Risk Factors of Epilepsy: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANGBo-wen ^1,2 , CHENXin ^1,2 , SUNHao ^1,2 , ZOUSa-feng ³ ,  SHIJing-pu ^1,2

1. Department of Clinical Epidemiology, The First Alienated Hospital, China Medical University, Shenyang 110001, China;
2. Evidence-Based Center of Liaoning Province, Shenyang 110001, China;
3. Dalian Central Hospital Affiliated to Dalian Medical University, Dalian 116001, China;

Corresponding?author：

SHIJing-pu, Email: sjp56@yahoo.com

Keywords：

Epilepsy; Risk factor; Case-control study; Meta-analysis

DOI：

10.7507/1672-2531.20140016

Video：

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Objective To explore the main risk factors related to the incidence of epilepsy and the cause of epilepsy, so as to provide basis for decision making on epilepsy prevention. Methods Such databases as PubMed (1980 to 2013.1.2), EMbase (1980 to 2013.1.2) and CNKI (1987 to 2013.1.2) were electronically searched to collect case-control studies on risk factors for epilepsy. Meanwhile, relevant studies were also manually retrieved. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, meta-analysis was performed using RevMan 5.2 software. Results 17 studies involving 6 641 participants (including 3 114 cases and 3 527 controls) were included. The results of meta-analysis showed that, family history of epilepsy, traumatic brain injury, febrile seizures, neonatal disease, and risk factors during pregnancy were associated with the incidence of epilepsy, with pooled OR (95%CI) values of 5.11 (3.19, 8.20), 4.14 (3.63, 4.73), 5.10 (2.64, 9.87), 3.33 (1.84, 6.05), and 3.23 (1.80, 5.78), respectively. Conclusion Currently evidence shows that the risk factors influencing the incidence of epilepsy are family history of epilepsy, traumatic brain injury, febrile seizures, neonatal disease, and risk factors during pregnancy.

Citation： YANGBo-wen, CHENXin, SUNHao, ZOUSa-feng, SHIJing-pu. Risk Factors of Epilepsy: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(1): 94-100. doi: 10.7507/1672-2531.20140016 Copy

1.	?Annegers J. Epidemiology and genetics of epilepsy. Neurol Clinics, 1994, 12(1):15.
2.	Beghi E, Berg A, Carpio A, et al. Comment on epileptic seizures and epilepsy:definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(10):1698-1699.
3.	李明.癲癇發病危險因素及原發性癲癇遺傳流行病學研究.濟南:山東大學, 2010.
4.	DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials:an update. Contemp Clin Trials, 2007, 28(2):105-114.
5.	楊春霞, 張思霖.原發性癲癇的病例對照研究.現代預防醫學1997, 24(4):397-398.
6.	李明, 車峰遠, 薛付忠.癲癇危險因素病例對照研究.中國公共衛生2010, (6):789-790.
7.	楊金升, 吳志英, 郭起棠, 等.西北五省區兒童癲癇流行病學研究.實用兒科臨床雜志1990, 2(2):3.
8.	曾軍, 洪震, 黃茂盛, 等.人群癲癇危險因素及社會心理因素病例對照研究.中華流行病學雜志, 2003, 24(2):116-118.
9.	吳志英.中國西北癲癇遺傳流行病學病例對照研究.蘭后衛生, 1994, 15(1):1-2.
10.	Masri A, Badran E, Hamamy H, et al. Etiologies, outcomes, and risk factors for epilepsy in infants:A case-control study. Clin Neurol Neurosurg, 2008, 110(4):352-356.
11.	Asadi-Pooya AA, Hojabri K. Risk factors for childhood epilepsy:a case-control study. Epilepsy Behav, 2005, 6(2):203.
12.	Kannoth S, Unnikrishnan JP, Santhosh Kumar T, et al. Risk factors for epilepsy:A population-based case-control study in Kerala, southern India. Epilepsy Behav, 2009, 16(1):58-63.
13.	Matuja W, Kilonzo G, Mbena P, et al. Risk Factors for Epilepsy in a Rural Area in Tanzania. Neuroepidemiology, 2001, 20(4):242-247.
14.	Ogunniyi A, Osuntokun B, Bademosi O, et al. Risk factors for epilepsy:case-control study in Nigerians. Epilepsia, 1987, 28(3):280.
15.	Attumalil T, Sundaram A, Varghese V, et al. Risk factors of childhood epilepsy in Kerala. Ann Indian Acad Neurol, 2011, 14(4):283.
16.	Daoud A, Batieha A, Bashtawi M, et al. Risk factors for childhood epilepsy:a case-control study from Irbid, Jordan. Seizure, 2003, 12(3):171-174.
17.	Tran DS, Odermatt P, Le Oanh T, et al. Risk factors for epilepsy in rural Lao PDR:a case-control study. Southeast Asian J Trop Med Public Health, 2007, 38(3):537-542.
18.	Kwong KL, Sung WY, Wong SN, et al. Early predictors of medical intractability in childhood epilepsy. Pediatr Neurol, 2003, 29(1):46-52.
19.	Bhalla D, Chea K, Hun C, et al. Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap. PLoS One, 2012, 7(10):e46296.
20.	Matias-Guiu J, Galiano L, Vioque J, et al. A case-control study to evaluate the association of epilepsy and migraine. Neuroepidemiology, 1992, 11(4-6):313-314.
21.	Sawhney I, Singh A, Kaur P, et al. A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. J Neurol Sci, 1999, 165(1):31-35.
22.	Scheffer IE, Berkovic SF. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain, 1997, 120(3):479-490.
23.	龔珂, 王紅霞.顱腦損傷并發癲癇的觀察與分析.河南實用神經疾病雜志, 2002, 5(5):47.
24.	張美林, 黃斌, 陳陽美.缺血性卒中后癲癇發作危險因素的臨床分析.重慶醫科大學學報, 2010, 35(4):608-612.
25.	張策.顱腦損傷后預防應用抗癲癇藥物療效Meta分析.中華神經醫學雜志, 2011, 10(4):4.
26.	趙永波, 邵麗.顱腦損傷后癲癇.臨床神經病學雜志, 2006, 19(5):397-398.
27.	林慶, 主編.實用小兒癲癇病學.第1版.北京:科學技術出版社, 2004:58-113.
28.	李袁華, 周春雷, 趙德明, 等.癲癇持續狀態致MODS的發生率及其相關因素分析.中華全科醫學, 2008, 6(9):925-926.
29.	秦兵, 廖衛平.癲癇:全球重點防治的神經精神疾病.實用醫學雜志, 2012, 28(13):2109-2111.

