環狀RNA在急性肺損傷中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

高金煇 , 方翔 , 丁玲 , 沈續瑞 , 楊陵懿 ,  王佳佳

蘇州大學附屬第一醫院呼吸與危重癥醫學科（江蘇蘇州 215000）;

Corresponding?author：

王佳佳, Email: wangjjsuda@126.com

Keywords：

DOI：

10.7507/1671-6205.202308012

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Citation： 高金煇, 方翔, 丁玲, 沈續瑞, 楊陵懿, 王佳佳. 環狀RNA在急性肺損傷中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(3): 211-216. doi: 10.7507/1671-6205.202308012 Copy

1.	Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA, 2016, 315(8): 788-800.
2.	Thompson BT, Chambers RC, Liu KD. Acute respiratory distress syndrome. N Engl J Med, 2017, 377(6): 562-572.
3.	Zhao X, Zhong Y, Wang X, et al. Advances in circular RNA and its applications. Int J Med Sci, 2022, 19(6): 975-985.
4.	徐康喬, 夏世金, 王堅, 等. 環狀RNA與呼吸系統疾病. 中國呼吸與危重監護雜志, 2020, 19(6): 611-616.
5.	Misir S, Wu N, Yang BB. Specific expression and functions of circular RNAs. Cell Death Differ, 2022, 29(3): 481-491.
6.	Li X, Yang L, Chen LL. The biogenesis, functions, and challenges of circular RNAs. Mol Cell, 2018, 71(3): 428-442.
7.	Sakshi S, Jayasuriya R, Ganesan K, et al. Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications. Mol Ther Nucleic Acids, 2021, 26: 1291-1302.
8.	Panda AC. Circular RNAs Act as miRNA Sponges. Adv Exp Med Biol, 2018, 1087: 67-79.
9.	Fu Y, Sun H. Biogenesis, cellular effects, and biomarker value of circHIPK3. Cancer Cell Int, 2021, 21(1): 256.
10.	Du WW, Zhang C, Yang W, et al. Identifying and characterizing circRNA-protein interaction. Theranostics, 2017, 7(17): 4183-4191.
11.	Huang A, Zheng H, Wu Z, et al. Circular RNA-protein interactions: functions, mechanisms, and identification. Theranostics, 2020, 10(8): 3503-3517.
12.	Abdelmohsen K, Panda AC, Munk R, et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 2017, 14(3): 361-369.
13.	Garikipati VNS, Verma SK, Cheng Z, et al. Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nat Commun, 2019, 10(1): 4317.
14.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
15.	Xu X, Zhang J, Tian Y, G, et al. CircRNA inhibits DNA damage repair by interacting with host gene. Mol Cancer, 2020, 24,19(1): 128.
16.	Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
17.	Lei M, Zheng G, Ning Q, et al. Translation and functional roles of circular RNAs in human cancer. Mol Cancer, 2020, 19(1): 30.
18.	Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst, 2018, 110(3): 304-315.
19.	Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N⁶-methyladenosine. Cell Res, 2017, 27(5): 626-641.
20.	Sun HD, Xu ZP, Sun ZQ, et al. Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep, 2018, 8(1): 10111.
21.	Butt Y, Kurdowska A, Allen TC. Acute lung injury: a clinical and molecular review. Arch Pathol Lab Med, 2016, 140(4): 345-350.
22.	Kim WY, Hong SB. Sepsis and acute respiratory distress syndrome: recent update. Tuberc Respir Dis (Seoul), 2016, 79(2): 53-57.
23.	Lu S, Wu X, Xin S, et al. Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/mitogen-activated protein kinase 1 axis. Bioengineered, 2022, 13(3): 5803-5817.
