Correlation analysis of red blood cell distribution width and disease severity of acute exacerbation of bronchiectasis in the elderly patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 XU Ying , JIANG Ping , YANG Mingjing , PENG Shifeng

Department of Respiratory and Critical Care Medicine, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, P. R. China;

Corresponding?author：

XU Ying, Email: yanbaba060421@163.com

Keywords：

Bronchiectasis; Acute exacerbation; Red blood cell distribution width; Bronchiectasis severity index; Correlation analysis

DOI：

10.7507/1671-6205.201901044

Video：

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Objective To investigate the relationship between the red blood cell distribution width (RDW) and the severity of acute exacerbation of bronchiectasis in elderly patients.Methods The clinical data of 216 elderly patients with acute exacerbation of bronchiectasis admitted from January 2015 to October of 2018 were analyzed retrospectively. The severity of acute exacerbation of bronchiectasis in the elderly was evaluated by bronchiectasis severity index (BSI) score. Meanwhile, 50 elderly people receiving qualified medical examination were collected as a healthy control group in the same period. The distributions of BSI score, RDW, procalcitonin (PCT), neutrophil percentage (NEU%) and C-reactive protein (CRP) were described in the patients with different risk degree. The severity of acute exacerbation of bronchiectasis in the elderly was evaluated by BSI. The patients were divided into three groups by BSI score: a low risk group, a middle risk group, and a high risk group. The indexes were described including the distribution of stratified BSI score, RDW, PCT, NEU%, CRP at different risk levels. The correlation of each index was analyzed by Spearman correlation. The threshold value of RDW was calculated by general linear regression, and the influencing factors of BSI score were analyzed by multivariate linear regression analysis.Results The higher the risk stratification, the higher the BSI score, RDW, PCT, NEU% and CRP were. RDW was positively correlated with PCT, NEU% and CRP (r values were 0.425, 0.311, 0.177, respectively, P<0.05). BSI score was positively correlated with RDW, PCT, NEU%, and CRP (r values were 0.425, 0.394, 0.650, 0.578, respectively, P<0.05). RDW was positively correlated with PSI score (r=0.425, P<0.05). The thresholds of RDW were 11.45% and 14.03%. Multiple linear regression showed that RDW, PCT, NEU% and CRP were all influential factors of BSI score and explained 52.3% of the total mutation rate.Conclusion RDW is related to the severity of acute exacerbation of bronchiectasis in the elderly, and can predict the severity of acute exacerbation of bronchiectasis in the elderly.

Citation： XU Ying, JIANG Ping, YANG Mingjing, PENG Shifeng. Correlation analysis of red blood cell distribution width and disease severity of acute exacerbation of bronchiectasis in the elderly patients. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(4): 348-351. doi: 10.7507/1671-6205.201901044 Copy

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12.	盛偉利, 張永祥, 趙瑩, 等. 支氣管擴張嚴重度指數和 FACED 評分對支氣管擴張癥預后評估的比較. 國際呼吸雜志, 2016, 36(12): 926-929.
13.	中國醫藥教育協會感染疾病專業委員會. 感染相關生物標志物臨床意義解讀專家共識. 中華結核和呼吸雜志, 2017, 40(4): 243-257.
14.	楊德平, 狄勇. PCT、WBC、CRP 聯合檢測對早期細菌感染性疾病的診斷價值. 國際檢驗醫學雜志, 2014, 35(11): 1485-1486.
15.	李樹林, 顧暢. 降鈣素原、C-反應蛋白、白細胞計數和中性粒細胞百分比在肺部感染性疾病早期診斷中的應用. 中國衛生檢驗雜志, 2016, 26(16): 2343-2345.
16.	陳麗萍, 叢立, 陳穎, 等. 血清降鈣素原檢測對革蘭陰性菌或革蘭陽性菌血流感染的診斷價值. 中國呼吸與危重監護雜志, 2014, 13(4): 374-377.
17.	Alis R, Fuster O, Rivera L, et al. Influence of age and gender on red blood cell distribution width. Clin Chem Lab Med, 2015, 53(2): e25-e28.
18.	何思春, 萬紹恒, 魏忠華, 等. 年齡和性別對紅細胞分布寬度的影響. 國際檢驗醫學雜志, 2017, 38(1): 121-123.