1. ?Annegers J. Epidemiology and genetics of epilepsy. Neurol Clinics, 1994, 12(1):15.
2. Beghi E, Berg A, Carpio A, et al. Comment on epileptic seizures and epilepsy:definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(10):1698-1699.
3. 李明.癲癇發病危險因素及原發性癲癇遺傳流行病學研究.濟南:山東大學, 2010.
4. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials:an update. Contemp Clin Trials, 2007, 28(2):105-114.
5. 楊春霞, 張思霖.原發性癲癇的病例對照研究.現代預防醫學1997, 24(4):397-398.
6. 李明, 車峰遠, 薛付忠.癲癇危險因素病例對照研究.中國公共衛生2010, (6):789-790.
7. 楊金升, 吳志英, 郭起棠, 等.西北五省區兒童癲癇流行病學研究.實用兒科臨床雜志1990, 2(2):3.
8. 曾軍, 洪震, 黃茂盛, 等.人群癲癇危險因素及社會心理因素病例對照研究.中華流行病學雜志, 2003, 24(2):116-118.
9. 吳志英.中國西北癲癇遺傳流行病學病例對照研究.蘭后衛生, 1994, 15(1):1-2.
10. Masri A, Badran E, Hamamy H, et al. Etiologies, outcomes, and risk factors for epilepsy in infants:A case-control study. Clin Neurol Neurosurg, 2008, 110(4):352-356.
11. Asadi-Pooya AA, Hojabri K. Risk factors for childhood epilepsy:a case-control study. Epilepsy Behav, 2005, 6(2):203.
12. Kannoth S, Unnikrishnan JP, Santhosh Kumar T, et al. Risk factors for epilepsy:A population-based case-control study in Kerala, southern India. Epilepsy Behav, 2009, 16(1):58-63.
13. Matuja W, Kilonzo G, Mbena P, et al. Risk Factors for Epilepsy in a Rural Area in Tanzania. Neuroepidemiology, 2001, 20(4):242-247.
14. Ogunniyi A, Osuntokun B, Bademosi O, et al. Risk factors for epilepsy:case-control study in Nigerians. Epilepsia, 1987, 28(3):280.
15. Attumalil T, Sundaram A, Varghese V, et al. Risk factors of childhood epilepsy in Kerala. Ann Indian Acad Neurol, 2011, 14(4):283.
16. Daoud A, Batieha A, Bashtawi M, et al. Risk factors for childhood epilepsy:a case-control study from Irbid, Jordan. Seizure, 2003, 12(3):171-174.
17. Tran DS, Odermatt P, Le Oanh T, et al. Risk factors for epilepsy in rural Lao PDR:a case-control study. Southeast Asian J Trop Med Public Health, 2007, 38(3):537-542.
18. Kwong KL, Sung WY, Wong SN, et al. Early predictors of medical intractability in childhood epilepsy. Pediatr Neurol, 2003, 29(1):46-52.
19. Bhalla D, Chea K, Hun C, et al. Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap. PLoS One, 2012, 7(10):e46296.
20. Matias-Guiu J, Galiano L, Vioque J, et al. A case-control study to evaluate the association of epilepsy and migraine. Neuroepidemiology, 1992, 11(4-6):313-314.
21. Sawhney I, Singh A, Kaur P, et al. A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. J Neurol Sci, 1999, 165(1):31-35.
22. Scheffer IE, Berkovic SF. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain, 1997, 120(3):479-490.
23. 龔珂, 王紅霞.顱腦損傷并發癲癇的觀察與分析.河南實用神經疾病雜志, 2002, 5(5):47.
24. 張美林, 黃斌, 陳陽美.缺血性卒中后癲癇發作危險因素的臨床分析.重慶醫科大學學報, 2010, 35(4):608-612.
25. 張策.顱腦損傷后預防應用抗癲癇藥物療效Meta分析.中華神經醫學雜志, 2011, 10(4):4.
26. 趙永波, 邵麗.顱腦損傷后癲癇.臨床神經病學雜志, 2006, 19(5):397-398.
27. 林慶, 主編.實用小兒癲癇病學.第1版.北京:科學技術出版社, 2004:58-113.
28. 李袁華, 周春雷, 趙德明, 等.癲癇持續狀態致MODS的發生率及其相關因素分析.中華全科醫學, 2008, 6(9):925-926.
29. 秦兵, 廖衛平.癲癇:全球重點防治的神經精神疾病.實用醫學雜志, 2012, 28(13):2109-2111.

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