Relationship between occupation and tumor<b>-</b>related characteristics in patients with colorectal cancer: a real<b>-</b>world data study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Yuanxi ^1,2 , XIA Yuyang ^1,2 , ZHENG Jiaqi ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Division of Gastrointestinal Surgery, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; tumor feature; database; occupation

DOI：

10.7507/1007-9424.202402019

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the relationship between occupation and tumor characteristics of colorectal patients served by West China Hospital of Sichuan University as a regional center in the current version of Database from Colorectal Cancer (DACCA). Methods The data of DACCA was updated on January 5, 2022. All data items included occupation, tumor morphology, distance of tumor from dentate line, tumor site, properties of tumor, differentiation degree, postoperative complex physiological index (CPI) stage, tumor comorbidities, tumor location, and tumor occurrence. According to the 2015 edition of the Occupational Classification of the People’s Republic of China, the occupational parameters of patients in this study were divided into three groups: Mental workers, physical workers and unemployed residents. Results The DACCA database was filtered according to the conditions, obtaining 3 215 valid data. In terms of tumor complications, there were significant differences in the proportion of tumor bleeding, perforation grade, mechanical intestinal obstruction degree and pain degree among the different occupational groups (P<0.05). There were no significant difference in the ratio of edema degree and intussusception of tumor site among the different occupational groups (P>0.05). There were no significant difference in the composition ratio of tumor differentiation degree, tumor occurrence, tumor orientation and tumor morphology among the different occupational groups (P>0.05). The composition ratio of CPI staging of colorectal cancer, the distance between tumor and dentate line, the composition ratio of different tumor pathological properties, and the composition ratio of tumor located in rectum and colon were statistically significant (P<0.05). Conclusion Preoperative tumor characteristics of patients with colorectal cancer are associated with various occupations. In patients with rectal cancer, the distance from the dentate line to the physical work of the tumor is smaller, lower site, some tumor complications are more severe, and the stage is relatively later.

Citation： LI Yuanxi, XIA Yuyang, ZHENG Jiaqi, WANG Xiaodong, LI Li. Relationship between occupation and tumor-related characteristics in patients with colorectal cancer: a real-world data study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2024, 31(9): 1070-1076. doi: 10.7507/1007-9424.202402019 Copy

