Advances in the clinicopathological characteristics and treatment of papillary thyroid carcinoma of the isthmus_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIANG Yuhan , TU Hanyun , YANG Yi , JIANG Tianyuchen ,  SU Anping

Department of General Surgery, Thyroid Surgery Ward, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

SU Anping, Email: suanping15652@163.com

Keywords：

papillary thyroid carcinoma of the isthmus; total thyroidectomy; isthmusectomy; lymph node metastasis; review

DOI：

10.7507/1007-9424.202607114

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize advances in research on papillary thyroid carcinoma of the isthmus (PTCI) and provide a basis for further optimizing its diagnostic and therapeutic strategies. Methods Relevant literatures on PTCI published in recent years were searched and reviewed, focusing on its clinicopathological characteristics, molecular biological features, patterns of lymph node metastasis, high-risk factors, and treatment strategies. Results PTCI has distinct anatomical and clinicopathological characteristics. Some studies reported that it has higher risks of capsular invasion, extrathyroidal extension, and central lymph node metastasis. However, whether PTCI is more aggressive than lobar papillary thyroid carcinoma remains controversial. Tumor size, capsular invasion, extrathyroidal extension, and multifocality may be associated with lymph node metastasis. Different surgical approaches may be appropriate for selected patients, and the extent of surgery should be individualized according to tumor characteristics and the risk of lymph node metastasis. Conclusions PTCI differs from lobar papillary thyroid carcinoma in clinicopathological characteristics and surgical strategies. Treatment decisions should be individualized based on tumor burden, local invasion, and the risk of lymph node metastasis, rather than extending the surgical extent solely because of the isthmic location of the tumor.

Citation： JIANG Yuhan, TU Hanyun, YANG Yi, JIANG Tianyuchen, SU Anping. Advances in the clinicopathological characteristics and treatment of papillary thyroid carcinoma of the isthmus. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2026, 33(9): 1307-1315. doi: 10.7507/1007-9424.202607114 Copy

1.
2.	Bray F, Laversanne M, Sung H , et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2024, 74(3): 229-263.
3.
4.
5.
6.
7.	Pastorello R, Valerio E, Lobo A, et al. Do thyroid nodules that arise in the isthmus have a higher risk of malignancy? [J]. Cancer Cytopathol, 2020, 128(8): 520-522.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.	Song CM, Lee DW, Ji YB, et al. Frequency and pattern of central lymph node metastasis in papillary carcinoma of the thyroid isthmus [J/OL]. Head Neck, 2016, 38 Suppl 1: e412-e416. doi: 10.1002/hed.24009.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.	Wang J, Sun H, Gao L, et al. Evaluation of thyroid isthmusectomy as a potential treatment for papillary thyroid carcinoma limited to the isthmus: a clinical study of 73 patients [J/OL]. Head Neck, 2015, 38 Suppl 1: e1510-e1514. doi: 10.1002/hed.24270.
56.
57.	Vasileiadis I, Boutzios G, Karalaki M, et al. Papillary thyroid carcinoma of the isthmus: total thyroidectomy or isthmusectomy? [J]. Am J Surg, 2017, 216(1): 135-139.
58.
59.
60.
61.
62.
63.
64.
65.	Mili?i? B, Prsta?i? R, Prgomet D. Skip metastases in papillary thyroid carcinoma - prevalence, predictive and clinicopathological factors [J]. Acta Clin Croat, 2020, 59(Suppl 1): 122-128.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
77.

1.
2. Bray F, Laversanne M, Sung H , et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2024, 74(3): 229-263.
3.
4.
5.
6.
7. Pastorello R, Valerio E, Lobo A, et al. Do thyroid nodules that arise in the isthmus have a higher risk of malignancy? [J]. Cancer Cytopathol, 2020, 128(8): 520-522.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32. Song CM, Lee DW, Ji YB, et al. Frequency and pattern of central lymph node metastasis in papillary carcinoma of the thyroid isthmus [J/OL]. Head Neck, 2016, 38 Suppl 1: e412-e416. doi: 10.1002/hed.24009.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55. Wang J, Sun H, Gao L, et al. Evaluation of thyroid isthmusectomy as a potential treatment for papillary thyroid carcinoma limited to the isthmus: a clinical study of 73 patients [J/OL]. Head Neck, 2015, 38 Suppl 1: e1510-e1514. doi: 10.1002/hed.24270.
56.
57. Vasileiadis I, Boutzios G, Karalaki M, et al. Papillary thyroid carcinoma of the isthmus: total thyroidectomy or isthmusectomy? [J]. Am J Surg, 2017, 216(1): 135-139.
58.
59.
60.
61.
62.
63.
64.
65. Mili?i? B, Prsta?i? R, Prgomet D. Skip metastases in papillary thyroid carcinoma - prevalence, predictive and clinicopathological factors [J]. Acta Clin Croat, 2020, 59(Suppl 1): 122-128.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
77.

Previous Article
Advances in diagnosis and treatment of follicular thyroid carcinoma
Next Article
The bile acid-macrophage axis in the immune microenvironment of hepatocellular carcinoma

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advances in the clinicopathological characteristics and treatment of papillary thyroid carcinoma of the isthmus

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content