Value of Intra-operative Ultrasound in Diagnosis of Tumor Residue after Resection of Intracranial Gliomas: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 GAOYing , GAOJun-xi ,  YAOLan-hui

Department of Ultrasound Diagnostic, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;

Corresponding?author：

YAOLan-hui, Email: yaolanhui6082@yahoo.com.cn

Keywords：

Intra-operative ultrasound; Gliomas; Residue; Meta-analysis; Diagnostic test

DOI：

10.7507/1672-2531.20140098

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the value of intra-operative ultrasound in diagnosis of tumor residue after resection of intracranial gliomas. Methods Such databases as PubMed, EMbase, The Cochrane Library, CBM, CNKI, WanFang Data and VIP were electronically searched for the diagnostic test about intra-operative ultrasound in diagnosis of tumor residue after resection of intracranial gliomas by March 31st, 2013. Meanwhile, search engines such as Google, Baidu were also used for relevant search. According to the inclusion and exclusion criteria, the literature was screened and the data were extracted. The methodological quality was evaluated in accordance with the quality assessment tool for diagnostic accuracy studies (QUADAS) and then meta-analysis was conducted using Meta-DiSc 1.4 software. Results A total of 10 studies involving 423 patients were included. The results of meta-analysis showed that the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio (DOR) were 0.78 (95%CI 0.74 to 0.82), 0.90 (95%CI 0.88 to 0.90), 5.12 (95%CI 2.86 to 9.16), 0.29 (95%CI 0.21 to 0.39) and 25.00 95%CI (13.27 to 47.10), respectively; and the AUC was 0.89. In the subgroup analysis, for low grade intracranial gliomas, the results of meta-analysis showed that the sensitivity, specificity and DOR were 0.87 (95%CI 0.77 to 0.94), 0.88 (95%CI 0.78 to 0.94) and 28.93 (95%CI 7.46 to 112.14), respectively, and the AUC was 0.92. For high grade gliomas, the results of meta-analysis showed that the sensitivity, specificity and DOR were 0.80 (95%CI 0.72 to 0.87), 0.67 (95%CI 0.53 to 0.79) and 7.20 (95%CI 3.04 to 17.09), respectively, and the AUC was 0.80. Conclusion Intra-operative ultrasound is useful for the diagnosis of tumor residue after resection of intracranial gliomas, especially for low grade gliomas.

Citation： GAOYing, GAOJun-xi, YAOLan-hui. Value of Intra-operative Ultrasound in Diagnosis of Tumor Residue after Resection of Intracranial Gliomas: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(5): 592-597. doi: 10.7507/1672-2531.20140098 Copy

1.	Sosna J, Barth MM, Kruskaal JB, et al. Intraoperative sonography for neurosurgery. J Ultrasound Med, 2005, 24(12):1671-1682.
2.	Erdogan N, Tucer B, Mavili E, et al. Ultrasound guidance in intracranial tumor resection:correlation with postoperative magnetic resonance findings. Acta Radiol, 2005, 46(7):743-749.
3.	Woydt M, Krone A, Becker G, et al. Correlation of intra-operative ultrasound with histopathologic findings after tumor resection in supratentorial gliomas. A method to improve gross total tumour resection. Acta Neurochir (Wien), 1996, 138(12):1391-1398.
4.	Unsgaard G, Selbekk T, Brostrup M T, et al. Ability of navigated 3D ultrasound to delineate gliomas and metastaseses-comparison of image interpretations with histopathology. Acta Neurochir(Wien), 2005, 147(12):1259-1269.
5.	賀焱, 何文, 杜麗娟, 等.術中超聲造影對提高腦膠質瘤完全切除的臨床應用價值.中華醫學超聲雜志:電子版, 2012, 9(1):36-39.
6.	王立淑, 何文, 劉會昭, 等.術中超聲與病理評價顱腦膠質瘤切除程度的對照研究.中華醫學超聲雜志:電子版, 2009, 6(3):500-506.
7.	田永吉, 林松, 劉會昭, 等.術中超聲判定腦膠質瘤邊界的應用價值.中華醫學雜志, 2009, 89(19):1305-1308.
8.	郭少瓊, 陳遠洪, 羅建彬.術中超聲對腦膠質瘤術后殘余腫瘤的觀察研究.實用醫學雜志, 2011, 27(5):852-854.
9.	陳運洪, 王向宇, 余力, 等.改進高分辨超聲在腦膠質瘤術中應用技術.中華神經外科, 2006, 5(7):702-705.
10.	劉晶, 姚蘭輝.術中超聲對幕上膠質瘤術后殘余的評價.烏魯木齊:新疆醫科大學, 2009.
11.	Becker G, Hofmann E, Woydt M, et al. Postoperative neuroimaging of high-grade gliomas:comparison of transcranial sonography, magnetic resonance imaging, and computed tomography. Neurosurgery, 1999, 44(3):469-477.
12.	Chacko AG, Kumar NK, Chacko G, et al. Intraoperative ultrasound in determining the extent of resection of parenchymal brain tumours-a comparative study with computed tomography and histopathology. Acta Neurochir(Wien), 2003, 145(9):743-748.
13.	Gerganov VM, Samii A, Giordano M, et al. Two-dimensional highend ultrasound imaging compared to intraoperative MRI during resection of low-grade gliomas. J Clin Neurosci, 2011, 18(5):669-673.
14.	Whiting P, Rutjes Aw, Reitsma JB, et al. The development of QUADAS:a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25-38.
15.	黃強, 陳忠平, 蘭青.膠質瘤.第1版.北京:中國科技出版社, 2000: 156-158.
16.	蔣傳路, 江濤, 李永利, 等.膠質瘤的侵襲性生長與手術策略.中華神經外科雜志, 2004, 20(6):510.
17.	Enzmann DR, Wheat R, Marshall WH, et al. Tumors of the central nervous system studied by computed tomography and ultrasound. Radiology, 1985, 154(2):393-399.
18.	Hammoud MA, Ligon L, Mph RE, et al. Use of intra-operative ultrasound for localizing study with magnetic resonance imaging. J Neuresurg, 1996, 84(6):737-741.
19.	Matsushita Y, Okayama Y, Matsuo S. The role of intraoperative ultrasonography. Rinsho Byori, 2008, 56(6):498-507.
20.	歐亞夢蘭, 李力, 高琨. TERC基因對宮頸高級別病變(≥CIN II)診斷價值的Meta分析.中國循證醫學雜志, 2013, 13(3):325-331.

