Stasis-resolving and Detoxifying Effect of Xuebijing Injection on Severe Pneumonia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHUMing-jin ,  ZHANGGeng , HUMa-hong , ChenYang-bo , JIChun-lian

Intensive Care Unit, Zhejiang Tongde Hospital, Hangzhou 310012, China;

Corresponding?author：

ZHANGGeng, Email: docbright@163.com

Keywords：

Xuebijing injection; Severe pneumonia; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20140080

Video：

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Objective To systematically review the effectiveness of Xuebijing injection combined with routine therapy versus routine therapy alone in treating severe pneumonia. Methods Databases including PubMed (1990-2013.4), EMbase (1990-2013.4), The Cochran Library (Issue 4, 2013), CNKI (1982-2013.4), WangFang Data (1990-2013.4), VIP (1989-2013.4) and CBM (1978-2013.4) were searched from inception to April, 2013, for randomized controlled trials (RCTs) on Xuebijing injection for severe pneumonia. Studies were screened according to the inclusion and exclusion criteria, data were extracted, and methodological quality was evaluated. Meta-analysis was then performed using RevMan 5.2 software. Results A total of 12 studies involving 860 patients were included. The results of meta-analysis showed that, routine therapy plus Xuebijing injection had higher total effective and excellent rates, and the combined therapy reduced the average hospitalization days, and they had better improvement in WBC, CRP, CPIS, IL-6, IL-8, TNF-α. Conclusion This current evidence shows that Xuebijing injection has a better clinical efficacy in treating severe pneumonia. Traditional Chinese herbs with the function of "promoting blood circulation to remove blood stasis" may exert their pharmacological effects via a multi-target way in treating severe pneumonia, which have a great potential for both clinical work and scientific research. Due to the limited quality and quantity of the included studies, better designed RCTs are needed to support Xuebijing's clinical efficacy in the treatment of severe pneumonia.

Citation： ZHUMing-jin, ZHANGGeng, HUMa-hong, ChenYang-bo, JIChun-lian. Stasis-resolving and Detoxifying Effect of Xuebijing Injection on Severe Pneumonia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 462-468. doi: 10.7507/1672-2531.20140080 Copy

1.	白云蘋, 王海峰, 王明航, 等.中藥復方針劑血必凈注射液輔助治療重癥肺炎隨機對照試驗的系統評價.中國中西醫結合急救雜志, 2012, 19(5):257-262.
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3.	Mandell LA, Wunderink RG, Anzueto A, et al.Infectious Diseases Society of America/American Thoracic Society consensus guidelines for the management of community acquired pneumonia in adults.Clin Infect Dis, 2007(44):S27-72.
4.	Higgins JPT, Green S (editors).Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011].The Cochrane Collaboration, 2011.Available at:www.cochrane-handbook.org.
5.	Qi F, Liang ZX, She DY, et al.A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients.J Traditional Chinese Medicine, 2011, 31(1):46-49.
6.	程興梅, 陳曉英, 沈維.血必凈聯合抗生素治療重癥肺炎的臨床研究.中國保健營養(下旬刊), 2012, 22(11):4337-4338.
7.	方志成, 周昌娥, 鄭翔, 等.血必凈聯合烏司他丁治療重癥肺炎的臨床研究.臨床和實驗醫學雜志, 2013, 12(4):268-270.
8.	王志鋼, 龍英姿, 張國明.血必凈治療老年重癥肺炎的療效觀察.江西醫藥, 2013, 48(1):41-42.
9.	邢柏, 曾琦, 王日興, 等.血必凈注射液對重癥肺炎患者的肺保護作用.中國中西醫結合急救雜志, 2007, 14(5):317-318.
10.	陳建南, 何平, 孫定衛.血必凈注射液對重癥肺炎患者的影響研究.中國全科醫學, 2010, 13(9):3081-3083.
11.	劉龍, 蔡國良.血必凈注射液對重癥肺炎患者血清中IL-6、IL-10的影響.西部醫學, 2011, 23(10):1862-1864.
12.	傅園花, 葛國平.血必凈注射液結合西醫常規療法治療老年重癥肺炎療效觀察.上海中醫藥雜志, 2011, 45(1):39-40.
13.	張琦, 許玲華, 李萍.血必凈注射液治療老年重癥肺炎患者療效觀察.中國醫藥導報, 2008, 5(33):68-69.
14.	周干, 林峰, 左文杰.血必凈注射液治療重癥肺炎84例療效觀察.藥物評價研究, 2012, 35(3):197-198.
15.	盧萬向.中西藥聯合治療老年重癥社區獲得性肺炎臨床體會.內蒙古中醫藥, 2012, 31(10):21-22.
16.	趙俊.血必凈聯合泰能治療高原老年性重癥肺炎療效觀察.中國醫學創新, 2010, 7(23):90-91.
17.	張淑文, 孫成棟, 文艷, 等.血必凈注射液對膿毒癥大鼠血清炎癥介質及T h1/2的影響.中國危重病急救醫學, 2006, 18(11):673-676.
18.	卞兆祥, 商洪才, 吳泰相, 等.中藥注射劑不良反應/不良事件的反思.中國循證醫學雜志, 2010, 10(2):116-121.
19.	任德權.理性看待中藥注射劑促其科學發展.中國循證醫學雜志, 2010, 10(2):105-106.
20.	崔小花, 王莉, 李幼平, 等.魚腥草注射液治療呼吸系統疾病有效性評價.中國循證醫學雜志, 2011, 11(7):786-798.
21.	王今達, 雪琳.細菌、內毒素、炎性介質并治——治療重癥膿毒病的新對策.中國危重病急救醫學, 1998, 10(6):323-325.
22.	孫軍平, 汪建新, 郭麗娜.內毒素致兔急性肺損傷及血必凈保護作用.軍醫進修學院學報, 2009, 30(1):102-104.
23.	明自強, 俞林明, 呂銀祥, 等.血必凈注射液治療膿毒癥患者抗炎作用觀察.現代中西醫結合雜志, 2007, 16(6):731-732.
24.	張宏, 王夢義, 陳櫻, 等.G-菌肺感染早期活血化瘀中藥干預治療對細胞因子釋放的影響.中國中西醫結合急救雜志, 2001, 8(4):219-221.

