Efficacy of Electroacupuncture in Animal Hyperlipidemia Models: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIUMai-lan , LICheng-wen , WANGHou-lian , GUOAn-lin , LIUMi ,  CHANGXiao-rong

College of Acupuncture & Moxibustion and Tui-na, Hunan University of Chinese Medicine, Changsha 410007, China;

Corresponding?author：

CHANGXiao-rong, Email: xrchang1956@163.com

Keywords：

Electroacupuncture; Animal hyperlipidemia models; Meta-analysis; Animal study

DOI：

10.7507/1672-2531.20150059

Video：

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Objective To systematically review the efficacy and safety of electroacupuncture in animal hyperlipidemia models. Methods Databases such as CNKI, WanFang Data, VIP, CBM, PubMed, EMbase and The Cochrane Library (Issue 12, 2013) were searched for studies concerning the efficacy and safety of electroacupuncture in animal hyperlipidemia models up to December 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and assessed the methodological quality of included studies by using reformative CAMARADES List. Then, meta-analysis was performed by using RevMan 5.2 software. Results A total of 4 studies involving 89 rats were included. The average score of CAMARADES List was 4. The results of meta-analysis showed that:there were no significant differences between electroacupuncture group and medication group in reducing the levels of TC (MD=0.06, 95%CI -0.08 to 0.20, P=0.40), TG (MD=-0.01, 95%CI -0.08 to 0.06, P=0.74), LDL-C (MD=0.01, 95%CI -0.04 to 0.03, P=0.65) and increasing the level of HDL-C (MD=-0.00, 95%CI -0.09 to 0.08, P=0.93). Conclusion Current evidence shows that there are no differences between electroacupuncture and medication in reducing levels of TC, TG, LDL-C and increasing the level of HDL-C in hyperlipidaemia rats. But due to the limitation of sample size of included studies, more large-scale, high quality studies are needed.

Citation： LIUMai-lan, LICheng-wen, WANGHou-lian, GUOAn-lin, LIUMi, CHANGXiao-rong. Efficacy of Electroacupuncture in Animal Hyperlipidemia Models: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(3): 353-357. doi: 10.7507/1672-2531.20150059 Copy

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14.	齊鳳軍, 孫國杰. 電針對高脂血癥大鼠脂肪肝的影響. 中華中醫藥學刊, 2007, 25(6):1281-1283.
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19.	Macleod MR, O'Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
20.	陳華, 苗華, 田婷, 等. 代謝組學技術在高脂血癥研究中的應用. 藥物分析雜志, 2014, 34(4):563-569.
21.	張寶珍, 張凱, 劉玉珍. 針灸豐隆治療高脂血癥臨床隨機對照試驗Meta分析. 中國中醫藥信息雜志, 2014,21(8):11-15.
22.	吳思丹, 王莖. 針灸治療高脂血癥研究進展. 中醫藥臨床雜志, 2012, 14(6):583-586.

1. 姜志瑩. 腦血管病與血脂異常的前瞻性研究. 中國醫藥指南, 2013, 11(2):76-78.
2. 趙水平. 臨床血脂學. 長沙:湖南科學括術出版社, 1997:169-198.
3. 樂薇. 電針豐隆對高脂血癥模型大鼠膽固醇逆轉運通路的影響. 湖北中醫藥大學學位論文, 2013.
4. 中國成人血脂異常防治指南. 中華心血管病雜志, 2007, 5:390-419.
5. 湯茜, 余焯燊, 伍洲梁, 等. 針灸治療高脂血癥的臨床研究綜述. 中國醫藥指南, 2013, 11(21):95-97.
6. 馬占強. 針灸治療高脂血癥安全性和有效性的薈萃分析. 河南中醫, 2012, 32(10):1398-1401.
7. 衛生部法監司. 保健食品檢驗與評價技術規范. 北京:衛生部法監司, 2003:35-37.
8. Peters JL, Sutton AJ, Jones DR, et al. A systematic review of systematic reviews and meta-analyses of animal experiment with guidelines for reporting. J Environ Sci Health B, 2006, 41(7):1245-1258.
9. Crossley NA, Sena E, Goehler J, et al. Empirical evidence of bias in the design of experimental stroke studies:a metaepidemiologic approach. Stroke, 2008, 39(3):929-934.
10. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. J Clin Epidemiol, 2009, 62(10):1006-1012.
11. 周利, 萬文俊, 劉靈光, 等. 電針"豐隆"穴對高脂血癥大鼠NO、ET及CGRP的影響. 中國針灸, 2008, 28(1):57-60.
12. 張紅星, 王英淑, 周利, 等. 電針豐隆穴對高血脂癥型地鼠肝臟LPL、HL的影響. 中國康復, 2011, 26(4):250-252.
13. 楊金梅, 張唐法, 張紅星, 等. 電針豐隆穴早期干預金黃地鼠高脂血癥的機制. 中國康復, 2011, 26(2):89-90.
14. 齊鳳軍, 孫國杰. 電針對高脂血癥大鼠脂肪肝的影響. 中華中醫藥學刊, 2007, 25(6):1281-1283.
15. 羅杰, 冷衛東, 主編. 系統評價/Meta分析理論與實踐. 北京:軍事醫學科學出版社, 2013:490.
16. Macleod MR, O'Collins T, Horky LL. FK506對實驗性卒中療效的系統評價和Meta分析. 中國循證醫學雜志, 2006, 6(5):430-438.
17. Pound P, Ebrahim S, Sandercock P, et al. Where is the evidence that animal research benefits humans? BMJ, 2004, 328(7438):514-517.
18. Peters JL, Sutton AJ, Jones DR, et al. A systematic review of systematic reviews and meta-analyses of animal experiment with guidelines for reporting. J Environ Sci Health B, 2006, 41(7):1245-1258.
19. Macleod MR, O'Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
20. 陳華, 苗華, 田婷, 等. 代謝組學技術在高脂血癥研究中的應用. 藥物分析雜志, 2014, 34(4):563-569.
21. 張寶珍, 張凱, 劉玉珍. 針灸豐隆治療高脂血癥臨床隨機對照試驗Meta分析. 中國中醫藥信息雜志, 2014,21(8):11-15.
22. 吳思丹, 王莖. 針灸治療高脂血癥研究進展. 中醫藥臨床雜志, 2012, 14(6):583-586.

Chinese Journal of Evidence-Based Medicine

Efficacy of Electroacupuncture in Animal Hyperlipidemia Models: A Meta-analysis

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