Risk Factors of Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction in China: A Cross-sectional Study_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGJian-hua ¹ , XIAOLei ² , ZHANGZhe ² , HELi-yun ³ , YANShi-yan ³ , WANGXin ³ ,  YANGGuan-lin ¹

1. Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;
2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;
3. Clinical Evaluation Center of China Academy of Chinese Medical Sciences, Beijing 100700, China;

Corresponding?author：

YANGGuan-lin, Email: yangguanlin945@163.com

Keywords：

Angina pectoris complicated with atheroschlerotic thrombotic cerebral infarction; Angina pectoris; Atherosclerotic thrombotic cerebral infarction; Risk factor; Epidemiological study

DOI：

10.7507/1672-2531.20140071

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Objective To compare the risk factors of angina pectoris and atherosclerotic thrombotic cerebral infarction, and to study the possible risk factors of angina pectoris complicated with atherosclerotic thrombotic cerebral infarction (XNHB abbr. in Chinese) and provide the basis for the prevention of XNHB. Methods Clinical epidemiological cross-sectional survey methods were used. Information of angina pectoris patients, atherosclerotic thrombotic cerebral infarction patients and XNHB patients were collected. The statistical software SPSS 17.0 was used to analyze the single risk factors, and then logistic regression analysis was used to filter the independent risk factors of XNHB. Results 1 002 cases of angina pectoris, 963 cases of atherosclerotic thormbotic cerebral infaction and 982 cases of XNHB were included. There were significant differences among the three diseases in the following index:age (P=0.000 0), gender (P < 0.000 1), resting lifestyle (P=0.000 0), body mass index (BMI) (P=0.000 0), diabetes (P=0.001 9), hypertension (P < 0.000 1), diabetes complicated with hypertension (P < 0.000 1), smoking (P < 0.000 1), alcohol consumption (P < 0.000 1), and the combination of more than 3 risk factors (P=0.000 0). Age (OR=1.690, 95%CI 1.420 to 2.012), hypertension (OR=1.558, 95%CI 1.312 to 1.850), abnormal BMI (OR=1.356, 95%CI 1.158 to 1.587) and resting lifestyle (OR=1.319, 95%CI 1.107 to 1.572) were shown as the independent risk factors of XNHB filtering by logistic multiple regression analysis. Conclusion The elderly with hypertension, abnormal BMI or live a resting way of life are more likely to have XNHB, so positive control of risk factors should be needed.

Citation： WANGJian-hua, XIAOLei, ZHANGZhe, HELi-yun, YANShi-yan, WANGXin, YANGGuan-lin. Risk Factors of Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction in China: A Cross-sectional Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 408-413. doi: 10.7507/1672-2531.20140071 Copy