1.	Labianca R, Nordlinger B, Beretta GD, et al. Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up. Ann Oncol, 2010, 21 Suppl 5: v70- v77. doi: 10.1093/annonc/mdq168.
2.	Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol, 2019, 14(2): 89-103.
3.	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
4.	Arbman G, Axelson O, Fredriksson M, et al. Do occupational factors influence the risk of colon and rectal cancer in different ways? Cancer, 1993, 72(9): 2543-2549.
5.	Fraser G, Pearce N. Occupational physical activity and risk of cancer of the colon and rectum in New Zealand males. Cancer Causes Control, 1993, 4(1): 45-50.
6.	Garabrant DH, Peters JM, Mack TM, et al. Job activity and colon cancer risk. Am J Epidemiol, 1984, 119(6): 1005-1014.
7.	Pukkala E, Martinsen JI, Lynge E, et al. Occupation and cancer—follow-up of 15 million people in five Nordic countries. Acta Oncol, 2009, 48(5): 646-790.
8.	Steindorf K, Jedrychowski W, Schmidt M, et al. Case-control study of lifetime occupational and recreational physical activity and risks of colon and rectal cancer. Eur J Cancer Prev, 2005, 14(4): 363-371.
9.	汪曉東, 劉健博, 李立. 數據庫建設第六部分: 結直腸癌分期的標簽與結構化. 中國普外基礎與臨床雜志, 2020, 27(7): 873-879.
10.	汪曉東, 劉健博, 李立. 數據庫建設第五部分?結直腸癌的腫瘤特征—模塊的設計(二). 中國普外基礎與臨床雜志, 2020, 27(4): 483-488.
11.	汪曉東, 劉健博, 李立. 數據庫建設第五部分: 結直腸癌的腫瘤特征—模塊的設計(一). 中國普外基礎與臨床雜志, 2020, 27(3): 345-349.
12.	國家職業分類大典修訂工作委員會. 中華人民共和國職業分類大典. 第 2 版. 北京: 中國勞動社會保障出版社, 2015: 1-10.
13.	湯曉偉, 陳振東. 重視長期生存老年腫瘤患者的合并癥的綜合評估. 安徽醫藥, 2010, 14(2): 222-224.
14.	周艷萍, 管梅, 陳書長. 合并癥對老年腫瘤患者二線化療的影響. 癌癥進展, 2014, 12(4): 403-408.
15.	周艷萍, 管梅, 陳書長, 等. 合并癥對晚期老年腫瘤患者一線化療療效和預后的影響. 北京醫學, 2014, 36(5): 362-366.
16.	Cong YJ, Gan Y, Sun HL, et al. Association of sedentary behaviour with colon and rectal cancer: a meta-analysis of observational studies. Br J Cancer, 2014, 110(3): 817-826.
17.	Gerhardsson de Verdier M, Plato N, Steineck G, et al. Occupational exposures and cancer of the colon and rectum. Am J Ind Med, 1992, 22(3): 291-303.
18.	Lee J, Lee J, Ahn J, et al. Association of sedentary work with colon and rectal cancer: systematic review and meta-analysis. Occup Environ Med, 2022, 79(4): 277-286.
19.	Pahwa M, Harris MA, MacLeod J, et al. Sedentary work and the risks of colon and rectal cancer by anatomical sub-site in the Canadian census health and environment cohort (CanCHEC). Cancer Epidemiol, 2017, 49: 144-151.
20.	Tavani A, Braga C, La Vecchia C, et al. Physical activity and risk of cancers of the colon and rectum: an Italian case-control study. Br J Cancer, 1999, 79(11-12): 1912-1916.
21.	王若愚, 王慶才, 孫華君. 結直腸癌支架置入術后并發癥危險因素及預防. 胃腸病學和肝病學雜志, 2014, 23(1): 9-12.
22.	周陽. 早期結直腸癌及癌前病變ESD遲發性出血風險評估模型的建立. 西南醫科大學, 2021.
23.	陳東魁. 結直腸癌腹膜轉移的治療及合并癥處理. 醫學臨床研究, 2019, 36(5): 933-937.
24.	黃國榮, 王德進, 汪河清, 等. 大腸癌合并急性結腸梗阻的處理. 中國當代醫藥, 2013, 20(30): 195-196.
25.	郜輝, 王之龍, 許婷, 等. 14例轉移性結直腸癌合并消化道穿孔臨床病理特征及預后的回顧性系列分析. 胃腸病學和肝病學雜志, 2022, 31(1): 56-60.
26.	劉偉明, 周建輝, 王素輝, 等. 結腸癌穿孔26例治療體會. 現代中西醫結合雜志, 2001, 10(3): 247-248.
27.	中華醫學會外科學分會結直腸外科學組, 中華醫學會外科學分會腹腔鏡與內鏡外科學組. 中低位直腸癌手術消化道重建中國專家共識(2021版). 中國實用外科雜志, 2021, 41(10): 1081-1089.

