NieXiaohong , XiongShuguang , WangHui , LiXuemei
  • Department of Respiratory Medicine, The 416 Hospital of Nuclear Industry, Chengdu, Sichuan, 610051, China;
NieXiaohong, Email: xhnie1226@sina.com
Chronic obstructive pulmonary disease; Body mass index; Leptin; Tumor necrosis factor alpha; Inflammatory factors
10.7507/1671-6205.2014004
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Objective To explore the levels of serum leptin,TNF-α,IL-8 and hypersensitivity C-reactive protein (hs-CRP) in stable COPD patients with different body mass index (BMI). Methods 30 healthy controls with BMI 18.5 to 23.9 kg/m2 and 105 patients with stable COPD were recruited in the study. The serum levels of leptin,TNF-α,and IL-8 were determined by radioimmunoassay and hs-CRP level was determined by versatile biochemical automatic analyzer. The COPD patients were divided into a low BMI group (BMI<18.5 kg/m2,n=32),a normal BMI group (BMI 18.5-23.9 kg/m2,n=48),and a high BMI group (BMI≥23.9 kg/m2,n=25). Results Serum leptin level in the COPD patients was significantly reduced compared with the control subjects (P<0.05). Serum leptin levels were reduced in the low BMI and the high BMI groups compare with the normal BMI group [(7.89±3.16)ng/L and (10.52±5.98)ng/L vs. (13.04±5.73) ng/L,P<0.01 or P<0.05]. Leptin level in the low BMI group was lower than that in the high BMI group (P<0.05). Serum TNF-α levels were significantly increased in the low BMI group compared with the normal BMI and high BMI groups [(229.39±89.57)μg/L vs. (180.06±74.24) μg/L and (189.46±82.41) μg/L,P<0.01]. Serum TNF-α level in the COPD patients was significantly increased compared with the control subjects [(192.37±83.65) μg/L vs. (178.59±60.38) μg/L,P<0.05]. The IL-8 levels were not significant different among three BMI groups with COPD. The hs-CRP level in the high BMI group was higher than that in the low BMI and normal BMI groups (P<0.05). Conclusion Leptin and TNF-α may be involved in weight-loss of COPD malnutritional patients.

Citation： NieXiaohong, XiongShuguang, WangHui, LiXuemei. Spectrum of Inflammatory Factors in Stable COPD Patients with Three Different Types of Body Mass Index. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(1): 14-17. doi: 10.7507/1671-6205.2014004 Copy

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