1. Sosna J, Barth MM, Kruskaal JB, et al. Intraoperative sonography for neurosurgery. J Ultrasound Med, 2005, 24(12):1671-1682.
2. Erdogan N, Tucer B, Mavili E, et al. Ultrasound guidance in intracranial tumor resection:correlation with postoperative magnetic resonance findings. Acta Radiol, 2005, 46(7):743-749.
3. Woydt M, Krone A, Becker G, et al. Correlation of intra-operative ultrasound with histopathologic findings after tumor resection in supratentorial gliomas. A method to improve gross total tumour resection. Acta Neurochir (Wien), 1996, 138(12):1391-1398.
4. Unsgaard G, Selbekk T, Brostrup M T, et al. Ability of navigated 3D ultrasound to delineate gliomas and metastaseses-comparison of image interpretations with histopathology. Acta Neurochir(Wien), 2005, 147(12):1259-1269.
5. 賀焱, 何文, 杜麗娟, 等.術中超聲造影對提高腦膠質瘤完全切除的臨床應用價值.中華醫學超聲雜志:電子版, 2012, 9(1):36-39.
6. 王立淑, 何文, 劉會昭, 等.術中超聲與病理評價顱腦膠質瘤切除程度的對照研究.中華醫學超聲雜志:電子版, 2009, 6(3):500-506.
7. 田永吉, 林松, 劉會昭, 等.術中超聲判定腦膠質瘤邊界的應用價值.中華醫學雜志, 2009, 89(19):1305-1308.
8. 郭少瓊, 陳遠洪, 羅建彬.術中超聲對腦膠質瘤術后殘余腫瘤的觀察研究.實用醫學雜志, 2011, 27(5):852-854.
9. 陳運洪, 王向宇, 余力, 等.改進高分辨超聲在腦膠質瘤術中應用技術.中華神經外科, 2006, 5(7):702-705.
10. 劉晶, 姚蘭輝.術中超聲對幕上膠質瘤術后殘余的評價.烏魯木齊:新疆醫科大學, 2009.
11. Becker G, Hofmann E, Woydt M, et al. Postoperative neuroimaging of high-grade gliomas:comparison of transcranial sonography, magnetic resonance imaging, and computed tomography. Neurosurgery, 1999, 44(3):469-477.
12. Chacko AG, Kumar NK, Chacko G, et al. Intraoperative ultrasound in determining the extent of resection of parenchymal brain tumours-a comparative study with computed tomography and histopathology. Acta Neurochir(Wien), 2003, 145(9):743-748.
13. Gerganov VM, Samii A, Giordano M, et al. Two-dimensional highend ultrasound imaging compared to intraoperative MRI during resection of low-grade gliomas. J Clin Neurosci, 2011, 18(5):669-673.
14. Whiting P, Rutjes Aw, Reitsma JB, et al. The development of QUADAS:a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 3: 25-38.
15. 黃強, 陳忠平, 蘭青.膠質瘤.第1版.北京:中國科技出版社, 2000: 156-158.
16. 蔣傳路, 江濤, 李永利, 等.膠質瘤的侵襲性生長與手術策略.中華神經外科雜志, 2004, 20(6):510.
17. Enzmann DR, Wheat R, Marshall WH, et al. Tumors of the central nervous system studied by computed tomography and ultrasound. Radiology, 1985, 154(2):393-399.
18. Hammoud MA, Ligon L, Mph RE, et al. Use of intra-operative ultrasound for localizing study with magnetic resonance imaging. J Neuresurg, 1996, 84(6):737-741.
19. Matsushita Y, Okayama Y, Matsuo S. The role of intraoperative ultrasonography. Rinsho Byori, 2008, 56(6):498-507.
20. 歐亞夢蘭, 李力, 高琨. TERC基因對宮頸高級別病變(≥CIN II)診斷價值的Meta分析.中國循證醫學雜志, 2013, 13(3):325-331.

Chinese Journal of Evidence-Based Medicine

Value of Intra-operative Ultrasound in Diagnosis of Tumor Residue after Resection of Intracranial Gliomas: A Meta-Analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content