Health-Related Quality of Life for Disease Population in China based on EQ-5D: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHOUTing ¹ , GUANHai-jing ² , GordonG. LIU ^2,3 ,  MAAi-xia ¹

1. School of International Pharmaceutical Business of China Pharmaceutical University, Nanjing 211198, China;
2. Peking University China Center for Health Economic Research, Beijing 100080, China;
3. Peking University National School of Development, PKU China Center for Health Economic Research, Beijing 100871, China;

Corresponding?author：

MAAi-xia, Email: ma86128@sina.com

Keywords：

EQ-5D; Disease population in China; Quality of life; Systematic Review

DOI：

10.7507/1672-2531.20160024

Video：

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Objective To systematically review the health-related quality of life (QOL) based on EQ-5D instrument for disease population in China. Methods We searched databases including PubMed, The Cochrane Library (Issue 5, 2015), EMbase, CNKI, VIP and WanFang Data from inception to August 2015, to identify studies involving healthrelated QOL about different diseases in China. A descriptive analysis was used to analyze health utility by disease and the proportion of patients who having problem in five dimensions, as well as comparing health-related QOL in different diseases. Results A total of 26 studies were included, involving 15 kinds of diseases. The health utility in different studies about the same disease was different. Diabetes ranged from 0.79 to 0.94, liver disease infected by HBV was from 0 to 0.80, hypertension was from 0.78 to 0.93, coronary heart disease was from 0.75 to 0.90, and chronic obstructive pulmonary disease was from 0.64 to 0.73. After ranking the health utility of fifteen kinds of diseases, the utility of kashin-beck disease and rheumatoid arthritis were 0.45 and 0.56, respectively, and the utility of children cerebral palsy was 0.44, which was the lowest. "Pain/discomfort" was the dimension with highest proportion of patients who having problem for most diseases while atrial fibrillation and children cerebral palsy were the "Self-care" and "Usual Activities". Conclusion EQ-5D is widely used in health-related QOL studies among different diseases in China. Many factors including sample source, severity of disease, complication and value set have influence on the measurement results of health utility.

Citation： ZHOUTing, GUANHai-jing, GordonG. LIU, MAAi-xia. Health-Related Quality of Life for Disease Population in China based on EQ-5D: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2016, 16(2): 135-142. doi: 10.7507/1672-2531.20160024 Copy

