腦電圖在慢性呼吸系統疾病中的應用價值及研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

劉欣蕊 ¹ , 倪夕秀 ¹ , 陳穎 ¹ , 楊佐琴 ² ,  趙凌 ¹

1. ;
2. ;

Corresponding?author：

趙凌, Email: zhaoling@cdutcm.edu.cn

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DOI：

10.7507/1671-6205.202410036

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Citation： 劉欣蕊, 倪夕秀, 陳穎, 楊佐琴, 趙凌. 腦電圖在慢性呼吸系統疾病中的應用價值及研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(3): 212-217. doi: 10.7507/1671-6205.202410036 Copy

1.	朱衣興, 常德. 慢性呼吸系統疾病管理的現狀和展望. 結核與肺部疾病雜志, 2024, 5(6): 567-572.
2.	Dodd JW, Charlton RA. Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD. Chest, 2013, 144(1): 119-127.
3.	Areza-Fegyveres R, Kairalla RA. Cognition and chronic hypoxia in pulmonary diseases. Dement Neuropsychol, 2010, 4(1): 14-22.
4.	Fan VS, Meek PM. Anxiety, depression, and cognitive impairment in patients with chronic respiratory disease. Clin Chest Med, 2014, 35(2): 399-409.
5.	陳琰, 錢頻, 袁琳等. 慢性阻塞性肺疾病肺外合并癥的治療現狀和研究進展. 中華肺部疾病雜志(電子版), 2020, 13(1): 100-103.
6.	Similowski T. Treat the lungs, fool the brain and appease the mind: towards holistic care of patients who suffer from chronic respiratory diseases. Eur Respir J, 2018, 51(2): 1800316.
7.	Janssens T, De Peuter S, Stans L, et al. Dyspnea perception in COPD: Association between anxiety, dyspnea-related fear, and dyspnea in a pulmonary rehabilitation program. Chest, 2011, 140(3): 618-625.
8.	岳丹, 羅志梅, 范林婕, 等. 手持風扇療法在緩解呼吸困難中的研究現狀. 中國呼吸與危重監護雜志, 2024, 23(8): 605-608.
9.	王瑋. 慢性阻塞性肺疾病患者腦功能及結構網絡變化的MRI研究. 中國人民解放軍海軍軍醫大學, 2021.
10.	Finnegan SL, Harrison OK, Harmer CJ, et al. Breathlessness in COPD: linking symptom clusters with brain activity. Eur Respir J, 2021, 58(5): 2004099.
11.	Wang M, Wang Y, Wang Z, et al. The abnormal alternations of brain imaging in patients with chronic obstructive pulmonary disease: a systematic review. J Alzheimers Dis Rep, 2023(1): 901-919.
12.	Nunez PL, Srinivasan R. A theoretical basis for standing and traveling brain waves measured with human EEG with implications for an integrated consciousness. Clin Neurophysiol, 2006, 17(11): 2424-35.
13.	鄭貝思, 陳健爾. 定量腦電圖在認知功能障礙康復中的應用研究進展. 中華物理醫學與康復雜志, 2024, 46(8): 764-768.
14.	覃慧怡, 丁麗洪, 段威, 等. 腦電的重測信度: 在多項靜息態和任務態實驗中的對比. 心理學報, 2023, 55(10): 1587-1596.
15.	段宏霞, 劉沁欣, 趙仙麗, 等. 認知功能評價工具在慢性阻塞性肺疾病中的應用進展. 中國康復醫學雜志, 2023, 38(4): 539-545.
16.	何曉燕, 朱沂, 李紅燕, 等. 癡呆評估量表與事件相關電位P300對輕度認知功能障礙患者認知功能的評價. 中國老年學雜志, 2011, 31(16): 3041-3043.
17.	陳甄, 張廣波, 周迪, 等. 急性高原低氧環境對不同情緒狀態腦電功率的影響. 中國應用生理學雜志, 2020, 36(6): 556-561.
18.	聶聃, 王曉韡, 段若男, 等. 基于腦電的情緒識別研究綜述. 中國生物醫學工程學報, 2012, 31(4): 595-606.
19.	Zhuang N, Zeng Y, Tong L, et al. Emotion recognition from eeg signals using multidimensional information in EMD domain. Biomed Res Int, 2017, 2017: 8317357.
