阻塞性睡眠呼吸暫停低通氣綜合征的流行病學及臨床研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

程建琴 ¹ , 趙丹 ^2,3 ,  張湘燕 ^2,3

1. ;
2. ;
3. ;

Corresponding?author：

張湘燕, Email: zxy35762@126.com

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DOI：

10.7507/1671-6205.202211021

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Citation： 程建琴, 趙丹, 張湘燕. 阻塞性睡眠呼吸暫停低通氣綜合征的流行病學及臨床研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(12): 899-903. doi: 10.7507/1671-6205.202211021 Copy

1.	何權瀛, 王莞爾. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南 (基層版). 中國呼吸與危重監護雜志, 2015, 14(4): 398-405.
2.	Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med, 1993, 328(17): 1230-1235.
3.	蘇小鳳, 劉霖, 仲琳, 等. 中國阻塞性睡眠呼吸暫停綜合征患病率的 Meta 分析. 中國循證醫學雜志, 2021, 21(10): 1187-1194.
4.	Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med, 2019, 7(8): 687-698.
5.	李學忠, 劉洪英, 蔡曉嵐. 阻塞性睡眠呼吸暫停低通氣綜合征疾病管理認知度調查. 山東大學耳鼻喉眼學報, 2014, 28(4): 11-15.
6.	胡慶磊, 杜翠萍, 楊揚, 等. 上海市普陀區 20 歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征流行病學調查. 中國眼耳鼻喉科雜志, 2017, 17(1): 49-54.
7.	蘇軼, 徐偉偉, 王向云, 等. 東營市東營區老年人阻塞性睡眠呼吸暫停低通氣綜合征流行病學調查. 臨床耳鼻咽喉頭頸外科雜志, 2016, 30(4): 299-305.
8.	馬恒杰, 吳京波, 張靜, 等. 蓬萊市人群睡眠呼吸暫停綜合征流行病學調查的研究. 中國衛生產業, 2017, 14(21): 1-2.
9.	鄒小量, 朱勝華, 李多洛, 等. 邵陽市 20 歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征的流行病學調查. 中國現代醫學雜志, 2007(8): 956-959.
10.	穆婭沙·塔衣爾, 曹媛媛, 朱晴, 等. 肥胖相關基因多態性與阻塞性睡眠呼吸暫停低通氣綜合征遺傳易感性的關系. 醫學研究雜志, 2022, 51(3): 62-68.
11.	郭娟. 分析阻塞性睡眠呼吸暫停低通氣綜合征與甲狀腺功能減退癥的關系. 世界睡眠醫學雜志, 2022, 9(1): 158-160.
12.	Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation, 2021, 144(3): e56-e67.
13.	耿燕, 陳偉軍, 徐錦, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與胃食管反流病相關性 Meta 分析. 浙江中西醫結合雜志, 2021, 31(7): 660-663.
14.	吳丹, 余紅, 張程, 等. 貴陽市567名駕駛員阻塞性睡眠呼吸暫停低通氣綜合征的流行病學調查. 醫學信息, 2016, 29(32): 30-32.
15.	Shah AJ, Quek E, Alqahtani JS, et al. Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: a systematic review and meta-analysis. Sleep Med Rev, 2022, 63: 101627.
16.	Shawon MSR, Perret JL, Senaratna CV, et al. Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Sleep Med Rev, 2017, 32: 58-68.
17.	張曉雷, 張慧, 高博, 等. 慢性阻塞性肺疾病與致纖維化型間質性肺疾病患者阻塞性睡眠呼吸暫停對比研究. 中國實用內科雜志, 2020, 40(4): 300-305.
18.	Lancaster LH, Mason WR, Parnell JA, et al. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest, 2009, 136(3): 772-778.
19.	Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med, 2011, 183(6): 788-824.
20.	Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary hypertension. Prog Cardiovasc Dis, 2009, 51(5): 363-370.
21.	Adir Y, Humbert M, Chaouat A. Sleep-related breathing disorders and pulmonary hypertension. Eur Respir , 2021, 57: 2002258.
22.	Alonso-Fernández A, de la Pe?a M, Romero D, et al. Association between obstructive sleep apnea and pulmonary embolism. Mayo Clin Proc, 2013, 88(6): 579-587.
23.	Peng YH, Liao WC, Chung WS, et al. Association between obstructive sleep apnea and deep vein thrombosis/pulmonary embolism: a population-based retrospective cohort study. Thromb Res, 2014, 134(2): 340-345.
24.	Varol E, Ozturk O, Yucel H, et al. The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea. Platelets, 2011, 22(7): 552-556.
25.	Prasad B, Nyenhuis SM, Imayama I, et al. Asthma and obstructive sleep apnea overlap: what has the evidence taught us? Am J Respir Crit Care Med, 2020, 201(11): 1345-1357.
26.	Cabezas E, Pérez-Warnisher MT, Troncoso MF, et al. Sleep disordered breathing is highly prevalent in patients with lung cancer: results of the sleep apnea in lung cancer study. Respiration, 2019, 97(2): 119-124.
27.	Kendzerska T, Leung RS, Hawker G, et al. Obstructive sleep apnea and the prevalence and incidence of cancer. CMAJ, 2014, 186(13): 985-992.
