Meta-analysis for the effect of preoperative pulmonary rehabilitation on lung cancer patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

CHEN Weihai ¹ , LI Jian’an ² , XU Bin ³ , WU Yanming ¹ , SHEN Jun ¹ , NI Jun ⁴ ,  YOU Hua ¹

1. Department of Cardiology, Suzhou Ninth People’s Hospital, Suzhou, Jiangsu 215200, P. R. China;
2. Department of Rehabilitation, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P. R. China;
3. Nursing Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P. R. China;
4. Department of Rehabilitation, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, P. R. China;

Corresponding?author：

YOU Hua, Email: 13861909863@163.com

Keywords：

Lung cancer; Preoperative pulmonary rehabilitation; Meta-analysis

DOI：

10.7507/1671-6205.201903062

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Objective To clarify the effectiveness of preoperative pulmonary rehabilitation (PPR) and provide evidence for the application of PPR on lung cancer patients by meta-analysis.Methods According to inclusion and exclusion criteria, literatures related to PPR on lung cancer patients were retrieved from major databases between the date of establishment of each database and January 2019, and then data required were extracted from the selected literatures. Meta-analysis was conducted by RevMan 5.0.Results Twelve randomized controlled trials were involved in meta-analysis, including 658 patients who were well-diagnosed and prepared for surgery, with 307 patients in the PPR group and 351 patients in the control group. The results of the meta-analysis showed that in the PPR group, the pulmonary function including forced vital capacity [MD=0.31, 95%CI (0.21, 0.42), P<0.01], forced expiratory volume in one second [MD=0.27, 95%CI (0.20, 0.34), P<0.01] and activity tolerance including 6-minute walk distance [MD=50.55, 95%CI (35.98, 65.13), P<0.01] were significantly better than the control group, and the postoperative complication rate was lower ［MD=0.28, 95%CI (0.18, 0.43), P<0.01］, postoperative hospital stay was shorter [MD=–2.09, 95%CI (–2.41, –1.77), P<0.01].Conclusions A period of PPR on lung cancer patients can improve postoperative pulmonary function and activity tolerance, and reduce postoperative complications and hospital stay, which is beneficial to postoperative recovery.

Citation： CHEN Weihai, LI Jian’an, XU Bin, WU Yanming, SHEN Jun, NI Jun, YOU Hua. Meta-analysis for the effect of preoperative pulmonary rehabilitation on lung cancer patients. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(6): 568-576. doi: 10.7507/1671-6205.201903062 Copy

