Effect of surgical treatment on prognosis in patients with rectal small cell neuroendocrine carcinoma based on SEER database_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUANG Kun , HE Yunsheng , ZHAO Pan ,  ZHAO Pingwu

Department of General Surgery, Mianyang Traditional Chinese Medicine Hospital, Mianyang, Sichuan 621000, P. R. China;

Corresponding?author：

ZHAO Pingwu, Email: zhaopingwu01@hotmail.com

Keywords：

rectal small cell neuroendocrine carcinoma; surgical treatment; prognosis; SEER database

DOI：

10.7507/1007-9424.202208041

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the value of surgical treatment in rectal small cell neuroendocrine carcinoma (RSCC). Method The clinical data of patients with pathologically diagnosed as RSCC from 2000 to 2019 were extracted from the Surveillance, Epidemiology and End Results (SEER) database, to explore the effect of surgical treatment on cancer-specific survival (CSS) and overall survival (OS). Results A total of 348 cases were included with the median follow-up of 8 months (IQR: 3–16 months). Of the 101 patients in the operation group, 84 died (83.2%), including 56 tumor-related deaths (55.4%). Of the 247 patients in the non-operation group, 215 died (87.0%), including 131 tumor-related deaths (53.0%). The estimated 1-year OS of the operation group and the non-operation group were 49.6% and 34.4%, respectively, and the estimated 1-year CSS of those were 62.2% and 49.2%, respectively. There were significant differences between the two groups (both P<0.05). Results of multivariate prognostic analysis by Cox proportional hazard model showed that differentiation, SEER stage, receiving operative treatment or not, receiving chemotherapy or not, and receiving radiotherapy or not were independent influencing factors for OS, and SEER stage, receiving operative treatment or not, receiving chemotherapy or not, and receiving radiotherapy or not were independent influencing factors for CSS (all P<0.05). The OS [RR=0.61, 95%CI was (0.45, 0.81), P<0.001] and CSS [RR=0.67, 95%CI was (0.47, 0.95), P=0.025] in RSCC patients were significantly improved by surgical treatment. Conclusion Surgical treatment can improve the OS and CSS in RSCC patients.

Citation： HUANG Kun, HE Yunsheng, ZHAO Pan, ZHAO Pingwu. Effect of surgical treatment on prognosis in patients with rectal small cell neuroendocrine carcinoma based on SEER database. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(2): 179-184. doi: 10.7507/1007-9424.202208041 Copy