1.	Sheppard MR, Vinay K, Abul KA, et al.Robbins basic pathology:with student consult online access, 8^th edition.Philadelphia:Saunders, 2007:201-265.
2.	Shen Q, Zhu TB.Tissue factor (TF) enhanced the expression of macrophage inflammatory protein-1α(MIP-1α) in cultured human umbilical vein endothelial cells.Chin J Atle, 2006, 14(6):286-288.
3.	張艷, 楊關林, 閻峻, 等.心腦動脈粥樣硬化中醫證型與血脂的相關性研究.遼寧中醫雜志, 2010, 37(3):419-420.
4.	賈連群, 楊關林.動脈粥樣硬化中醫痰濁血瘀證候的現代生物學基礎研究.中西醫結合心腦血管病雜志, 2010, 8(1):95-96.
5.	中華醫學會心血管病學分會.不穩定性心絞痛和非ST段抬高心肌梗死診斷與治療指南.中華心血管病雜志, 2007, 35(4):295-304.
6.	中國《慢性穩定性心絞痛診斷與治療指南》新聞發布會暨高層專家研討會.慢性穩定性心絞痛診斷與治療指南.中華心血管病雜志, 2007, 35(3):195-206.
7.	中華醫學會第四屆全國腦血管病學術會議.各類腦血管病診斷要點.中華神經內科雜志, 1996, 29(6):379-395.
8.	中華醫學會神經病學分會第六屆全國腦血管病學術會議.中國腦血管病防治指南.中風與神經疾病雜志, 2005, 22(5):388-393.
9.	劉志隆, 簡春燕, 周志超, 等.廠礦職工心腦血管疾病流行病學調查分析.臨床醫藥實踐, 2009, 18(10):95-96.
10.	吳華英, 李靜.蘇北地區城鎮人口心腦血管疾病主要危險因素的流行病學研究.中國社區醫師, 2008, 18(10):158-159.
11.	鄭黎強, 李覺, 胡大一, 等.遼寧農村地區主要心腦血管疾病危險因素的流行病學調查.山西醫藥雜志, 2006, 35(12):1065-1067.
12.	楊凱.心腦血管病危險因素流行病學調查及分析.吉林醫學, 2013, 34(18):3611-3612.
13.	勞云飛, 王啟林, 謝懷平.從青少年的行為危險因素談預防心腦血管疾病的干預措施.中國健康教育, 1998, 14(9):16-17.
14.	吳剛.心腦血管疾病:預防重點在低齡, 中國勞動保障報, 2006-12-15(003).
15.	Esposito E, Iacono A, Raso GM, et al.Rabxifene a selective estrogen receptor modulator, reduces carrageenan-induced acute inflammation in normal and ovariectomized rats.Endocrinology, 2005, 146(8):3301-3308.
16.	Dantas APV, Sandberg K.Estrogen regulation of tumor necrosis factor-alpha-A missing link between menopause and cardiovascular risk in women.Hypertension, 2005, 46(2):21-22.
17.	Christian RG, Timothy PP, Elizabeth JK.Aging and estrogen modulation of infalmmatory responses after injury.Exp Gerontol, 2007, 42(3):451-456.
18.	Koh KK, Yoon BK.Controversies regarding hormone therapy.Insights from inflammation and hemostasis.Cardiovasc Res, 2006, 70(2):22-30.
19.	Last JM.A dictionary of epidemiology, 2^nd edition.New York:Oxford University, 1988:169-263.
20.	Hulley SB, Cummings SR, Browner WS, et al.Designing clinical research:an epidemiologic approach.2^nd Edition.Baltimore:Lippincott Williams and Wilkins, 2001:131-186.
21.	Samuel P, Antonisamy B, Raghupathy P, et al.Socio-economic status and cardiovascular risk factors in rural and urban areas of Vellore, Tamilnadu, South India.Int J Epidemiol, 2012, 41(5):1315-1327.
22.	Tinti F, Mitterhofer AP, Muiesan P.Liver transplantation:role of immunosuppression, renal dysfunction and cardiovascular risk factors.Minerva Chir, 2012, 67(1):1-13.
23.	Hwang WJ, Hong O.Work-related cardiovascular disease risk factors using a socioecological approach:implications for practice and research.Eur J Cardiovasc Nurs, 2012, 11(1):114-126.
24.	Subramanyam MA, Diez-Roux AV, Hickson DA, et al.Subjective social status and psychosocial and metabolic risk factors for cardiovascular disease among African Americans in the Jackson Heart Study.Soc Sci Med, 2012, 14(8):86-93.
25.	White JS.Sugar-sweetened beverage link to cardiovascular risk factors is unsupported.Am J Clin Nutr, 2012, 95(3):773.
26.	El Oudi M, Aouni Z, Mazigh C, et al.Total homocysteine levels and cardiovascular risk factors in healthy Tunisians.East Mediterr Health J, 2011, 17(12):937-942.
27.	Williams DM, Fraser A, Sayers A, et al.Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood:cross-sectional findings from the avon longitudinal study of parents and children.J Clin Endocrinol Metab, 2012, 16(2):115-132.
28.	Selvarajah S, Haniff J, Kaur G, et al.Risk-factor clustering:clustering of cardiovascular risk factors in a middle-income country:a call for urgency.Eur J Prev Cardiolog, 2012, 24(1):91-96.
29.	Justin ZM, Patel A, Jan S, et al.Socio-economic position:socioeconomic distribution of cardiovascular risk factors and knowledge in rural India.Int J Epidemiol, 2012, 16(9):581-604.
30.	Fraser A, Nelson SM, Macdonald-Wallis C, et al.Associations of pregnancy pomplications with calculated CVD risk and cardiovascular risk factors in middle age:the avon longitudinal study of parents and children.Circulation, 2012, 17(9):352-389.
31.	Chung CP, Giles JT, Petri M, et al.Prevalence of traditional modifiable cardiovascular risk factors in patients with rheumatoid arthritis:comparison with control subjects from the multi-ethnic study of atherosclerosis.Semin Arthritis Rheum, 2012, 41(4):535-544.
32.	Dzakula A, Ivezi? J, Zili? M, et al.Cardiovascular risk factors and visiting nurse intervention--evaluation of a croatian survey and intervention model:the crohort study.Coll Antropol, 2012, 36(1):21-25.
33.	Andri? A, Vuleti? S.Community nurse assessment of cardiovascular behavioural risk factors-a qualitative analysis within the CroHort study.Coll Antropol, 2012, 36(1):27-34.

