Lung Capacity and Diffusing Capacity in Patients with Chronic Persistent Asthma with Different Severities_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

DuJing , LiLinwei , ZuPing , DengYan , HeTailing , YuanYuru ,  LiangBinmiao

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China;

Corresponding?author：

LiangBinmiao, Email: liangbinmiao@163.com

Keywords：

Asthma; Lung capacity; Diffusing capacity for carbon monoxide

DOI：

10.7507/1671-6205.2016015

Video：

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Objective To assess the lung capacity and diffusing capacity in patients with chronic persistent asthma with different severities. Methods Patients diagnosed with chronic persistent asthma in West China Hospital between January 2014 and April 2015 were recruited in the study.The data of clinical characteristics were collected.The forced expiratory volume in the first second (FEV₁) was determined by spirometry test.Total lung capacity (TLC) and residual volume (RV) were determined by body plethysmography and helium dilution method.Single breath diffusing capacity for carbon monoxide (D_LCO) was also measured.Lung capacity and the deviations between two methods, and D_LCO%pred were compared among different patient groups with mild, moderate and severe asthmas.The correlation between spirometry with lung capacity and D_LCO%pred were analyzed. Results A total of 93 patients with chronic persistent asthma were enrolled.With the severity of asthma, TLC%pred, RV%pred, RV/TLC and the deviations of the ones between two methods increased significantly, but D_LCO%pred reduced slightly.FEV₁%pred were negatively correlative with the deviations of lung capacity between two methods, and positively correlative with D_LCO%pred. Conclusions Compared with helium dilution method, the body plethysmography is more accurate for evaluating the lung capacity of chronic persistent asthma.With the severity of airflow limitation, the diffusing capacity of asthma is decreasing gradually, but still within the normal limits.

Citation： DuJing, LiLinwei, ZuPing, DengYan, HeTailing, YuanYuru, LiangBinmiao. Lung Capacity and Diffusing Capacity in Patients with Chronic Persistent Asthma with Different Severities. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(1): 60-63. doi: 10.7507/1671-6205.2016015 Copy

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7.	Ding DJ, Martin JG, Macklem PT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol, 1987, 62:1324-1330.
8.	O Donnell CR, Bankier AA, Stiebellehner L, et al. Comparison of plethysmographic and helium dilution lung volumes:which is best for COPD? Chest, 2010, 137:1108-1115.
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10.	van der Lee I, Zanen P, van den Bosch JM, et al. Pattern of diffusion disturbance related to clinical diagnosis:The KCO has no diagnostic value next to the D_LCO. Respir Med, 2006, 100:101-109.
11.	Gelb AF, Licuanan J, Shinar CM, et al. Unsuspected loss of lung elastic recoil in chronic persistent asthma. Chest, 2002, 121:715-721.
12.	Boulet LP, Lemière C, Archambault F, et al. Smoking and asthma:clinical and radiologic features, lung function, and airway inflammation. Chest, 2006, 129:661-668.

1. Global Initiative for Asthma (GINA) 2014:Global strategy for asthma management and prevention. http://www.ginasthma.org.
2. 中華醫學會呼吸病學分會肺功能專業組.肺功能檢查指南-肺容量檢查.中華結核和呼吸雜志, 2014, 38:255-260.
3. 中華醫學會呼吸病學分會肺功能專業組.肺功能檢查指南-肺彌散功能檢查.中華結核和呼吸雜志, 2014, 38:163-169.
4. 中華醫學會呼吸病學分會哮喘學組.支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療和管理方案).中華哮喘雜志(電子版), 2008, 2:3-13.
5. 中華醫學會呼吸病學分會肺功能專業組.肺功能檢查指南(第二部分)-肺量計檢查.中華結核和呼吸雜志, 2014, 37:481-486.
6. Maselli R, Paciocco G. Asthma:pathophysiology of the bronchial obstruction. Allergy, 2000, 61:49-51.
7. Ding DJ, Martin JG, Macklem PT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol, 1987, 62:1324-1330.
8. O Donnell CR, Bankier AA, Stiebellehner L, et al. Comparison of plethysmographic and helium dilution lung volumes:which is best for COPD? Chest, 2010, 137:1108-1115.
9. Shaw RJ, Djukanovic R, Tashkin DP, et al. The role of small airways in lung disease. Respir Med, 2002, 96:67-80.
10. van der Lee I, Zanen P, van den Bosch JM, et al. Pattern of diffusion disturbance related to clinical diagnosis:The KCO has no diagnostic value next to the D_LCO. Respir Med, 2006, 100:101-109.
11. Gelb AF, Licuanan J, Shinar CM, et al. Unsuspected loss of lung elastic recoil in chronic persistent asthma. Chest, 2002, 121:715-721.
12. Boulet LP, Lemière C, Archambault F, et al. Smoking and asthma:clinical and radiologic features, lung function, and airway inflammation. Chest, 2006, 129:661-668.

Chinese Journal of Respiratory and Critical Care Medicine

Lung Capacity and Diffusing Capacity in Patients with Chronic Persistent Asthma with Different Severities

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