生長分化因子-15 在肺栓塞中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

劉露 ¹ , 胡天佑 ² ,  張一梅 ¹

2. ;
1. ;

Corresponding?author：

張一梅, Email: zhangyimei1957@163.com

Keywords：

DOI：

10.7507/1671-6205.201605010

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Citation： 劉露, 胡天佑, 張一梅. 生長分化因子-15 在肺栓塞中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(2): 206-208. doi: 10.7507/1671-6205.201605010 Copy

1.	中華醫學會心血管病學分會肺血管病血組, 中國醫師協會心血管內科醫師分會. 急性肺血栓栓塞癥診斷治療中國專家共識. 中華內科雜志, 2010, 49(1): 74-81.
2.	Ago T, Sadoshima J. GDF-15, a cardioprotective TGF-beta superfamily protein. Circ Res, 2006, 98(3): 294-297.
3.	Schopfer DW, Ku IA, Regan M, et al. Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study). Am Heart J, 2014, 167(2): 186-192.
4.	Lin JF, Wu S, Hsu SY, et al. Growth-differentiation factor-15 and major cardiac events. Am J Med Sci, 2014, 347(4): 305-311.
5.	Olechnicki M, Kasprzak K, Goch A. Growth differentiation factor 15- - a new marker in heart diseases. Pol Merkur Lekarski, 2010, 28(168): 470-472.
6.	顧宇英, 趙萌濤, 宗明. 上海地區漢族健康人群血清GDF-15水平分析. 同濟大學學報, 2010, 31(3): 96-99.
7.	Azhar M, Schultz Jel J, Grupp I, et al. Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev, 2003, 14(5): 391-407.
8.	Kempf T, Zarbock A, Widera C, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med, 2011, 17(5): 581-588.
9.	Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA, 1997, 94(21): 11514-11519.
10.	Xu J, Kimball TR, Lorenz JN, et al. GDF-15/MIC-1 function as a protective antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res, 2006, 98(3): 342-350.
11.	Nickel N, Jonigk D, Kempf T, et al. GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells. Respir Res, 2011, 12(1): 62.
12.	Frank D, Kulm C, Brors B, et al. Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension, 2008, 51(2): 309-318.
13.	Clerk A, Kenp TJ, Zoumpoulidon G, et al. Cardiac myocyte gene expression profiling during H₂O₂-induced apoptosis. Physiol Genomics, 2007, 29(2): 118-127.
14.	Brown DA, Breit SN, Buring J, et al. Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet, 2002, 359(9324): 2159-2163.
15.	Lankeit M, Kempf T, Dellas C, et al. Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism. Am J Respir Crit Care Med, 2008, 177(9): 1018-1025.
16.	Rossaint J, Vestweber D, Zarbock A, et al. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost, 2013, 11(2): 335-44.
17.	阮麗波, 金會艷, 陳軍. 家兔急性肺栓塞對生長分化因子-15的影響及意義. 中國現代醫學雜志, 2015, 25(4): 12-16.
18.	Guidelines on diagnosis and management of acute pulmonary embolism. Task Force on Pulmonary Embolism, European Society of Cardiology. Eur Heart J, 2000, 21(16): 1301-1336.
19.	Watts JA, Gellar MA, Stuart L, et al. Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism. Histol Histopathol, 2011, 26(10): 1287-1294.
20.	Nickel N, Kempf T, Tapken H, et al. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med, 2008, 178(5): 534-541.
21.	Lind L, Wallentin L, Kempf T, et al. Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study. Eur Heart J, 2009, 30(19): 2346-2353.
22.	田偉萌, 王華, 梁天亞, 等. 住院心力衰竭患者GDF-15的改變及相關研究. 中國醫刊, 2016, 51(2): 38-41.
23.	Duran L, Kayhan S, Guzel A, et al. The prognostic values of GDF-15 in comparison with NT-proBNP in patients with normotesive acute pulmonary embolism. Clin Lab, 2014, 60(8): 1365-1371.
24.	方建江, 李波, 何旭娟, 等. 血漿肌鈣蛋白I、B型鈉尿肽及D-二聚體檢測在急性肺栓塞預后評估中的意義. 中國呼吸與危重監護雜志, 2012, 11(1): 61-64.
25.	呂亞輝, 李杰. 聯合檢測BNP、TNI、CRP及D-二聚體在肺栓塞患者中的診斷、病情判定及預后的指導意義. 中國醫藥導刊, 2014, 16(10): 1290-1292.

