Yidantong recipe combined with Jinhuang powder in treating non-severe acute pancreatitis from the perspective of “blood stasis”: a retrospective cohort study_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DENG Gao ¹ , WU Pengyu ² , QIN Haizhi ¹ , XI Heng ³ , WANG Xinxin ¹ ,  CHEN Min ¹

1. Department of Traditional Chinese Medicine, The Third People’s Hospital of Chengdu, AffiliatedHospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu 610014, P. R. China;
2. Department of Gastroenterology, The Third People’s Hospital of Chengdu, AffiliatedHospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu 610014, P. R. China;
3. Department of Pharmacy, The Third People’s Hospital of Chengdu, AffiliatedHospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu 610014, P. R. China;

Corresponding?author：

CHEN Min, Email: 150325684@qq.com

Keywords：

non-severe acute pancreatitis; Yidantong recipe; Jinhuang powder external application therapy; promoting blood circulation and resolving blood stasis; retrospective cohort study

DOI：

10.7507/1007-9424.202401049

Video：

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Objective To determine the effectiveness of Yidantong recipe retained enema combined with external application of Jinhuang powder on non-severe acute pancreatitis (NSAP). Methods A total of 134 patients with NSAP, admitted to the Third People’s Hospital of Chengdu from September 2019 to August 2022 were included in this retrospective cohort study. All patients received routine Western medicine treatment, and they were divided into a observation group (n=66) and a control group (n=68) based on whether they underwent treatment of Yidantong recipe retained enema combined with external application of Jinhuang powder. The variables including incidence of adverse clinical outcome events, severity scores after treatment, the recovery time of flatus and bowel movement, duration of fasting food and water, scores of traditional Chinese medicine (TCM) syndromes and numerical value of blood indices before and after treatment, and the treatment effect of the two groups were statistically analyzed. Results Compared with that of the control group, the incidence of multiple organ dysfunction syndrome (MODS) and severe acute pancreatitis (SAP) of the observation group was lower (P<0.05), and the reduction before and after treatment of APACHEⅡ score, BISAP score and Ranson score in the observation group was more than those in the control group (P<0.05). Compared with that of the control group, the recovery time of flatus and bowel movement and duration of fasting food and water of the observation group was shorter (P<0.05). The reduction before and after treatment of the scores of TCM syndromes (abdominal pain, abdominal distention, nausea and vomiting, dry mouth and bitter taste) and numerical value of blood amylase (AMY), alanine aminotransferase (ALT), alanine aminotransferase (AST) and C-reactive protein (CRP) in the observation group were more than those in the control group (P<0.05). Compared with that of the control group (83.33%), the total effective rate of the scores of TCM syndromes (95.59%) of the observation group was higher (P<0.05).Conclusion Yidantong recipe retained enema combined with external application of Jinhuang powder in the treatment of NSAP is effective by combining with routine Western medicine.

Citation： DENG Gao, WU Pengyu, QIN Haizhi, XI Heng, WANG Xinxin, CHEN Min. Yidantong recipe combined with Jinhuang powder in treating non-severe acute pancreatitis from the perspective of “blood stasis”: a retrospective cohort study. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2024, 31(2): 182-188. doi: 10.7507/1007-9424.202401049 Copy

