Effects of edaravone on serum inflammatory factors and adhesion molecules in elderly OSAHS patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHANG Panpan ¹ , WANG Yanhui ² , HAN Xiaoqing ¹ , MENG Qingling ³ , WNAG Ling ¹ , LIU Chen ¹ , WANG Yuan ¹ , HUANG Chao ¹ ,  WANG Hongyang ¹

1. Department of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P. R. China;
2. College of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei 063210, P. R. China;
3. Internal medicine, People Hospitsal of Qianxi, Qianxi, Heibei 063005, P. R. China;

Corresponding?author：

WANG Hongyang, Email: tsmywhy@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Elderly; Edaravone; Interleukin-6; Tumor necrosis factor-α; Intercellular adhesion molecule-1

DOI：

10.7507/1671-6205.201903047

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Objective To investigate the effects and clinical significance of edaravone on serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A total of 90 elderly patients with moderate to severe OSAHS confirmed by polysomnography were recruited from North China University of Science and Technology Affiliated Hospital in February 2016 to October 2017. According to random number table method the OSAHS patients were randomly divided into group A (n=30), group B (n=30) and group C (n=30). Group A received continuous positive airway pressure treatment for six months, group B received edaravone therapy and continuous positive airway pressure treatment for six months, and group C only received edaravone therapy for six months. The changes of serum TNF-α, IL-6 and ICAM-1 were detected by enzyme-linked immunosorbent assay before and after treatment.Results The differences of serum TNF-α, IL-6 and ICAM-1 before treatment in the three groups were not statistically significant (P>0.05). Compared with before treatment, the levels of serum TNF-α, IL-6 and ICAM-1 decreased in the three groups (P<0.05). After six months of treatment, the levels of serum TNF-α, IL-6 and ICAM-1 decreased in group A and group B compared with group C (P<0.05), and decreased significantly in group B compared with group A (P<0.05).Conclusion Edaravone can inhibit the expressions of serum TNF-α, IL-6 and ICAM-1 in elderly patients with moderate to severe OSAHS, and thereby reduce vascular endothelial dysfunction and injury.

Citation： ZHANG Panpan, WANG Yanhui, HAN Xiaoqing, MENG Qingling, WNAG Ling, LIU Chen, WANG Yuan, HUANG Chao, WANG Hongyang. Effects of edaravone on serum inflammatory factors and adhesion molecules in elderly OSAHS patients. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(1): 32-35. doi: 10.7507/1671-6205.201903047 Copy