1. Ringshausen FC, de Roux A, Diel R, et al. Bronchiectasis in Germany: a population-based estimation of disease prevalence. Eur Respir J, 2015, 46(6): 1805-1807.
2. Quint JK, Millett ER, Joshi M, et al. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study. Eur Respir J, 2016, 47(1): 186-193.
3. Kwak HJ, Moon JY, Choi YW, et al. High prevalence of bronchiectasis in adults: analysis of CT findings in a health screening program. Tohoku J Exp Med, 2010, 222(4): 237-242.
4. Ellis HC, Cowman S, Fernandes M, et al. Predicting mortality in bronchiectasis using BSI and FRACED scores: a 19-year cohort study. Eur Respir J, 2016, 47(2): 482-489.
5. Balta S, Demirkol S, Hatipoglu M, et al. Red cell distribution width is a predictor of mortality in patients with severe sepsis and septic shock. Am J Emerg Med, 2013, 31(6): 989-990.
6. Salvagno GL, Sanchis-Gomar F, Picanza A, et al. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci, 2015, 52(2): 86-105.
7. 張靜, 劉冬, 許西琳, 等. 紅細胞分布寬度與成人社區獲得性肺炎嚴重程度的相關性分析. 中國呼吸與危重監護雜志, 2018, 17(2): 134-137.
8. 葛均波, 徐永健, 梅長林, 等. 內科學. 第 8 版. 北京: 人民衛生出版社, 2015, 37-40.
9. 成人支氣管擴張癥診治專家共識編寫組. 成人支氣管擴張癥診治專家共識. 中華結核和呼吸雜志, 2012, 35(7): 485-492.
10. Chalmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med, 2014, 189(5): 576-585.
11. 陳榮昌, 關偉杰, 鐘南山. 支氣管擴張癥: 需要更多的關注和研究. 中華結核和呼吸雜志, 2017, 40(1): 5-7.
12. 盛偉利, 張永祥, 趙瑩, 等. 支氣管擴張嚴重度指數和 FACED 評分對支氣管擴張癥預后評估的比較. 國際呼吸雜志, 2016, 36(12): 926-929.
13. 中國醫藥教育協會感染疾病專業委員會. 感染相關生物標志物臨床意義解讀專家共識. 中華結核和呼吸雜志, 2017, 40(4): 243-257.
14. 楊德平, 狄勇. PCT、WBC、CRP 聯合檢測對早期細菌感染性疾病的診斷價值. 國際檢驗醫學雜志, 2014, 35(11): 1485-1486.
15. 李樹林, 顧暢. 降鈣素原、C-反應蛋白、白細胞計數和中性粒細胞百分比在肺部感染性疾病早期診斷中的應用. 中國衛生檢驗雜志, 2016, 26(16): 2343-2345.
16. 陳麗萍, 叢立, 陳穎, 等. 血清降鈣素原檢測對革蘭陰性菌或革蘭陽性菌血流感染的診斷價值. 中國呼吸與危重監護雜志, 2014, 13(4): 374-377.
17. Alis R, Fuster O, Rivera L, et al. Influence of age and gender on red blood cell distribution width. Clin Chem Lab Med, 2015, 53(2): e25-e28.
18. 何思春, 萬紹恒, 魏忠華, 等. 年齡和性別對紅細胞分布寬度的影響. 國際檢驗醫學雜志, 2017, 38(1): 121-123.

Chinese Journal of Respiratory and Critical Care Medicine

Correlation analysis of red blood cell distribution width and disease severity of acute exacerbation of bronchiectasis in the elderly patients

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