Synchronous Double Primary Lung Cancer: One Case Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LiZhao ¹ , SongMin ² ,  JiangLuning ¹ , SuNa ²

1. Affiliated Hospital of Jining Medical University, Jining, Shandong, 272067, China;
2. ;

Corresponding?author：

JiangLuning, Email: w13001786181@126.com

Keywords：

Bronchoscope; Double primary lung cancer; Squamous cell carcinoma; Small cell lung carcinoma

DOI：

10.7507/1671-6205.2016136

Video：

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Objective To improve the knowledge of double primary lung cancer. Methods A case of synchronous double primary lung cancers, who was diagnosed by bronchoscopic examination and immunohistochemical staining in our department in 2012, was analyzed retrospectively. The literatures were review with "double primary, lung cancer, squamous cell carcinoma, small cell lung carcinoma" as the research terms in Wanfang, CNKI and PubMed database. Results A 76-year-old male patient complained of intermittent cough, chest pain and wheezing over half a month. Chest computer tomography showed masslike lesion with high density in hilum of right lung. The patient received bronchoscopic examination, the pathological and immunohistochemical findings was squamous cell carcinoma and small cell lung carcinoma. The imaging manifestations and bronchoscopy findings were consistent with pathologic diagnosis. A total of 7 pieces of literature were retrived in above-mentioned databases. Seven patients had long smoke history and 6 were male. Four patients complained about couph and sputum, and 1 patient had chest pain. CT showed masses in the lung or hilus with or without stenosis and obliteration of the bronchus. Five patients were proven by bronchoscopy and biopsy. Conclusion Double primary lung cancer has characteristics in radiologic features and bronchoscopy performance, so can be early diagnosed by bronchoscopy and histopathology.

Citation： LiZhao, SongMin, JiangLuning, SuNa. Synchronous Double Primary Lung Cancer: One Case Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 597-602. doi: 10.7507/1671-6205.2016136 Copy

1.	Griffioen GH, Lagerwaard FJ, Haasbeek CJ, et al. Treatment of multiple primary lung cancers using stereotactic radiotherapy, either with or without surgery. Radiother Oncol, 2013, 107:403-408.
2.	Gazdar AF, Minnat JD. Multifocal lung cancers-clonality vs field cencerization and does it matter? J Natl Cancer Inst, 2009, 101:541-543.
3.	李月越, 吳繼華, 王瑞娟, 等.肺小細胞癌混合肺鱗癌1例.臨床肺科志, 2012, 17:1740.
4.	林曉, 林其昌, 黃東煜, 等.多原發性肺癌1例報告并文獻復習.國際呼吸雜志, 2013, 33:157-159.
5.	Liu XD, Qu Y, Lu SS. Synchronous double primary lung cancer:a report of three cases. Chin J Cancer Res, 2014, 26:E17-E21.
6.	Gogakos AS, Paliouras D, Rallis T, et al. Double primary non-small cell lung cancer with synchronous small cell lung cancer N2 nodes:a case report. Ann Transl Med, 2015, 3:157.
7.	李樂, 張晨媛, 祖金池, 等.同時、同側、異葉雙原發肺癌1例.中華保健醫學雜志, 2015, 17:57-58.
8.	劉冬梅, 李棟, 孫文逵, 等.同時性雙原發肺癌1例.臨床腫瘤學雜志, 2015, 20:572-574.
9.	吳波, 丁笑笑, 徐紅燕, 等.雙原發肺癌多發轉移一例報告.新醫學, 2016, 47:412-416.
10.	Dai L, Yang HL, Yan WP, et al. The equivalent efficacy of multiple operations for multiple primary lung cancer and a single operation for single primary lung cancer. J Thorac Dis, 2016, 8:855-861.
11.	Takao M, Watanabe F, Shimamoto A, et al. Analyses of multiple primary lung cancers recent trend. Kyobu Geka, 2002, 55:15-19.
12.	王國鳳, 來茂德, 陳培輝.多原發性肺癌與支氣管肺泡上皮異型增生關系的研究.浙江大學學報(醫學版), 2005, 34:427-431.
13.	Tanvetyanon T, Finley DJ, Fabian T, et al. Prognostic factors for survival after complete resections of synchronous lung cancers in multiple lobes:pooled analysis based on individual patient data. Ann Oncol, 2013, 24:889-894.
14.	蔣丹, 徐香玖, 黃剛.中央型肺小細胞癌和鱗癌的鑒別診斷:MSCT征象對照及其回歸分析.實用放射學雜志, 2008, 24:173-175.
15.	張高峰, 先正元, 陳華.40例小細胞肺癌的螺旋CT表現.醫學影像學雜志, 2008, 18:603-605.
16.	Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol, 2012, 25:S18-S30.
17.	陳克終, 王迅, 楊帆, 等.不同影像學表現的多原發肺癌的臨床特點及診療效果分析.中華外科雜志, 2015, 53:731-736.
18.	Nicholson SA, Beasley MB, Brambilla E, et al. Small cell lung carcinoma (SCLC):a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol, 2002, 26:1184-1197.
19.	McElvaney G, Miller RR, Muller NL, et al. Multicentricity of adenocarcinoma of the lung. Chest, 1989, 95:151-154.
20.	李紅方, 梁冰鋒, 王辰生, 等.肺小細胞癌和鱗狀細胞癌患者ASHl及獨立生長因子-1的表達與預后的相關性.中華結核和呼吸雜志, 2012, 35:534-536.
21.	李麗華, 史健.腫瘤微環境與肺癌相關性研究進展.中國腫瘤雜志, 2015, 24:501-504.
22.	Ishikawa Y, Nakayama H, Ito H, et al. Surgical treatment for synchronous primary lung adenocarcinomas. Ann Thorac Surg, 2014, 98:1983-1988.
23.	Ye C, Wang J, Li W, et al. Novel strategy for synchronous multiple primary lung cancer displaying unique molecular profiles. Ann Thorac Surg, 2016, 101:e45-47.
24.	Takahashi E, Koshiishi H, Sakaniwa N, et al. Photodynamic therapy for multiple central type lung cancer--a case report. Gan to Kagaku Ryoho, 2014, 41:2042-2043.
25.	Simone CB 2nd, Cengel KA. Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol, 2014, 41:820-830.

