Effectiveness and Safety of Dezocine versus Fentanyl for Postoperative Patient-controlled Intravenous Analgesia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 ZOUDan ¹ , WUFeng-bo ¹ , LIUYong ²

1. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China;
2. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

Dezocine; Fentanyl; Postoperative patient-controlled intravenous analgesia; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20140012

Video：

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Objective To systematically evaluate the effectiveness and safety of dezocine versus fentanyl for postoperative patient-controlled intravenous analgesia (PCIA). Methods We electronically searched the specialized trials registered in The Cochrane Library (Issue 2, 2013), the Cochrane anesthesia group, MEDLINE, EMbase, CBM, CNKI, VIP and WanFang Data from inception to February, 2013. Randomized controlled trials (RCTs) on dezocine versus Fentanyl for postoperative PCIA were included. RevMan 5.0 software was used for meta-analysis after critically literature screening, data extracting and assessing of methodological quality independently by two reviewers. Results A total of 15 RCTs involving 1 116 patients were finally included. The results of meta-analysis showed that there was no significant difference in postoperative analgesia and sedation at the hour-points of 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, and 48 h after surgery. As for safety, the incidences of postoperative nausea, vomiting, skin pruritus, respiratory depression and uroschesis in the dezocine group were lower than those in the fentanyl group. Conclusion Compared with fentanyl, dezocine has the same effects of analgesia and sedation for PCIA; its incidence of adverse reactions is lower, so dezocine is safer in clinic.

Citation： ZOUDan, WUFeng-bo, LIUYong. Effectiveness and Safety of Dezocine versus Fentanyl for Postoperative Patient-controlled Intravenous Analgesia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2014, 14(1): 65-71. doi: 10.7507/1672-2531.20140012 Copy

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2.	焦向陽, 賀顯建, 薛璋明, 等.地佐辛與芬太尼用于術后靜脈鎮痛的療效比較.陜西醫學雜志, 2011, 40(10):1365-1367.
3.	金震, 文艷.地佐辛應用于剖宮產術后靜脈鎮痛臨床效果觀察.現代醫藥衛生, 2011, 27(21):3292-3293.
4.	蘭群飛, 樊理華, 戴仁鋒, 等.地佐辛在靜脈自控鎮痛的臨床觀察.海峽藥學, 2011, 23(9):97-98.
5.	劉衛校, 丁華, 萬營.地佐辛用于乳腺癌根治術后靜脈自控鎮痛的臨床觀察.中國現代醫生, 2012, 50(14):93-94.
6.	劉新偉, 郭艷巍.芬太尼與地佐辛對老年骨科病人術后鎮痛效果的對比.中國老年學雜志, 2011, 31(22):4465-4466.
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9.	任培才.腸道腫瘤切除手術術后地佐辛靜脈自控鎮痛的評價.廣州醫藥, 2012, 43(5):24-26.
10.	陶巖, 鄂爽, 陳琦, 等.地佐辛用于頸椎手術術后鎮痛的臨床研究.中外醫療, 2013, (2):109-111.
11.	王軍, 王志萍, 黃東曉.地佐辛與芬太尼患者自控靜脈鎮痛的比較.實用臨床醫藥雜志, 2011, 15(5):109-110.
12.	王磊. 0.05%的地佐辛用于術后靜脈自控鎮痛臨床觀察.吉林醫學, 2012, 33(15):3211.
13.	謝國柱, 錢濤, 姜琳.地佐辛用于婦科術后鎮痛的臨床觀察.海南醫學, 2011, 22(21):48-50.
14.	葉秀麗.地佐辛與芬太尼用于子宮切除術后鎮痛效果的比較.中國醫藥指南, 2011, 9(25):267-268.
15.	張貴權, 高秀敏.地佐辛用于術后鎮痛的臨床觀察.吉林醫學, 2013, 34(3):480-481.
16.	趙森, 呂國義, 孫成亮, 等.地佐辛與芬太尼用于懸雍垂腭咽成形術后鎮痛的評價.天津醫藥, 2012, 40(9):905-907.
17.	師小偉, 熊源長, 劉佩蓉.地佐辛臨床鎮痛的研究進展.醫學綜述, 2013, 19(6):1105-1107.
18.	Kaczor A, Matosiuk D. Non-peptide opioid receptor ligands-recent advances. PartII-antagonists. Curr Med Chem, 2002, 9(17):1591-1603.
19.	Gal TJ, DiFazio CA.Ventilatory and analgesic effects of dezocine in human. Anesthesiology, 1984, 61(6):716-722.
20.	Zacny JP, Lichtor JL, De Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesth Analg, 1992, 74(4):523-530.