28.	Gozal D, Farré R, Nieto F J. Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. Chest, 2015, 148(5): 1140-1147.
29.	Brenner R, Kivity S, Peker M, et al. Increased risk for cancer in young patients with severe obstructive sleep apnea. Respiration, 2019, 97(1): 15-23.
30.	Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med, 2009, 6(8): e1000132.
31.	Zinchuk A, Yaggi K, Wenlan Z, et al. Obstructive Sleep Apnea Increases the Risk of Diastolic Heart Failure: Results of a Large Population Study[M]//A77. EFFECT OF SLEEP DISORDERED BREATHING ON CARDIOMETABOLIC AND NEUROCOGNITIVE OUTCOMES. American Thoracic Society, 2018: A7694-A7694.
32.	蘇小鳳, 韓繼明, 高瑩卉, 等. 老年阻塞性睡眠呼吸暫停與代謝綜合征各組分的相關性及其對遠期不良心血管事件發生風險的影響. 南方醫科大學學報, 2021, 41(11): 1592-1599.
33.	Traaen GM, Aaker?y L, Hunt TE, et al. Effect of continuous positive airway pressure on arrhythmia in atrial fibrillation and sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med, 2021, 204(5): 573-582.
34.	Baillieul S, Dekkers M, Brill AK, et al. Sleep apnoea and ischaemic stroke: current knowledge and future directions. Lancet Neurol, 2022, 21(1): 78-88.
35.	Seiler A, Camilo M, Korostovtseva L, et al. Prevalence of sleep-disordered breathing after stroke and TIA: a meta-analysis. Neurology, 2019, 92(7): e648-e654.
36.	嵇朋, 孫根, 江利敏, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與急性缺血性腦卒中預后的關系. 中華老年心腦血管病雜志, 2020, 22(12): 1297-1300.
37.	Owen JE, Benediktsdóttir B, Gislason T, et al. Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea. Sleep, 2019, 42(1): zsy199.
38.	李東洙. 持續氣道正壓通氣治療2型糖尿病伴阻塞性睡眠呼吸暫停低通氣綜合征患者的療效觀察. 世界睡眠醫學雜志, 2022, 9(3): 548-550.
39.	Reutrakul S, Mokhlesi B. Obstructive sleep apnea and diabetes: a state of the art review. Chest, 2017, 152(5): 1070-1086.
40.	劉然, 陸菊明, 劉劍鋒, 等. 2 型糖尿病患者阻塞性睡眠呼吸暫停綜合征患病狀況及相關因素分析. 中華老年心腦血管病雜志, 2013, 15(1): 29-31.
41.	李媛媛, 姚曉光, 蔡昕添, 等. 阻塞性睡眠呼吸暫停合并 2 型糖尿病患者 CAPA 治療后對血糖影響的 meta 分析. 新疆醫學, 2020, 50(3): 236-239.
42.	陳晶, 柯亭羽, 舒筠然, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與甲狀腺功能減退癥的相關性研究進展. 醫學綜述, 2018, 24(23): 4705-4709.
43.	李友堂, 蘇霞, 羅馬長, 等. 阻塞性睡眠呼吸暫停綜合征并胃食管反流病的分析及研究. 世界睡眠醫學雜志, 2019, 6(10): 1455-1456.
44.	Wu ZH, Yang XP, Niu X, et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep Breath, 2019, 23: 389-397.
45.	梁國良, 周志森, 楊智學, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與夜間咽喉反流的相關性研究. 中國醫學創新, 2015, 12(29): 27-29.
46.	Javaheri S, Redline S. Insomnia and risk of cardiovascular disease. Chest, 2017, 152(2): 435-444.
47.	Zhang Y, Ren R, Lei F, et al. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med Rev, 2019, 45: 1-17.
48.	Edinger JD, Bonnet MH, Bootzin RR, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep, 2004, 27(8): 1567-1596.
49.	Luyster FS, Buysse DJ, Strollo Jr PJ. Comorbid insomnia and obstructive sleep apnea: challenges for clinical practice and research. J Clin Sleep Med, 2010, 6(2): 196-204.
50.	Bertisch SM, Pollock BD, Mittleman MA, et al. Insomnia with objective short sleep duration and risk of incident cardiovascular disease and all-cause mortality: Sleep Heart Health Study. Sleep, 2018, 41(6): zsy047.
51.	Kadono M, Hasegawa G. Insomnia disorder comorbid with diabetes. Nihon Rinsho, 2014, 72(5): 977-982.
52.	Smith S, Sullivan K, Hopkins W, et al. Frequency of insomnia report in patients with obstructive sleep apnoea hypopnea syndrome (OSAHS). Sleep Med, 2004, 5(5): 449-456.
53.	Garbarino S, Bardwell WA, Guglielmi O, et al. Association of anxiety and depression in obstructive sleep apnea patients: a systematic review and meta-analysis. Behav Sleep Med, 2020, 18(1): 35-57.
54.	Saunam?ki T, Jehkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review. Acta Neurol Scand, 2007, 116(5): 277-288.