20.	陳旭東, 鐘恒, 皇甫潔, 等. 腦電信號情緒識別綜述. 計算機應用, 2023, 43(S1): 323-332.
21.	Wang T, Mao L, Wang J, et al. Influencing factors and exercise intervention of cognitive impairment in elderly patients with chronic obstructive pulmonary disease. Clin Interv Aging, 2020, 15: 557-566.
22.	Li QY, Li XM, Hu HY, et al. Associations of lung function decline with risks of cognitive impairment and dementia: a meta-analysis and systematic review. J Alzheimers Dis, 2023, 92(3): 853-873.
23.	Medvidovic S, Titlic M, Maras-Simunic M. P300 evoked potential in patients with mild cognitive impairment. Acta Inform Med, 2013, 21(2): 89-92.
24.	Krishnamurthy S, Sivagnaname Y, Gumallapu GC. Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential. Monaldi Arch Chest Dis, 2019, 89(2).
25.	于雅潔, 張新安. 太極拳運動對COPD-OSAHS重疊綜合征患者認知電位p300及肺通氣功能的影響. 沈陽體育學院學報, 2019, 38(5): 91-97.
26.	Van Dinteren R, et al. P300 development across the lifespan: a systematic review and meta-analysis. PloS One, 2014, 9(2): e87347.
27.	Tselebis A, Pachi A, Ilias I, et al. Strategies to improve anxiety and depression in patients with COPD: a mental health perspective. Neuropsychiatr Dis Treat, 2016, 12: 297-328.
28.	Pooler A, Beech R. Examining the relationship between anxiety and depression and exacerbations of COPD which result in hospital admission: a systematic review. Int J Chron Obstruct Pulmon Dis, 2014, 9: 315-30.
29.	Pierobon A, et al. Screening for neuropsychological impairment in COPD patients undergoing rehabilitation. PLoS One, 2018, 13(8): e0199736.
30.	Anonymous. Automated diagnosis of depression from EEG signals using traditional and deep learning approaches: a comparative analysis. Biocybern Biomed Eng, 2022, 42(1): 108-142.
31.	De Aguiar Neto FS, Rosa JLG. Depression biomarkers using non-invasive EEG: A review. Neurosci Biobehav Rev, 2019, 105: 83-93.
32.	Fitzgerald PJ, Watson BO. Gamma oscillations as a biomarker for major depression: an emerging topic. Transl Psychiatry, 2018, 8(1): 177.
33.	Muhammad F. Human state anxiety classification framework using EEG signals in response to exposure therapy. PLoS One, 2022, 17(3): e0265679.
34.	王亞茹. OSAHS患者睡眠參數變化與焦慮抑郁及認知障礙的關系. 吉林大學, 2023.
35.	Markiewcz R. The use of EEG Biofeedback/Neurofeedback in psychiatric rehabilitation. Psychiatr Pol, 2017, 51(6): 1095-1106. English, Polish.
36.	Hou Y, Zhang S, Li N, et al. Neurofeedback training improves anxiety trait and depressive symptom in GAD. Brain Behav, 2021, 11(3): e02024.
37.	Loriette C, et al. Neurofeedback for cognitive enhancement and intervention and brain plasticity. Rev Neurol (Paris), 2021, 177(9): 1133-1144.