1.	Chen ZZ, Huang W, Wei ZQ. Small-cell neuroendocrine carcinoma of the rectum - a rare tumor type with poor prognosis: A case report and review of literature. World J Clin Cases, 2020, 8(23): 6095-6102.
2.	Grossman RA, Pedroso FE, Byrne MM, et al. Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? J Surg Oncol, 2011, 104(6): 604-612.
3.	陳忠勝, 李梁和, 張建棟, 等. 原發直腸肛管小細胞癌1例報告并文獻復習. 中國普通外科雜志, 2020, 29(10): 1172-1177.
4.	WHO classification of tumours. Digestive system tumours. Lyon: IARC Press, 2019.
5.	Dasari A, Mehta K, Byers LA, et al. Comparative study of lung and extrapulmonary poorly differentiated neuroendocrine carcinomas: A SEER database analysis of 162 983 cases. Cancer, 2018, 124(4): 807-815.
6.	Alese OB, Jiang R, Shaib W, et al. High-grade gastrointestinal neuroendocrine carcinoma management and outcomes: A national cancer database study. Oncologist, 2019, 24(7): 911-920.
7.	Aytac E, Ozdemir Y, Ozuner G. Long term outcomes of neuroendocrine carcinomas (high-grade neuroendocrine tumors) of the colon, rectum, and anal canal. J Visc Surg, 2014, 151(1): 3-7.
8.	Dores GM, Qubaiah O, Mody A, et al. A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992-2010. BMC Cancer, 2015, 15: 185. doi: 10.1186/s12885-015-1188-y.
9.	Groeschl RT, Christians KK, Turaga KK, et al. Management of primary hepatopancreatobiliary small cell carcinoma. J Surg Oncol, 2013, 107(7): 692-695.
10.	Crippa S, Cirocchi R, Weiss MJ, et al. A systematic review of surgical resection of liver-only synchronous metastases from pancreatic cancer in the era of multiagent chemotherapy. Updates Surg, 2020, 72(1): 39-45.
11.	黃坤, 趙平武, 白斗, 等. 不同病理學類型的腹膜后脂肪肉瘤患者的預后分析及臨床評價. 中國普通外科雜志, 2021, 30(10): 1212-1228.
12.	陳茂山, 李芳芳, 楊宏偉, 等. 基于SEER數據庫分析142 007例乳腺癌診斷時婚姻狀態與預后的關系. 重慶醫科大學學報, 2020, 45(11): 1567-1572.
13.	Smith JD, Reidy DL, Goodman KA, et al. A retrospective review of 126 high-grade neuroendocrine carcinomas of the colon and rectum. Ann Surg Oncol, 2014, 21(9): 2956-2962.
14.	Lee H, Choi HJ, Park IY. Small cell carcinoma of the gallbladder: a case report. Ann Hepatobiliary Pancreat Surg, 2017, 21(3): 168-171.
15.	Bakogeorgos M, Kalkanis D, Katsaounis P, et al. Small cell carcinoma of the stomach: A report of two cases and a review of the literature. Mol Clin Oncol, 2018, 9(1): 11-16.
16.	Wu QQ, Qiang WG, Wang F, et al. Management of primary gastric small cell carcinoma in China. Int J Clin Exp Med, 2015, 8(2): 1589-1597.
17.	董銳增, 師英強, 葉延偉, 等. 23例胃低分化神經內分泌癌的臨床病理特點和預后分析. 中華胃腸外科雜志, 2010, 13(8): 583-586.
18.	黃帥, 鄭朝旭, 徐泉, 等. 胃小細胞癌41例臨床病理特征與預后相關性分析. 中華外科雜志, 2013, 15(3): 225-229.
19.	Abdelfatah E, Guzzetta AA, Nagarajan N, et al. Long-term outcomes in treatment of retroperitoneal sarcomas: A 15 year single-institution evaluation of prognostic features. J Surg Oncol, 2016, 114(1): 56-64.
20.	Usmani S, Pazooki M, Bilgrami SF. Small cell carcinoma of the gall bladder: role of adjuvant chemotherapy. J Gastrointest Cancer, 2010, 41(1): 84-87.
21.	Modrek AS, Hsu HC, Leichman CG, et al. Radiation therapy improves survival in rectal small cell cancer-Analysis of Surveillance Epidemiology and End Results (SEER) data. Radiat Oncol, 2015, 10: 101. doi: 10.1186/s13014-015-0411-y.
22.	Choi PW. Synchronous small cell carcinoma and adenocarcinoma of the rectum. J Surg Case Rep, 2017, 2017(4): rjx069. doi: 10.1093/jscr/rjx069.
23.	Kanetkar AV, Patkar S, Khobragade KH, et al. Neuroendocrine carcinoma of gallbladder: A step beyond palliative therapy, experience of 25 cases. J Gastrointest Cancer, 2019, 50(2): 298-303.
24.	Song W, Chen W, Zhang S, et al. Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy. Diagn Pathol, 2012, 7: 163. doi: 10.1186/1746-1596-7-163.
25.	Jiao X, Pulgar S, Boyd M, et al. Treatment patterns and clinical outcomes in patients with metastatic gastroenteropancreatic neuroendocrine tumors treated in the community practice setting in the United States. Pancreas, 2018, 47(2): 173-182.
26.	Basuroy R, Haji A, Ramage JK, et al. Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther, 2016, 44(4): 332-345.
27.	Fields AC, Lu P, Vierra BM, et al. Survival in patients with high-grade colorectal neuroendocrine carcinomas: The role of surgery and chemotherapy. Ann Surg Oncol, 2019, 26(4): 1127-1133.
28.	Brieau B, Lepère C, Walter T, et al. Radiochemotherapy versus surgery in nonmetastatic anorectal neuroendocrine carcinoma: A multicenter study by the association des gastro-entérologues oncologues. Medicine (Baltimore), 2015, 94(42): e1864. doi: 10.1097/MD.0000000000001864.

