外泌體在急性肺損傷中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

李婧雯 ,  李超乾

廣西醫科大學第一附屬醫院（廣西南寧 530021）;

Corresponding?author：

李超乾, Email: 2534776680@qq.com

Keywords：

DOI：

10.7507/1671-6205.202303008

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Citation： 李婧雯, 李超乾. 外泌體在急性肺損傷中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(2): 144-149. doi: 10.7507/1671-6205.202303008 Copy

1.	Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA, 2016, 315(8): 788-800.
2.	Huppert LA, Matthay MA, Ware LB. Pathogenesis of Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med, 2019, 40(1): 31-39.
3.	Nanchal RS, Truwit JD. Recent advances in understanding and treating acute respiratory distress syndrome. F1000Res, 2018, 7: F1000.
4.	Derwall M, Martin L, Rossaint R. The acute respiratory distress syndrome: pathophysiology, current clinical practice, and emerging therapies. Expert Rev Respir Med, 2018, 12(12): 1021-1029.
5.	Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem, 2019, 88: 487-514.
6.	Liu X, Gao C, Wang Y, et al. BMSC-Derived Exosomes Ameliorate LPS-Induced Acute Lung Injury by miR-384-5p-Controlled Alveolar Macrophage Autophagy. Oxidative Medicine and Cellular Longevity, 2021, 2021: 9973457.
7.	Zhao S, Mi Y, Guan B, et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. J Hematol Oncol, 2020, 13(1): 156.
8.	Kalluri R, Lebleu VS. The biology function and biomedical applications of exosomes. Science, 2020, 367(6478): eaau6977.
9.	Wozniak AL, Adams A, King KE, et al. The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation. J Cell Biol, 2020, 219(10): e201912074.
10.	Zhang J, Li S, Li L, et al. Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics, 2015, 13(1): 17-24.
11.	Liu C, Xiao K, Xie L. Advances in the use of exosomes for the treatment of ALI/ARDS. Frontiers In Immunology, 2022, 13: 971189.
12.	Deb A, Gupta S, Mazumder PB. Exosomes: A new horizon in modern medicine. Life Sci, 2021, 264: 118623.
13.	Admyre C, Grunewald J, Thyberg J, et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J, 2003, 22(4): 578-583.
14.	Hu C, Meiners S, Lukas C, et al. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif, 2020, 53(6): e12828.
15.	Li MY, Liu LZ, Dong M. Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis. Mol Cancer, 2021, 20(1): 22.
16.	Liu Z, Yan J, Tong L, et al. The role of exosomes from BALF in lung disease. J Cell Physiol, 2022, 237(1): 161-168.
17.	Chen Z, Dong W-H, Qiu Z-M, et al. The Monocyte-Derived Exosomal CLMAT3 Activates the CtBP2-p300-NF-κB Transcriptional Complex to Induce Proinflammatory Cytokines in ALI. Mol Ther Nucleic Acids, 2020, 21: 1100-1110.
18.	Jiao Y, Zhang T, Zhang C, et al. Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. Crit Care, 2021, 25(1): 356.
19.	Liu F, Peng W, Chen J, et al. Exosomes Derived From Alveolar Epithelial Cells Promote Alveolar Macrophage Activation Mediated by miR-92a-3p in Sepsis-Induced Acute Lung Injury. Front Cell Infect Microbiol, 2021, 11: 646546.
20.	Li ZG, Scott MJ, Brzóska T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Mil Med Res, 2018, 5(1): 24.
21.	Feng Z, Zhou J, Liu Y, et al. Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response. Cell Death Differ, 2021, 28(7): 2238-2256.
22.	Jiang K, Yang J, Guo S, et al. Peripheral Circulating Exosome-Mediated Delivery of miR-155 as a Novel Mechanism for Acute Lung Inflammation. Molecular Therapy : the Journal of the American Society of Gene Therapy, 2019, 27(10): 1758-1771.
23.	Wu XB, Sun HY, Luo ZL, et al. Plasma-derived exosomes contribute to pancreatitis-associated lung injury by triggering NLRP3-dependent pyroptosis in alveolar macrophages. Biochim Biophys Acta Mol Basis Dis, 2020, 1866(5): 165685.
24.	Wong MH, Chapin OC, Johnson MD. LPS-stimulated cytokine production in type I cells is modulated by the renin-angiotensin system. Am J Respir Cell Mol Biol, 2012, 46(5): 641-650.
25.	Ruaro B, Salton F, Braga L, et al. The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung. Int J Mol Sci, 2021, 22(5): 2566.
26.	Ma J, Xu LY, Sun QH, et al. Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. Mol Cell Biochem, 2021, 476(10): 3745-3756.
27.	Yuan Z, Bedi B, Sadikot RT. Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury. J Vis Exp, 2018(135): 57737.