1.	李蓉, 楊愛榮, 楊發滿, 等. 老年睡眠呼吸暫停低通氣綜合征患者血清 HIF-1α、VEGF、hs-CRP、NT-proBNP 的水平. 中國老年學雜志, 2015, 35(23): 6814-6815.
2.	Ryan CM, Battisti-Charbonney A, Sobczyk O, et al. Evaluation of cerebrovascular reactivity in subjects with and without obstructive sleep apnea. J Stroke Cerebrovasc Dis, 2018, 27(1): 162-168.
3.	Floras JS. Sleep apnea and cardiovascular disease: an enigmatic risk factor. Circ Res, 2018, 122(12): 1741-1764.
4.	Rowley JA, Chowdhuri S. Leukocytes: a potential link between obstructive sleep apnea and cardiovascular disease?. Ann Am Thorac Soc, 2018, 15(8): 918-919.
5.	Jin F, Liu JN, Zhang XW, et al. Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep, 2017, 16(5): 6334-6339.
6.	徐彥飛, 劉露, 周舟, 等. 持續氣道正壓通氣對阻塞性睡眠呼吸暫停低通氣綜合征合并難治性高血壓患者血壓及相關炎性因子的影響. 中國呼吸與危重監護雜志, 2019, 18(4): 322-326.
7.	張盼盼, 韓曉慶, 王紅陽, 等. 持續氣道正壓通氣對中重度阻塞性睡眠呼吸暫停綜合征患者血清 S100β 及 NSE 的影響. 臨床耳鼻咽喉頭頸外科雜志, 2015, 29(6): 509-511.
8.	張盼盼, 韓曉慶, 王紅陽, 等. 持續氣道正壓通氣對老年睡眠呼吸暫停患者神經損傷因子的影響. 中華老年心腦血管病雜志, 2015, 17(7): 739-741.
9.	韓曉慶, 張盼盼, 王紅陽, 等. 雙水平氣道正壓通氣治療對老年阻塞性睡眠呼吸暫停低通氣綜合征患者認知功能及血清 5-羥色胺的影響. 中國老年學雜志, 2017, 37(3): 636-637.
10.	馬勛龍, 劉洋貝, 劉榮雁, 等. 依達拉奉聯合阿托伐他汀鈣對老年血管性癡呆者血液流變學及頸動脈硬化斑塊的影響. 解放軍醫藥雜志, 2017, 29(7): 77-81.
11.	何權瀛, 陳寶元. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南(2011 年修訂版)解讀. 中華結核和呼吸雜志, 2012, 35(1): 7-8.
12.	王錦華, 陳強, 汪東良. 老年急性腦梗死患者依達拉奉聯合神經節苷脂治療的臨床效果及對炎癥因子的影響. 中華醫院感染學雜志, 2015, 25(10): 2179-2181.
13.	Kikuchi K, Tancharoen S, Takeshige N, et al. The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Int J Mol Sci, 2013, 14(7): 13909-13930.
14.	郭華, 陳炅, 索冬衛. 依達拉奉對急性腦梗死患者炎癥因子、6-酮-前列腺素 F1α、血栓素 B2、血管內皮功能和肽素及 N 末端腦鈉素原的影響. 中國生化藥物雜志, 2015, 35(4): 77-80.
15.	李立群, 張嘉賓, 王紅陽, 等. 依達拉奉對重疊綜合征伴認知障礙患者認知功能的影響. 實用心腦肺血管病雜志, 2015, 23(11): 74-76.
16.	韓曉慶, 張盼盼, 李琳. 依達拉奉對重度間歇低氧大鼠認知功能及 Nogo-A 表達的影響. 中國中西醫結合急救雜志, 2017, 24(6): 570-574.
17.	Taylor CT, Kent BD, Crinion SJ, et al. Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression. Biochem Biophys Res Commun, 2014, 447(4): 660-665.
18.	邊麗麗, 谷小芳, 劉芳, 等. 依達拉奉聯合丹紅對急性腦梗死患者炎癥反應及氧化應激的影響. 醫學臨床研究, 2017, 34(3): 558-560.
19.	王雁冰, 蘇梅, 張希龍. 持續氣道正壓通氣對重疊綜合征患者血清中相關炎癥因子水平的影響. 中華醫學雜志, 2014, 94(6): 416-419.
20.	Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation, 2008, 117(17): 2270-2278.
21.	Fotis L, Agrogiannis G, Vlachosi S, et al. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model. Vivo, 2012, 26(2): 243.
22.	Chang YT, Lin HC, Chang WN, et al. Impact of inflammation and oxidative stress on carotid intima-media thickness in obstructive sleep apnea patients without metabolic syndrome. J Sleep Res, 2017, 26(2): 151-158.

