Relation between marital status of patients with colorectal cancer and decision<b>-</b>making and treatment effect of neoadjuvant regimens: a real<b>-</b>world study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Jing ^1,2 , YI Hongxia ^1,2 , CEN Yueyan ³ , QI Yuhan ⁴ , WANG Xiaodong ¹ ,  LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Nursing, Sichuan University, Chengdu 610041, P. R. China;
3. West China School of Stomatology, Sichuan University, Chengdu 610041, P. R. China;
4. West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

LI Li, Email: drlili116@126.com

Keywords：

marital status; colorectal cancer; neoadjuvant therapy; Database from Colorectal Cancer

DOI：

10.7507/1007-9424.202209043

Video：

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Objective To analyze the relation between the marital status of patients with colorectal cancer and neoadjuvant therapy (NAT) regimen decision-making and outcomes in the current version of the Database from Colorectal Cancer (DACCA). Methods The version of DACCA selected for this analysis was updated on June 29, 2022. The patients were enrolled according to the established screening criteria and then assigned to 5 groups: the unmarried, married, divorced, remarried and widowed groups. The differences in the NAT regimen decision-making and changes of symptom, imaging, and cancer markers in these 5 groups were analyzed. Results A total of 3 053 data that met the screened criteria were enrolled. The results of statistical analysis reflected that the difference in the constituent ratio of patients chosen NAT strategies among 5 groups was obviously statistically significant (χ²=27.944, P=0.004), showing that remarried patients were inclined to adopt combined target drug. No statistical differences were found in changes of symptom (H=5.717, P=0.221), image (H=8.551, P=0.073), and cancer markers (H=11.351, P=0.183) of the 5 groups after NAT. Conclusion Through analysis of DACCA data, it is found that in the selection of NAT strategy for colorectal cancer, more married and remarried patients tended to choose chemotherapy combined target drug regimen.

Citation： LIU Jing, YI Hongxia, CEN Yueyan, QI Yuhan, WANG Xiaodong, LI Li. Relation between marital status of patients with colorectal cancer and decision-making and treatment effect of neoadjuvant regimens: a real-world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(12): 1632-1637. doi: 10.7507/1007-9424.202209043 Copy

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2.	杜茜茜. 結直腸癌腸造口患者夫妻親密關系、自我表露與適應水平的相關性研究. 河南大學, 2020.
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11.	Chen ZH, Yang KB, Zhang YZ, et al. Assessment of modifiable factors for the association of marital status with cancer-specific survival. JAMA Netw Open, 2021, 4(5): e2111813. doi: 10.1001/jamanetworkopen.
12.	Buja A, Lago L, Lago S, et al. Marital status and stage of cancer at diagnosis: A systematic review. Eur J Cancer Care (Engl), 2018, 27(1): 12755. doi: 10.1111/ecc.12755.
13.	馬智偉, 朱蘇雨. 高位直腸癌輔助性放療的問題與爭議探討. 中國腫瘤臨床, 2022, 49(7): 367-371.
14.	陳雨靜, 黃銘霞, 李先越, 等. 結直腸癌術后患者支持性照顧需求現狀及影響因素的研究. 護理與康復, 2021, 20(7): 17-22.
15.	宋張駿, 雷雙燕, 謝娟. 重視癌癥患者支持性照顧需求提高患者生存質量. 中國衛生質量管理, 2019, 26(1): 74-77.
16.	Miniotti M, Bassino S, Fanchini L, et al. Supportive care needs, quality of life and psychological morbidity of advanced colorectal cancer patients. Eur J Oncol Nurs, 2019, 43: 101668. doi: 10.1016/j.ejon.2019.09.009.
17.	麻亮. 結直腸癌術后患者社會支持現狀及影響因素分析. 齊魯護理雜志, 2018, 24(2): 25-28.
18.	Cho D, Chu Q, Lu Q. Associations among physical symptoms, fear of cancer recurrence, and emotional well-being among Chinese American breast cancer survivors: a path model. Support Care Cancer, 2018, 26(6): 1755-1761.
19.	林華琴. CEA對局部進展期直腸癌放療價值的影響及獲益人群篩選. 福建醫科大學, 2021.
20.	駱億. 第二原發結直腸癌臨床特征分析及其腫瘤相關死亡預測模型的構建與臨床應用研究. 揚州大學, 2020.