1. 何權瀛, 王莞爾. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南 (基層版). 中國呼吸與危重監護雜志, 2015, 14(4): 398-405.
2. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med, 1993, 328(17): 1230-1235.
3. 蘇小鳳, 劉霖, 仲琳, 等. 中國阻塞性睡眠呼吸暫停綜合征患病率的 Meta 分析. 中國循證醫學雜志, 2021, 21(10): 1187-1194.
4. Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med, 2019, 7(8): 687-698.
5. 李學忠, 劉洪英, 蔡曉嵐. 阻塞性睡眠呼吸暫停低通氣綜合征疾病管理認知度調查. 山東大學耳鼻喉眼學報, 2014, 28(4): 11-15.
6. 胡慶磊, 杜翠萍, 楊揚, 等. 上海市普陀區 20 歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征流行病學調查. 中國眼耳鼻喉科雜志, 2017, 17(1): 49-54.
7. 蘇軼, 徐偉偉, 王向云, 等. 東營市東營區老年人阻塞性睡眠呼吸暫停低通氣綜合征流行病學調查. 臨床耳鼻咽喉頭頸外科雜志, 2016, 30(4): 299-305.
8. 馬恒杰, 吳京波, 張靜, 等. 蓬萊市人群睡眠呼吸暫停綜合征流行病學調查的研究. 中國衛生產業, 2017, 14(21): 1-2.
9. 鄒小量, 朱勝華, 李多洛, 等. 邵陽市 20 歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征的流行病學調查. 中國現代醫學雜志, 2007(8): 956-959.
10. 穆婭沙·塔衣爾, 曹媛媛, 朱晴, 等. 肥胖相關基因多態性與阻塞性睡眠呼吸暫停低通氣綜合征遺傳易感性的關系. 醫學研究雜志, 2022, 51(3): 62-68.
11. 郭娟. 分析阻塞性睡眠呼吸暫停低通氣綜合征與甲狀腺功能減退癥的關系. 世界睡眠醫學雜志, 2022, 9(1): 158-160.
12. Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation, 2021, 144(3): e56-e67.
13. 耿燕, 陳偉軍, 徐錦, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與胃食管反流病相關性 Meta 分析. 浙江中西醫結合雜志, 2021, 31(7): 660-663.
14. 吳丹, 余紅, 張程, 等. 貴陽市567名駕駛員阻塞性睡眠呼吸暫停低通氣綜合征的流行病學調查. 醫學信息, 2016, 29(32): 30-32.
15. Shah AJ, Quek E, Alqahtani JS, et al. Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: a systematic review and meta-analysis. Sleep Med Rev, 2022, 63: 101627.
16. Shawon MSR, Perret JL, Senaratna CV, et al. Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Sleep Med Rev, 2017, 32: 58-68.
17. 張曉雷, 張慧, 高博, 等. 慢性阻塞性肺疾病與致纖維化型間質性肺疾病患者阻塞性睡眠呼吸暫停對比研究. 中國實用內科雜志, 2020, 40(4): 300-305.
18. Lancaster LH, Mason WR, Parnell JA, et al. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest, 2009, 136(3): 772-778.
19. Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med, 2011, 183(6): 788-824.
20. Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary hypertension. Prog Cardiovasc Dis, 2009, 51(5): 363-370.
21. Adir Y, Humbert M, Chaouat A. Sleep-related breathing disorders and pulmonary hypertension. Eur Respir , 2021, 57: 2002258.
22. Alonso-Fernández A, de la Pe?a M, Romero D, et al. Association between obstructive sleep apnea and pulmonary embolism. Mayo Clin Proc, 2013, 88(6): 579-587.
23. Peng YH, Liao WC, Chung WS, et al. Association between obstructive sleep apnea and deep vein thrombosis/pulmonary embolism: a population-based retrospective cohort study. Thromb Res, 2014, 134(2): 340-345.
24. Varol E, Ozturk O, Yucel H, et al. The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea. Platelets, 2011, 22(7): 552-556.
25. Prasad B, Nyenhuis SM, Imayama I, et al. Asthma and obstructive sleep apnea overlap: what has the evidence taught us? Am J Respir Crit Care Med, 2020, 201(11): 1345-1357.
26. Cabezas E, Pérez-Warnisher MT, Troncoso MF, et al. Sleep disordered breathing is highly prevalent in patients with lung cancer: results of the sleep apnea in lung cancer study. Respiration, 2019, 97(2): 119-124.