1. 中華醫學會心血管病學分會肺血管病血組, 中國醫師協會心血管內科醫師分會. 急性肺血栓栓塞癥診斷治療中國專家共識. 中華內科雜志, 2010, 49(1): 74-81.
2. Ago T, Sadoshima J. GDF-15, a cardioprotective TGF-beta superfamily protein. Circ Res, 2006, 98(3): 294-297.
3. Schopfer DW, Ku IA, Regan M, et al. Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study). Am Heart J, 2014, 167(2): 186-192.
4. Lin JF, Wu S, Hsu SY, et al. Growth-differentiation factor-15 and major cardiac events. Am J Med Sci, 2014, 347(4): 305-311.
5. Olechnicki M, Kasprzak K, Goch A. Growth differentiation factor 15- - a new marker in heart diseases. Pol Merkur Lekarski, 2010, 28(168): 470-472.
6. 顧宇英, 趙萌濤, 宗明. 上海地區漢族健康人群血清GDF-15水平分析. 同濟大學學報, 2010, 31(3): 96-99.
7. Azhar M, Schultz Jel J, Grupp I, et al. Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev, 2003, 14(5): 391-407.
8. Kempf T, Zarbock A, Widera C, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med, 2011, 17(5): 581-588.
9. Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA, 1997, 94(21): 11514-11519.
10. Xu J, Kimball TR, Lorenz JN, et al. GDF-15/MIC-1 function as a protective antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res, 2006, 98(3): 342-350.
11. Nickel N, Jonigk D, Kempf T, et al. GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells. Respir Res, 2011, 12(1): 62.
12. Frank D, Kulm C, Brors B, et al. Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension, 2008, 51(2): 309-318.
13. Clerk A, Kenp TJ, Zoumpoulidon G, et al. Cardiac myocyte gene expression profiling during H₂O₂-induced apoptosis. Physiol Genomics, 2007, 29(2): 118-127.
14. Brown DA, Breit SN, Buring J, et al. Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet, 2002, 359(9324): 2159-2163.
15. Lankeit M, Kempf T, Dellas C, et al. Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism. Am J Respir Crit Care Med, 2008, 177(9): 1018-1025.
16. Rossaint J, Vestweber D, Zarbock A, et al. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost, 2013, 11(2): 335-44.
17. 阮麗波, 金會艷, 陳軍. 家兔急性肺栓塞對生長分化因子-15的影響及意義. 中國現代醫學雜志, 2015, 25(4): 12-16.
18. Guidelines on diagnosis and management of acute pulmonary embolism. Task Force on Pulmonary Embolism, European Society of Cardiology. Eur Heart J, 2000, 21(16): 1301-1336.
19. Watts JA, Gellar MA, Stuart L, et al. Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism. Histol Histopathol, 2011, 26(10): 1287-1294.
20. Nickel N, Kempf T, Tapken H, et al. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med, 2008, 178(5): 534-541.
21. Lind L, Wallentin L, Kempf T, et al. Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study. Eur Heart J, 2009, 30(19): 2346-2353.
22. 田偉萌, 王華, 梁天亞, 等. 住院心力衰竭患者GDF-15的改變及相關研究. 中國醫刊, 2016, 51(2): 38-41.
23. Duran L, Kayhan S, Guzel A, et al. The prognostic values of GDF-15 in comparison with NT-proBNP in patients with normotesive acute pulmonary embolism. Clin Lab, 2014, 60(8): 1365-1371.
24. 方建江, 李波, 何旭娟, 等. 血漿肌鈣蛋白I、B型鈉尿肽及D-二聚體檢測在急性肺栓塞預后評估中的意義. 中國呼吸與危重監護雜志, 2012, 11(1): 61-64.
25. 呂亞輝, 李杰. 聯合檢測BNP、TNI、CRP及D-二聚體在肺栓塞患者中的診斷、病情判定及預后的指導意義. 中國醫藥導刊, 2014, 16(10): 1290-1292.

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