Relationship between ABO blood type of patients with colorectal cancer and surgical characteristics and postoperative complications: a real world study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEI Yuhao ^1,2 , XIE Xinyu ^1,2 , ZHAO Tianlang ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

ABO blood type; colorectal cancer; postoperative complications; surgical type; nature of surgery

DOI：

10.7507/1007-9424.202207048

Video：

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Objective To analyze the influence of the ABO blood types of colorectal cancer patients served by West China Hospital as a regional center on surgical characteristics and postoperative complications in the current version of Database from Colorectal Cancer (DACCA). Methods The DACCA version was updated on January 5, 2022. The data items included ABO blood type, sex, type of operation, nature of operation and postoperative complications. The operative characteristics and complications at different stages after operation (in hospital, short-term and long-term after operation) of colorectal cancer patients with different blood types (A, B, AB, O) were analyzed. Results According to the DACCA database, we obtained 5 010 analysable data rows, covering 2005–2022. The results of blood types analysis showed that there was no significant difference among different blood types in the overall postoperative complications and the occurrence of complications in hospital, short-term and long-term after operation (P>0.05). Further subgroup analysis showed that only the difference of anastomotic leakage among different blood types was statistically significant (χ²=9.588, P=0.022). There was no significant difference among different blood types in whether the primary focus of colon cancer surgery was removed or not, the degree of radical resection of the primary focus, and whether the anus was preserved or not in rectal cancer surgery (P>0.05), and there was significant difference among different blood types with different degrees of radical resection of primary rectal cancer (χ²=15.773, P=0.001). Conclusions The ABO blood types of patients with colorectal cancer has nothing to do with the occurrence of overall complications in the short and long term after operation, and has no impact on the implementation of different surgical methods. However, the occurrence of a single postoperative anastomotic leakage is related to blood type, and its possible causes need to be further explored.

Citation： WEI Yuhao, XIE Xinyu, ZHAO Tianlang, WANG Xiaodong, LI Li. Relationship between ABO blood type of patients with colorectal cancer and surgical characteristics and postoperative complications: a real world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(9): 1226-1230. doi: 10.7507/1007-9424.202207048 Copy

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6.	汪曉東, 孟鑫宇, 劉健博, 等. 數據庫研究第八部分: 結直腸癌術后風險與并發癥. 中國普外基礎與臨床雜志, 2021, 28(3): 369-375.
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8.	顏登國, 張汝一, 甄運寰, 等. 結直腸癌切除術后吻合口瘺的治療. 中華胃腸外科雜志, 2006, 9(5): 408.
9.	柯海林, 池畔, 林惠銘, 等. 直腸癌術后吻合口瘺對長期預后的影響. 中華胃腸外科雜志, 2015, 18(9): 920-924.
10.	王利紅. ABO血型因素對術后認知功能障礙的影響. 醫學綜述, 2015, 21(6): 983-985.
11.	黃津. 血清前白蛋白水平與食管癌術后吻合口瘺發生的臨床研究. 重慶醫科大學, 2020.
12.	張佩范, 呂化先, 白雅珍, 等. 遠端結腸、直腸癌血型物質消長規律的初步研究—附89例手術切除標本病理形態分析(摘要). 浙江腫瘤通訊, 1980, 4: 164.
13.	曾志良. 結腸直腸癌的臨床病例特征及預后分析. 醫學理論與實踐, 2013, 26(3): 283-284.

1. 汪曉東, 林容若, 劉健博, 等. 數據庫建設第七部分: 結直腸癌手術特征的標簽與結構化(一). 中國普外基礎與臨床雜志, 2020, 27(9): 1150-1152.
2. 汪曉東, 劉健博, 孟鑫宇, 等. 數據庫建設第八部分: 結直腸癌手術反應及圍術期并發癥的標簽與結構化. 中國普外基礎與臨床雜志, 2021, 28(4): 508-511.
3. 龔佳祺, 劉瑩, 曾渝, 等. 結直腸癌患者的就診年齡與術前腫瘤相關特征的關系: 基于DACCA的真實世界數據研究. 中國普外基礎與臨床雜志, 2022, 29(3): 362-370.
4. 許沈華, 戴惠芳, 錢麗娟, 等. 2 014例結、直腸癌與ABO血型的關系. 浙江腫瘤通訊, 1990, 2: 29-32.
5. Bolliger M, Kroehnert JA, Molineus F, et al. Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients. Eur Surg, 2018, 50(6): 256-261.
6. 汪曉東, 孟鑫宇, 劉健博, 等. 數據庫研究第八部分: 結直腸癌術后風險與并發癥. 中國普外基礎與臨床雜志, 2021, 28(3): 369-375.
7. Sparreboom CL, van Groningen JT, Lingsma HF, et al. Different risk factors for early and late colorectal anastomotic leakage in a nationwide audit. Dis Colon Rectum, 2018, 61(11): 1258-1266.
8. 顏登國, 張汝一, 甄運寰, 等. 結直腸癌切除術后吻合口瘺的治療. 中華胃腸外科雜志, 2006, 9(5): 408.
9. 柯海林, 池畔, 林惠銘, 等. 直腸癌術后吻合口瘺對長期預后的影響. 中華胃腸外科雜志, 2015, 18(9): 920-924.
10. 王利紅. ABO血型因素對術后認知功能障礙的影響. 醫學綜述, 2015, 21(6): 983-985.
11. 黃津. 血清前白蛋白水平與食管癌術后吻合口瘺發生的臨床研究. 重慶醫科大學, 2020.
12. 張佩范, 呂化先, 白雅珍, 等. 遠端結腸、直腸癌血型物質消長規律的初步研究—附89例手術切除標本病理形態分析(摘要). 浙江腫瘤通訊, 1980, 4: 164.
13. 曾志良. 結腸直腸癌的臨床病例特征及預后分析. 醫學理論與實踐, 2013, 26(3): 283-284.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship between ABO blood type of patients with colorectal cancer and surgical characteristics and postoperative complications: a real world study based on DACCA

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