24.	Zhu J, Zhong F, Chen F, et al. circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury. Open Med (Wars), 2022, 28,17(1): 403-413.
25.	Ren Y, Li L, Wang M, et al. Knockdown of circRNA paralemmin 2 ameliorates lipopolysaccharide-induced murine lung epithelial cell injury by sponging miR-330-5p to reduce ROCK2 expression. Immunol Invest, 2022, 51(6): 1707-1724.
26.	李慧芬, 何宣. 環狀RNA circ_0001454在膿毒癥誘導的急性肺損傷大鼠中的表達. 中國臨床藥理學雜志, 2022, 38(8): 807-810, 821.
27.	Ke J, Chen M, Ma S, et al. Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis. Bioengineered, 2022, 13(3): 5453-5466.
28.	Cheng S, Chen C, Wang L, et al. Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis. Transpl Immunol, 2022, 74: 101635.
29.	Liu G, Wan Q, Li J, et al. Circ_0038467 regulates lipopolysaccharide-induced inflammatory injury in human bronchial epithelial cells through sponging miR-338-3p. Thorac Cancer, 2020, 11(5): 1297-1308.
30.	Xia F, Yang L, Zhu X, et al. Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia. Microb Pathog, 2022, 173(Pt A): 105819.
31.	Ding F, Zhu J, Hu Y, et al. Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux. Acta Cir Bras, 2023, 38: e380323.
32.	Li Y, Zhang C, Zhao Z, et al. CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway. Mol Cell Toxicol, 2023, 25: 1-12.
33.	Liao H, Chai Y, Sun Y, et al. Hsa_circ_0074158 regulates the endothelial barrier function in sepsis and its potential value as a biomarker. Front Genet, 2022, 13(2): 1002344.
34.	郭飛波, 吳斌. CircRNA ANKRD36靶向miR-127-5p調控膿毒癥血管內皮細胞凋亡和氧化應激的分子機制研究. 中國細胞生物學學報, 2021, 43(9): 1756-1766.
35.	Shen MJ, Yan ST, Zhang XY, et al. The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis. Aging (Albany NY), 2022, 14(12): 5059-5074.
36.	Bao X, Zhang Q, Liu N, et al. Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. J Cell Mol Med, 2019, 23(10): 7111-7115.
37.	Zhao D, Wang C, Liu X, et al. CircN4bp1 facilitates sepsis-induced acute respiratory distress syndrome through mediating macrophage polarization via the miR-138-5p/EZH2 Axis. Mediators Inflamm, 2021, 2021: 7858746.
38.	Xu F, Hu L, Wang S, et al. Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. Cell Signal, 2023, 103: 110561.
39.	Zhou L, Wu B, Yang J, et al. Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice. Respir Res, 2021, 22(1): 294.
40.	Liu QP, Ge P, Wang QN, et al. Circular RNA-CDR1as is involved in lung injury induced by long-term formaldehyde inhalation. Inhal Toxicol, 2021, 33(9-14): 325-333.
41.	Yang YQ, Ge P, Lv MQ, et al. Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. Ecotoxicol Environ Saf, 2022, 25(1): 254-267.
42.	Jiang Y, Zhu F, Wu GS, et al. Microarray and bioinformatics analysis of circular RNAs expression profile in traumatic lung injury. Exp Ther Med, 2020, 20(1): 227-234.
43.	Wang J, Zhang Y, Zhu F, et al. CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury. J Biosci, 2021, 46(2): 38.
44.	Li Y, Zou L, Chu L, et al. Identification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model. J Inflamm Res, 2021, 14: 4421-4431.
45.	Chen S, Xia J, Zhan Q, et al. Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury. Front Physiol, 2022, 13: 838196.

1. Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA, 2016, 315(8): 788-800.
2. Thompson BT, Chambers RC, Liu KD. Acute respiratory distress syndrome. N Engl J Med, 2017, 377(6): 562-572.
3. Zhao X, Zhong Y, Wang X, et al. Advances in circular RNA and its applications. Int J Med Sci, 2022, 19(6): 975-985.
4. 徐康喬, 夏世金, 王堅, 等. 環狀RNA與呼吸系統疾病. 中國呼吸與危重監護雜志, 2020, 19(6): 611-616.
5. Misir S, Wu N, Yang BB. Specific expression and functions of circular RNAs. Cell Death Differ, 2022, 29(3): 481-491.
6. Li X, Yang L, Chen LL. The biogenesis, functions, and challenges of circular RNAs. Mol Cell, 2018, 71(3): 428-442.
7. Sakshi S, Jayasuriya R, Ganesan K, et al. Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications. Mol Ther Nucleic Acids, 2021, 26: 1291-1302.
8. Panda AC. Circular RNAs Act as miRNA Sponges. Adv Exp Med Biol, 2018, 1087: 67-79.
9. Fu Y, Sun H. Biogenesis, cellular effects, and biomarker value of circHIPK3. Cancer Cell Int, 2021, 21(1): 256.
10. Du WW, Zhang C, Yang W, et al. Identifying and characterizing circRNA-protein interaction. Theranostics, 2017, 7(17): 4183-4191.
11. Huang A, Zheng H, Wu Z, et al. Circular RNA-protein interactions: functions, mechanisms, and identification. Theranostics, 2020, 10(8): 3503-3517.
12. Abdelmohsen K, Panda AC, Munk R, et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 2017, 14(3): 361-369.
13. Garikipati VNS, Verma SK, Cheng Z, et al. Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nat Commun, 2019, 10(1): 4317.
14. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
15. Xu X, Zhang J, Tian Y, G, et al. CircRNA inhibits DNA damage repair by interacting with host gene. Mol Cancer, 2020, 24,19(1): 128.
16. Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
17. Lei M, Zheng G, Ning Q, et al. Translation and functional roles of circular RNAs in human cancer. Mol Cancer, 2020, 19(1): 30.
18. Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst, 2018, 110(3): 304-315.
19. Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N⁶-methyladenosine. Cell Res, 2017, 27(5): 626-641.
20. Sun HD, Xu ZP, Sun ZQ, et al. Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep, 2018, 8(1): 10111.
21. Butt Y, Kurdowska A, Allen TC. Acute lung injury: a clinical and molecular review. Arch Pathol Lab Med, 2016, 140(4): 345-350.
22. Kim WY, Hong SB. Sepsis and acute respiratory distress syndrome: recent update. Tuberc Respir Dis (Seoul), 2016, 79(2): 53-57.
23. Lu S, Wu X, Xin S, et al. Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/mitogen-activated protein kinase 1 axis. Bioengineered, 2022, 13(3): 5803-5817.
24. Zhu J, Zhong F, Chen F, et al. circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury. Open Med (Wars), 2022, 28,17(1): 403-413.
25. Ren Y, Li L, Wang M, et al. Knockdown of circRNA paralemmin 2 ameliorates lipopolysaccharide-induced murine lung epithelial cell injury by sponging miR-330-5p to reduce ROCK2 expression. Immunol Invest, 2022, 51(6): 1707-1724.
26. 李慧芬, 何宣. 環狀RNA circ_0001454在膿毒癥誘導的急性肺損傷大鼠中的表達. 中國臨床藥理學雜志, 2022, 38(8): 807-810, 821.
27. Ke J, Chen M, Ma S, et al. Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis. Bioengineered, 2022, 13(3): 5453-5466.
28. Cheng S, Chen C, Wang L, et al. Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis. Transpl Immunol, 2022, 74: 101635.
29. Liu G, Wan Q, Li J, et al. Circ_0038467 regulates lipopolysaccharide-induced inflammatory injury in human bronchial epithelial cells through sponging miR-338-3p. Thorac Cancer, 2020, 11(5): 1297-1308.
30. Xia F, Yang L, Zhu X, et al. Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia. Microb Pathog, 2022, 173(Pt A): 105819.
31. Ding F, Zhu J, Hu Y, et al. Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux. Acta Cir Bras, 2023, 38: e380323.
32. Li Y, Zhang C, Zhao Z, et al. CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway. Mol Cell Toxicol, 2023, 25: 1-12.
33. Liao H, Chai Y, Sun Y, et al. Hsa_circ_0074158 regulates the endothelial barrier function in sepsis and its potential value as a biomarker. Front Genet, 2022, 13(2): 1002344.
34. 郭飛波, 吳斌. CircRNA ANKRD36靶向miR-127-5p調控膿毒癥血管內皮細胞凋亡和氧化應激的分子機制研究. 中國細胞生物學學報, 2021, 43(9): 1756-1766.
35. Shen MJ, Yan ST, Zhang XY, et al. The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis. Aging (Albany NY), 2022, 14(12): 5059-5074.
36. Bao X, Zhang Q, Liu N, et al. Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. J Cell Mol Med, 2019, 23(10): 7111-7115.
37. Zhao D, Wang C, Liu X, et al. CircN4bp1 facilitates sepsis-induced acute respiratory distress syndrome through mediating macrophage polarization via the miR-138-5p/EZH2 Axis. Mediators Inflamm, 2021, 2021: 7858746.
38. Xu F, Hu L, Wang S, et al. Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS. Cell Signal, 2023, 103: 110561.
39. Zhou L, Wu B, Yang J, et al. Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice. Respir Res, 2021, 22(1): 294.
40. Liu QP, Ge P, Wang QN, et al. Circular RNA-CDR1as is involved in lung injury induced by long-term formaldehyde inhalation. Inhal Toxicol, 2021, 33(9-14): 325-333.
41. Yang YQ, Ge P, Lv MQ, et al. Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. Ecotoxicol Environ Saf, 2022, 25(1): 254-267.
42. Jiang Y, Zhu F, Wu GS, et al. Microarray and bioinformatics analysis of circular RNAs expression profile in traumatic lung injury. Exp Ther Med, 2020, 20(1): 227-234.
43. Wang J, Zhang Y, Zhu F, et al. CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury. J Biosci, 2021, 46(2): 38.
44. Li Y, Zou L, Chu L, et al. Identification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model. J Inflamm Res, 2021, 14: 4421-4431.
45. Chen S, Xia J, Zhan Q, et al. Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury. Front Physiol, 2022, 13: 838196.

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環狀RNA在急性肺損傷中的研究進展

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