1. Chen ZZ, Huang W, Wei ZQ. Small-cell neuroendocrine carcinoma of the rectum - a rare tumor type with poor prognosis: A case report and review of literature. World J Clin Cases, 2020, 8(23): 6095-6102.
2. Grossman RA, Pedroso FE, Byrne MM, et al. Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? J Surg Oncol, 2011, 104(6): 604-612.
3. 陳忠勝, 李梁和, 張建棟, 等. 原發直腸肛管小細胞癌1例報告并文獻復習. 中國普通外科雜志, 2020, 29(10): 1172-1177.
4. WHO classification of tumours. Digestive system tumours. Lyon: IARC Press, 2019.
5. Dasari A, Mehta K, Byers LA, et al. Comparative study of lung and extrapulmonary poorly differentiated neuroendocrine carcinomas: A SEER database analysis of 162 983 cases. Cancer, 2018, 124(4): 807-815.
6. Alese OB, Jiang R, Shaib W, et al. High-grade gastrointestinal neuroendocrine carcinoma management and outcomes: A national cancer database study. Oncologist, 2019, 24(7): 911-920.
7. Aytac E, Ozdemir Y, Ozuner G. Long term outcomes of neuroendocrine carcinomas (high-grade neuroendocrine tumors) of the colon, rectum, and anal canal. J Visc Surg, 2014, 151(1): 3-7.
8. Dores GM, Qubaiah O, Mody A, et al. A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992-2010. BMC Cancer, 2015, 15: 185. doi: 10.1186/s12885-015-1188-y.
9. Groeschl RT, Christians KK, Turaga KK, et al. Management of primary hepatopancreatobiliary small cell carcinoma. J Surg Oncol, 2013, 107(7): 692-695.
10. Crippa S, Cirocchi R, Weiss MJ, et al. A systematic review of surgical resection of liver-only synchronous metastases from pancreatic cancer in the era of multiagent chemotherapy. Updates Surg, 2020, 72(1): 39-45.
11. 黃坤, 趙平武, 白斗, 等. 不同病理學類型的腹膜后脂肪肉瘤患者的預后分析及臨床評價. 中國普通外科雜志, 2021, 30(10): 1212-1228.
12. 陳茂山, 李芳芳, 楊宏偉, 等. 基于SEER數據庫分析142 007例乳腺癌診斷時婚姻狀態與預后的關系. 重慶醫科大學學報, 2020, 45(11): 1567-1572.
13. Smith JD, Reidy DL, Goodman KA, et al. A retrospective review of 126 high-grade neuroendocrine carcinomas of the colon and rectum. Ann Surg Oncol, 2014, 21(9): 2956-2962.
14. Lee H, Choi HJ, Park IY. Small cell carcinoma of the gallbladder: a case report. Ann Hepatobiliary Pancreat Surg, 2017, 21(3): 168-171.
15. Bakogeorgos M, Kalkanis D, Katsaounis P, et al. Small cell carcinoma of the stomach: A report of two cases and a review of the literature. Mol Clin Oncol, 2018, 9(1): 11-16.
16. Wu QQ, Qiang WG, Wang F, et al. Management of primary gastric small cell carcinoma in China. Int J Clin Exp Med, 2015, 8(2): 1589-1597.
17. 董銳增, 師英強, 葉延偉, 等. 23例胃低分化神經內分泌癌的臨床病理特點和預后分析. 中華胃腸外科雜志, 2010, 13(8): 583-586.
18. 黃帥, 鄭朝旭, 徐泉, 等. 胃小細胞癌41例臨床病理特征與預后相關性分析. 中華外科雜志, 2013, 15(3): 225-229.
19. Abdelfatah E, Guzzetta AA, Nagarajan N, et al. Long-term outcomes in treatment of retroperitoneal sarcomas: A 15 year single-institution evaluation of prognostic features. J Surg Oncol, 2016, 114(1): 56-64.
20. Usmani S, Pazooki M, Bilgrami SF. Small cell carcinoma of the gall bladder: role of adjuvant chemotherapy. J Gastrointest Cancer, 2010, 41(1): 84-87.
21. Modrek AS, Hsu HC, Leichman CG, et al. Radiation therapy improves survival in rectal small cell cancer-Analysis of Surveillance Epidemiology and End Results (SEER) data. Radiat Oncol, 2015, 10: 101. doi: 10.1186/s13014-015-0411-y.
22. Choi PW. Synchronous small cell carcinoma and adenocarcinoma of the rectum. J Surg Case Rep, 2017, 2017(4): rjx069. doi: 10.1093/jscr/rjx069.
23. Kanetkar AV, Patkar S, Khobragade KH, et al. Neuroendocrine carcinoma of gallbladder: A step beyond palliative therapy, experience of 25 cases. J Gastrointest Cancer, 2019, 50(2): 298-303.
24. Song W, Chen W, Zhang S, et al. Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy. Diagn Pathol, 2012, 7: 163. doi: 10.1186/1746-1596-7-163.
25. Jiao X, Pulgar S, Boyd M, et al. Treatment patterns and clinical outcomes in patients with metastatic gastroenteropancreatic neuroendocrine tumors treated in the community practice setting in the United States. Pancreas, 2018, 47(2): 173-182.
26. Basuroy R, Haji A, Ramage JK, et al. Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther, 2016, 44(4): 332-345.
27. Fields AC, Lu P, Vierra BM, et al. Survival in patients with high-grade colorectal neuroendocrine carcinomas: The role of surgery and chemotherapy. Ann Surg Oncol, 2019, 26(4): 1127-1133.
28. Brieau B, Lepère C, Walter T, et al. Radiochemotherapy versus surgery in nonmetastatic anorectal neuroendocrine carcinoma: A multicenter study by the association des gastro-entérologues oncologues. Medicine (Baltimore), 2015, 94(42): e1864. doi: 10.1097/MD.0000000000001864.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of surgical treatment on prognosis in patients with rectal small cell neuroendocrine carcinoma based on SEER database

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content