1. Labianca R, Nordlinger B, Beretta GD, et al. Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up. Ann Oncol, 2010, 21 Suppl 5: v70- v77. doi: 10.1093/annonc/mdq168.
2. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol, 2019, 14(2): 89-103.
3. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
4. Arbman G, Axelson O, Fredriksson M, et al. Do occupational factors influence the risk of colon and rectal cancer in different ways? Cancer, 1993, 72(9): 2543-2549.
5. Fraser G, Pearce N. Occupational physical activity and risk of cancer of the colon and rectum in New Zealand males. Cancer Causes Control, 1993, 4(1): 45-50.
6. Garabrant DH, Peters JM, Mack TM, et al. Job activity and colon cancer risk. Am J Epidemiol, 1984, 119(6): 1005-1014.
7. Pukkala E, Martinsen JI, Lynge E, et al. Occupation and cancer—follow-up of 15 million people in five Nordic countries. Acta Oncol, 2009, 48(5): 646-790.
8. Steindorf K, Jedrychowski W, Schmidt M, et al. Case-control study of lifetime occupational and recreational physical activity and risks of colon and rectal cancer. Eur J Cancer Prev, 2005, 14(4): 363-371.
9. 汪曉東, 劉健博, 李立. 數據庫建設第六部分: 結直腸癌分期的標簽與結構化. 中國普外基礎與臨床雜志, 2020, 27(7): 873-879.
10. 汪曉東, 劉健博, 李立. 數據庫建設第五部分?結直腸癌的腫瘤特征—模塊的設計(二). 中國普外基礎與臨床雜志, 2020, 27(4): 483-488.
11. 汪曉東, 劉健博, 李立. 數據庫建設第五部分: 結直腸癌的腫瘤特征—模塊的設計(一). 中國普外基礎與臨床雜志, 2020, 27(3): 345-349.
12. 國家職業分類大典修訂工作委員會. 中華人民共和國職業分類大典. 第 2 版. 北京: 中國勞動社會保障出版社, 2015: 1-10.
13. 湯曉偉, 陳振東. 重視長期生存老年腫瘤患者的合并癥的綜合評估. 安徽醫藥, 2010, 14(2): 222-224.
14. 周艷萍, 管梅, 陳書長. 合并癥對老年腫瘤患者二線化療的影響. 癌癥進展, 2014, 12(4): 403-408.
15. 周艷萍, 管梅, 陳書長, 等. 合并癥對晚期老年腫瘤患者一線化療療效和預后的影響. 北京醫學, 2014, 36(5): 362-366.
16. Cong YJ, Gan Y, Sun HL, et al. Association of sedentary behaviour with colon and rectal cancer: a meta-analysis of observational studies. Br J Cancer, 2014, 110(3): 817-826.
17. Gerhardsson de Verdier M, Plato N, Steineck G, et al. Occupational exposures and cancer of the colon and rectum. Am J Ind Med, 1992, 22(3): 291-303.
18. Lee J, Lee J, Ahn J, et al. Association of sedentary work with colon and rectal cancer: systematic review and meta-analysis. Occup Environ Med, 2022, 79(4): 277-286.
19. Pahwa M, Harris MA, MacLeod J, et al. Sedentary work and the risks of colon and rectal cancer by anatomical sub-site in the Canadian census health and environment cohort (CanCHEC). Cancer Epidemiol, 2017, 49: 144-151.
20. Tavani A, Braga C, La Vecchia C, et al. Physical activity and risk of cancers of the colon and rectum: an Italian case-control study. Br J Cancer, 1999, 79(11-12): 1912-1916.
21. 王若愚, 王慶才, 孫華君. 結直腸癌支架置入術后并發癥危險因素及預防. 胃腸病學和肝病學雜志, 2014, 23(1): 9-12.
22. 周陽. 早期結直腸癌及癌前病變ESD遲發性出血風險評估模型的建立. 西南醫科大學, 2021.
23. 陳東魁. 結直腸癌腹膜轉移的治療及合并癥處理. 醫學臨床研究, 2019, 36(5): 933-937.
24. 黃國榮, 王德進, 汪河清, 等. 大腸癌合并急性結腸梗阻的處理. 中國當代醫藥, 2013, 20(30): 195-196.
25. 郜輝, 王之龍, 許婷, 等. 14例轉移性結直腸癌合并消化道穿孔臨床病理特征及預后的回顧性系列分析. 胃腸病學和肝病學雜志, 2022, 31(1): 56-60.
26. 劉偉明, 周建輝, 王素輝, 等. 結腸癌穿孔26例治療體會. 現代中西醫結合雜志, 2001, 10(3): 247-248.
27. 中華醫學會外科學分會結直腸外科學組, 中華醫學會外科學分會腹腔鏡與內鏡外科學組. 中低位直腸癌手術消化道重建中國專家共識(2021版). 中國實用外科雜志, 2021, 41(10): 1081-1089.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship between occupation and tumor-related characteristics in patients with colorectal cancer: a real-world data study based on DACCA

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content