Case analysis: CT manifestations of hepatoid adenocarcinoma of gallbladder with liver involvement_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Senhao , ZHU Fei , Lü Su ,  CHEN Weixia

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

CHEN Weixia, Email: wxchen25@126.com

Keywords：

gallbladder; hepatoid adenocarcinoma; alpha fetoprotein; imaging manifestations

DOI：

10.7507/1007-9424.202501004

Video：

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The authors presented CT manifestations of a patient with hepatoid adenocarcinoma of gallbladder with liver involvement and briefly described the clinical features, imaging manifestations, and differential diagnosis of the disease in order to enhance the readers’ better awareness of the imaging manifestations, thus to reduce the misdiagnosis of the disease.

Citation： LIU Senhao, ZHU Fei, Lü Su, CHEN Weixia. Case analysis: CT manifestations of hepatoid adenocarcinoma of gallbladder with liver involvement. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2025, 32(7): 839-842. doi: 10.7507/1007-9424.202501004 Copy

1.	Metzgeroth G, Str?bel P, Baumbusch T, et al. Hepatoid adenocarcinoma—Review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie, 2010, 33(5): 263-269.
2.	Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review. World J Gastroenterol, 2013, 19(3): 321-327.
3.	王鶴霖, 戴朝六. 膽囊肝樣腺癌的診斷與治療現狀. 中華消化外科雜志, 2017, 16(11): 1163-1166.
4.	方會娟, 徐小艷. 膽囊肝樣腺癌的鏡下特征: 相互交織移行的肝樣分化區和腺癌區. 中國普外基礎與臨床雜志, 2024, 31(4): 474-478.
5.	李巧轉, 周志華, 王倩, 等. 膽囊肝樣腺癌4例臨床病理分析. 武警醫學, 2023, 34(1): 54-57.
6.	Devi NR, Sathyalakshmi R, Devi J, et al. Hepatoid adenocarcinoma of the gall bladder—A rare variant. J Clin Diagn Res, 2015, 9(8): ED09-ED10. doi: 10.7860/JCDR/2015/10799.6324.
7.	Li Z, Jiang Q, Chen X, et al. Primary hepatoid adenocarcinoma of gallbladder with MB21D2/GALNT12/ARID2 mutations: A case report. Front Endocrinol (Lausanne), 2022, 12: 791153. doi: 10.3389/fendo.2021.791153.
8.	van den Bos IC, Hussain SM, Dwarkasing RS, et al. Hepatoid adenocarcinoma of the gallbladder: A mimicker of hepatocellular carcinoma. Br J Radiol, 2007, 80(960): e317-e320. doi: 10.1259/bjr/97773297.
9.	舒適, 黃燕濤, 冷媛媛, 等. 膽囊原發性肝樣腺癌影像學特征分析及文獻復習. 中國CT和MRI雜志, 2024, 22(3): 182-183.
10.	張帥, 郭茜, 李琦, 等. 肝樣腺癌CT及MRI表現. 中國醫學影像技術, 2023, 39(4): 555-559.
11.	Dixit N, Trivedi S, Bansal VK. Clear-cell adenocarcinoma of the gallbladder with alpha-fetoprotein production: A case report and review of the literature. Gastrointest Tumors, 2021, 8(2): 52-57.
12.	Fujii H, Yamaguchi K, Ohnishi N, et al. Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein. Clin J Gastroenterol, 2012, 5(4): 261-267.
13.	Mita J, Tada K, Kuboyama Y, et al. Poorly differentiated adenocarcinoma with signet ring cells of the gallbladder producing a high level of alpha-fetoprotein: A case report. Int J Surg Case Rep, 2022, 101: 107780. doi: 10.1016/j.ijscr.2022.107780.
14.	Lee JH, Lee KG, Paik SS, et al. Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein. J Korean Surg Soc, 2011, 80(6): 440-444.
15.	Qian X, Zhou D, Gao B, et al. An alpha-fetoprotein-negative hepatoid adenocarcinoma of the gallbladder with squamous differentiation. Hepatobiliary Surg Nutr, 2020, 9(1): 116-118.
16.	Iwasaki S, Hidaka H, Uojima H, et al. A case of successful treatment with lenvatinib in primary hepatoid adenocarcinoma of the gallbladder that was difficult to distinguish from hepatocellular carcinoma. Clin J Gastroenterol, 2022, 15(6): 1108-1114.
17.	Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of primary liver cancer (2022 Edition). Liver Cancer, 2023, 12(5): 405-444.

