Correlation analysis of red blood cell distribution width and disease severity of adult patients with community-acquired pneumonia_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHANG Jing ¹ , LIU Dong ² ,  XU Xilin ² , ZHAO Yue ¹ , XIN Wenyan ²

1. Medical College of Shihezi University, Shihezi, Xinjiang 832000, P. R. China;
2. Department of Respiratory Medicine, Medical College of Shihezi University, Shihezi, Xinjiang 832000, P. R. China;

Corresponding?author：

XU Xilin, Email: xuxilinxjshz@126.com

Keywords：

Community-acquired pneumonia; Severity stratification; Red blood cell distribution width; Correlation analysis

DOI：

10.7507/1671-6205.201710040

Video：

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Objective To investigate the relationship between the red blood cell distribution width (RDW) and the severity of community-acquired pneumonia (CAP). Methods The clinical data of 285 adult patients with CAP admitted from November 2014 to August of 2017 were analyzed retrospectively. The severity of CAP was evaluated by pneumonia severity index (PSI) score. Meanwhile, 60 cases with qualified medical examination were collected as a healthy control group. The distributions of PSI score, RDW, procalcitonin (PCT), C-reactive protein (CRP) and neutrophil percentage (NEU%) were described in the patients with different risk degree. The correlation analysis of various indicators were analyzed by Spearman correlation. The threshold of RDW(%) was calculated through the construction of the general linear regression equation. The risk factors of PSI score were analyzed with multiple linear regression. Results The higher the risk stratification, the higher the distribution of PSI scores, RDW, PCT, CRP and NEU% were. RDW was positively correlated with PCT, CRP, and NEU% (r values were 0.417, 0.252, 0.318, respectively, P<0.05). PSI score was positively correlated with RDW, PCT, CRP, and NEU% (r values were 0.537,0.598, 0.557, 0.482, respectively, P<0.05). RDW was positively correlated with PSI score (r=0.537, P<0.05). The thresholds of RDW(%) were 14.514 and 19.041. Multiple linear regression showed that RDW, PCT, CRP and NEU% were all influential factors of PSI scores and explained 46.9% of the total mutation rate. Conclusion RDW is correlated with the severity of CAP, and can predict the severity of CAP.

Citation： ZHANG Jing, LIU Dong, XU Xilin, ZHAO Yue, XIN Wenyan. Correlation analysis of red blood cell distribution width and disease severity of adult patients with community-acquired pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(2): 134-137. doi: 10.7507/1671-6205.201710040 Copy

1.	中華醫學會呼吸病學分會. 中國成人社區獲得性肺炎診斷和治療指南（2016 年版）. 中華結核和呼吸雜志, 2016, 39(4): 253-279.
2.	劉月, 劉曉民, 馬雨霞, 等. 紅細胞分布寬度與社區獲得性肺炎嚴重程度及預后的關系. 中華肺部疾病雜志, 2016, 9(4): 434-435.
3.	劉勝寶, 季漢華. 紅細胞分布寬度及高敏 C 反應蛋白與行冠狀動脈介入治療的急性冠狀動脈綜合征患者出現對比劑腎病相關性研究. 中國循環雜志, 2015, 30(3): 220-224.
4.	巫雪飛, 李巧, 趙連山. 紅細胞分布寬度檢驗在慢性心衰患者早期診斷中的應用效果觀察. 中國實驗診斷學, 2015, 19(2): 235-237.
5.	Balta S, Demirkol S, Hatipoglu M, et al. Red cell distribution width is a predictor of mortality in patients with severe sepsis and septic shock. Am J Emerg Med, 2013, 31(6): 989-990.
6.	侯勇, 王聯發, 周文兵, 等. 紅細胞分布寬度、胱抑素 C 與冠狀動脈病變程度的相關性分析. 心肺血管病雜志, 2014, 33(3): 353-355.
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9.	Welte T, Kohnlein T. Global and local epidemiology of community-acquired pneumonia : the experience of the CAPNETZ network.Semin Respir Crit Care Med, 2009, 30(2):127-135.
10.	但勇, 覃雙全. PSI 評分和 CURB-65 評分對社區獲得性肺炎患者病情及預后的對比研究. 臨床研究, 2012, 19(21): 29-32.
11.	劉旭, 沈湘波, 李小玲. PSI 分數與 CURB-65 在社區獲得性肺炎嚴重程度評價中的比較. 中國醫學創新, 2011, 8(18): 181-182.
12.	Falk G, Fahey T. C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of diagnostic accuracy studies. Fam Pract, 2009, 26(1): 10-21.
13.	易高, 方向明, 林純意, 等. 紅細胞分布寬度在社區獲得性肺炎嚴重度分層中的預測價值. 中國呼吸與危重監護雜志, 2014, 13(4): 374-377.
14.	中國醫藥教育協會感染疾病專業委員會. 感染相關生物標志物臨床意義解讀專家共識. 中華結核和呼吸雜志, 2017, 40(4): 243-257.
15.	楊德平, 狄勇. PCT、WBC、CRP 聯合檢測對早期細菌感染性疾病的診斷價值. 國際檢驗醫學雜志, 2014, 35(11): 1485-1486.
16.	李樹林, 顧暢. 降鈣素原、C-反應蛋白、白細胞計數和中性粒細胞百分比在肺部感染性疾病早期診斷中的應用. 中國衛生檢驗雜志, 2016, 26(16): 2343-2345.
17.	陳麗萍, 叢立, 陳穎, 等. 血清降鈣素原檢測對革蘭陰性菌或革蘭陽性菌血流感染的診斷價值. 中國呼吸與危重監護雜志, 2014, 13(4): 374-377.
18.	周冰, 邢菊, 周麗娟. C-反應蛋白、臨床肺部感染評分在社區獲得性肺炎中的臨床價值.實用臨床醫學. 2016, 17(6): 8-10.
19.	朱婉凌, 王敏, 王小亞. 乳酸、降鈣素原、CURB-65 評分在老年社區獲得性肺炎預后評估中的作用.中國醫學工程, 2015, 23(1): 9-10.
20.	江桂忠, 廖偉群, 賴曉宇. 紅細胞分布寬度與老年重癥社區獲得性肺炎患者病情嚴重程度及預后的相關性分析. 廣州醫藥, 2016, 47(1): 67-70.
21.	張儼, 李文強. 降鈣素原對社區獲得性肺炎死亡率及病情評估的價值. 臨床肺科雜志, 2015, 20(8): 1468-1471.