1. Sheppard MR, Vinay K, Abul KA, et al.Robbins basic pathology:with student consult online access, 8^th edition.Philadelphia:Saunders, 2007:201-265.
2. Shen Q, Zhu TB.Tissue factor (TF) enhanced the expression of macrophage inflammatory protein-1α(MIP-1α) in cultured human umbilical vein endothelial cells.Chin J Atle, 2006, 14(6):286-288.
3. 張艷, 楊關林, 閻峻, 等.心腦動脈粥樣硬化中醫證型與血脂的相關性研究.遼寧中醫雜志, 2010, 37(3):419-420.
4. 賈連群, 楊關林.動脈粥樣硬化中醫痰濁血瘀證候的現代生物學基礎研究.中西醫結合心腦血管病雜志, 2010, 8(1):95-96.
5. 中華醫學會心血管病學分會.不穩定性心絞痛和非ST段抬高心肌梗死診斷與治療指南.中華心血管病雜志, 2007, 35(4):295-304.
6. 中國《慢性穩定性心絞痛診斷與治療指南》新聞發布會暨高層專家研討會.慢性穩定性心絞痛診斷與治療指南.中華心血管病雜志, 2007, 35(3):195-206.
7. 中華醫學會第四屆全國腦血管病學術會議.各類腦血管病診斷要點.中華神經內科雜志, 1996, 29(6):379-395.
8. 中華醫學會神經病學分會第六屆全國腦血管病學術會議.中國腦血管病防治指南.中風與神經疾病雜志, 2005, 22(5):388-393.
9. 劉志隆, 簡春燕, 周志超, 等.廠礦職工心腦血管疾病流行病學調查分析.臨床醫藥實踐, 2009, 18(10):95-96.
10. 吳華英, 李靜.蘇北地區城鎮人口心腦血管疾病主要危險因素的流行病學研究.中國社區醫師, 2008, 18(10):158-159.
11. 鄭黎強, 李覺, 胡大一, 等.遼寧農村地區主要心腦血管疾病危險因素的流行病學調查.山西醫藥雜志, 2006, 35(12):1065-1067.
12. 楊凱.心腦血管病危險因素流行病學調查及分析.吉林醫學, 2013, 34(18):3611-3612.
13. 勞云飛, 王啟林, 謝懷平.從青少年的行為危險因素談預防心腦血管疾病的干預措施.中國健康教育, 1998, 14(9):16-17.
14. 吳剛.心腦血管疾病:預防重點在低齡, 中國勞動保障報, 2006-12-15(003).
15. Esposito E, Iacono A, Raso GM, et al.Rabxifene a selective estrogen receptor modulator, reduces carrageenan-induced acute inflammation in normal and ovariectomized rats.Endocrinology, 2005, 146(8):3301-3308.
16. Dantas APV, Sandberg K.Estrogen regulation of tumor necrosis factor-alpha-A missing link between menopause and cardiovascular risk in women.Hypertension, 2005, 46(2):21-22.
17. Christian RG, Timothy PP, Elizabeth JK.Aging and estrogen modulation of infalmmatory responses after injury.Exp Gerontol, 2007, 42(3):451-456.
18. Koh KK, Yoon BK.Controversies regarding hormone therapy.Insights from inflammation and hemostasis.Cardiovasc Res, 2006, 70(2):22-30.
19. Last JM.A dictionary of epidemiology, 2^nd edition.New York:Oxford University, 1988:169-263.
20. Hulley SB, Cummings SR, Browner WS, et al.Designing clinical research:an epidemiologic approach.2^nd Edition.Baltimore:Lippincott Williams and Wilkins, 2001:131-186.
21. Samuel P, Antonisamy B, Raghupathy P, et al.Socio-economic status and cardiovascular risk factors in rural and urban areas of Vellore, Tamilnadu, South India.Int J Epidemiol, 2012, 41(5):1315-1327.
22. Tinti F, Mitterhofer AP, Muiesan P.Liver transplantation:role of immunosuppression, renal dysfunction and cardiovascular risk factors.Minerva Chir, 2012, 67(1):1-13.