1. Griffioen GH, Lagerwaard FJ, Haasbeek CJ, et al. Treatment of multiple primary lung cancers using stereotactic radiotherapy, either with or without surgery. Radiother Oncol, 2013, 107:403-408.
2. Gazdar AF, Minnat JD. Multifocal lung cancers-clonality vs field cencerization and does it matter? J Natl Cancer Inst, 2009, 101:541-543.
3. 李月越, 吳繼華, 王瑞娟, 等.肺小細胞癌混合肺鱗癌1例.臨床肺科志, 2012, 17:1740.
4. 林曉, 林其昌, 黃東煜, 等.多原發性肺癌1例報告并文獻復習.國際呼吸雜志, 2013, 33:157-159.
5. Liu XD, Qu Y, Lu SS. Synchronous double primary lung cancer:a report of three cases. Chin J Cancer Res, 2014, 26:E17-E21.
6. Gogakos AS, Paliouras D, Rallis T, et al. Double primary non-small cell lung cancer with synchronous small cell lung cancer N2 nodes:a case report. Ann Transl Med, 2015, 3:157.
7. 李樂, 張晨媛, 祖金池, 等.同時、同側、異葉雙原發肺癌1例.中華保健醫學雜志, 2015, 17:57-58.
8. 劉冬梅, 李棟, 孫文逵, 等.同時性雙原發肺癌1例.臨床腫瘤學雜志, 2015, 20:572-574.
9. 吳波, 丁笑笑, 徐紅燕, 等.雙原發肺癌多發轉移一例報告.新醫學, 2016, 47:412-416.
10. Dai L, Yang HL, Yan WP, et al. The equivalent efficacy of multiple operations for multiple primary lung cancer and a single operation for single primary lung cancer. J Thorac Dis, 2016, 8:855-861.
11. Takao M, Watanabe F, Shimamoto A, et al. Analyses of multiple primary lung cancers recent trend. Kyobu Geka, 2002, 55:15-19.
12. 王國鳳, 來茂德, 陳培輝.多原發性肺癌與支氣管肺泡上皮異型增生關系的研究.浙江大學學報(醫學版), 2005, 34:427-431.
13. Tanvetyanon T, Finley DJ, Fabian T, et al. Prognostic factors for survival after complete resections of synchronous lung cancers in multiple lobes:pooled analysis based on individual patient data. Ann Oncol, 2013, 24:889-894.
14. 蔣丹, 徐香玖, 黃剛.中央型肺小細胞癌和鱗癌的鑒別診斷:MSCT征象對照及其回歸分析.實用放射學雜志, 2008, 24:173-175.
15. 張高峰, 先正元, 陳華.40例小細胞肺癌的螺旋CT表現.醫學影像學雜志, 2008, 18:603-605.
16. Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol, 2012, 25:S18-S30.
17. 陳克終, 王迅, 楊帆, 等.不同影像學表現的多原發肺癌的臨床特點及診療效果分析.中華外科雜志, 2015, 53:731-736.
18. Nicholson SA, Beasley MB, Brambilla E, et al. Small cell lung carcinoma (SCLC):a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol, 2002, 26:1184-1197.
19. McElvaney G, Miller RR, Muller NL, et al. Multicentricity of adenocarcinoma of the lung. Chest, 1989, 95:151-154.
20. 李紅方, 梁冰鋒, 王辰生, 等.肺小細胞癌和鱗狀細胞癌患者ASHl及獨立生長因子-1的表達與預后的相關性.中華結核和呼吸雜志, 2012, 35:534-536.
21. 李麗華, 史健.腫瘤微環境與肺癌相關性研究進展.中國腫瘤雜志, 2015, 24:501-504.
22. Ishikawa Y, Nakayama H, Ito H, et al. Surgical treatment for synchronous primary lung adenocarcinomas. Ann Thorac Surg, 2014, 98:1983-1988.
23. Ye C, Wang J, Li W, et al. Novel strategy for synchronous multiple primary lung cancer displaying unique molecular profiles. Ann Thorac Surg, 2016, 101:e45-47.
24. Takahashi E, Koshiishi H, Sakaniwa N, et al. Photodynamic therapy for multiple central type lung cancer--a case report. Gan to Kagaku Ryoho, 2014, 41:2042-2043.
25. Simone CB 2nd, Cengel KA. Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol, 2014, 41:820-830.

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