1. 白云蘋, 王海峰, 王明航, 等.中藥復方針劑血必凈注射液輔助治療重癥肺炎隨機對照試驗的系統評價.中國中西醫結合急救雜志, 2012, 19(5):257-262.
2. Niederman MS, Mandell LA, Anzueto A, et al.Guidelines for the management of adults with community-acquired pneumonia.Diagnosis, assessment of severity, antimicrobial therapy, and prevention.Am J Respir Crit Care Med, 2001, 163(7):1730-1754.
3. Mandell LA, Wunderink RG, Anzueto A, et al.Infectious Diseases Society of America/American Thoracic Society consensus guidelines for the management of community acquired pneumonia in adults.Clin Infect Dis, 2007(44):S27-72.
4. Higgins JPT, Green S (editors).Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[Updated March 2011].The Cochrane Collaboration, 2011.Available at:www.cochrane-handbook.org.
5. Qi F, Liang ZX, She DY, et al.A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients.J Traditional Chinese Medicine, 2011, 31(1):46-49.
6. 程興梅, 陳曉英, 沈維.血必凈聯合抗生素治療重癥肺炎的臨床研究.中國保健營養(下旬刊), 2012, 22(11):4337-4338.
7. 方志成, 周昌娥, 鄭翔, 等.血必凈聯合烏司他丁治療重癥肺炎的臨床研究.臨床和實驗醫學雜志, 2013, 12(4):268-270.
8. 王志鋼, 龍英姿, 張國明.血必凈治療老年重癥肺炎的療效觀察.江西醫藥, 2013, 48(1):41-42.
9. 邢柏, 曾琦, 王日興, 等.血必凈注射液對重癥肺炎患者的肺保護作用.中國中西醫結合急救雜志, 2007, 14(5):317-318.
10. 陳建南, 何平, 孫定衛.血必凈注射液對重癥肺炎患者的影響研究.中國全科醫學, 2010, 13(9):3081-3083.
11. 劉龍, 蔡國良.血必凈注射液對重癥肺炎患者血清中IL-6、IL-10的影響.西部醫學, 2011, 23(10):1862-1864.
12. 傅園花, 葛國平.血必凈注射液結合西醫常規療法治療老年重癥肺炎療效觀察.上海中醫藥雜志, 2011, 45(1):39-40.
13. 張琦, 許玲華, 李萍.血必凈注射液治療老年重癥肺炎患者療效觀察.中國醫藥導報, 2008, 5(33):68-69.
14. 周干, 林峰, 左文杰.血必凈注射液治療重癥肺炎84例療效觀察.藥物評價研究, 2012, 35(3):197-198.
15. 盧萬向.中西藥聯合治療老年重癥社區獲得性肺炎臨床體會.內蒙古中醫藥, 2012, 31(10):21-22.
16. 趙俊.血必凈聯合泰能治療高原老年性重癥肺炎療效觀察.中國醫學創新, 2010, 7(23):90-91.
17. 張淑文, 孫成棟, 文艷, 等.血必凈注射液對膿毒癥大鼠血清炎癥介質及T h1/2的影響.中國危重病急救醫學, 2006, 18(11):673-676.
18. 卞兆祥, 商洪才, 吳泰相, 等.中藥注射劑不良反應/不良事件的反思.中國循證醫學雜志, 2010, 10(2):116-121.
19. 任德權.理性看待中藥注射劑促其科學發展.中國循證醫學雜志, 2010, 10(2):105-106.
20. 崔小花, 王莉, 李幼平, 等.魚腥草注射液治療呼吸系統疾病有效性評價.中國循證醫學雜志, 2011, 11(7):786-798.
21. 王今達, 雪琳.細菌、內毒素、炎性介質并治——治療重癥膿毒病的新對策.中國危重病急救醫學, 1998, 10(6):323-325.
22. 孫軍平, 汪建新, 郭麗娜.內毒素致兔急性肺損傷及血必凈保護作用.軍醫進修學院學報, 2009, 30(1):102-104.
23. 明自強, 俞林明, 呂銀祥, 等.血必凈注射液治療膿毒癥患者抗炎作用觀察.現代中西醫結合雜志, 2007, 16(6):731-732.
24. 張宏, 王夢義, 陳櫻, 等.G-菌肺感染早期活血化瘀中藥干預治療對細胞因子釋放的影響.中國中西醫結合急救雜志, 2001, 8(4):219-221.

Chinese Journal of Evidence-Based Medicine

Stasis-resolving and Detoxifying Effect of Xuebijing Injection on Severe Pneumonia: A Systematic Review

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