Value of Contrast-Enhanced Ultrasound in Differential Diagnosis of Preoperative Benign and Malignant Breast Mass: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHANGXiao-guang ¹ , ZHANGXiao-li ² , Palida·Paerhati ¹ , ZHANGYu ³ ,  Nadire·Tieliewuhan ¹

1. Ultrasound Diagnosis Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;
2. Department of Orthopedics, People's Hospital of Zhecheng County, Henan Province, Shangqiu 476200, China;
3. Physical Check-ups and Health Management Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;

Corresponding?author：

Nadire·Tieliewuhan, Email: nadire607@163.com

Keywords：

Breast mass; Contrast-enhanced ultrasonography; Differential diagnosis; Systematically review; Diagnostic test

DOI：

10.7507/1672-2531.20140014

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the clinical value of the contrast-enhanced ultrasonic in the diagnosis of breast tumors. Methods We electronically and comprehensively searched the databases including The Cochrane Library (Issue 2, 2013), PubMed, CNKI, WanFang Data, Chaoxing medalink, VIP, and CBM for clinical research reports of diagnosing breast cancer with Contrast-enhance ultrasonic (all from foundation to May 2013). Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of the included studies according to the QUADAS items. The Meta-DiSc software (version 1.4) was used to conduct pooling on sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio. Heterogeneity test was performed and the summary receiver operating characteristic (SROC) curve was drawn for area under the curve (AUC). Results A total of 19 studies involving 1 161 participants were included. The results of meta-analysis showed that, specificity, the pooled sensitivity, positive likelihood ratio, negative likelihood ratio and DOR were 0.79 (95%CI 0.75 to 0.82), 0.86 (95%CI 0.83 to 0.89), 3.92 (95%CI 2.77 to 6.56), 0.18 (95%CI 0.13 to 0.26), and 25.86 (95%CI 13.77 to 48.55), respectively. The AUC of the SROC curve was 0.917 0. Conclusion The current evidence shows that contrast-enhanced ultrasonic has high sensitivity and specificity in the diagnosis of preoperative benign and malignant breast mass, which indicates that it could be used as a good method to diagnosing breast tumors.

Citation： ZHANGXiao-guang, ZHANGXiao-li, Palida·Paerhati, ZHANGYu, Nadire·Tieliewuhan. Value of Contrast-Enhanced Ultrasound in Differential Diagnosis of Preoperative Benign and Malignant Breast Mass: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(1): 79-84. doi: 10.7507/1672-2531.20140014 Copy

