Association of Colonic Adenomatous Polyps and Helicobacter Pylori Infection: A Case-control Study_Chinese Journal of Evidence-Based Medicine

Authors：

 TANGBin , ZHANGJun , TANGYou-pan , LIYue-ping , LEICong-shan , JIANGBo , SHUOu

Department of Gastroenterology, People's Hospital of Zhongjiang County, Zhongjiang 618100, China;

Corresponding?author：

Keywords：

Helicobacter pylori; Colon; Adenomatous polyps; Case-control study

DOI：

10.7507/1672-2531.20160080

Video：

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Objective To investigate the relation between colonic adenomatous polyps and Helicobacter pylori infection. Methods A case-control study was conducted to collect clinical data of patients with colonic adenomatous polyps in People's Hospital of Zhongjiang County from February 2014 to September 2015. Patients with healthy colon of the corresponding period of the hospital were collected as a control group. The difference of positive rate of Hp infection was compared between the colonic adenomatous polyps group and the control group. According to the age, gender, living condition, location, type of pedicle, pathological type and number, the colonic adenomatous polyps group was divided into subgroups and the differences of positive rate of Hp infection were compared among the subgroups. Results A total of 219 patients involving 119 cases and 100 controls were included. The positive rate of Hp infection in the colonic adenomatous polyps group was significantly higher than that in the control group (69.7% vs. 52.0%) with a significant difference (χ²=7.239, P=0.007). Among 119 patients with colonic adenomatous polyps, no statistical differences were found in the positive rate of Hp infection among subgroups of different age, gender, living condition, location, type of pedicle, pathological type and number (all P values>0.05). Conclusion Hp infection may increase the risk of developing colonic adenomatous polyps.

Citation： TANGBin, ZHANGJun, TANGYou-pan, LIYue-ping, LEICong-shan, JIANGBo, SHUOu. Association of Colonic Adenomatous Polyps and Helicobacter Pylori Infection: A Case-control Study. Chinese Journal of Evidence-Based Medicine, 2016, 16(5): 513-516. doi: 10.7507/1672-2531.20160080 Copy

1.	Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection——the Maastricht IV/Florence Consensus Report. Gut, 2012, 61(5): 646-664.
2.	Rokkas T, Sechopoulos P, Pistiolas D, et al. The relationship of Helicobacter pylori infection and colon neoplasia, on the basis of meta-analysis. Eur J Gastroenterol Hepatol, 2013, 25(11): 1286-1294.
3.	Zuniga R, Bautista J, Sapra K, et al. Combination of Triple Therapy and Chronic PPI Use May Decrease Risk of Colonic Adenomatous Polyps in Helicobacter pylori Infection. Gastroenterol Res Pract, 2015(Epub 2015 May 12).
4.	Abbass K, Gul W, Beck G, et al. Association of Helicobacter pylori infection with the development of colorectal polyps and colorectal carcinoma. South Med J, 2011, 104(7): 473-476.
5.	Robertson DJ, Sandler RS, Ahnen DJ, et al. Gastrin, Helicobacter pylori, and colorectal adenomas. Clin Gastroenterol Hepatol, 2009, 7(2): 163-167.
6.	孫自勤, 劉曉峰. 腸道病學. 濟南: 山東科學技術出版社, 2005: 1126.
7.	中華醫學會消化病學分會幽門螺桿菌學組. 第四次全國幽門螺桿菌感染處理共識報告. 中華內科雜志, 2012, 51(10): 832-837.
8.	Imperiale TF, Wagner DR, Lin CY, et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med, 2000, 343(3): 169-174.
9.	房靜遠. 中國大腸腫瘤篩查、早診早治和綜合預防共識意見. 胃腸病學和肝病學雜志, 2011, (11): 979-995.
10.	Liou JM, Lin JW, Huang SP, et al. Helicobacter pylori infection is not associated with increased risk of colorectal polyps in Taiwanese. Int J Cancer, 2006, 119(8): 1999-2000.
11.	Oset P, Jasińska A, Szcze?niak P, et al. Analysis of serum gastrin levels in patients with adenomatous polyps of the colon. Pol Merkur Lekarski, 2009, 26(155): 458-461.
12.	Smith AM, Watson SA. Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. Gut, 2000, 47(6): 820-824.
13.	Kim SH, Margalit O, Katoh H, et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs, 2014, 32(6): 1105-1112.
14.	Temraz S, Mukherji D, Shamseddine A, et al. Potential targets for colorectal cancer prevention. Int J Mol Sci, 2013, 14(9): 17279-17303.
15.	Sierra JC, Hobbs S, Chaturvedi R, et al. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol, 2013, 305(2): G196-G203.
16.	鄭榮娟, 胡愛萍, 李海英, 等. 結腸息肉、結腸癌患者HP感染與血漿胃泌素-17及環氧合酶-2的相關性. 天津醫藥, 2012, 40(7): 734-735.
17.	張萬岱, 胡伏蓮, 蕭樹東, 等. 中國自然人群幽門螺桿菌感染的流行病學調查. 現代消化及介入診療, 2010: 15(5): 265-270.
18.	陳鎮, 榮亮, 侯慧, 等. 152例結直腸腫瘤患者幽門螺桿菌感染情況分析. 中華消化雜志, 2014, 34(10): 666-670.
19.	Brim H, Zahaf M, Laiyemo AO, et al. Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer, 2014, 14: 296.
20.	阮玉鳳, 萬霜, 孫璟, 等. 幽門螺桿菌感染與結直腸息肉發生的關系. 國際消化病雜志, 2014, 34(05): 344-347.
21.	張雪梅, 劉麗娜, 馬紅霞, 等. 幽門螺桿菌、高胃泌素血癥對結腸腺瘤形成的作用. 世界華人消化雜志, 2010. 18(13): 1390-1394.

1. Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection——the Maastricht IV/Florence Consensus Report. Gut, 2012, 61(5): 646-664.
2. Rokkas T, Sechopoulos P, Pistiolas D, et al. The relationship of Helicobacter pylori infection and colon neoplasia, on the basis of meta-analysis. Eur J Gastroenterol Hepatol, 2013, 25(11): 1286-1294.
3. Zuniga R, Bautista J, Sapra K, et al. Combination of Triple Therapy and Chronic PPI Use May Decrease Risk of Colonic Adenomatous Polyps in Helicobacter pylori Infection. Gastroenterol Res Pract, 2015(Epub 2015 May 12).
4. Abbass K, Gul W, Beck G, et al. Association of Helicobacter pylori infection with the development of colorectal polyps and colorectal carcinoma. South Med J, 2011, 104(7): 473-476.
5. Robertson DJ, Sandler RS, Ahnen DJ, et al. Gastrin, Helicobacter pylori, and colorectal adenomas. Clin Gastroenterol Hepatol, 2009, 7(2): 163-167.
6. 孫自勤, 劉曉峰. 腸道病學. 濟南: 山東科學技術出版社, 2005: 1126.
7. 中華醫學會消化病學分會幽門螺桿菌學組. 第四次全國幽門螺桿菌感染處理共識報告. 中華內科雜志, 2012, 51(10): 832-837.
8. Imperiale TF, Wagner DR, Lin CY, et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med, 2000, 343(3): 169-174.
9. 房靜遠. 中國大腸腫瘤篩查、早診早治和綜合預防共識意見. 胃腸病學和肝病學雜志, 2011, (11): 979-995.
10. Liou JM, Lin JW, Huang SP, et al. Helicobacter pylori infection is not associated with increased risk of colorectal polyps in Taiwanese. Int J Cancer, 2006, 119(8): 1999-2000.
11. Oset P, Jasińska A, Szcze?niak P, et al. Analysis of serum gastrin levels in patients with adenomatous polyps of the colon. Pol Merkur Lekarski, 2009, 26(155): 458-461.
12. Smith AM, Watson SA. Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. Gut, 2000, 47(6): 820-824.
13. Kim SH, Margalit O, Katoh H, et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs, 2014, 32(6): 1105-1112.
14. Temraz S, Mukherji D, Shamseddine A, et al. Potential targets for colorectal cancer prevention. Int J Mol Sci, 2013, 14(9): 17279-17303.
15. Sierra JC, Hobbs S, Chaturvedi R, et al. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol, 2013, 305(2): G196-G203.
16. 鄭榮娟, 胡愛萍, 李海英, 等. 結腸息肉、結腸癌患者HP感染與血漿胃泌素-17及環氧合酶-2的相關性. 天津醫藥, 2012, 40(7): 734-735.
17. 張萬岱, 胡伏蓮, 蕭樹東, 等. 中國自然人群幽門螺桿菌感染的流行病學調查. 現代消化及介入診療, 2010: 15(5): 265-270.
18. 陳鎮, 榮亮, 侯慧, 等. 152例結直腸腫瘤患者幽門螺桿菌感染情況分析. 中華消化雜志, 2014, 34(10): 666-670.
19. Brim H, Zahaf M, Laiyemo AO, et al. Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer, 2014, 14: 296.
20. 阮玉鳳, 萬霜, 孫璟, 等. 幽門螺桿菌感染與結直腸息肉發生的關系. 國際消化病雜志, 2014, 34(05): 344-347.
21. 張雪梅, 劉麗娜, 馬紅霞, 等. 幽門螺桿菌、高胃泌素血癥對結腸腺瘤形成的作用. 世界華人消化雜志, 2010. 18(13): 1390-1394.

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Chinese Journal of Evidence-Based Medicine

Association of Colonic Adenomatous Polyps and Helicobacter Pylori Infection: A Case-control Study

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