Screening and analyzing risk factors for obstructive sleep apnea hypopnea syndrome in patients with snoring_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

SUN Kai ,  NIE Hongyu , XU Donglan , LIU Yong , MA Shengjun , TANG Liang

Department of Respiratory and Critical Care Medicine, Zigong Fourth People’s Hospital, Zigong, Sichuan 643000, P. R. China;

Corresponding?author：

NIE Hongyu, Email: 26576628@qq.com

Keywords：

Snoring; Obstructive sleep apnea hypopnea syndrome; Screening; Risk factors

DOI：

10.7507/1671-6205.201805020

Video：

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Objective To establish a screening model for obstructive sleep apnea hypopnea syndrome (OSAHS) through data analysis, and explore the risk factors of OSAHS. Methods A total of 558 patients who underwent polysomnography in the Sleep Monitoring Room of Zigong Fourth People’s Hospital were recruited in the study. Among them there were 163 cases in a snore group and 395 cases in an OSAHS group. Risk factors of OSAHS were screened by both univariate analysis and multivariate analysis, then the model was established by means of binary logistic regression analysis. Finally, the screening model was evaluated by receiver operating characteristic (ROC) curve of the combined predictive factor. Results The screening model of OSAHS was established as: X=–10.286+0.280×body mass index+1.057×snoring degree+1.124×sex+0.085×Epworth score+0.036×age. In this equation, sex value was 1 for men and 0 for women. If the value of X is higher than 1.123, it is likely that OSAHS would occur, and the probability (P)=e^x/(1+e^x). The sensitivity of the screening model was 77.70%, the specificity was 85.89%, the area under the ROC curve was 0.890, and the 95% confidence interval ranged from 0.862 to 0.918. Conclusion This study demonstrates that a screening model based on the snoring degree, Epworth score, and body measurement data is a valuable tool to predict and screen OSAHS in patients with snoring, and the screening model could be useful in clinical diagnosis of OSAHS.

Citation： SUN Kai, NIE Hongyu, XU Donglan, LIU Yong, MA Shengjun, TANG Liang. Screening and analyzing risk factors for obstructive sleep apnea hypopnea syndrome in patients with snoring. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(1): 26-30. doi: 10.7507/1671-6205.201805020 Copy

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8.	閆涵, 董霄松. 便攜式睡眠監測代替多導睡眠監測診斷在我國廣泛應用尚不成熟. 中華結核和呼吸雜志, 2014, 37(12): 947-948.
9.	Seetho IW, Parker RJ, Craig S, et al. Obstructive sleep apnea is associated with increased arterial stiffness in severe obesity. J Sleep Res, 2014, 23(6): 700-708.
10.	Daltro C, Gregorio PB, Alves E, et al. Prevalence and severity of sleep apnea in a group of morbidly obese patients. Obes Surg, 2007, 17(6): 809-814.
11.	Shah N, Roux F. The relationship of obesity and obstructive sleep apnea. Clin Chest Med, 2009, 30: 455-465.
12.	BaHammam AS, Pandi-Perumal SR, Piper A, et al. Gender differences in patients with obesity hypoventilation syndrome. J Sleep Res, 2016, 25(4): 445-453.
13.	王俊力, 夏進, 王菊芬, 等. 女性阻塞性睡眠呼吸暫停低通氣綜合征的危險因素及治療現狀分析. 四川大學學報 (醫學版), 2011, 42(4): 535-539.
14.	Gabbay IE, Lavie P. Age- and gender-related characteristics of obstructive sleep apnea. Sleep Breath, 2012, 16(2): 453-460.

1. Hiestand DM, Britz P, Goldman M, et al. Prevalence of symptoms and risk of sleep apnea in the US population: Results from the national sleep foundation sleep in America 2005 poll. Chest, 2006, 130(3): 780-786.
2. 葛瑞鋒, 劉文君, 梅栩彬, 等. 青島地區阻塞性睡眠呼吸暫停低通氣綜合征的患病率及影響因素的相關性分析. 中國耳鼻咽喉顱底外科雜志, 2009, 15(4): 272-275.
3. White DP. Sleep apnea. Proc Am Thorac Soc, 2006, 3(1): 124-128.
4. 何權瀛, 王莞爾. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南 (基層版). 中國呼吸與危重監護雜志, 2015, 14(4): 398-405.
5. Berry RB, Brooks R, Gamaldo CE, et al. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. VERSION 2.0. Darien IL: American Academy of Sleep Medicine, 2012: 16-58.
6. 中華醫學會呼吸病學分會睡眠呼吸疾病學組. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南 (2011 年修訂版). 中華結核和呼吸雜志, 2012, 35(1): 9-12.
7. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 1991, 14(6): 540-545.
8. 閆涵, 董霄松. 便攜式睡眠監測代替多導睡眠監測診斷在我國廣泛應用尚不成熟. 中華結核和呼吸雜志, 2014, 37(12): 947-948.
9. Seetho IW, Parker RJ, Craig S, et al. Obstructive sleep apnea is associated with increased arterial stiffness in severe obesity. J Sleep Res, 2014, 23(6): 700-708.
10. Daltro C, Gregorio PB, Alves E, et al. Prevalence and severity of sleep apnea in a group of morbidly obese patients. Obes Surg, 2007, 17(6): 809-814.
11. Shah N, Roux F. The relationship of obesity and obstructive sleep apnea. Clin Chest Med, 2009, 30: 455-465.
12. BaHammam AS, Pandi-Perumal SR, Piper A, et al. Gender differences in patients with obesity hypoventilation syndrome. J Sleep Res, 2016, 25(4): 445-453.
13. 王俊力, 夏進, 王菊芬, 等. 女性阻塞性睡眠呼吸暫停低通氣綜合征的危險因素及治療現狀分析. 四川大學學報 (醫學版), 2011, 42(4): 535-539.
14. Gabbay IE, Lavie P. Age- and gender-related characteristics of obstructive sleep apnea. Sleep Breath, 2012, 16(2): 453-460.

Chinese Journal of Respiratory and Critical Care Medicine

Screening and analyzing risk factors for obstructive sleep apnea hypopnea syndrome in patients with snoring

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