速度測定的新認識. 國外醫學-心血管疾病分冊, 2000, 27(2): 70-72.

1. 王浩, 楊文. 老年代謝綜合征患病情況及特點. 實用老年醫學, 2003, 17(3): 142-149.
2. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care, 2001, 24(4): 683-689.
3. McNeill AM, Rosamond WD, Girman CJ, et al. The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study. Diabetes Care, 2005, 28(2): 385-390.
4. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension, 2001, 37(5): 1236-1241.
5. 謝曉亮, 李覺, 胡大一. 脈搏波傳導速度測定方法及臨床意義. 中國心血管病研究雜志, 2007, 5(6): 465-468.
6. Mancia G, Laurent S, Agabiti-Rosei E, et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens, 2009, 27(11): 2121-2158.
7. Greenland P, Alpert J S, Beller G A, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol, 2010, 56(25): e50-e103.
8. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values'. Eur Heart J, 2010, 31(19): 2338-2350.
9. Laurent S, Cockcroft J, van BorteI L, et al. Expert consensus document on arterial stiffness methodological issues and clinical applications. Eur Heart J, 2006, 27(21): 2588-2605.
10. 唐世凡, 王朝暉, 董曉雁, 等. 代謝綜合癥與臂踝脈搏波速度的關系. 中國全科醫學, 2015, 18(17): 2005-2009.
11. 劉淼, 何耀, 姜斌, 等. 北京某社區老年人群肱踝脈搏波傳導速度與代謝綜合癥的現狀研究. 北京大學學報(醫學版), 2014, 46(3): 429-434.
12. 李建軍. 代謝綜合癥組分數與肱踝脈搏波傳導速度的相關性研究. 中國糖尿病雜志, 2014, 22(9): 793-795.
13. 曾莎, 張蘊, 孫寧. 老年代謝綜合征及其組成成分與脈搏波傳導速度關系. 天津醫科大學學報, 2012, 18(3): 356-362.
14. 陳民, 李玉曉, 李莉, 等. 中年代謝綜合征?糖尿病及糖尿病合并冠心病脈搏波傳導速度?踝肱指數對比分析. 中國醫藥指南, 2012, 10(10): 98-100.
15. 郭遠, 寶輝, 李衛, 等. 代謝綜合征對老年糖尿病患者動脈僵硬度的影響. 中華老年心腦血管病雜志, 2011, 13(12): 1070-1072.
16. Antonino Tuttolomondo, Domenico Di Raimondo, Riccardo Di Sciacca, et al. Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome. Atherosclerosis, 2012, 225: 216-219.
17. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness Systematic Review and Meta-Analysis. J Am Coll Cardiol, 2010, 55(13): 1318-1327.
18. Shin JY, Lee HR, Lee DC. Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes. Cardiovasc Diabetol, 2011, 10: 1-5.
19. Kawamoto R, Tabara Y, Kusunoki T, et al. A slightly high-normal glucose level is associated with increased arterial stiffness in Japanese community-dwelling persons with pre-diabetes. Vasc Med, 2013, 18(5): 251-256.
20. 張艷芬, 佟偉軍, 劉洋, 等. 代謝綜合征與心腦血管病及死亡前瞻性隊列研究. 中國公共衛生, 2013, 29(10): 1405-1409.
21. 王宏宇, 龔蘭生, 張維中. 脈搏波傳導速度測定的新認識. 國外醫學-心血管疾病分冊, 2000, 27(2): 70-72.

Chinese Journal of Evidence-Based Medicine

Correlation between Metabolic Syndrome and Arterial Stiffness in Elderly People: A Population-based Study in Communities of Northern Shanghai

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