1.	?Ricci P, Cantisani V, Ballesio L, et al. Benign and malignant breast lesions:efficacy of real time contrast enhanced ultrasound VS. magnetic resonance imaging. Ultras hall Med, 2007, 28(1):57-62.
2.	Yon HA, Westendorff J, Gregor M. Contrastenhanced ultrasound with sonovue:differentiation between benign and malignant focal liver lesions in 317 patients. Clin Ultrasound, 2010, 38(1):1-9.
3.	王小燕, 康利克, 藍春勇, 等.乳腺惡性腫塊超聲造影特征表現及診斷.中國超聲醫學雜志, 2012, 28(8):705-708.
4.	刁驤, 艾昌林, 秦莉, 等譯. QUADAS的制定:用于系統評價診斷性研究質量的工具.中國循證醫學雜志, 2007, 7(4):296-306.
5.	張曉光, 帕麗達·帕爾哈提, 張雨, 等.彩色多普勒超聲對女性乳腺癌診斷價值的Meta分析.中國循證醫學雜志, 2013, 13(9):1073-1079.
6.	張天嵩, 鐘文昭. Meta-DiSc軟件在診斷試驗Meta分析中的應用.循證醫學, 2008, 8(2):97-100.
7.	Kedar RP, Cosgrove D, mc Cready VP, et al. Microbubble contrast agent for color Doppler US:effect on breast masses Work in progress. Radiology, 1996, 198(3):679-686.
8.	Huber S, Helbich T, Kettenbach J, et al. Effects of a micro bubble contrast agent on breast tumors:computer-assisted quantitative assessment with color Doppler US-early experience. Radiology, 1998, 208(2):485-489.
9.	Stuhrmann M, Aronius R, Schietzel M. Tumor vascularity of breast lesions:potentials and limits of contrast enhanced Doppler sonography. AJR Am J Roentgenol, 2000, 175(6):1585-1589.
10.	Moon WK, Im JG, Noh DY, et al. Nopalpable breast lesions:evaluation with power Doppler US and a microbubble contrast agent-initial experience. Radiology, 2000, 217(1):240-246.
11.	Yang WT, Metreweli C, Lam PK, et al. Benign and malignant breast masses and axillary nodes:evaluation with echo-enhanced color power Doppler US. Radiology, 2001, 220(3):795-802.
12.	Kook SH, Kwag HJ. Value of contrast-enhanced power Doppler sonography using a microbubble echo-enhancing gent in evaluation of small breast lesions. Clin Ultrasound, 2003, 31(5):227-238.
13.	Forsberg F, Goldberg BB, Merritt CR, et al. Diagnosing breast lesions with contrast-enhanced 3-dimensional power Doppler imaging. Ultrasound Med, 2004, 23(2):173-182.
14.	Zdemir A, Kilic K, Ozdemir H, et al. Contrast-enhanced power Doppler sonography in breast lesions:effect on differential diagnosis after mammography and gray scale sonography. Ultrasound Med, 2004, 23(2):183-195.
15.	Kettenbach J, Elbich T H, Huber S, et al. Computer-assisted quantitative assessment of power Doppler US:effects of micro bubble contrast agent in the differentiation of breast tumors. Eur J Radiol, 2005, 53(2):238-244.
16.	Jung EM, Jungius KP, Rupp N, et al. Contrast enhanced Harmon cult resound for differentiating breast tumors-first results. Cli Clin Hemorheol Microcirc, 2005, 33(2):109-120.
17.	Liu H, Jang YX, Liu JB, et al. Evaluation of breast lesions with contrast-enhanced ultrasound using the micro vascular imaging technique:initial observations. Breast, 2008, 17(5):532-539.
18.	Du J, Li FH, Fang H, et al. Micro vascular architecture of breast lesions:evaluation with cont rats-enhanced ultrasonographic micro flow imaging. Ultrasound Med, 2008, 27(6):833-842.
19.	趙紅佳, 董寶瑋, 許榮, 等.超聲造影定量分析在乳腺腫瘤診斷中的應用價值.中華乳腺病雜志(電子版), 2008, 2(6):634-640.
20.	尤厚成, 劉健, 尤楠, 等.超聲造影對乳腺良惡性腫塊鑒別診斷的價值.中國普外基礎與臨床雜志, 2011, 18(8):861-865.
21.	迪麗努爾·買買提明, 尹科, 等.實時超聲造影對乳腺良、惡性腫瘤的鑒別診斷價值.新疆醫科大學學報, 2011, 34(8):847-849, 854.
22.	陳俊, 丁炎, 周鋒盛, 等.乳腺癌超聲造影與MRI診斷價值比較分析.海南醫學, 2011, 22(21):100-102.
23.	邵小慧, 董曉秋, 王思明, 等.彩色多普勒超聲與實時灰階超聲造影對乳腺腫瘤的診斷價值比較.實用腫瘤學雜志, 2012, 26(3):232-235.
24.	陳杰, 吳曉萍, 李旭霞, 等.超聲造影和彩色多普勒超聲聯合檢查乳腺腫塊的臨床價值.醫學影像學雜志, 2012, 22(2):286-287.
25.	Broumas AR, Pollard RE, Bloch SH, et al. Contrast-enhanced computed tomography and ultrasound for the evaluation of tumor blood flow. Invest Radiol, 2005, 40(3):134-147.
26.	Houssami N, Cuzick J, Dixon JM. The prevention, detection, and management of breast cancer. Med J Aust, 2006, 184(5):230-234.
27.	Taylor D, Lazberger J, Ives A, et al. Reducing delay in the diagnosis of pregnancy-associated breast cancer:how imaging can help us. Med Imaging Radiat Oncol, 2011, 55(1):33-42.