1.	官海靜, 劉國恩. 中國四地城鄉居民生命質量的比較分析. 中國衛生經濟, 2015, 33(2):5-12.
2.	Rabin R, de Charro F. EQ-5D:a measure of health status from the EuroQol Group. Ann Med, 2001, 33(5):337-343.
3.	Horsman J, Furlong W, Feeny D, et al. The Health Utilities Index (HUI):concepts, measurement properties and applications. Health Qual Life Out, 2003, 1(1):54.
4.	Brazier J, Roberts J, Deverill M. The estimation of a preferencebased measure of health from the SF-36. J Health Econ, 2002, 21(2): 271-292.
5.	Brooks, R. EuroQol:The current state of play. Health Policy, 1996, 37(1), 53-72.
6.	中華人民共和國衛生部. 2013中國衛生統計年鑒. Available at:http://www.nhfpc.gov.cn/htmlfiles/zwgkzt/ptjnj/year2013/index2013.html.
7.	朱銀潮. 2型糖尿病患者口服藥物治療模式和生活質量現狀的研究. 浙江:浙江大學, 2013.
8.	梁敏紅. 北京社區Ⅱ型糖尿病患者生命質量及其影響因素研究. 北京:北京中醫藥大學, 2014.
9.	羅婭珺, 方蕓, 丁選勝. 采用EQ-5D評估2型糖尿病患者的生活質量及影響因素研究. 中國藥物經濟學, 2009, 4(2):12-18.
10.	唐曉梅, 姚美華, 陳國, 平. 農村糖尿病患者生活質量評價研究. 浙江預防醫學, 2015, 27(5):458-461.
11.	韓月蓉, 吳晶, 蔡德鴻, 等. 中國城市口服降糖藥物治療的2型糖尿病患者合并癥與生活質量評價. 中華內分泌代謝雜志, 2013, 29(8):656-659.
12.	Chang K. Comorbidities, quality of life and patients' willingness to pay for a cure for type 2 diabetes in Taiwan. Public Health, 2010, 124(5):284-294.
13.	曹洋, 唐迅, 楊莉, 等. 應用EQ-5D量表對北京房山農村中老年人慢性病患者生命質量及影響因素的研究. 中華流行病學雜志, 2014, 33(1):17-22.
14.	李陽, 董朝暉, 孫利華. 高血壓社區管理對患者生命質量影響的調查分析. 中國藥房, 2014, 25(12):1080-1083.
15.	何敏媚, 范長生, 曾光, 等. 北京市高血壓患者用藥依從性與生命質量相關分析. 中國初級衛生保健, 2013, 27(3):57-58.
16.	熊琴梅, 周瓊瓊, 劉勇, 等. 冠心病患者生活質量現狀及其相關影響因素分析. 臨床心血管病雜志, 2014, 30(1):27-30.
17.	Wang L, Wu Y Q, Tang X, et al. Profile and Correlates of Healthrelated Quality of Life in Chinese Patients with Coronary Heart Disease. Chinese Med J-Peking, 2015, 128(14):1853-1861.
18.	Wu J, Han Y, Xu J, et al. Chronic Stable Angina Is Associated with Lower Health-Related Quality of Life:Evidence from Chinese Patients. PloS One, 2014, 9(5):e97294.
19.	Wu J, Han Y, Zhao FL, et al. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients. Heal Qual Life Out, 2014, 12(1): 156-167.
20.	Wu M, Zhao Q, Chen Y, et al. Quality of life and its association with direct medical costs for COPD in urban China. Heal Qual Life Out, 2015, 13(1):57-62.
21.	Chen J, Wong CKH, McGhee SM, et al. A Comparison between the EQ-5D and the SF-6D in Patients with Chronic Obstructive Pulmonary Disease (COPD). PLoS One, 2014, 9(11):e112389.
22.	Che Y H, You J, Chongsuvivatwong V, et al. Dynamics and liver disease specific aspects of quality of life among patients with chronic liver disease in yunnan, china. Asian Pac J Cancer Prev, 2013, 15(12): 4765-4771.
23.	金輝. 江蘇省乙肝母嬰阻斷相關免疫策略及衛生經濟學評價. 南京:東南大學, 2011.
24.	Gao L, Xia L, Pan SQ, et al. Psychometric properties of Chinese language Liverpool Seizure Severity Scale 2.0 (LSSS 2.0) and status and determinants of seizure severity for patients with epilepsy in China. Epilepsy Behav, 2014, 31(1):187-193.
25.	Zhao F, Yue M, Yang H, et al. Validation and comparison of EuroQol and short form 6D in chronic prostatitis patients. Value in Health, 2010, 13(5):649-656.
26.	Lin JC, Yu JH. Assessment of quality of life among Taiwanese patients with visual impairment. J Formos Med Assoc, 2012, 111(10): 572-579.
27.	崔巍. 河北省腦癱患兒生存質量狀況調查與經濟負擔評價. 吉林: 吉林大學, 2014.
28.	顧杰. 類風濕關節炎疾病效用值測量方法的比較. 上海:復旦大學, 2009.
29.	胡永勤, 王來根, 方杭燕, 等. 歐洲EQ-5D量表用于杭州市余杭區慢性淋巴絲蟲病生命質量調查. 中國農村衛生事業管理, 2012, 32(3):274-276.
30.	Wang KL, Wu CH, Huang CC, et al. Complexity of atrial fibrillation patients and management in Chinese ethnicity in routine daily practice:Insights from the RealiseAF Taiwanese cohort. J Cardiol, 2014, 64(3):211-217.
31.	Shi JF, Kang DJ, Qi SZ, et al. Impact of genital warts on health related quality of life in men and women in mainland China:a multicenter hospital-based cross-sectional study. BMC Public Health, 2012, 12(1):153-161.
32.	Farooq U, Guo X, Chuang LH, et al. Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Qual Life Res, 2011, 20(3):425-429.
33.	Liu GG, Wu H, Li M, et al. Chinese time trade-off values for EQ-5D health states. Value in Health, 2014, 17(5):597-604.
34.	李平, 李澤楷, 鄧愛玲. 腦癱患兒家庭支持的研究進展. 中華護理雜志, 2013, 48(4):365-367.
35.	王權, 李秀霞, 李倫, 等. 硒與大骨節病相關性的Meta分析. 中國循證醫學雜志, 2013, 13(12):1421-1430.

