Meta-Analysis of Rates and Software Implementation_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHOUBo ^1,2 , CHENXin ^1,2 ,  SHIJing-pu ^1,2 , FULing-yu ^1,2 , WANGHai-long ^1,2 , WUXiao-mei ^1,2

1. Department of Clinical Epidemiology and Evidence-based Medicine, First Affiliated Hospital, China Medical University, Shenyang 110001, China;
2. Evidence-based Medicine Center of Liaoning Province, Shenyang 110001, China;

Corresponding?author：

SHIJing-pu, Email: sjp56@sina.com

Keywords：

Rate; Meta-analysis; Heterogeneity

DOI：

10.7507/1672-2531.20140166

Video：

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Many meta-analysis studies evaluate rates as parameter to assess the overall estimate of effects. However, none of these studies address systematic approaches for the meta-analysis of rates. This paper outlines the conditions, analysis and software operation procedures for the meta-analysis of rates. It also compares different operation procedures of three types of commonly-used R software (Comprehensive Meta-Analysis, Stata and MetaAnalyst) through real application examples. The biggest challenge for the meta-analysis of rates is to determine whether rates can be pooled, and how to evaluate heterogeneity between studies' outcomes needs further discussion.

Citation： ZHOUBo, CHENXin, SHIJing-pu, FULing-yu, WANGHai-long, WUXiao-mei. Meta-Analysis of Rates and Software Implementation. Chinese Journal of Evidence-Based Medicine, 2014, 14(8): 1009-1016. doi: 10.7507/1672-2531.20140166 Copy

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15.	Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology(STROBE): explanation and elaboration. PLOS Med, 2007, 4(10): e297.
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17.	曾憲濤, 包翠萍, 曹世義, 等. Meta分析系列之三:隨機對照試驗的質量評價工具.中國循證心血管醫學雜志, 2012, 4(3): 183-185.
18.	曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四:觀察性研究的質量評價工具.中國循證心血管醫學雜志, 2012, 4(4): 297-299.
19.	顧勁揚, 柏建嶺, 施曉雷, 等.膽管癌肝移植有效性與安全性的Meta分析.中華外科雜志, 2011, 49(4): 351-356.
20.	Gao X, Cui Q, Shi X, et al. Prevalence and trend of hepatitis C virus infection among blood donors in Chinese mainland: a systematic review and meta-analysis. BMC Infect Dis, 2011, 11: 88.
21.	胡軍, 劉鋒, 呂征, 等.同期與分期雙膝關節置換術后死亡率的Meta分析.中華骨科雜志, 2011, 31(8): 852-858.
22.	何倩, 王靜, 朱玉, 等.中國內地居民2000-2009年被動吸煙率Meta分析.中華流行病學雜志, 2011, 32(2): 159-163.
23.	王丹, 翟俊霞, 牟振云, 等. Meta分析中的異質性及其處理方法.中國循證醫學雜志, 2009, 9(10): 1115-1118.

1. ?Glass GV. Primary, secondary, and meta-analysis of research. Educ Res, 1976, 5: 3.
2. Hussain N, Chien T, Hussain F, et al. Simultaneous versus staged bilateral total knee arthroplasty: a meta-analysis evaluating mortality, peri-operative complications and infection rates. HSS J, 2013, 9(1): 50-59.
3. Jin YL, Ding LL, Yao YS, et al. Obesity detection rate among primary school students in the People's Republic of China: a meta-analysis. Ther Clin Risk Manag, 2013, 9: 383-390.
4. 周煜, 李秀央, 陳坤, 等.大氣顆粒物與居民腦卒中發作或死亡之間關系的Meta分析.中華流行病學雜志, 2010, 31(11): 1300-1305.
5. 邵曉丹, 張鐵軍, 何納.單純皰疹病毒2型新發感染率及其危險因素的Meta分析.中華流行病學雜志, 2011, 32(2): 170-176.
6. 曾憲濤, 孫竹, 湯紅明. Meta分析系列之十:合格標準的制定.中國循證心血管醫學雜志, 2013, 2(5): 6-9.
7. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration. 2011 [2012-03-30]. Available at: http://www.cochrane-handbook.org.
8. Jadad AR1, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials, 1996, 17(1):1-12.
9. Centre for Evidence-Based Physiotherapy at The George Institute for Global Health. Physiotherapy Evidence Database(PEDro). (1999-06-21) [2012-03-30]. Available at: http://www.pedro.org.au/english/downloads/pedro-scale.
10. Verhagen AP, de Vet HC, de Bie RA, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol, 1998, 51(12): 1235-1241.
11. Ibbotson T, Grimshaw J, Grant A. Evaluation of a programme of workshops for promoting the teaching of critical appraisal skills. Med Educ, 1998, 32(5): 486-491.
12. Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg, 2011, 9(8): 672-677.
13. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analysis. Eur J Epidemiol, 2010, 25(9): 603-605.
14. Rockville. Celiac Disease: Agency for Healthcare Research and Quality(US); 2004. (Evidence Reports/Technology Assessments, No.104) Appendix D. Quality Assessment Forms. Available at: http://www.ncbi.nlm.nih.gov/books/NBK35156.
15. Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology(STROBE): explanation and elaboration. PLOS Med, 2007, 4(10): e297.
16. Whiting P, Rutjes AWS, Reitsma JB, 等. QUADAS的制定:用于系統評價中評價診斷性研究質量的工具.中國循證醫學雜志, 2007, 7(4): 296-306.
17. 曾憲濤, 包翠萍, 曹世義, 等. Meta分析系列之三:隨機對照試驗的質量評價工具.中國循證心血管醫學雜志, 2012, 4(3): 183-185.
18. 曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四:觀察性研究的質量評價工具.中國循證心血管醫學雜志, 2012, 4(4): 297-299.
19. 顧勁揚, 柏建嶺, 施曉雷, 等.膽管癌肝移植有效性與安全性的Meta分析.中華外科雜志, 2011, 49(4): 351-356.
20. Gao X, Cui Q, Shi X, et al. Prevalence and trend of hepatitis C virus infection among blood donors in Chinese mainland: a systematic review and meta-analysis. BMC Infect Dis, 2011, 11: 88.
21. 胡軍, 劉鋒, 呂征, 等.同期與分期雙膝關節置換術后死亡率的Meta分析.中華骨科雜志, 2011, 31(8): 852-858.
22. 何倩, 王靜, 朱玉, 等.中國內地居民2000-2009年被動吸煙率Meta分析.中華流行病學雜志, 2011, 32(2): 159-163.
23. 王丹, 翟俊霞, 牟振云, 等. Meta分析中的異質性及其處理方法.中國循證醫學雜志, 2009, 9(10): 1115-1118.

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