1. 張雷, 傅仲學. 結直腸癌新輔助治療進展. 重慶醫學, 2013, 42(5): 581-583.
2. 杜茜茜. 結直腸癌腸造口患者夫妻親密關系、自我表露與適應水平的相關性研究. 河南大學, 2020.
3. 汪曉東, 由屹先, 余其澳, 等. 數據庫建設第九部分: 結直腸癌新輔助治療的標簽與結構化. 中國普外基礎與臨床雜志, 2021, 28(6): 799-804.
4. 汪曉東, 李立. 數據庫建設第一部分: 個人數據的標簽與結構化. 中國普外基礎與臨床雜志, 2019, 26(3): 335-342.
5. 中國結直腸癌診療規范(2020年版). 中國實用外科雜志, 2020, 40(6): 601-625.
6. 李衛華, 于吉梅, 陸超君, 等. 基于積極心理學的心理干預對直腸癌患者心理狀態、自我效能和生活質量的影響. 癌癥進展, 2020, 18(21): 2265-2268.
7. Dean LT, Gehlert S, Neuhouser ML, et al. Social factors matter in cancer risk and survivorship. Cancer Causes Control. 2018, 29(7): 611-618.
8. Yang CC, Cheng LC, Lin YW, et al. The impact of marital status on survival in patients with surgically treated colon cancer. Medicine (Baltimore), 2019, 98(11): e14856. doi: 10.1097/MD.0000000000014856.
9. Gomez SL, Hurley S, Canchola AJ, et al. Effects of marital status and economic resources on survival after cancer: A population-based study. Cancer, 2016, 122(10): 1618-1625.
10. Lee S, Ma C, Zhang S, et al. Marital status, living arrangement, and cancer recurrence and survival in patients with stage Ⅲ colon cancer: Findings from CALGB 89803 (Alliance). Oncologist, 2022, 27(6): e494-e505. doi: 10.1093/oncolo/oyab070.
11. Chen ZH, Yang KB, Zhang YZ, et al. Assessment of modifiable factors for the association of marital status with cancer-specific survival. JAMA Netw Open, 2021, 4(5): e2111813. doi: 10.1001/jamanetworkopen.
12. Buja A, Lago L, Lago S, et al. Marital status and stage of cancer at diagnosis: A systematic review. Eur J Cancer Care (Engl), 2018, 27(1): 12755. doi: 10.1111/ecc.12755.
13. 馬智偉, 朱蘇雨. 高位直腸癌輔助性放療的問題與爭議探討. 中國腫瘤臨床, 2022, 49(7): 367-371.
14. 陳雨靜, 黃銘霞, 李先越, 等. 結直腸癌術后患者支持性照顧需求現狀及影響因素的研究. 護理與康復, 2021, 20(7): 17-22.
15. 宋張駿, 雷雙燕, 謝娟. 重視癌癥患者支持性照顧需求提高患者生存質量. 中國衛生質量管理, 2019, 26(1): 74-77.
16. Miniotti M, Bassino S, Fanchini L, et al. Supportive care needs, quality of life and psychological morbidity of advanced colorectal cancer patients. Eur J Oncol Nurs, 2019, 43: 101668. doi: 10.1016/j.ejon.2019.09.009.
17. 麻亮. 結直腸癌術后患者社會支持現狀及影響因素分析. 齊魯護理雜志, 2018, 24(2): 25-28.
18. Cho D, Chu Q, Lu Q. Associations among physical symptoms, fear of cancer recurrence, and emotional well-being among Chinese American breast cancer survivors: a path model. Support Care Cancer, 2018, 26(6): 1755-1761.
19. 林華琴. CEA對局部進展期直腸癌放療價值的影響及獲益人群篩選. 福建醫科大學, 2021.
20. 駱億. 第二原發結直腸癌臨床特征分析及其腫瘤相關死亡預測模型的構建與臨床應用研究. 揚州大學, 2020.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relation between marital status of patients with colorectal cancer and decision-making and treatment effect of neoadjuvant regimens: a real-world study based on DACCA

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