1.	王維瓊. 2016 年中國惡性腫瘤發病和死亡分析. 臨床醫藥文獻電子雜志, 2017, 4(19): 3604-3604.
2.	支修益, 石遠凱, 于金明. 中國原發性肺癌診療規范(2015 年版). 中華腫瘤雜志, 2015, 37(1): 67-78.
3.	Loganathan RS, Stover DE, Shi W, et al. Prevalence of COPD in women compared to men around the time of diagnosis of primary lung cancer. Chest, 2006, 129(5): 1305-1312.
4.	Arbane G, Tropman D, Jackson D, et al. Evaluation of an early exercise intervention after thoracotomy for non-small cell lung cancer (NSCLC), effects on quality of life, muscle strength and exercise tolerance: randomised controlled trial. Lung Cancer, 2011, 71(2): 229-34.
5.	Cesario A, Ferri L, Galetta D, et al. Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancer. Lung Cancer, 2007, 57(2): 175-180.
6.	Granger CL, Chao C, Mcdonald CF, et al. Safety and feasibility of an exercise intervention for patients following lung resection: a pilot randomized controlled trial. Integr Cancer Ther, 2013, 12(3): 213-224.
7.	王遠, 姚繼方, 楊俊英. 康復鍛煉對肺癌術后患者肺功能恢復結局的影響. 中國組織工程研究, 2005, 9(24): 66-68.
8.	潘友民, 潘鐵成, 張良華, 等. 呼吸訓練改善肺癌患者手術后肺功能和生存質量的臨床研究. 中華物理醫學與康復雜志, 2005, 27(9): 548-550.
9.	Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Resp Crit Care, 2013, 188(8): 13-64.
10.	Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series[M]//Cochrane handbook for systematic reviews of interventions /. 2008.
11.	Sekine Y, Chiyo M, Iwata T, et al. Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease. Jpn J Thorac Cardiovasc Surg, 2005, 53(5): 237-243.
12.	Pehlivan E, Turna A, Gurses A, et al. The effects of preoperative short-term intense physical therapy in lung cancer patients: a randomized controlled trial. Ann Thorac Cardiovas, 2011, 17(17): 461-468.
13.	Benzo R, Wigle D, Novotny P, et al. Preoperative pulmonary rehabilitation before lung cancer resection: results from two randomized studies. Lung Cancer, 2011, 74(3): 441-445.
14.	Morano MT, Araújo AS, Nascimento FB, et al. Preoperative pulmonary rehabilitation versus chest physical therapy in patients undergoing lung cancer resection: a pilot randomized controlled trial. Arch Phys Med Rehab, 2013, 94(1): 53-58.
15.	方翼, 趙擎宇, 黃東鋒, 等. 運動訓練對低肺功能肺癌患者手術耐受性的影響. 中國康復醫學雜志, 2013, 28(7): 619-623.
16.	張慧明, 趙岳. 術前肺康復運動訓練對老年肺癌合并中度慢性阻塞性肺疾病病人肺康復的影響. 護理研究, 2014, 28(5A): 1625-1627.
17.	于艷萍. 護理干預聯合肺康復運動對肺癌全肺切除術患者肺功能恢復及并發癥的影響. 實用臨床護理學電子雜志, 2016, 1(5): 139-140.
18.	朱紅霞, 楊新雅, 包曉燕. 強化肺康復鍛煉在重度肺通氣功能障礙肺癌患者圍手術期中的應用. 中國腫瘤臨床與康復, 2016, 23(11): 1360-1363.
19.	Lai Y, Huang J, Yang M, et al. Seven-day intensive preoperative rehabilitation for elderly patients with lung cancer: a randomized controlled trial. J Surg Res, 2017, 209: 30-36.
20.	高珂, 賴玉田, 黃健, 等. 非小細胞肺癌患者術前肺康復訓練前后血清肺表面活性蛋白 D (SP-D) 改變與術后肺部并發癥相關性的隨機對照試驗. 中國胸心血管外科臨床雜志, 2017, 24(5): 330-337.
21.	賴玉田, 蘇建華, 楊梅, 等. 術前短期綜合肺康復訓練對肺癌合并輕中度慢性阻塞性肺病患者的影響: 一項前瞻性隨機對照試驗. 中國肺癌雜志, 2016, 19(11): 746-753.
22.	劉明強, 洪志鵬. 肺腫瘤手術治療的現狀與未來. 中華肺部疾病雜志(電子版), 2013, 6(1): 53-55.
23.	支修益, 劉寶東. 微創物理靶向治療肺癌的首選技術——射頻消融. 結核病與肺部健康雜志, 2013, 2(1): 5-6.
24.	宋雪. 基于超高效液相色譜—質譜聯用的肺癌代謝組學輪廓分析[D]. 大連醫科大學, 2013.
25.	Ogawa F, Miyata S, Nakashima H, et al. Clinical impact of lung age on postoperative complications in non–small cell lung cancer patients aged >70y. J Surg Res, 2014, 188(2): 373.
26.	倪高順, 陳洋. 綜合物理治療對肺癌合并慢性阻塞性肺疾病患者術后肺功能的影響. 中國呼吸與危重監護雜志, 2017, 16(4): 318-323.
27.	Cesario A, Ferri L, Galetta D, et al. Pre-operative pulmonary rehabilitation and surgery for lung cancer. Lung Cancer, 2007, 57(1): 118-119.
28.	Stefanelli F, Meoli I, Cobuccio R, et al. High-intensity training and cardiopulmonary exercise testing in patients with chronic obstructive pulmonary disease and non-small-cell lung cancer undergoing lobectomy. Eur J Cardiothorac Surg, 2013, 44(4): e260-e265.
29.	車國衛, 劉倫旭. 肺康復訓練有助于肺癌患者術后快速康復嗎?. 中國胸心血管外科臨床雜志, 2017, 24(8): 575-579.

