Relationship between Gln223Arg polymorphism of leptin receptor gene and obstructive sleep apnea hypopnea syndrome in Han population in Southwest China_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

CHEN Yunfen ¹ ,  ZHANG Xiangyan ² , LIU Weijia ² , ZHANG Cheng ² , WANG Zhongxin ²

1. The Sixth People's Hospital of Guiyang, Guiyang, Guizhou 550011, P. R. China;
2. Department of Respiratory and Critical Care Medicine, Guizhou People's Hospital, Guiyang, Guizhou 550002, P. R. China;

Corresponding?author：

ZHANG Xiangyan, Email: zxy35762@126.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Leptin repetor; Gene Gln223Arg polymorphism

DOI：

10.7507/1671-6205.201608059

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Objective To investigate the relatingship between leptin receptor gene Gln223Arg polymorphism and obstructive sleep apnea hyponea syndrome (OSAHS) in Han population in Southwest China. Methods Two hundred and fifteen cases of subjects (including 116 cases in OSAHS group and 99 cases in control group) were selected in Han population in Southwest China. Polymerase chain reaction (PCR) was used to analyse Gln223Arg leptin receptor gene polymorphism. The levels of serum LEP and TI were determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Simultaneous determination of body mass index (BMI) and neck circumference (NC) and waist circumference (WC) were conducted. Results In the OSAHS group, the leptin receptor gene polymorphism Gln223Arg GG, AA and GA genotype frequency was 0.854, 0.017 and 0.129, respectively. G allele and A allele frequency frequency was 0.918 and 0.082, respectively. In the control group, leptin receptor gene polymorphisms Gln223Arg GG, AA and GA genotype frequency was 0.840, 0.020 and 0.14,respectively. G allele and A allele frequency was 0.90 and 0.10, respectively. Genotype frequencies of the two groups were not statistically significant (χ²=0.784, P>0.05). There were differences in BMI, WC and NC between the OSAHS patients with GG and the OSAHS patients with (GA+AA) genotype (P<0.05), but no difference was found in LEP and TI levels (allP>0.05). In control, mild, moderate and severe OSAHS group, the levels of serum LEP and TI were increased gradually, and the difference was statistically significant (allP<0.05). Conclusions Gln223Arg leptin receptor genotype polymorphisms may be involved in obesity, but they have no relationship with the incidence of OSAHS in Han population in Southwest China. In OSAHS patients, Gln223Arg polymorphism has no relationship with LEP or TI. Patients with OSAHS have hyperleptinemia and hyperinsulinemia.

Citation： CHEN Yunfen, ZHANG Xiangyan, LIU Weijia, ZHANG Cheng, WANG Zhongxin. Relationship between Gln223Arg polymorphism of leptin receptor gene and obstructive sleep apnea hypopnea syndrome in Han population in Southwest China. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(5): 474-477. doi: 10.7507/1671-6205.201608059 Copy

1.	Young T, Peppard PE, Gottlieb DJ.Epidemiology of obstructive sleep apnea. Respir Crit Care Med, 2002, 165(9): 1217-1239.
2.	李建瑞, 談藝, 魏永祥, 等. 瘦素受體基因 Gln223Arg 多態性與阻塞性睡眠呼吸暫停低通氣綜合征的相關性.中國耳鼻咽喉頭頸外科雜志, 2014, 21(9): 495-497.0.
3.	潘若望, 石南松. 瘦素受體基因 Gln223Arg 多態性與溫州地區高血壓合并肥胖的相關性研究.解放軍醫學雜志, 2008, 33(10): 1192-1194.0.
4.	中華醫學會呼吸病學分會睡眠呼吸疾病學組. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南(2011 年修訂版). 中華結核和呼吸雜志, 2012, 35(1): 9-12.0.
5.	Mateuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subjects : evidence against either obesity causing mutaions or association of sequence variants with obesity.Diabetologin, 1997, 40: 1204-1210.
6.	黃蓉, 黃席珍, 黎明, 等. 瘦素受體基因 Gln223Arg 多態性與阻塞性睡眠呼吸暫停低通氣綜合征的關系. 中華結核和呼吸雜志, 2003, 26(9): 517-521.0.
7.	Thompson DB, Ravussin E, Bennet PH, et al. Structure and sequence vaviation at the human leptin receptor gene in lean and obese pima Indians.Hum Mol Genet, 1997, 6(5): 675-679.
8.	Yiannakouris N, Yannakoulia M, Melistas L, et al. The Gln223Arg polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability.J Clin Endocrinol Metab, 2001, 86(9): 4434-4439.
9.	Phillips BG, Kato M, Narkiewicz K, et al. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea.Am Physiol Heart Circ Physiol, 2007, 279(1): 234-237.
10.	Ozturk L, Unal M, Tamer L, et al. The association of the severity of obstructive sleep apnea with plasma leptin levels.Arch Otolaryngol Hcad NeckSurg, 2003, 29(1): 538-540.
11.	Eun YG, Kim MG, Kwon KH, et al. Short-term effect of multilevel surgery on adipokines and proinflammatory cytokines in patients with obstructive sleepapnea.Acta Otolaryngol, 2010, 130(12): 1394-1398.

1. Young T, Peppard PE, Gottlieb DJ.Epidemiology of obstructive sleep apnea. Respir Crit Care Med, 2002, 165(9): 1217-1239.
2. 李建瑞, 談藝, 魏永祥, 等. 瘦素受體基因 Gln223Arg 多態性與阻塞性睡眠呼吸暫停低通氣綜合征的相關性.中國耳鼻咽喉頭頸外科雜志, 2014, 21(9): 495-497.0.
3. 潘若望, 石南松. 瘦素受體基因 Gln223Arg 多態性與溫州地區高血壓合并肥胖的相關性研究.解放軍醫學雜志, 2008, 33(10): 1192-1194.0.
4. 中華醫學會呼吸病學分會睡眠呼吸疾病學組. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南(2011 年修訂版). 中華結核和呼吸雜志, 2012, 35(1): 9-12.0.
5. Mateuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subjects : evidence against either obesity causing mutaions or association of sequence variants with obesity.Diabetologin, 1997, 40: 1204-1210.
6. 黃蓉, 黃席珍, 黎明, 等. 瘦素受體基因 Gln223Arg 多態性與阻塞性睡眠呼吸暫停低通氣綜合征的關系. 中華結核和呼吸雜志, 2003, 26(9): 517-521.0.
7. Thompson DB, Ravussin E, Bennet PH, et al. Structure and sequence vaviation at the human leptin receptor gene in lean and obese pima Indians.Hum Mol Genet, 1997, 6(5): 675-679.
8. Yiannakouris N, Yannakoulia M, Melistas L, et al. The Gln223Arg polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability.J Clin Endocrinol Metab, 2001, 86(9): 4434-4439.
9. Phillips BG, Kato M, Narkiewicz K, et al. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea.Am Physiol Heart Circ Physiol, 2007, 279(1): 234-237.
10. Ozturk L, Unal M, Tamer L, et al. The association of the severity of obstructive sleep apnea with plasma leptin levels.Arch Otolaryngol Hcad NeckSurg, 2003, 29(1): 538-540.
11. Eun YG, Kim MG, Kwon KH, et al. Short-term effect of multilevel surgery on adipokines and proinflammatory cytokines in patients with obstructive sleepapnea.Acta Otolaryngol, 2010, 130(12): 1394-1398.

Chinese Journal of Respiratory and Critical Care Medicine

Relationship between Gln223Arg polymorphism of leptin receptor gene and obstructive sleep apnea hypopnea syndrome in Han population in Southwest China

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