Value of Mass Screening of Serum Pepsinogen Test for Asian Population with High-risk Gastric Carcinoma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 MADi-wa ¹ , NIUXiao-dong ¹ , TIANHong-liang ² , WANGWen-tao ¹ , LUXian-ming ¹ , SUHai-xia ¹ ,  JIANGLei ³

1. Second Clinical Medicine College Lanzhou University, Lanzhou 730000, China;
2. Department of Oncological Surgery, First Hospital, Lanzhou University, Lanzhou 730000, China;
3. Evidence-based Medicine Center, Lanzhou University, Lanzhou 730000, China;

Corresponding?author：

JIANGLei, Email: goodjianglei@163.com

Keywords：

Pepsinogen; Gastric carcinoma; Screening; Systematic review; Meta-analysis; Diagnostic test

DOI：

10.7507/1672-2531.20150031

Video：

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Objective To systematically review the value of mass screening of serum pepsinogen test for Asian population with high-risk gastric carcinoma. Methods We electronically searched databases including PubMed, EMbase, The Cochrane Library (Issue 12, 2013), CNKI, WanFang Data, VIP and CBM for diagnostic tests on serum pepsinogen test versus with pathological biopsy/X-ray examination (gold standard) between January 2004 and January 2014. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality of included studies. Then meta-analysis was conducted using Meta-DiSc software (version 1.4). Results A total of 15 studies involving 180 934 subjects were included. ROC curve showed "shoulder-arm shape" distribution. The results of Spearman correlation analysis suggested a significance of the threshold effect (P=0.001). The results of meta-analysis showed that, the area under curve (AUC) was 0.74. Conclusion Serum pepsinogen has good value in the screening of gastric carcinoma among Asian permanent residents. Due to limited quality of studies, the above conclusion should be verified by conducting more high quality studies.

Citation： MADi-wa, NIUXiao-dong, TIANHong-liang, WANGWen-tao, LUXian-ming, SUHai-xia, JIANGLei. Value of Mass Screening of Serum Pepsinogen Test for Asian Population with High-risk Gastric Carcinoma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 176-180. doi: 10.7507/1672-2531.20150031 Copy