1. 王維瓊. 2016 年中國惡性腫瘤發病和死亡分析. 臨床醫藥文獻電子雜志, 2017, 4(19): 3604-3604.
2. 支修益, 石遠凱, 于金明. 中國原發性肺癌診療規范(2015 年版). 中華腫瘤雜志, 2015, 37(1): 67-78.
3. Loganathan RS, Stover DE, Shi W, et al. Prevalence of COPD in women compared to men around the time of diagnosis of primary lung cancer. Chest, 2006, 129(5): 1305-1312.
4. Arbane G, Tropman D, Jackson D, et al. Evaluation of an early exercise intervention after thoracotomy for non-small cell lung cancer (NSCLC), effects on quality of life, muscle strength and exercise tolerance: randomised controlled trial. Lung Cancer, 2011, 71(2): 229-34.
5. Cesario A, Ferri L, Galetta D, et al. Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancer. Lung Cancer, 2007, 57(2): 175-180.
6. Granger CL, Chao C, Mcdonald CF, et al. Safety and feasibility of an exercise intervention for patients following lung resection: a pilot randomized controlled trial. Integr Cancer Ther, 2013, 12(3): 213-224.
7. 王遠, 姚繼方, 楊俊英. 康復鍛煉對肺癌術后患者肺功能恢復結局的影響. 中國組織工程研究, 2005, 9(24): 66-68.
8. 潘友民, 潘鐵成, 張良華, 等. 呼吸訓練改善肺癌患者手術后肺功能和生存質量的臨床研究. 中華物理醫學與康復雜志, 2005, 27(9): 548-550.
9. Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Resp Crit Care, 2013, 188(8): 13-64.
10. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series[M]//Cochrane handbook for systematic reviews of interventions /. 2008.
11. Sekine Y, Chiyo M, Iwata T, et al. Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease. Jpn J Thorac Cardiovasc Surg, 2005, 53(5): 237-243.
12. Pehlivan E, Turna A, Gurses A, et al. The effects of preoperative short-term intense physical therapy in lung cancer patients: a randomized controlled trial. Ann Thorac Cardiovas, 2011, 17(17): 461-468.
13. Benzo R, Wigle D, Novotny P, et al. Preoperative pulmonary rehabilitation before lung cancer resection: results from two randomized studies. Lung Cancer, 2011, 74(3): 441-445.
14. Morano MT, Araújo AS, Nascimento FB, et al. Preoperative pulmonary rehabilitation versus chest physical therapy in patients undergoing lung cancer resection: a pilot randomized controlled trial. Arch Phys Med Rehab, 2013, 94(1): 53-58.
15. 方翼, 趙擎宇, 黃東鋒, 等. 運動訓練對低肺功能肺癌患者手術耐受性的影響. 中國康復醫學雜志, 2013, 28(7): 619-623.
16. 張慧明, 趙岳. 術前肺康復運動訓練對老年肺癌合并中度慢性阻塞性肺疾病病人肺康復的影響. 護理研究, 2014, 28(5A): 1625-1627.
17. 于艷萍. 護理干預聯合肺康復運動對肺癌全肺切除術患者肺功能恢復及并發癥的影響. 實用臨床護理學電子雜志, 2016, 1(5): 139-140.
18. 朱紅霞, 楊新雅, 包曉燕. 強化肺康復鍛煉在重度肺通氣功能障礙肺癌患者圍手術期中的應用. 中國腫瘤臨床與康復, 2016, 23(11): 1360-1363.
19. Lai Y, Huang J, Yang M, et al. Seven-day intensive preoperative rehabilitation for elderly patients with lung cancer: a randomized controlled trial. J Surg Res, 2017, 209: 30-36.
20. 高珂, 賴玉田, 黃健, 等. 非小細胞肺癌患者術前肺康復訓練前后血清肺表面活性蛋白 D (SP-D) 改變與術后肺部并發癥相關性的隨機對照試驗. 中國胸心血管外科臨床雜志, 2017, 24(5): 330-337.
21. 賴玉田, 蘇建華, 楊梅, 等. 術前短期綜合肺康復訓練對肺癌合并輕中度慢性阻塞性肺病患者的影響: 一項前瞻性隨機對照試驗. 中國肺癌雜志, 2016, 19(11): 746-753.
22. 劉明強, 洪志鵬. 肺腫瘤手術治療的現狀與未來. 中華肺部疾病雜志(電子版), 2013, 6(1): 53-55.
23. 支修益, 劉寶東. 微創物理靶向治療肺癌的首選技術——射頻消融. 結核病與肺部健康雜志, 2013, 2(1): 5-6.
24. 宋雪. 基于超高效液相色譜—質譜聯用的肺癌代謝組學輪廓分析[D]. 大連醫科大學, 2013.
25. Ogawa F, Miyata S, Nakashima H, et al. Clinical impact of lung age on postoperative complications in non–small cell lung cancer patients aged >70y. J Surg Res, 2014, 188(2): 373.
26. 倪高順, 陳洋. 綜合物理治療對肺癌合并慢性阻塞性肺疾病患者術后肺功能的影響. 中國呼吸與危重監護雜志, 2017, 16(4): 318-323.
27. Cesario A, Ferri L, Galetta D, et al. Pre-operative pulmonary rehabilitation and surgery for lung cancer. Lung Cancer, 2007, 57(1): 118-119.
28. Stefanelli F, Meoli I, Cobuccio R, et al. High-intensity training and cardiopulmonary exercise testing in patients with chronic obstructive pulmonary disease and non-small-cell lung cancer undergoing lobectomy. Eur J Cardiothorac Surg, 2013, 44(4): e260-e265.
29. 車國衛, 劉倫旭. 肺康復訓練有助于肺癌患者術后快速康復嗎?. 中國胸心血管外科臨床雜志, 2017, 24(8): 575-579.

Chinese Journal of Respiratory and Critical Care Medicine

Meta-analysis for the effect of preoperative pulmonary rehabilitation on lung cancer patients

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