1. 李蓉, 楊愛榮, 楊發滿, 等. 老年睡眠呼吸暫停低通氣綜合征患者血清 HIF-1α、VEGF、hs-CRP、NT-proBNP 的水平. 中國老年學雜志, 2015, 35(23): 6814-6815.
2. Ryan CM, Battisti-Charbonney A, Sobczyk O, et al. Evaluation of cerebrovascular reactivity in subjects with and without obstructive sleep apnea. J Stroke Cerebrovasc Dis, 2018, 27(1): 162-168.
3. Floras JS. Sleep apnea and cardiovascular disease: an enigmatic risk factor. Circ Res, 2018, 122(12): 1741-1764.
4. Rowley JA, Chowdhuri S. Leukocytes: a potential link between obstructive sleep apnea and cardiovascular disease?. Ann Am Thorac Soc, 2018, 15(8): 918-919.
5. Jin F, Liu JN, Zhang XW, et al. Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep, 2017, 16(5): 6334-6339.
6. 徐彥飛, 劉露, 周舟, 等. 持續氣道正壓通氣對阻塞性睡眠呼吸暫停低通氣綜合征合并難治性高血壓患者血壓及相關炎性因子的影響. 中國呼吸與危重監護雜志, 2019, 18(4): 322-326.
7. 張盼盼, 韓曉慶, 王紅陽, 等. 持續氣道正壓通氣對中重度阻塞性睡眠呼吸暫停綜合征患者血清 S100β 及 NSE 的影響. 臨床耳鼻咽喉頭頸外科雜志, 2015, 29(6): 509-511.
8. 張盼盼, 韓曉慶, 王紅陽, 等. 持續氣道正壓通氣對老年睡眠呼吸暫停患者神經損傷因子的影響. 中華老年心腦血管病雜志, 2015, 17(7): 739-741.
9. 韓曉慶, 張盼盼, 王紅陽, 等. 雙水平氣道正壓通氣治療對老年阻塞性睡眠呼吸暫停低通氣綜合征患者認知功能及血清 5-羥色胺的影響. 中國老年學雜志, 2017, 37(3): 636-637.
10. 馬勛龍, 劉洋貝, 劉榮雁, 等. 依達拉奉聯合阿托伐他汀鈣對老年血管性癡呆者血液流變學及頸動脈硬化斑塊的影響. 解放軍醫藥雜志, 2017, 29(7): 77-81.
11. 何權瀛, 陳寶元. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南(2011 年修訂版)解讀. 中華結核和呼吸雜志, 2012, 35(1): 7-8.
12. 王錦華, 陳強, 汪東良. 老年急性腦梗死患者依達拉奉聯合神經節苷脂治療的臨床效果及對炎癥因子的影響. 中華醫院感染學雜志, 2015, 25(10): 2179-2181.
13. Kikuchi K, Tancharoen S, Takeshige N, et al. The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Int J Mol Sci, 2013, 14(7): 13909-13930.
14. 郭華, 陳炅, 索冬衛. 依達拉奉對急性腦梗死患者炎癥因子、6-酮-前列腺素 F1α、血栓素 B2、血管內皮功能和肽素及 N 末端腦鈉素原的影響. 中國生化藥物雜志, 2015, 35(4): 77-80.
15. 李立群, 張嘉賓, 王紅陽, 等. 依達拉奉對重疊綜合征伴認知障礙患者認知功能的影響. 實用心腦肺血管病雜志, 2015, 23(11): 74-76.
16. 韓曉慶, 張盼盼, 李琳. 依達拉奉對重度間歇低氧大鼠認知功能及 Nogo-A 表達的影響. 中國中西醫結合急救雜志, 2017, 24(6): 570-574.
17. Taylor CT, Kent BD, Crinion SJ, et al. Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression. Biochem Biophys Res Commun, 2014, 447(4): 660-665.
18. 邊麗麗, 谷小芳, 劉芳, 等. 依達拉奉聯合丹紅對急性腦梗死患者炎癥反應及氧化應激的影響. 醫學臨床研究, 2017, 34(3): 558-560.
19. 王雁冰, 蘇梅, 張希龍. 持續氣道正壓通氣對重疊綜合征患者血清中相關炎癥因子水平的影響. 中華醫學雜志, 2014, 94(6): 416-419.
20. Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation, 2008, 117(17): 2270-2278.
21. Fotis L, Agrogiannis G, Vlachosi S, et al. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model. Vivo, 2012, 26(2): 243.
22. Chang YT, Lin HC, Chang WN, et al. Impact of inflammation and oxidative stress on carotid intima-media thickness in obstructive sleep apnea patients without metabolic syndrome. J Sleep Res, 2017, 26(2): 151-158.

Chinese Journal of Respiratory and Critical Care Medicine

Effects of edaravone on serum inflammatory factors and adhesion molecules in elderly OSAHS patients

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