38.	馬文, 鄒濤, 等. 腦電生物反饋治療對老年慢性阻塞性肺疾病患者情緒及睡眠狀況的影響. 貴州醫科大學學報, 2022, 47(5): 576-580.
39.	王晶波, 楊靜玲, 王鑫. 肺性腦病中西醫治療現狀與研究進展. 遼寧中醫雜志, 2023, 50(2): 216-220.
40.	石金榮. 腦電圖在肺性腦病診斷中的價值. 華北煤炭醫學院學報, 2002, 4(2): 199.
41.	曹政紅, 費世早. 肺性腦病腦電圖的臨床應用分析. 皖南醫學院學報, 2015, 34(3): 244-246.
42.	李艷紅. 32例肺性腦病腦電圖動態觀察. 臨床醫學, 2010, 30(4): 70-71.
43.	Schmidt M, Demoule A, Polito A, et al. Dyspnea in mechanically ventilated critically ill patients. Crit Care Med, 2011, 39(9): 2059-65.
44.	Decavèle M, et al. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care, 2019, 25(1): 86-94.
45.	Raux M, Straus C, Redolfi S, et al. Electroencephalographic evidence for pre-motor cortex activation during inspiratory loading in humans. J Physiol, 2007, 578(Pt 2): 569-578.
46.	Raux M, Ray P, Prella M, et al. Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation. Anesthesiology, 2007, 107(5): 746-755.
47.	Navarro-Sune X, et al. Riemannian Geometry applied to detection of respiratory states from EEG signals: the basis for a brain-ventilator interface. IEEE Trans Biomed Eng, 2017, 64(5): 1138-1148.
48.	陳柏茹, 陳貴華, 李琴. COPD患者認知功能障礙影響因素模型研究. 現代醫藥衛生, 2022, 38(10): 1639-1644,1649.
49.	王衛紅, 何國平, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者認知功能與焦慮情緒相關研究. 中國全科醫學, 2012, 15(13): 1513-1515.
50.	宋雨, 劉楊, 高強, 等. 基于腦電多域特征融合的跨任務認知負荷研究. 實驗技術與管理, 2024, 41(2): 73-80.
51.	李錚, 陳欣, 樹海峰. 負面情緒的腦電特征及功能連接環路的研究進展. 東南國防醫藥, 2023, 25(3): 307-311.
52.	李曉華, 高磊, 于可君. 基于圖論的不同情緒狀態下腦網絡功能連接研究. 醫療衛生裝備, 2023, 44(11): 9-14.
53.	Dimitrakopoulos GN, Kakkos I, Dai Z, et al. Task-independent mental workload classification based upon common multiband eeg cortical connectivity. IEEE Trans Neural Syst Rehabil Eng, 2017, 25(11): 1940-1949.
54.	劉淑玲. 阻塞性睡眠呼吸暫停低通氣綜合征患者合并情緒障礙的臨床及腦電活動特征. 蘇州大學, 2024.
55.	Noble MI, Frankel HL, Else W, et al. The ability of man to detect added resistive loads to breathing. Clin Sci, 1971, 41(3): 285-7.
56.	Von Leupoldt A, et al. Emotions and neural processing of respiratory sensations investigated with respiratory-related evoked potentials. Psychosom Med, 2013, 75(3): 244-52.
57.	Von Leupoldt A, et al. The impact of emotion on respiratory-related evoked potentials. Psychophysiology, 2010, 47(3): 579-586.
58.	Reijnders T, Troosters T, Janssens W, et al. Brain activations to dyspnea in patients with COPD. Front Physiol, 2020, 11: 7.
59.	Hammond CS, et al. Respiratory-related evoked potential elicited by expiratory occlusion. J Appl Physiol (1985), 1999, 87(2): 835-842.
60.	劉瀟雅, 劉爽, 郭冬月, 等. 抑郁癥腦電特異性研究進展. 中國生物醫學工程學報, 2020, 39(3): 351-361.
61.	賈天宇, 錢超, 李翀, 等. 基于個性化導聯選擇策略的腦機交互康復訓練臨床初步研究. 清華大學學報(自然科學版), 2020, 60(11): 920-926.