28.	Su G, Ma X, Wei H. Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment. Biomed Res Int, 2020, 2020: 5608382.
29.	Gong T, Zhang X, Peng Z, et al. Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell. Commun Biol, 2022, 5(1): 543.
30.	Bourdonnay E, Zas?ona Z, Penke LRK, et al. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. J Exp Med, 2015, 212(5): 729-742.
31.	Gao M, Yu T, Liu D, et al. Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1. Clin Sci (Lond), 2021, 135(2): 347-365.
32.	Ali A, Zambrano R, Duncan MR, et al. Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats. Sci Rep, 2021, 11(1): 8791.
33.	Gambim MH, Do Carmo ADO, Marti L, et al. Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction. Crit Care, 2007, 11(5): R107.
34.	Zhang C, Guo F, Chang M, et al. Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-κB signaling axis and glycocalyx enhancement. Exp Cell Res, 2019, 384(1): 111596.
35.	Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers, 2019, 5(1): 18.
36.	Obeid S, Sung PS, Le Roy B, et al. NanoBioAnalytical characterization of extracellular vesicles in 75-nm nanofiltered human plasma for transfusion: A tool to improve transfusion safety. Nanomedicine, 2019, 20: 101977.
37.	Jiao Y, Li W, Wang W, et al. Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock. Crit Care, 2020, 24(1): 380.
38.	Liu B, Jin Y, Yang J, et al. Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation. J Extracell Vesicles, 2022, 11(5): e12223.
39.	王皓飛, 胡文瀚, 宋倩文, 等. 肺泡灌洗液和血漿中外泌體含量與早期急性呼吸窘迫綜合征患者肺損傷嚴重程度及預后的關系. 中華醫學雜志, 2022, 102(13): 935-941.
40.	Kim TH, Hong SB, Lim CM, et al. The Role of Exosomes in Bronchoalveloar Lavage from Patients with Acute Respiratory Distress Syndrome. J Clin Med, 2019, 8(8): 1148.
41.	Papadopoulos S, Kazepidou E, Antonelou MH, et al. Secretory Phospholipase A-IIA Protein and mRNA Pools in Extracellular Vesicles of Bronchoalveolar Lavage Fluid from Patients with Early Acute Respiratory Distress Syndrome: A New Perception in the Dissemination of Inflammation? Pharmaceuticals (Basel), 2020, 13(11) : 415.
42.	Wu X, Wu C, Gu W, et al. Serum Exosomal MicroRNAs Predict Acute Respiratory Distress Syndrome Events in Patients with Severe Community-Acquired Pneumonia. Biomed Res Int, 2019, 2019: 3612020.
43.	Tian C, Liu J, Di X, et al. Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis. Sci Rep, 2021, 11(1): 14141.
44.	Im Y, Yoo H, Ko RE, et al. Exosomal CD63 in critically ill patients with sepsis. Sci Rep, 2021, 11(1): 20300.
45.	Wang X, Liu D, Zhang X, et al. Exosomes from adipose-derived mesenchymal stem cells alleviate sepsis-induced lung injury in mice by inhibiting the secretion of IL-27 in macrophages. Cell Death Discov, 2022, 8(1): 18.
46.	Wei X, Yi X, Lv H, et al. MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy. Cell Death Dis, 2020, 11(8): 657.
47.	Yi X, Wei X, Lv H, et al. Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3. Exp Cell Res, 2019, 383(2): 111454.
48.	Mizuta Y, Akahoshi T, Guo J, et al. Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells. Stem Cell Res Ther, 2020, 11(1): 508.
49.	Sengupta V, Sengupta S, Lazo A, et al. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. Stem Cells Dev, 2020, 29(12): 747-54.
50.	Chu M, Wang H, Bian L, et al. Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia. Stem Cell Rev Rep, 2022, 18(6): 2152-2163.
51.	Zhou Y, Li P, Goodwin AJ, et al. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care, 2019, 23(1): 44.
52.	Wu X, Liu Z, Hu L, et al. Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126. Exp Cell Res, 2018, 370(1): 13-23.
53.	Jiang L, Ni J, Shen G, et al. Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha. Inflamm Res, 2021, 70(2): 205-216.
54.	He N, Tan H, Deng X, et al. MiR-223-3p-loaded exosomes from bronchoalveolar lavage fluid promote alveolar macrophage autophagy and reduce acute lung injury by inhibiting the expression of STK39. Hum Cell, 2022, 35(6): 1736-1751.
55.	Kim G, Lee Y, Ha J, et al. Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation. J Control Release, 2021, 330: 684-695.
56.	Li Y, Zhang H, Chen C, et al. Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis. Adv Mater, 2022, 34(19): e2108476.

1. Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA, 2016, 315(8): 788-800.
2. Huppert LA, Matthay MA, Ware LB. Pathogenesis of Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med, 2019, 40(1): 31-39.
3. Nanchal RS, Truwit JD. Recent advances in understanding and treating acute respiratory distress syndrome. F1000Res, 2018, 7: F1000.
4. Derwall M, Martin L, Rossaint R. The acute respiratory distress syndrome: pathophysiology, current clinical practice, and emerging therapies. Expert Rev Respir Med, 2018, 12(12): 1021-1029.
5. Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem, 2019, 88: 487-514.
6. Liu X, Gao C, Wang Y, et al. BMSC-Derived Exosomes Ameliorate LPS-Induced Acute Lung Injury by miR-384-5p-Controlled Alveolar Macrophage Autophagy. Oxidative Medicine and Cellular Longevity, 2021, 2021: 9973457.
7. Zhao S, Mi Y, Guan B, et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. J Hematol Oncol, 2020, 13(1): 156.
8. Kalluri R, Lebleu VS. The biology function and biomedical applications of exosomes. Science, 2020, 367(6478): eaau6977.
9. Wozniak AL, Adams A, King KE, et al. The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation. J Cell Biol, 2020, 219(10): e201912074.
10. Zhang J, Li S, Li L, et al. Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics, 2015, 13(1): 17-24.
11. Liu C, Xiao K, Xie L. Advances in the use of exosomes for the treatment of ALI/ARDS. Frontiers In Immunology, 2022, 13: 971189.
12. Deb A, Gupta S, Mazumder PB. Exosomes: A new horizon in modern medicine. Life Sci, 2021, 264: 118623.
13. Admyre C, Grunewald J, Thyberg J, et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J, 2003, 22(4): 578-583.
14. Hu C, Meiners S, Lukas C, et al. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif, 2020, 53(6): e12828.
15. Li MY, Liu LZ, Dong M. Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis. Mol Cancer, 2021, 20(1): 22.
16. Liu Z, Yan J, Tong L, et al. The role of exosomes from BALF in lung disease. J Cell Physiol, 2022, 237(1): 161-168.
17. Chen Z, Dong W-H, Qiu Z-M, et al. The Monocyte-Derived Exosomal CLMAT3 Activates the CtBP2-p300-NF-κB Transcriptional Complex to Induce Proinflammatory Cytokines in ALI. Mol Ther Nucleic Acids, 2020, 21: 1100-1110.
18. Jiao Y, Zhang T, Zhang C, et al. Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. Crit Care, 2021, 25(1): 356.
19. Liu F, Peng W, Chen J, et al. Exosomes Derived From Alveolar Epithelial Cells Promote Alveolar Macrophage Activation Mediated by miR-92a-3p in Sepsis-Induced Acute Lung Injury. Front Cell Infect Microbiol, 2021, 11: 646546.
20. Li ZG, Scott MJ, Brzóska T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Mil Med Res, 2018, 5(1): 24.
21. Feng Z, Zhou J, Liu Y, et al. Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response. Cell Death Differ, 2021, 28(7): 2238-2256.
22. Jiang K, Yang J, Guo S, et al. Peripheral Circulating Exosome-Mediated Delivery of miR-155 as a Novel Mechanism for Acute Lung Inflammation. Molecular Therapy : the Journal of the American Society of Gene Therapy, 2019, 27(10): 1758-1771.
23. Wu XB, Sun HY, Luo ZL, et al. Plasma-derived exosomes contribute to pancreatitis-associated lung injury by triggering NLRP3-dependent pyroptosis in alveolar macrophages. Biochim Biophys Acta Mol Basis Dis, 2020, 1866(5): 165685.
24. Wong MH, Chapin OC, Johnson MD. LPS-stimulated cytokine production in type I cells is modulated by the renin-angiotensin system. Am J Respir Cell Mol Biol, 2012, 46(5): 641-650.
25. Ruaro B, Salton F, Braga L, et al. The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung. Int J Mol Sci, 2021, 22(5): 2566.
26. Ma J, Xu LY, Sun QH, et al. Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. Mol Cell Biochem, 2021, 476(10): 3745-3756.
27. Yuan Z, Bedi B, Sadikot RT. Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury. J Vis Exp, 2018(135): 57737.
28. Su G, Ma X, Wei H. Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment. Biomed Res Int, 2020, 2020: 5608382.
29. Gong T, Zhang X, Peng Z, et al. Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell. Commun Biol, 2022, 5(1): 543.