27. Kendzerska T, Leung RS, Hawker G, et al. Obstructive sleep apnea and the prevalence and incidence of cancer. CMAJ, 2014, 186(13): 985-992.
28. Gozal D, Farré R, Nieto F J. Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. Chest, 2015, 148(5): 1140-1147.
29. Brenner R, Kivity S, Peker M, et al. Increased risk for cancer in young patients with severe obstructive sleep apnea. Respiration, 2019, 97(1): 15-23.
30. Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med, 2009, 6(8): e1000132.
31. Zinchuk A, Yaggi K, Wenlan Z, et al. Obstructive Sleep Apnea Increases the Risk of Diastolic Heart Failure: Results of a Large Population Study[M]//A77. EFFECT OF SLEEP DISORDERED BREATHING ON CARDIOMETABOLIC AND NEUROCOGNITIVE OUTCOMES. American Thoracic Society, 2018: A7694-A7694.
32. 蘇小鳳, 韓繼明, 高瑩卉, 等. 老年阻塞性睡眠呼吸暫停與代謝綜合征各組分的相關性及其對遠期不良心血管事件發生風險的影響. 南方醫科大學學報, 2021, 41(11): 1592-1599.
33. Traaen GM, Aaker?y L, Hunt TE, et al. Effect of continuous positive airway pressure on arrhythmia in atrial fibrillation and sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med, 2021, 204(5): 573-582.
34. Baillieul S, Dekkers M, Brill AK, et al. Sleep apnoea and ischaemic stroke: current knowledge and future directions. Lancet Neurol, 2022, 21(1): 78-88.
35. Seiler A, Camilo M, Korostovtseva L, et al. Prevalence of sleep-disordered breathing after stroke and TIA: a meta-analysis. Neurology, 2019, 92(7): e648-e654.
36. 嵇朋, 孫根, 江利敏, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與急性缺血性腦卒中預后的關系. 中華老年心腦血管病雜志, 2020, 22(12): 1297-1300.
37. Owen JE, Benediktsdóttir B, Gislason T, et al. Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea. Sleep, 2019, 42(1): zsy199.
38. 李東洙. 持續氣道正壓通氣治療2型糖尿病伴阻塞性睡眠呼吸暫停低通氣綜合征患者的療效觀察. 世界睡眠醫學雜志, 2022, 9(3): 548-550.
39. Reutrakul S, Mokhlesi B. Obstructive sleep apnea and diabetes: a state of the art review. Chest, 2017, 152(5): 1070-1086.
40. 劉然, 陸菊明, 劉劍鋒, 等. 2 型糖尿病患者阻塞性睡眠呼吸暫停綜合征患病狀況及相關因素分析. 中華老年心腦血管病雜志, 2013, 15(1): 29-31.
41. 李媛媛, 姚曉光, 蔡昕添, 等. 阻塞性睡眠呼吸暫停合并 2 型糖尿病患者 CAPA 治療后對血糖影響的 meta 分析. 新疆醫學, 2020, 50(3): 236-239.
42. 陳晶, 柯亭羽, 舒筠然, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與甲狀腺功能減退癥的相關性研究進展. 醫學綜述, 2018, 24(23): 4705-4709.
43. 李友堂, 蘇霞, 羅馬長, 等. 阻塞性睡眠呼吸暫停綜合征并胃食管反流病的分析及研究. 世界睡眠醫學雜志, 2019, 6(10): 1455-1456.
44. Wu ZH, Yang XP, Niu X, et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep Breath, 2019, 23: 389-397.
45. 梁國良, 周志森, 楊智學, 等. 阻塞性睡眠呼吸暫停低通氣綜合征與夜間咽喉反流的相關性研究. 中國醫學創新, 2015, 12(29): 27-29.
46. Javaheri S, Redline S. Insomnia and risk of cardiovascular disease. Chest, 2017, 152(2): 435-444.
47. Zhang Y, Ren R, Lei F, et al. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med Rev, 2019, 45: 1-17.
48. Edinger JD, Bonnet MH, Bootzin RR, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep, 2004, 27(8): 1567-1596.
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