1.	中華醫學會急診分會, 京津冀急診急救聯盟, 北京醫學會急診分會, 等. 急性胰腺炎急診診斷及治療專家共識. 中華急診醫學雜志, 2021, 30(2): 161-172.
2.	杜奕奇, 宋英曉. 高三酰甘油血癥急性胰腺炎的特點與處理. 中國實用內科雜志, 2021, 41(1): 10-13.
3.	李建洪, 鐵明慧, 龐永誠, 等. 中醫藥綜合治療急性胰腺炎的研究進展. 中國中醫急癥, 2022, 31(3): 549-552.
4.	中華中醫藥學會脾胃病分會. 急性胰腺炎中醫診療專家共識意見 (2017). 中華中醫藥雜志, 2017, 32(9): 4085-4088.
5.	Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
6.	中華人民共和國衛生部. 中藥新藥臨床研究指導原則. 北京: 中國醫藥科技出版社, 2002: 124-151.
7.	蘇越, 謝晶日. 謝晶日教授從“瘀”論治急性胰腺炎經驗. 中國中醫急癥, 2017, 26(12): 2127-2129.
8.	Yano T, Taniguchi M, Shirasaka T, et al. Effectiveness of soluble recombinant human thrombomodulin in patients with severe acute pancreatitis complicated by disseminated intravascular coagulation. Turk J Anaesthesiol Reanim, 2019, 47(4): 320-326.
9.	李曉渝, 陸俊, 付娟, 等. 基于KEAP1/NRF2信號通路探討柴黃清胰活血顆粒改善重癥急性胰腺炎模型大鼠胰腺微循環障礙的機制. 中藥藥理與臨床, 2023, 39(3): 26-31.
10.	龐克斌, 劉軍昌, 李曉光. 大黃牡丹湯灌腸對重癥急性胰腺炎患者炎癥反應及微循環的影響. 貴州醫藥, 2019, 43(4): 605-607.
11.	邊志遠, 廖健思, 文玲, 等. 中醫藥治療急性胰腺炎微循環障礙機制研究進展. 山東中醫雜志, 2021, 40(3): 324-329.
12.	Liu G, Liu F, Xiao L, et al. Narrative review of the mechanisms of action of dachengqi decoction in the treatment of hyperlipidemic pancreatitis on six-hollow-organs to be unblocked theory. Ann Palliat Med, 2020, 9(4): 2323-2329.
13.	沙盈盈, 梁超, 朱曉明, 等. 活血清解湯早期干預對重癥急性胰腺炎患者血液流變學及D二聚體、血栓素A2、前列環素I2的影響. 臨床肝膽病雜志, 2016, 32(4): 678-681.
14.	馬宏丹, 王露, 郭東艷. 經皮給藥系統與新載體的研究進展. 陜西中醫, 2017, 38(9): 1319-1320.
15.	何明珠, 程亮, 鐘婷, 等. 芒硝外敷聯合生長抑素治療急性胰腺炎臨床觀察. 實用中醫藥雜志, 2022, 38(10): 1696-1697.
16.	王敏, 羅小華, 盧娟娟. 通腑解毒方聯合六合丹輔助西醫治療急性胰腺炎臨床研究. 陜西中醫, 2023, 44(4): 471-474.
17.	王云, 張雪, 麻印蓮, 等. 熟大黃的炮制、藥效及臨床應用研究進展. 中國實驗方劑學雜志, 2018, 24(24): 219-226.
18.	彭穎, 敖明月, 權亮, 等. 炮制對川產郁金活血化瘀作用影響研究. 中華中醫藥學刊, 2022, 40(5): 180-183.
19.	宋杰, 銀艷桃, 雷力民, 等. 中醫藥從“瘀”論治急性胰腺炎微循環障礙研究進展. 遼寧中醫藥大學學報, 2020, 22(8): 62-66.
20.	劉振國, 王婷, 王順達, 等. 大黃芒硝對老年重癥急性胰腺炎患者胃腸功能及APACHEⅡ評分的影響研究. 陜西醫學雜志, 2017, 46(12): 1775-1776.
21.	陳立, 范玲, 譚小勇, 等. 大黃游離蒽醌對重癥急性胰腺炎大鼠腸道免疫功能的影響及其作用機制. 山東醫藥, 2016, 56(24): 13-16.
22.	Li M, Zhang X, Wang B, et al. Effect of JAK2/STAT3 signaling pathway on liver injury associated with severe acute pancreatitis in rats. Exp Ther Med, 2018, 16(3): 2013-2021.
23.	王張鵬, 吳俊, 景光旭, 等. 腹腔穿刺引流減輕重癥急性胰腺炎相關肝損傷: 歷史性隊列研究. 中國普外基礎與臨床雜志, 2023, 30(4): 413-419.
24.	李劫, 陳亞峰, 奉典旭. 大承氣湯對胰腺白介素18表達的影響. 時珍國醫國藥, 2020, 31(11): 2681-2684.
25.	孫文杰, 陳亞峰, 李紅昌, 等. 大承氣湯干預重癥急性胰腺炎并發肝損傷的作用機制. 中成藥, 2020, 42(1): 200-203.
26.	谷曉雨, 李會, 張佩, 等. 蒲公英、金銀花水提劑及顆粒劑對4種致病菌的抑菌作用. 臨床合理用藥雜志, 2023, 16(1): 5-8.
27.	蔣麗施, 李瀟彧, 羅曦, 等. 黃連的研究進展及其質量標志物預測分析. 中華中醫藥學刊, 2023, 41(8): 97-109.