1. ?徐建國, 吳新民, 羅愛倫, 等.成人術后疼痛處理專家共識.臨床麻醉學雜志, 2010, 26(3):190-196.
2. 焦向陽, 賀顯建, 薛璋明, 等.地佐辛與芬太尼用于術后靜脈鎮痛的療效比較.陜西醫學雜志, 2011, 40(10):1365-1367.
3. 金震, 文艷.地佐辛應用于剖宮產術后靜脈鎮痛臨床效果觀察.現代醫藥衛生, 2011, 27(21):3292-3293.
4. 蘭群飛, 樊理華, 戴仁鋒, 等.地佐辛在靜脈自控鎮痛的臨床觀察.海峽藥學, 2011, 23(9):97-98.
5. 劉衛校, 丁華, 萬營.地佐辛用于乳腺癌根治術后靜脈自控鎮痛的臨床觀察.中國現代醫生, 2012, 50(14):93-94.
6. 劉新偉, 郭艷巍.芬太尼與地佐辛對老年骨科病人術后鎮痛效果的對比.中國老年學雜志, 2011, 31(22):4465-4466.
7. 喬孝武, 徐瑱.地佐辛在婦科全麻手術后PCIA中的療效觀察.中國現代藥物應用, 2012, 6(11):77-79.
8. 秦革萍, 馬平康, 杜睿, 等.地佐辛用于剖宮產術后鎮痛的療效觀察.中國現代藥物應用, 2012, 6(13):84-85.
9. 任培才.腸道腫瘤切除手術術后地佐辛靜脈自控鎮痛的評價.廣州醫藥, 2012, 43(5):24-26.
10. 陶巖, 鄂爽, 陳琦, 等.地佐辛用于頸椎手術術后鎮痛的臨床研究.中外醫療, 2013, (2):109-111.
11. 王軍, 王志萍, 黃東曉.地佐辛與芬太尼患者自控靜脈鎮痛的比較.實用臨床醫藥雜志, 2011, 15(5):109-110.
12. 王磊. 0.05%的地佐辛用于術后靜脈自控鎮痛臨床觀察.吉林醫學, 2012, 33(15):3211.
13. 謝國柱, 錢濤, 姜琳.地佐辛用于婦科術后鎮痛的臨床觀察.海南醫學, 2011, 22(21):48-50.
14. 葉秀麗.地佐辛與芬太尼用于子宮切除術后鎮痛效果的比較.中國醫藥指南, 2011, 9(25):267-268.
15. 張貴權, 高秀敏.地佐辛用于術后鎮痛的臨床觀察.吉林醫學, 2013, 34(3):480-481.
16. 趙森, 呂國義, 孫成亮, 等.地佐辛與芬太尼用于懸雍垂腭咽成形術后鎮痛的評價.天津醫藥, 2012, 40(9):905-907.
17. 師小偉, 熊源長, 劉佩蓉.地佐辛臨床鎮痛的研究進展.醫學綜述, 2013, 19(6):1105-1107.
18. Kaczor A, Matosiuk D. Non-peptide opioid receptor ligands-recent advances. PartII-antagonists. Curr Med Chem, 2002, 9(17):1591-1603.
19. Gal TJ, DiFazio CA.Ventilatory and analgesic effects of dezocine in human. Anesthesiology, 1984, 61(6):716-722.
20. Zacny JP, Lichtor JL, De Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesth Analg, 1992, 74(4):523-530.

Chinese Journal of Evidence-Based Medicine

Effectiveness and Safety of Dezocine versus Fentanyl for Postoperative Patient-controlled Intravenous Analgesia: A Systematic Review

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