1. 朱衣興, 常德. 慢性呼吸系統疾病管理的現狀和展望. 結核與肺部疾病雜志, 2024, 5(6): 567-572.
2. Dodd JW, Charlton RA. Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD. Chest, 2013, 144(1): 119-127.
3. Areza-Fegyveres R, Kairalla RA. Cognition and chronic hypoxia in pulmonary diseases. Dement Neuropsychol, 2010, 4(1): 14-22.
4. Fan VS, Meek PM. Anxiety, depression, and cognitive impairment in patients with chronic respiratory disease. Clin Chest Med, 2014, 35(2): 399-409.
5. 陳琰, 錢頻, 袁琳等. 慢性阻塞性肺疾病肺外合并癥的治療現狀和研究進展. 中華肺部疾病雜志(電子版), 2020, 13(1): 100-103.
6. Similowski T. Treat the lungs, fool the brain and appease the mind: towards holistic care of patients who suffer from chronic respiratory diseases. Eur Respir J, 2018, 51(2): 1800316.
7. Janssens T, De Peuter S, Stans L, et al. Dyspnea perception in COPD: Association between anxiety, dyspnea-related fear, and dyspnea in a pulmonary rehabilitation program. Chest, 2011, 140(3): 618-625.
8. 岳丹, 羅志梅, 范林婕, 等. 手持風扇療法在緩解呼吸困難中的研究現狀. 中國呼吸與危重監護雜志, 2024, 23(8): 605-608.
9. 王瑋. 慢性阻塞性肺疾病患者腦功能及結構網絡變化的MRI研究. 中國人民解放軍海軍軍醫大學, 2021.
10. Finnegan SL, Harrison OK, Harmer CJ, et al. Breathlessness in COPD: linking symptom clusters with brain activity. Eur Respir J, 2021, 58(5): 2004099.
11. Wang M, Wang Y, Wang Z, et al. The abnormal alternations of brain imaging in patients with chronic obstructive pulmonary disease: a systematic review. J Alzheimers Dis Rep, 2023(1): 901-919.
12. Nunez PL, Srinivasan R. A theoretical basis for standing and traveling brain waves measured with human EEG with implications for an integrated consciousness. Clin Neurophysiol, 2006, 17(11): 2424-35.
13. 鄭貝思, 陳健爾. 定量腦電圖在認知功能障礙康復中的應用研究進展. 中華物理醫學與康復雜志, 2024, 46(8): 764-768.
14. 覃慧怡, 丁麗洪, 段威, 等. 腦電的重測信度: 在多項靜息態和任務態實驗中的對比. 心理學報, 2023, 55(10): 1587-1596.
15. 段宏霞, 劉沁欣, 趙仙麗, 等. 認知功能評價工具在慢性阻塞性肺疾病中的應用進展. 中國康復醫學雜志, 2023, 38(4): 539-545.
16. 何曉燕, 朱沂, 李紅燕, 等. 癡呆評估量表與事件相關電位P300對輕度認知功能障礙患者認知功能的評價. 中國老年學雜志, 2011, 31(16): 3041-3043.
17. 陳甄, 張廣波, 周迪, 等. 急性高原低氧環境對不同情緒狀態腦電功率的影響. 中國應用生理學雜志, 2020, 36(6): 556-561.
18. 聶聃, 王曉韡, 段若男, 等. 基于腦電的情緒識別研究綜述. 中國生物醫學工程學報, 2012, 31(4): 595-606.
19. Zhuang N, Zeng Y, Tong L, et al. Emotion recognition from eeg signals using multidimensional information in EMD domain. Biomed Res Int, 2017, 2017: 8317357.
20. 陳旭東, 鐘恒, 皇甫潔, 等. 腦電信號情緒識別綜述. 計算機應用, 2023, 43(S1): 323-332.
21. Wang T, Mao L, Wang J, et al. Influencing factors and exercise intervention of cognitive impairment in elderly patients with chronic obstructive pulmonary disease. Clin Interv Aging, 2020, 15: 557-566.
22. Li QY, Li XM, Hu HY, et al. Associations of lung function decline with risks of cognitive impairment and dementia: a meta-analysis and systematic review. J Alzheimers Dis, 2023, 92(3): 853-873.
23. Medvidovic S, Titlic M, Maras-Simunic M. P300 evoked potential in patients with mild cognitive impairment. Acta Inform Med, 2013, 21(2): 89-92.
24. Krishnamurthy S, Sivagnaname Y, Gumallapu GC. Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential. Monaldi Arch Chest Dis, 2019, 89(2).
25. 于雅潔, 張新安. 太極拳運動對COPD-OSAHS重疊綜合征患者認知電位p300及肺通氣功能的影響. 沈陽體育學院學報, 2019, 38(5): 91-97.
26. Van Dinteren R, et al. P300 development across the lifespan: a systematic review and meta-analysis. PloS One, 2014, 9(2): e87347.
27. Tselebis A, Pachi A, Ilias I, et al. Strategies to improve anxiety and depression in patients with COPD: a mental health perspective. Neuropsychiatr Dis Treat, 2016, 12: 297-328.
28. Pooler A, Beech R. Examining the relationship between anxiety and depression and exacerbations of COPD which result in hospital admission: a systematic review. Int J Chron Obstruct Pulmon Dis, 2014, 9: 315-30.
29. Pierobon A, et al. Screening for neuropsychological impairment in COPD patients undergoing rehabilitation. PLoS One, 2018, 13(8): e0199736.