1. ?Ricci P, Cantisani V, Ballesio L, et al. Benign and malignant breast lesions:efficacy of real time contrast enhanced ultrasound VS. magnetic resonance imaging. Ultras hall Med, 2007, 28(1):57-62.
2. Yon HA, Westendorff J, Gregor M. Contrastenhanced ultrasound with sonovue:differentiation between benign and malignant focal liver lesions in 317 patients. Clin Ultrasound, 2010, 38(1):1-9.
3. 王小燕, 康利克, 藍春勇, 等.乳腺惡性腫塊超聲造影特征表現及診斷.中國超聲醫學雜志, 2012, 28(8):705-708.
4. 刁驤, 艾昌林, 秦莉, 等譯. QUADAS的制定:用于系統評價診斷性研究質量的工具.中國循證醫學雜志, 2007, 7(4):296-306.
5. 張曉光, 帕麗達·帕爾哈提, 張雨, 等.彩色多普勒超聲對女性乳腺癌診斷價值的Meta分析.中國循證醫學雜志, 2013, 13(9):1073-1079.
6. 張天嵩, 鐘文昭. Meta-DiSc軟件在診斷試驗Meta分析中的應用.循證醫學, 2008, 8(2):97-100.
7. Kedar RP, Cosgrove D, mc Cready VP, et al. Microbubble contrast agent for color Doppler US:effect on breast masses Work in progress. Radiology, 1996, 198(3):679-686.
8. Huber S, Helbich T, Kettenbach J, et al. Effects of a micro bubble contrast agent on breast tumors:computer-assisted quantitative assessment with color Doppler US-early experience. Radiology, 1998, 208(2):485-489.
9. Stuhrmann M, Aronius R, Schietzel M. Tumor vascularity of breast lesions:potentials and limits of contrast enhanced Doppler sonography. AJR Am J Roentgenol, 2000, 175(6):1585-1589.
10. Moon WK, Im JG, Noh DY, et al. Nopalpable breast lesions:evaluation with power Doppler US and a microbubble contrast agent-initial experience. Radiology, 2000, 217(1):240-246.
11. Yang WT, Metreweli C, Lam PK, et al. Benign and malignant breast masses and axillary nodes:evaluation with echo-enhanced color power Doppler US. Radiology, 2001, 220(3):795-802.
12. Kook SH, Kwag HJ. Value of contrast-enhanced power Doppler sonography using a microbubble echo-enhancing gent in evaluation of small breast lesions. Clin Ultrasound, 2003, 31(5):227-238.
13. Forsberg F, Goldberg BB, Merritt CR, et al. Diagnosing breast lesions with contrast-enhanced 3-dimensional power Doppler imaging. Ultrasound Med, 2004, 23(2):173-182.
14. Zdemir A, Kilic K, Ozdemir H, et al. Contrast-enhanced power Doppler sonography in breast lesions:effect on differential diagnosis after mammography and gray scale sonography. Ultrasound Med, 2004, 23(2):183-195.
15. Kettenbach J, Elbich T H, Huber S, et al. Computer-assisted quantitative assessment of power Doppler US:effects of micro bubble contrast agent in the differentiation of breast tumors. Eur J Radiol, 2005, 53(2):238-244.
16. Jung EM, Jungius KP, Rupp N, et al. Contrast enhanced Harmon cult resound for differentiating breast tumors-first results. Cli Clin Hemorheol Microcirc, 2005, 33(2):109-120.
17. Liu H, Jang YX, Liu JB, et al. Evaluation of breast lesions with contrast-enhanced ultrasound using the micro vascular imaging technique:initial observations. Breast, 2008, 17(5):532-539.
18. Du J, Li FH, Fang H, et al. Micro vascular architecture of breast lesions:evaluation with cont rats-enhanced ultrasonographic micro flow imaging. Ultrasound Med, 2008, 27(6):833-842.
19. 趙紅佳, 董寶瑋, 許榮, 等.超聲造影定量分析在乳腺腫瘤診斷中的應用價值.中華乳腺病雜志(電子版), 2008, 2(6):634-640.
20. 尤厚成, 劉健, 尤楠, 等.超聲造影對乳腺良惡性腫塊鑒別診斷的價值.中國普外基礎與臨床雜志, 2011, 18(8):861-865.
21. 迪麗努爾·買買提明, 尹科, 等.實時超聲造影對乳腺良、惡性腫瘤的鑒別診斷價值.新疆醫科大學學報, 2011, 34(8):847-849, 854.
22. 陳俊, 丁炎, 周鋒盛, 等.乳腺癌超聲造影與MRI診斷價值比較分析.海南醫學, 2011, 22(21):100-102.
23. 邵小慧, 董曉秋, 王思明, 等.彩色多普勒超聲與實時灰階超聲造影對乳腺腫瘤的診斷價值比較.實用腫瘤學雜志, 2012, 26(3):232-235.
24. 陳杰, 吳曉萍, 李旭霞, 等.超聲造影和彩色多普勒超聲聯合檢查乳腺腫塊的臨床價值.醫學影像學雜志, 2012, 22(2):286-287.
25. Broumas AR, Pollard RE, Bloch SH, et al. Contrast-enhanced computed tomography and ultrasound for the evaluation of tumor blood flow. Invest Radiol, 2005, 40(3):134-147.
26. Houssami N, Cuzick J, Dixon JM. The prevention, detection, and management of breast cancer. Med J Aust, 2006, 184(5):230-234.
27. Taylor D, Lazberger J, Ives A, et al. Reducing delay in the diagnosis of pregnancy-associated breast cancer:how imaging can help us. Med Imaging Radiat Oncol, 2011, 55(1):33-42.

Previous Article
Human Epididymis Protein 4 in Early Diagnosis of Endometrial Cancer: A Systematic Review
Next Article
Atosiban for Threatened Premature Labor: A Systematic Review

Chinese Journal of Evidence-Based Medicine

Value of Contrast-Enhanced Ultrasound in Differential Diagnosis of Preoperative Benign and Malignant Breast Mass: A Systematic Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content