GAO Ting 1 , XU Yangling 2 , HE Xiaopeng 1 , MA Yujuan 1 , WANG Lizhen 2 , JIANG Yindi 3 , WU Changgang 2 , ZHANG Ming 2 , CHEN Jianhui 1
  • 1. Department of Respiratory and Critical Care Medicine, Xianyang Central Hospital, Xianyang, Shaanxi 712000, P. R. China;
  • 2. Shandong Liaocheng Infectious Disease Hospital, Liaocheng, Shandong 252000, P. R. China;
  • 3. Department of Hematology, Xianyang Central Hospital, Xianyang, Shaanxi 712000, P. R. China;
XU Yangling, Email: xyllyc9@163.com
Coronavirus disease 2019; Epidemiology; Clinical characteristics; Chest CT
10.7507/1671-6205.202002087
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Objective To explore the epidemiological characteristics, clinical manifestations, laboratory examination and imaging findings of patients with coronavirus disease 2019 (COVID-19) outside Hubei Province in 2019.Methods From January 21, 2020 to February 18, 2020, 17 patients with COVID-19 diagnosed by SARS-CoV-2 nucleic acid test in Xianyang Central Hospital of Shaanxi Province and 23 patients in Liaocheng Infectious Disease Hospital of Shandong Province were collected. The information of epidemiology, age, time of onset, first symptom, white blood cell, lymphocyte count, procalcitonin (PCT), serum amyloid protein A (SAA), C-reactive protein (CRP) and chest CT were collected and analyzed.Results 40.0% of the 40 patients had a clear history of contact with Wuhan or other areas of Hubei, 60.0% had no clear exposure history, 60.0% were aggregative diseases, 40.0% were imported patients; the average visit time was (4.9±3.5) d, 35% of the patients had underlying diseases; 75.0% of the patients had fever, 7.5% of the initial symptoms were cough, 5.0% pharyngitis, 2.5% headache, and 10.0% were asymptomatic. In the laboratory examination, 77.5% of the patients' white blood cells were normal, 45.0% of the patients' lymphocyte count could be decreased, 72.5% and 55.0% of the patients' SAA and CRP increased respectively, 92.5% of the patients' PCT was normal, 92.5% of the patients were positive for the first nucleic acid test, and 72.5% of the patients' chest CT showed multiple ground glass lesions in one or both lungs, and the positive coincidence rate between the initial nucleic acid test and the chest CT test was 92.5%. 90% of the patients in the group were common type, and all patients were treated with aerosol inhalation of α-interferon combined with lopinavir/ritonavir tablets, 62.5% were treated with antibiotics and 15.0% were treated with glucocorticoid. All patients were improved and 14 patients were cured and discharged from hospital.Conclusions SARS-COV-2 is highly contagious, family aggregation infection and asymptomatic infection may be the main mode of transmission outside Hubei Province, mild and common types are common, there are no specific changes in laboratory examination, and the condition is stable after treatment.

Citation： GAO Ting, XU Yangling, HE Xiaopeng, MA Yujuan, WANG Lizhen, JIANG Yindi, WU Changgang, ZHANG Ming, CHEN Jianhui. Epidemiological and clinical characteristics of 40 patients with coronavirus disease 2019 outside Hubei. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(2): 148-153. doi: 10.7507/1671-6205.202002087 Copy

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