23. Hwang WJ, Hong O.Work-related cardiovascular disease risk factors using a socioecological approach:implications for practice and research.Eur J Cardiovasc Nurs, 2012, 11(1):114-126.
24. Subramanyam MA, Diez-Roux AV, Hickson DA, et al.Subjective social status and psychosocial and metabolic risk factors for cardiovascular disease among African Americans in the Jackson Heart Study.Soc Sci Med, 2012, 14(8):86-93.
25. White JS.Sugar-sweetened beverage link to cardiovascular risk factors is unsupported.Am J Clin Nutr, 2012, 95(3):773.
26. El Oudi M, Aouni Z, Mazigh C, et al.Total homocysteine levels and cardiovascular risk factors in healthy Tunisians.East Mediterr Health J, 2011, 17(12):937-942.
27. Williams DM, Fraser A, Sayers A, et al.Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood:cross-sectional findings from the avon longitudinal study of parents and children.J Clin Endocrinol Metab, 2012, 16(2):115-132.
28. Selvarajah S, Haniff J, Kaur G, et al.Risk-factor clustering:clustering of cardiovascular risk factors in a middle-income country:a call for urgency.Eur J Prev Cardiolog, 2012, 24(1):91-96.
29. Justin ZM, Patel A, Jan S, et al.Socio-economic position:socioeconomic distribution of cardiovascular risk factors and knowledge in rural India.Int J Epidemiol, 2012, 16(9):581-604.
30. Fraser A, Nelson SM, Macdonald-Wallis C, et al.Associations of pregnancy pomplications with calculated CVD risk and cardiovascular risk factors in middle age:the avon longitudinal study of parents and children.Circulation, 2012, 17(9):352-389.
31. Chung CP, Giles JT, Petri M, et al.Prevalence of traditional modifiable cardiovascular risk factors in patients with rheumatoid arthritis:comparison with control subjects from the multi-ethnic study of atherosclerosis.Semin Arthritis Rheum, 2012, 41(4):535-544.
32. Dzakula A, Ivezi? J, Zili? M, et al.Cardiovascular risk factors and visiting nurse intervention--evaluation of a croatian survey and intervention model:the crohort study.Coll Antropol, 2012, 36(1):21-25.
33. Andri? A, Vuleti? S.Community nurse assessment of cardiovascular behavioural risk factors-a qualitative analysis within the CroHort study.Coll Antropol, 2012, 36(1):27-34.

Chinese Journal of Evidence-Based Medicine

Risk Factors of Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction in China: A Cross-sectional Study

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