1. 中華醫學會急診分會, 京津冀急診急救聯盟, 北京醫學會急診分會, 等. 急性胰腺炎急診診斷及治療專家共識. 中華急診醫學雜志, 2021, 30(2): 161-172.
2. 杜奕奇, 宋英曉. 高三酰甘油血癥急性胰腺炎的特點與處理. 中國實用內科雜志, 2021, 41(1): 10-13.
3. 李建洪, 鐵明慧, 龐永誠, 等. 中醫藥綜合治療急性胰腺炎的研究進展. 中國中醫急癥, 2022, 31(3): 549-552.
4. 中華中醫藥學會脾胃病分會. 急性胰腺炎中醫診療專家共識意見 (2017). 中華中醫藥雜志, 2017, 32(9): 4085-4088.
5. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
6. 中華人民共和國衛生部. 中藥新藥臨床研究指導原則. 北京: 中國醫藥科技出版社, 2002: 124-151.
7. 蘇越, 謝晶日. 謝晶日教授從“瘀”論治急性胰腺炎經驗. 中國中醫急癥, 2017, 26(12): 2127-2129.
8. Yano T, Taniguchi M, Shirasaka T, et al. Effectiveness of soluble recombinant human thrombomodulin in patients with severe acute pancreatitis complicated by disseminated intravascular coagulation. Turk J Anaesthesiol Reanim, 2019, 47(4): 320-326.
9. 李曉渝, 陸俊, 付娟, 等. 基于KEAP1/NRF2信號通路探討柴黃清胰活血顆粒改善重癥急性胰腺炎模型大鼠胰腺微循環障礙的機制. 中藥藥理與臨床, 2023, 39(3): 26-31.
10. 龐克斌, 劉軍昌, 李曉光. 大黃牡丹湯灌腸對重癥急性胰腺炎患者炎癥反應及微循環的影響. 貴州醫藥, 2019, 43(4): 605-607.
11. 邊志遠, 廖健思, 文玲, 等. 中醫藥治療急性胰腺炎微循環障礙機制研究進展. 山東中醫雜志, 2021, 40(3): 324-329.
12. Liu G, Liu F, Xiao L, et al. Narrative review of the mechanisms of action of dachengqi decoction in the treatment of hyperlipidemic pancreatitis on six-hollow-organs to be unblocked theory. Ann Palliat Med, 2020, 9(4): 2323-2329.
13. 沙盈盈, 梁超, 朱曉明, 等. 活血清解湯早期干預對重癥急性胰腺炎患者血液流變學及D二聚體、血栓素A2、前列環素I2的影響. 臨床肝膽病雜志, 2016, 32(4): 678-681.
14. 馬宏丹, 王露, 郭東艷. 經皮給藥系統與新載體的研究進展. 陜西中醫, 2017, 38(9): 1319-1320.
15. 何明珠, 程亮, 鐘婷, 等. 芒硝外敷聯合生長抑素治療急性胰腺炎臨床觀察. 實用中醫藥雜志, 2022, 38(10): 1696-1697.
16. 王敏, 羅小華, 盧娟娟. 通腑解毒方聯合六合丹輔助西醫治療急性胰腺炎臨床研究. 陜西中醫, 2023, 44(4): 471-474.
17. 王云, 張雪, 麻印蓮, 等. 熟大黃的炮制、藥效及臨床應用研究進展. 中國實驗方劑學雜志, 2018, 24(24): 219-226.
18. 彭穎, 敖明月, 權亮, 等. 炮制對川產郁金活血化瘀作用影響研究. 中華中醫藥學刊, 2022, 40(5): 180-183.
19. 宋杰, 銀艷桃, 雷力民, 等. 中醫藥從“瘀”論治急性胰腺炎微循環障礙研究進展. 遼寧中醫藥大學學報, 2020, 22(8): 62-66.
20. 劉振國, 王婷, 王順達, 等. 大黃芒硝對老年重癥急性胰腺炎患者胃腸功能及APACHEⅡ評分的影響研究. 陜西醫學雜志, 2017, 46(12): 1775-1776.
21. 陳立, 范玲, 譚小勇, 等. 大黃游離蒽醌對重癥急性胰腺炎大鼠腸道免疫功能的影響及其作用機制. 山東醫藥, 2016, 56(24): 13-16.
22. Li M, Zhang X, Wang B, et al. Effect of JAK2/STAT3 signaling pathway on liver injury associated with severe acute pancreatitis in rats. Exp Ther Med, 2018, 16(3): 2013-2021.
23. 王張鵬, 吳俊, 景光旭, 等. 腹腔穿刺引流減輕重癥急性胰腺炎相關肝損傷: 歷史性隊列研究. 中國普外基礎與臨床雜志, 2023, 30(4): 413-419.
24. 李劫, 陳亞峰, 奉典旭. 大承氣湯對胰腺白介素18表達的影響. 時珍國醫國藥, 2020, 31(11): 2681-2684.
25. 孫文杰, 陳亞峰, 李紅昌, 等. 大承氣湯干預重癥急性胰腺炎并發肝損傷的作用機制. 中成藥, 2020, 42(1): 200-203.
26. 谷曉雨, 李會, 張佩, 等. 蒲公英、金銀花水提劑及顆粒劑對4種致病菌的抑菌作用. 臨床合理用藥雜志, 2023, 16(1): 5-8.
27. 蔣麗施, 李瀟彧, 羅曦, 等. 黃連的研究進展及其質量標志物預測分析. 中華中醫藥學刊, 2023, 41(8): 97-109.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Yidantong recipe combined with Jinhuang powder in treating non-severe acute pancreatitis from the perspective of “blood stasis”: a retrospective cohort study

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