30. Bourdonnay E, Zas?ona Z, Penke LRK, et al. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. J Exp Med, 2015, 212(5): 729-742.
31. Gao M, Yu T, Liu D, et al. Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1. Clin Sci (Lond), 2021, 135(2): 347-365.
32. Ali A, Zambrano R, Duncan MR, et al. Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats. Sci Rep, 2021, 11(1): 8791.
33. Gambim MH, Do Carmo ADO, Marti L, et al. Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction. Crit Care, 2007, 11(5): R107.
34. Zhang C, Guo F, Chang M, et al. Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-κB signaling axis and glycocalyx enhancement. Exp Cell Res, 2019, 384(1): 111596.
35. Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers, 2019, 5(1): 18.
36. Obeid S, Sung PS, Le Roy B, et al. NanoBioAnalytical characterization of extracellular vesicles in 75-nm nanofiltered human plasma for transfusion: A tool to improve transfusion safety. Nanomedicine, 2019, 20: 101977.
37. Jiao Y, Li W, Wang W, et al. Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock. Crit Care, 2020, 24(1): 380.
38. Liu B, Jin Y, Yang J, et al. Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation. J Extracell Vesicles, 2022, 11(5): e12223.
39. 王皓飛, 胡文瀚, 宋倩文, 等. 肺泡灌洗液和血漿中外泌體含量與早期急性呼吸窘迫綜合征患者肺損傷嚴重程度及預后的關系. 中華醫學雜志, 2022, 102(13): 935-941.
40. Kim TH, Hong SB, Lim CM, et al. The Role of Exosomes in Bronchoalveloar Lavage from Patients with Acute Respiratory Distress Syndrome. J Clin Med, 2019, 8(8): 1148.
41. Papadopoulos S, Kazepidou E, Antonelou MH, et al. Secretory Phospholipase A-IIA Protein and mRNA Pools in Extracellular Vesicles of Bronchoalveolar Lavage Fluid from Patients with Early Acute Respiratory Distress Syndrome: A New Perception in the Dissemination of Inflammation? Pharmaceuticals (Basel), 2020, 13(11) : 415.
42. Wu X, Wu C, Gu W, et al. Serum Exosomal MicroRNAs Predict Acute Respiratory Distress Syndrome Events in Patients with Severe Community-Acquired Pneumonia. Biomed Res Int, 2019, 2019: 3612020.
43. Tian C, Liu J, Di X, et al. Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis. Sci Rep, 2021, 11(1): 14141.
44. Im Y, Yoo H, Ko RE, et al. Exosomal CD63 in critically ill patients with sepsis. Sci Rep, 2021, 11(1): 20300.
45. Wang X, Liu D, Zhang X, et al. Exosomes from adipose-derived mesenchymal stem cells alleviate sepsis-induced lung injury in mice by inhibiting the secretion of IL-27 in macrophages. Cell Death Discov, 2022, 8(1): 18.
46. Wei X, Yi X, Lv H, et al. MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy. Cell Death Dis, 2020, 11(8): 657.
47. Yi X, Wei X, Lv H, et al. Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3. Exp Cell Res, 2019, 383(2): 111454.
48. Mizuta Y, Akahoshi T, Guo J, et al. Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells. Stem Cell Res Ther, 2020, 11(1): 508.
49. Sengupta V, Sengupta S, Lazo A, et al. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. Stem Cells Dev, 2020, 29(12): 747-54.
50. Chu M, Wang H, Bian L, et al. Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia. Stem Cell Rev Rep, 2022, 18(6): 2152-2163.
51. Zhou Y, Li P, Goodwin AJ, et al. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care, 2019, 23(1): 44.
52. Wu X, Liu Z, Hu L, et al. Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126. Exp Cell Res, 2018, 370(1): 13-23.
53. Jiang L, Ni J, Shen G, et al. Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha. Inflamm Res, 2021, 70(2): 205-216.
54. He N, Tan H, Deng X, et al. MiR-223-3p-loaded exosomes from bronchoalveolar lavage fluid promote alveolar macrophage autophagy and reduce acute lung injury by inhibiting the expression of STK39. Hum Cell, 2022, 35(6): 1736-1751.
55. Kim G, Lee Y, Ha J, et al. Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation. J Control Release, 2021, 330: 684-695.
56. Li Y, Zhang H, Chen C, et al. Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis. Adv Mater, 2022, 34(19): e2108476.

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Chinese Journal of Respiratory and Critical Care Medicine

外泌體在急性肺損傷中的研究進展

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