1. Metzgeroth G, Str?bel P, Baumbusch T, et al. Hepatoid adenocarcinoma—Review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie, 2010, 33(5): 263-269.
2. Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review. World J Gastroenterol, 2013, 19(3): 321-327.
3. 王鶴霖, 戴朝六. 膽囊肝樣腺癌的診斷與治療現狀. 中華消化外科雜志, 2017, 16(11): 1163-1166.
4. 方會娟, 徐小艷. 膽囊肝樣腺癌的鏡下特征: 相互交織移行的肝樣分化區和腺癌區. 中國普外基礎與臨床雜志, 2024, 31(4): 474-478.
5. 李巧轉, 周志華, 王倩, 等. 膽囊肝樣腺癌4例臨床病理分析. 武警醫學, 2023, 34(1): 54-57.
6. Devi NR, Sathyalakshmi R, Devi J, et al. Hepatoid adenocarcinoma of the gall bladder—A rare variant. J Clin Diagn Res, 2015, 9(8): ED09-ED10. doi: 10.7860/JCDR/2015/10799.6324.
7. Li Z, Jiang Q, Chen X, et al. Primary hepatoid adenocarcinoma of gallbladder with MB21D2/GALNT12/ARID2 mutations: A case report. Front Endocrinol (Lausanne), 2022, 12: 791153. doi: 10.3389/fendo.2021.791153.
8. van den Bos IC, Hussain SM, Dwarkasing RS, et al. Hepatoid adenocarcinoma of the gallbladder: A mimicker of hepatocellular carcinoma. Br J Radiol, 2007, 80(960): e317-e320. doi: 10.1259/bjr/97773297.
9. 舒適, 黃燕濤, 冷媛媛, 等. 膽囊原發性肝樣腺癌影像學特征分析及文獻復習. 中國CT和MRI雜志, 2024, 22(3): 182-183.
10. 張帥, 郭茜, 李琦, 等. 肝樣腺癌CT及MRI表現. 中國醫學影像技術, 2023, 39(4): 555-559.
11. Dixit N, Trivedi S, Bansal VK. Clear-cell adenocarcinoma of the gallbladder with alpha-fetoprotein production: A case report and review of the literature. Gastrointest Tumors, 2021, 8(2): 52-57.
12. Fujii H, Yamaguchi K, Ohnishi N, et al. Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein. Clin J Gastroenterol, 2012, 5(4): 261-267.
13. Mita J, Tada K, Kuboyama Y, et al. Poorly differentiated adenocarcinoma with signet ring cells of the gallbladder producing a high level of alpha-fetoprotein: A case report. Int J Surg Case Rep, 2022, 101: 107780. doi: 10.1016/j.ijscr.2022.107780.
14. Lee JH, Lee KG, Paik SS, et al. Hepatoid adenocarcinoma of the gallbladder with production of alpha-fetoprotein. J Korean Surg Soc, 2011, 80(6): 440-444.
15. Qian X, Zhou D, Gao B, et al. An alpha-fetoprotein-negative hepatoid adenocarcinoma of the gallbladder with squamous differentiation. Hepatobiliary Surg Nutr, 2020, 9(1): 116-118.
16. Iwasaki S, Hidaka H, Uojima H, et al. A case of successful treatment with lenvatinib in primary hepatoid adenocarcinoma of the gallbladder that was difficult to distinguish from hepatocellular carcinoma. Clin J Gastroenterol, 2022, 15(6): 1108-1114.
17. Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of primary liver cancer (2022 Edition). Liver Cancer, 2023, 12(5): 405-444.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Case analysis: CT manifestations of hepatoid adenocarcinoma of gallbladder with liver involvement

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