1.	Yanaoka K, Oka M, Mukoubayashi C, et al. Cancer high-risk subjects identified by serum pepsinogen tests:outcomes after 10-year follow-up in asymptomatic middle-aged males. Cancer Epide Bio & Prev, 2008, 17(4):838-845.
2.	胡靨, 房靜遠, 蕭樹東. 新世紀里胃癌的發病率能進一步降低嗎? 胃腸病學, 2013, 18(1):2-5.
3.	鄭朝旭, 鄭榮壽, 陳萬青. 中國2009年胃癌發病與死亡分析. 中國腫瘤, 2013, 22(5):327-332.
4.	Ohata H, Oka M, Yanaoka K, et al. Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography. Cancer, 2005, 96(10):713-720.
5.	于中麟, 冀明, 楊迅, 等. 血清胃蛋白酶原對胃癌普查的價值探討. 中華消化內鏡雜志, 2008, 25(10):512-515.
6.	刁驤, 艾昌林, 秦莉, 等譯. QUADAS的制定:用于系統評價診斷性研究質量的工具. 中國循證醫學雜志, 2007, 7(4):296-306.
7.	張天嵩, 鐘文昭. Meta-DiSc軟件在診斷試驗Meta分析中的應用. 循證醫學雜志, 2008, 8(2):97-100.
8.	呂艷麗, 李毅, 劉光順, 等. 胃癌高發區血清胃蛋白酶原初篩加高危人群胃鏡檢查方案與直接胃鏡篩查方案的效果比較. 中華腫瘤雜志, 2013, 35(5):394-397.
9.	張志鎰, 吳正奇, 盧林芝, 等. 食管癌、胃癌均高發地區應用內鏡對上消化道癌篩查的探討. 中國腫瘤, 2012, 21(12):906-909.
10.	袁媛. 1997-2011年遼寧省莊河地區胃癌高危人群篩查效果評估. 中華腫瘤雜志, 2012, 34(7):538-542.
11.	徐巧蓮, 萬小勇, 杜燕, 等. 血清胃蛋白酶原檢測在胃癌篩查中的價值. 胃腸病學, 2012, 17(10):614-617.
12.	魏樹利, 常云波, 王建文. 胃蛋白酶原及其亞型含量測定在胃癌等胃部疾患中的診斷價值. 現代中西醫結合雜志, 2012, 21(13):1414-1415.
13.	張志鎰, 王貴齊, 吳正奇, 等. 血清胃蛋白酶原檢測在胃癌及其癌前病變篩查中的價值. 世界華人消化雜志, 2011, 19(14):1511-1514.
14.	劉衛東, 趙永富, 王建璽, 等. 血清胃蛋白酶原及胃鏡檢查用于胃癌早診篩查的探索性研究. 中華預防醫學雜志, 2011, 45(8):752-753.
15.	相英花, 楊永耿, 熊元治, 等. 血清胃蛋白酶原篩查高原農牧區成年人胃癌前病變和胃癌標準的初步研究. 高原醫學雜志, 2009, 19(2):19-23.
16.	Mizuno S, Kobayashi M, Tomita S, et al. Validation of the pepsinogen test method for gastric cancer screening using a followup study. Gastric Cancer, 2009, 12(3):158-163.
17.	Miki K, Fujishiro M, Kodashima S, et al. Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population. Dig Endosc, 2009, 21(2):78-81.
18.	Yanaoka K, Oka M, Mukoubayashi C, et al. Cancer high-risk subjects identified by serum pepsinogen tests:outcomes after 10-year follow-up in asymptomatic middle-aged males. Cancer Epide Bio & Prev, 2008, 17(4):838-845.
19.	Sun LP, Gong YH, Wang L, et al. Serum pepsinogen levels and their influencing factors:a population-based study in 6990 Chinese from North China. World J Gastroenterol, 2007, 13(48):6562-6567.
20.	張祥宏, 黃飚, 王俊靈, 等. 胃癌高發區居民血清胃蛋白酶原水平與胃黏膜病變的關系. 中華腫瘤雜志, 2006, 28(7):507-511.
21.	Ohata H, Oka M, Yanaoka K, et al. Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography. Cancer Sci, 2005, 96(10):713-720.
22.	王北寧, 楊劍, 徐東, 等. 胃蛋白酶原Ⅰ、Ⅱ的酶免疫分析. 標記免疫分析與臨床, 2006, 13(3):162-164.
23.	Miki K, Ichinose M, Shimizu A, et al. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterol Jpn, 1987, 22(2):133-141.
24.	Dinis-Ribeiro M, Yamaki G, Miki K, et al. Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening. J Med Screen, 2004, 11(3):141-147.