30. Anonymous. Automated diagnosis of depression from EEG signals using traditional and deep learning approaches: a comparative analysis. Biocybern Biomed Eng, 2022, 42(1): 108-142.
31. De Aguiar Neto FS, Rosa JLG. Depression biomarkers using non-invasive EEG: A review. Neurosci Biobehav Rev, 2019, 105: 83-93.
32. Fitzgerald PJ, Watson BO. Gamma oscillations as a biomarker for major depression: an emerging topic. Transl Psychiatry, 2018, 8(1): 177.
33. Muhammad F. Human state anxiety classification framework using EEG signals in response to exposure therapy. PLoS One, 2022, 17(3): e0265679.
34. 王亞茹. OSAHS患者睡眠參數變化與焦慮抑郁及認知障礙的關系. 吉林大學, 2023.
35. Markiewcz R. The use of EEG Biofeedback/Neurofeedback in psychiatric rehabilitation. Psychiatr Pol, 2017, 51(6): 1095-1106. English, Polish.
36. Hou Y, Zhang S, Li N, et al. Neurofeedback training improves anxiety trait and depressive symptom in GAD. Brain Behav, 2021, 11(3): e02024.
37. Loriette C, et al. Neurofeedback for cognitive enhancement and intervention and brain plasticity. Rev Neurol (Paris), 2021, 177(9): 1133-1144.
38. 馬文, 鄒濤, 等. 腦電生物反饋治療對老年慢性阻塞性肺疾病患者情緒及睡眠狀況的影響. 貴州醫科大學學報, 2022, 47(5): 576-580.
39. 王晶波, 楊靜玲, 王鑫. 肺性腦病中西醫治療現狀與研究進展. 遼寧中醫雜志, 2023, 50(2): 216-220.
40. 石金榮. 腦電圖在肺性腦病診斷中的價值. 華北煤炭醫學院學報, 2002, 4(2): 199.
41. 曹政紅, 費世早. 肺性腦病腦電圖的臨床應用分析. 皖南醫學院學報, 2015, 34(3): 244-246.
42. 李艷紅. 32例肺性腦病腦電圖動態觀察. 臨床醫學, 2010, 30(4): 70-71.
43. Schmidt M, Demoule A, Polito A, et al. Dyspnea in mechanically ventilated critically ill patients. Crit Care Med, 2011, 39(9): 2059-65.
44. Decavèle M, et al. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care, 2019, 25(1): 86-94.
45. Raux M, Straus C, Redolfi S, et al. Electroencephalographic evidence for pre-motor cortex activation during inspiratory loading in humans. J Physiol, 2007, 578(Pt 2): 569-578.
46. Raux M, Ray P, Prella M, et al. Cerebral cortex activation during experimentally induced ventilator fighting in normal humans receiving noninvasive mechanical ventilation. Anesthesiology, 2007, 107(5): 746-755.
47. Navarro-Sune X, et al. Riemannian Geometry applied to detection of respiratory states from EEG signals: the basis for a brain-ventilator interface. IEEE Trans Biomed Eng, 2017, 64(5): 1138-1148.
48. 陳柏茹, 陳貴華, 李琴. COPD患者認知功能障礙影響因素模型研究. 現代醫藥衛生, 2022, 38(10): 1639-1644,1649.
49. 王衛紅, 何國平, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者認知功能與焦慮情緒相關研究. 中國全科醫學, 2012, 15(13): 1513-1515.
50. 宋雨, 劉楊, 高強, 等. 基于腦電多域特征融合的跨任務認知負荷研究. 實驗技術與管理, 2024, 41(2): 73-80.
51. 李錚, 陳欣, 樹海峰. 負面情緒的腦電特征及功能連接環路的研究進展. 東南國防醫藥, 2023, 25(3): 307-311.
52. 李曉華, 高磊, 于可君. 基于圖論的不同情緒狀態下腦網絡功能連接研究. 醫療衛生裝備, 2023, 44(11): 9-14.
53. Dimitrakopoulos GN, Kakkos I, Dai Z, et al. Task-independent mental workload classification based upon common multiband eeg cortical connectivity. IEEE Trans Neural Syst Rehabil Eng, 2017, 25(11): 1940-1949.
54. 劉淑玲. 阻塞性睡眠呼吸暫停低通氣綜合征患者合并情緒障礙的臨床及腦電活動特征. 蘇州大學, 2024.
55. Noble MI, Frankel HL, Else W, et al. The ability of man to detect added resistive loads to breathing. Clin Sci, 1971, 41(3): 285-7.
56. Von Leupoldt A, et al. Emotions and neural processing of respiratory sensations investigated with respiratory-related evoked potentials. Psychosom Med, 2013, 75(3): 244-52.
57. Von Leupoldt A, et al. The impact of emotion on respiratory-related evoked potentials. Psychophysiology, 2010, 47(3): 579-586.
58. Reijnders T, Troosters T, Janssens W, et al. Brain activations to dyspnea in patients with COPD. Front Physiol, 2020, 11: 7.
59. Hammond CS, et al. Respiratory-related evoked potential elicited by expiratory occlusion. J Appl Physiol (1985), 1999, 87(2): 835-842.
60. 劉瀟雅, 劉爽, 郭冬月, 等. 抑郁癥腦電特異性研究進展. 中國生物醫學工程學報, 2020, 39(3): 351-361.
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