Effectiveness of External Application with JinHuang Powder for Diabetic Foot Ulcers: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 MALi ¹ , TIANXu ¹ , YILi-juan ¹ ,  WANGYan ²

1. Graduate College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
2. School of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;

Corresponding?author：

WANGYan, Email: yan2015wangly@163.com

Keywords：

JinHuang powder; Diabetic foot ulcer; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20150096

Video：

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Objective To systematically evaluate the potential effectiveness of JinHuang powder in the treatment of diabetic foot ulcers (DFUs). Methods Databases including PubMed, The Cochrane Library, Web of Science, CBM, WanFang data, VIP and CNKI were electronically searched from their inception to December 2013, to identify randomized controlled trials (RCTs) about JinHuang powder for DFUs. Two reviewers screened literature according to the inclusion and exclusion criteria, extracted data and assessed the methodological quality of included studies, and then meta-analysis was performed by using RevMan 5.1 software. Results A total of 3 RCTs involving 198 patients were included. The results of meta-analysis showed that:the JinHuang powder group were superior to the control group in total effective rate (RR=1.25, 95%CI 1.10 to 1.41, P=0.00) and the wound healing time (SMD=-3.32, 95%CI -5.69 to -0.96, P=0.00). Conclusion Current evidence suggests that the JinHuang powder is an effective therapeutic method for DFUs. Because of the limitations of quantity and quality of the eligible studies, large sample size studies are needed to validate the conclusion.

Citation： MALi, TIANXu, YILi-juan, WANGYan. Effectiveness of External Application with JinHuang Powder for Diabetic Foot Ulcers: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2015, 15(5): 581-585. doi: 10.7507/1672-2531.20150096 Copy

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14.	朱橲星. 現代糖尿病學. 上海:復旦大學出版社, 2002:157-182.
15.	周兆熊, 張柏根. 糖尿病足潰瘍的診斷與治療. 中國實用外科雜志, 2006, 26(2):97-98.
16.	Yang WY, Lu JM, Weng JP, et al. Prevalence of diabetes among men and women in China. N Engl J Med, 2010, 362(12):1090-1101.
17.	王玉珍, 許樟榮. 第五屆國際血管外科暨第一屆國際糖尿病血管疾病會議(糖尿病足部分)紀要. 中華糖尿病雜志, 2005, 13(5):152-153.
18.	Driver VR, Madsen J, Goodman RA. Reducing amputation rates in patients with diabetes at a military medical-center:the limb preservation service model. Diabetes Care, 2005, 28(2):248-253.
19.	羅炬蘭. 中醫護理在糖尿病足患者足部護理的臨床應用. 護理研究, 2011, 18(6):120-121.
20.	陳龍云, 鐘鵬飛. 糖尿病足的中醫病因病機探討. 中國醫學創新, 2010, 7(26):179-181.
21.	張友杰.中西醫結合治療糖尿病足的療效觀察. 吉林醫學, 2011, 32(23):4809-4810.
22.	柴政, 呂延偉. 糖尿病足的臨床研究近況. 實用中醫內科雜志, 2013, 27(1):155-157.
23.	Yi ZH. A meta analysis on expression of cyclooxygenase-2 in gastric carcinoma. Bulletin of Chinese Cancer, 2007, 16(5):365-367.
24.	王和鳴. 中醫傷科學. 北京:中國中醫藥出版社, 2002:352.

1. Peregrina-Barretoa H, Morales-Hernandezb LA, Rangel-Magdalenoa JJ, et al. Quantitative estimation of temperature variations in plantar angiosomes:a study case for diabetic foot. Computational and Mathematical Methods in Med, 2014:585306.
2. 李菊川. 糖尿病足潰瘍診療研究新進展. 北方藥學, 2014, 11(3):58-59.
3. Marineau ML, Herrington MT, Swenor KM, et al. Maggot debridement therapy in the treatment of complex diabetic wounds. Hawaii Med J, 2011, 70(3):121-124.
4. Yamamoto H, Watanabe L, Yamamoto, et al. RAGE in diabetic nephropathy. Curt Mol Med, 2007, 7(8):752-757.
5. Brod M. Quality of life issues in patients with diabetes and lower extremity ulcers:patients and care givers. Quality life Res, 1998, 7(4):365-372.
6. Ribu L, Wahl A. Living with diabetic foot ulcers, a life of fear, restrictions and pain. Ostomy Wound manage, 2004, 50(2):57-67.
7. Levin ME. Management of the diabetic foot:preventing amputation. South med J, 2002, 95(1):10-20.
8. 盛路芳, 張美英, 吳紅娟, 等. 金黃散加蜂蜜外敷治療皮膚過敏的效果觀察及護理. 現代臨床護理, 2013, 12(10):47-49.
9. Higgins JPT, Altman DG. Chapter 8:Assessing risk of bias in included studies. In:Higgins JPT, Green S (editors). Cochrane handbook for systematic reviews of interventions version 5.0.2 (updated September 2009). The Cochrane Collaboration, 2009.
10. 崔曉斌, 王英果, 羅振立. 局部清創換藥聯合金黃散外用治療糖尿病足臨床觀察. 中國醫藥指南, 2011, 9(24):318-319.
11. 賈秀卿, 孫喜明. 如意金黃散外敷在糖尿病足潰瘍護理中的應用. 臨床和實驗醫學雜志, 2010, 9(10):786-787.
12. 馬書田, 劉利珍. 如意金黃散外用聯合局部清創治療糖尿病足療效觀察. 現代中西醫結合雜志, 2011, 20(7):828-829.
13. 李仕明. 糖尿病足檢查方法及診斷標準(草案). 中國糖尿病雜志, 1996, 4(2):126.
14. 朱橲星. 現代糖尿病學. 上海:復旦大學出版社, 2002:157-182.
15. 周兆熊, 張柏根. 糖尿病足潰瘍的診斷與治療. 中國實用外科雜志, 2006, 26(2):97-98.
16. Yang WY, Lu JM, Weng JP, et al. Prevalence of diabetes among men and women in China. N Engl J Med, 2010, 362(12):1090-1101.
17. 王玉珍, 許樟榮. 第五屆國際血管外科暨第一屆國際糖尿病血管疾病會議(糖尿病足部分)紀要. 中華糖尿病雜志, 2005, 13(5):152-153.
18. Driver VR, Madsen J, Goodman RA. Reducing amputation rates in patients with diabetes at a military medical-center:the limb preservation service model. Diabetes Care, 2005, 28(2):248-253.
19. 羅炬蘭. 中醫護理在糖尿病足患者足部護理的臨床應用. 護理研究, 2011, 18(6):120-121.
20. 陳龍云, 鐘鵬飛. 糖尿病足的中醫病因病機探討. 中國醫學創新, 2010, 7(26):179-181.
21. 張友杰.中西醫結合治療糖尿病足的療效觀察. 吉林醫學, 2011, 32(23):4809-4810.
22. 柴政, 呂延偉. 糖尿病足的臨床研究近況. 實用中醫內科雜志, 2013, 27(1):155-157.
23. Yi ZH. A meta analysis on expression of cyclooxygenase-2 in gastric carcinoma. Bulletin of Chinese Cancer, 2007, 16(5):365-367.
24. 王和鳴. 中醫傷科學. 北京:中國中醫藥出版社, 2002:352.

Chinese Journal of Evidence-Based Medicine

Effectiveness of External Application with JinHuang Powder for Diabetic Foot Ulcers: A Systematic Review

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