1. Yanaoka K, Oka M, Mukoubayashi C, et al. Cancer high-risk subjects identified by serum pepsinogen tests:outcomes after 10-year follow-up in asymptomatic middle-aged males. Cancer Epide Bio & Prev, 2008, 17(4):838-845.
2. 胡靨, 房靜遠, 蕭樹東. 新世紀里胃癌的發病率能進一步降低嗎? 胃腸病學, 2013, 18(1):2-5.
3. 鄭朝旭, 鄭榮壽, 陳萬青. 中國2009年胃癌發病與死亡分析. 中國腫瘤, 2013, 22(5):327-332.
4. Ohata H, Oka M, Yanaoka K, et al. Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography. Cancer, 2005, 96(10):713-720.
5. 于中麟, 冀明, 楊迅, 等. 血清胃蛋白酶原對胃癌普查的價值探討. 中華消化內鏡雜志, 2008, 25(10):512-515.
6. 刁驤, 艾昌林, 秦莉, 等譯. QUADAS的制定:用于系統評價診斷性研究質量的工具. 中國循證醫學雜志, 2007, 7(4):296-306.
7. 張天嵩, 鐘文昭. Meta-DiSc軟件在診斷試驗Meta分析中的應用. 循證醫學雜志, 2008, 8(2):97-100.
8. 呂艷麗, 李毅, 劉光順, 等. 胃癌高發區血清胃蛋白酶原初篩加高危人群胃鏡檢查方案與直接胃鏡篩查方案的效果比較. 中華腫瘤雜志, 2013, 35(5):394-397.
9. 張志鎰, 吳正奇, 盧林芝, 等. 食管癌、胃癌均高發地區應用內鏡對上消化道癌篩查的探討. 中國腫瘤, 2012, 21(12):906-909.
10. 袁媛. 1997-2011年遼寧省莊河地區胃癌高危人群篩查效果評估. 中華腫瘤雜志, 2012, 34(7):538-542.
11. 徐巧蓮, 萬小勇, 杜燕, 等. 血清胃蛋白酶原檢測在胃癌篩查中的價值. 胃腸病學, 2012, 17(10):614-617.
12. 魏樹利, 常云波, 王建文. 胃蛋白酶原及其亞型含量測定在胃癌等胃部疾患中的診斷價值. 現代中西醫結合雜志, 2012, 21(13):1414-1415.
13. 張志鎰, 王貴齊, 吳正奇, 等. 血清胃蛋白酶原檢測在胃癌及其癌前病變篩查中的價值. 世界華人消化雜志, 2011, 19(14):1511-1514.
14. 劉衛東, 趙永富, 王建璽, 等. 血清胃蛋白酶原及胃鏡檢查用于胃癌早診篩查的探索性研究. 中華預防醫學雜志, 2011, 45(8):752-753.
15. 相英花, 楊永耿, 熊元治, 等. 血清胃蛋白酶原篩查高原農牧區成年人胃癌前病變和胃癌標準的初步研究. 高原醫學雜志, 2009, 19(2):19-23.
16. Mizuno S, Kobayashi M, Tomita S, et al. Validation of the pepsinogen test method for gastric cancer screening using a followup study. Gastric Cancer, 2009, 12(3):158-163.
17. Miki K, Fujishiro M, Kodashima S, et al. Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population. Dig Endosc, 2009, 21(2):78-81.
18. Yanaoka K, Oka M, Mukoubayashi C, et al. Cancer high-risk subjects identified by serum pepsinogen tests:outcomes after 10-year follow-up in asymptomatic middle-aged males. Cancer Epide Bio & Prev, 2008, 17(4):838-845.
19. Sun LP, Gong YH, Wang L, et al. Serum pepsinogen levels and their influencing factors:a population-based study in 6990 Chinese from North China. World J Gastroenterol, 2007, 13(48):6562-6567.
20. 張祥宏, 黃飚, 王俊靈, 等. 胃癌高發區居民血清胃蛋白酶原水平與胃黏膜病變的關系. 中華腫瘤雜志, 2006, 28(7):507-511.
21. Ohata H, Oka M, Yanaoka K, et al. Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography. Cancer Sci, 2005, 96(10):713-720.
22. 王北寧, 楊劍, 徐東, 等. 胃蛋白酶原Ⅰ、Ⅱ的酶免疫分析. 標記免疫分析與臨床, 2006, 13(3):162-164.
23. Miki K, Ichinose M, Shimizu A, et al. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterol Jpn, 1987, 22(2):133-141.
24. Dinis-Ribeiro M, Yamaki G, Miki K, et al. Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening. J Med Screen, 2004, 11(3):141-147.

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Value of Mass Screening of Serum Pepsinogen Test for Asian Population with High-risk Gastric Carcinoma: A Meta-analysis

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