LU Wei 1 , GUAN Xiaoyong 1 , LIANG Mingyan 1 , MO Daozhang 1 , QIN Hao 1 , KONG Jinliang 2
  • 1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi 545000, P. R. China;
  • 2. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China;
GUAN Xiaoyong, Email: gdszrmsjcsy@163.com; KONG Jinliang, Email: 1633211981@qq.com
Chronic obstructive pulmonary disease; acute exacerbation; pulmonary embolism; Wells score; thromboelastography; prediction
10.7507/1671-6205.202404043
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Objective  To explore the clinical value of Wells score combined with thromboelastography (TEG) in rapid prediction of pulmonary embolism (PE) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods  A total of 130 AECOPD patients admitted to the Department of Respiratory and Critical Care Medicine of Guangxi University of Science and Technology from January 2022 to March 2023 were selected as the study subjects. According to results of digital subtraction angiography (DSA) of the pulmonary artery, the patients were divided into a PE group (n=37) and a non-PE group (n=93). Both groups underwent Wells score analysis combined with TEG. Thromboelastographic parameters were comparing between the two groups, including Wells score, reaction time (R time), reaction time (K time), coagulation index (CI), and maximum amplitude (MA). The diagnostic value of different prediction models to diagnose AECOPD with PE was compared, including Wells score, thromboelogram and Wells score combined with TEG. Results  The Wells score of the patients in the PE group was significantly higher than that in the non-PE group, and R time of the patients in the PE group was significantly lower than that in the non-PE group. The K time, CI, MA and other parameter levels of the patients in the PE group were significantly higher than those in the non-PE group (all P<0.05). The sensitivity, specificity, and area under ROC curve of the combination of Wells score and TEG prediction model in diagnosing AECOPD complicated with PE were greater than those of the Wells score alone prediction model (P<0.05). Conclusion  The combination of Wells score and TEG has significant clinical value in quickly predicting AECOPD complicated with PE, and is worthy of clinical application and promotion.

Citation： LU Wei, GUAN Xiaoyong, LIANG Mingyan, MO Daozhang, QIN Hao, KONG Jinliang. A study on the combination of Wells score and thromboelastography for rapid prediction of acute exacerbation of COPD complicated with pulmonary embolism. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(3): 186-191. doi: 10.7507/1671-6205.202404043 Copy

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