1. 官海靜, 劉國恩. 中國四地城鄉居民生命質量的比較分析. 中國衛生經濟, 2015, 33(2):5-12.
2. Rabin R, de Charro F. EQ-5D:a measure of health status from the EuroQol Group. Ann Med, 2001, 33(5):337-343.
3. Horsman J, Furlong W, Feeny D, et al. The Health Utilities Index (HUI):concepts, measurement properties and applications. Health Qual Life Out, 2003, 1(1):54.
4. Brazier J, Roberts J, Deverill M. The estimation of a preferencebased measure of health from the SF-36. J Health Econ, 2002, 21(2): 271-292.
5. Brooks, R. EuroQol:The current state of play. Health Policy, 1996, 37(1), 53-72.
6. 中華人民共和國衛生部. 2013中國衛生統計年鑒. Available at:http://www.nhfpc.gov.cn/htmlfiles/zwgkzt/ptjnj/year2013/index2013.html.
7. 朱銀潮. 2型糖尿病患者口服藥物治療模式和生活質量現狀的研究. 浙江:浙江大學, 2013.
8. 梁敏紅. 北京社區Ⅱ型糖尿病患者生命質量及其影響因素研究. 北京:北京中醫藥大學, 2014.
9. 羅婭珺, 方蕓, 丁選勝. 采用EQ-5D評估2型糖尿病患者的生活質量及影響因素研究. 中國藥物經濟學, 2009, 4(2):12-18.
10. 唐曉梅, 姚美華, 陳國, 平. 農村糖尿病患者生活質量評價研究. 浙江預防醫學, 2015, 27(5):458-461.
11. 韓月蓉, 吳晶, 蔡德鴻, 等. 中國城市口服降糖藥物治療的2型糖尿病患者合并癥與生活質量評價. 中華內分泌代謝雜志, 2013, 29(8):656-659.
12. Chang K. Comorbidities, quality of life and patients' willingness to pay for a cure for type 2 diabetes in Taiwan. Public Health, 2010, 124(5):284-294.
13. 曹洋, 唐迅, 楊莉, 等. 應用EQ-5D量表對北京房山農村中老年人慢性病患者生命質量及影響因素的研究. 中華流行病學雜志, 2014, 33(1):17-22.
14. 李陽, 董朝暉, 孫利華. 高血壓社區管理對患者生命質量影響的調查分析. 中國藥房, 2014, 25(12):1080-1083.
15. 何敏媚, 范長生, 曾光, 等. 北京市高血壓患者用藥依從性與生命質量相關分析. 中國初級衛生保健, 2013, 27(3):57-58.
16. 熊琴梅, 周瓊瓊, 劉勇, 等. 冠心病患者生活質量現狀及其相關影響因素分析. 臨床心血管病雜志, 2014, 30(1):27-30.
17. Wang L, Wu Y Q, Tang X, et al. Profile and Correlates of Healthrelated Quality of Life in Chinese Patients with Coronary Heart Disease. Chinese Med J-Peking, 2015, 128(14):1853-1861.
18. Wu J, Han Y, Xu J, et al. Chronic Stable Angina Is Associated with Lower Health-Related Quality of Life:Evidence from Chinese Patients. PloS One, 2014, 9(5):e97294.
19. Wu J, Han Y, Zhao FL, et al. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients. Heal Qual Life Out, 2014, 12(1): 156-167.
20. Wu M, Zhao Q, Chen Y, et al. Quality of life and its association with direct medical costs for COPD in urban China. Heal Qual Life Out, 2015, 13(1):57-62.
21. Chen J, Wong CKH, McGhee SM, et al. A Comparison between the EQ-5D and the SF-6D in Patients with Chronic Obstructive Pulmonary Disease (COPD). PLoS One, 2014, 9(11):e112389.
22. Che Y H, You J, Chongsuvivatwong V, et al. Dynamics and liver disease specific aspects of quality of life among patients with chronic liver disease in yunnan, china. Asian Pac J Cancer Prev, 2013, 15(12): 4765-4771.
23. 金輝. 江蘇省乙肝母嬰阻斷相關免疫策略及衛生經濟學評價. 南京:東南大學, 2011.
24. Gao L, Xia L, Pan SQ, et al. Psychometric properties of Chinese language Liverpool Seizure Severity Scale 2.0 (LSSS 2.0) and status and determinants of seizure severity for patients with epilepsy in China. Epilepsy Behav, 2014, 31(1):187-193.
25. Zhao F, Yue M, Yang H, et al. Validation and comparison of EuroQol and short form 6D in chronic prostatitis patients. Value in Health, 2010, 13(5):649-656.
26. Lin JC, Yu JH. Assessment of quality of life among Taiwanese patients with visual impairment. J Formos Med Assoc, 2012, 111(10): 572-579.
27. 崔巍. 河北省腦癱患兒生存質量狀況調查與經濟負擔評價. 吉林: 吉林大學, 2014.
28. 顧杰. 類風濕關節炎疾病效用值測量方法的比較. 上海:復旦大學, 2009.
29. 胡永勤, 王來根, 方杭燕, 等. 歐洲EQ-5D量表用于杭州市余杭區慢性淋巴絲蟲病生命質量調查. 中國農村衛生事業管理, 2012, 32(3):274-276.
30. Wang KL, Wu CH, Huang CC, et al. Complexity of atrial fibrillation patients and management in Chinese ethnicity in routine daily practice:Insights from the RealiseAF Taiwanese cohort. J Cardiol, 2014, 64(3):211-217.
31. Shi JF, Kang DJ, Qi SZ, et al. Impact of genital warts on health related quality of life in men and women in mainland China:a multicenter hospital-based cross-sectional study. BMC Public Health, 2012, 12(1):153-161.
32. Farooq U, Guo X, Chuang LH, et al. Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Qual Life Res, 2011, 20(3):425-429.
33. Liu GG, Wu H, Li M, et al. Chinese time trade-off values for EQ-5D health states. Value in Health, 2014, 17(5):597-604.
34. 李平, 李澤楷, 鄧愛玲. 腦癱患兒家庭支持的研究進展. 中華護理雜志, 2013, 48(4):365-367.
35. 王權, 李秀霞, 李倫, 等. 硒與大骨節病相關性的Meta分析. 中國循證醫學雜志, 2013, 13(12):1421-1430.

Chinese Journal of Evidence-Based Medicine

Health-Related Quality of Life for Disease Population in China based on EQ-5D: A Systematic Review

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