1. 中華醫學會呼吸病學分會. 中國成人社區獲得性肺炎診斷和治療指南（2016 年版）. 中華結核和呼吸雜志, 2016, 39(4): 253-279.
2. 劉月, 劉曉民, 馬雨霞, 等. 紅細胞分布寬度與社區獲得性肺炎嚴重程度及預后的關系. 中華肺部疾病雜志, 2016, 9(4): 434-435.
3. 劉勝寶, 季漢華. 紅細胞分布寬度及高敏 C 反應蛋白與行冠狀動脈介入治療的急性冠狀動脈綜合征患者出現對比劑腎病相關性研究. 中國循環雜志, 2015, 30(3): 220-224.
4. 巫雪飛, 李巧, 趙連山. 紅細胞分布寬度檢驗在慢性心衰患者早期診斷中的應用效果觀察. 中國實驗診斷學, 2015, 19(2): 235-237.
5. Balta S, Demirkol S, Hatipoglu M, et al. Red cell distribution width is a predictor of mortality in patients with severe sepsis and septic shock. Am J Emerg Med, 2013, 31(6): 989-990.
6. 侯勇, 王聯發, 周文兵, 等. 紅細胞分布寬度、胱抑素 C 與冠狀動脈病變程度的相關性分析. 心肺血管病雜志, 2014, 33(3): 353-355.
7. Salvagno GL, Sanchis-Gomar F, Picanza A, et al. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci, 2015, 52(2): 86-105.
8. Fine MJ, Auble TE, Yealy DM, et, al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med, 1997, 336(4):243-250.
9. Welte T, Kohnlein T. Global and local epidemiology of community-acquired pneumonia : the experience of the CAPNETZ network.Semin Respir Crit Care Med, 2009, 30(2):127-135.
10. 但勇, 覃雙全. PSI 評分和 CURB-65 評分對社區獲得性肺炎患者病情及預后的對比研究. 臨床研究, 2012, 19(21): 29-32.
11. 劉旭, 沈湘波, 李小玲. PSI 分數與 CURB-65 在社區獲得性肺炎嚴重程度評價中的比較. 中國醫學創新, 2011, 8(18): 181-182.
12. Falk G, Fahey T. C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of diagnostic accuracy studies. Fam Pract, 2009, 26(1): 10-21.
13. 易高, 方向明, 林純意, 等. 紅細胞分布寬度在社區獲得性肺炎嚴重度分層中的預測價值. 中國呼吸與危重監護雜志, 2014, 13(4): 374-377.
14. 中國醫藥教育協會感染疾病專業委員會. 感染相關生物標志物臨床意義解讀專家共識. 中華結核和呼吸雜志, 2017, 40(4): 243-257.
15. 楊德平, 狄勇. PCT、WBC、CRP 聯合檢測對早期細菌感染性疾病的診斷價值. 國際檢驗醫學雜志, 2014, 35(11): 1485-1486.
16. 李樹林, 顧暢. 降鈣素原、C-反應蛋白、白細胞計數和中性粒細胞百分比在肺部感染性疾病早期診斷中的應用. 中國衛生檢驗雜志, 2016, 26(16): 2343-2345.
17. 陳麗萍, 叢立, 陳穎, 等. 血清降鈣素原檢測對革蘭陰性菌或革蘭陽性菌血流感染的診斷價值. 中國呼吸與危重監護雜志, 2014, 13(4): 374-377.
18. 周冰, 邢菊, 周麗娟. C-反應蛋白、臨床肺部感染評分在社區獲得性肺炎中的臨床價值.實用臨床醫學. 2016, 17(6): 8-10.
19. 朱婉凌, 王敏, 王小亞. 乳酸、降鈣素原、CURB-65 評分在老年社區獲得性肺炎預后評估中的作用.中國醫學工程, 2015, 23(1): 9-10.
20. 江桂忠, 廖偉群, 賴曉宇. 紅細胞分布寬度與老年重癥社區獲得性肺炎患者病情嚴重程度及預后的相關性分析. 廣州醫藥, 2016, 47(1): 67-70.
21. 張儼, 李文強. 降鈣素原對社區獲得性肺炎死亡率及病情評估的價值. 臨床肺科雜志, 2015, 20(8): 1468-1471.

Chinese Journal of Respiratory and Critical Care Medicine

Correlation analysis of red blood cell distribution width and disease severity of adult patients with community-acquired pneumonia

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