Relationship between age and surgical trauma reaction and postoperative complications inpatients with colorectal cancer: a real-world data study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GONG Jiaqi ^1,2 , ZENG Yu ^1,2 , LIU Ying ^1,2 , DU Yiling ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; age; surgical trauma reaction; postoperative complication in hospital; Database from Colorectal Cancer

DOI：

10.7507/1007-9424.202203057

Video：

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Objective To analyze the impact of age on surgical reaction and postoperative complications of patients with colorectal cancer served by West China Hospital of Sichuan University as a regional center in the Database from Colorectal Cancer (DACCA). Methods The data of DACCA was updated on January 5, 2022. All data items included age, surgical trauma reaction, elevated body temperature time, exhaust time, pain, mental status, and postoperative hospital complications. According to the age segmentation method in China, the patients can be divided into 3 groups: ≤35 years old (including infant, toddler, child, teenager and youth, set as the younger group), 36–59 years old (set as the middle-aged group), and ≥60 years old (set as the elderly group). Results After scanning, 5 224 data rows were analyzed. There was no significant difference in surgical trauma reaction (H=0.352, P=0.838), elevated body temperature time (H=3.999, P=0.135), exhaust time (H=1.940, P=0.379), mental status (H=2.075, P=0.354), incidence of postoperative complications (χ²=2.078, P=0.354), incidence of anastomotic bleeding (χ²=1.737, P=0.420), incidence of anastomotic leakage (χ²=0.573, P=0.751), and incidence of pulmonary infection (P=0.410) among different age groups, but the younger group had more severe pain (H=12.985, P=0.002) and higher incidence of inflammatory obstruction (χ²=7.789, P=0.020). Conclusions Age has little effect on trauma reaction related parameters and overall incidence of complications in colorectal cancer patients. However, younger patients with colorectal cancer showed increased pain levels and increased incidence of inflammatory obstruction after surgery. These clinical manifestations can provide clinicians with evidence for intervention, but more prospective intervention trials are needed.

Citation： GONG Jiaqi, ZENG Yu, LIU Ying, DU Yiling, WANG Xiaodong, LI Li. Relationship between age and surgical trauma reaction and postoperative complications inpatients with colorectal cancer: a real-world data study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(5): 666-671. doi: 10.7507/1007-9424.202203057 Copy

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2.	汪曉東, 孟鑫宇, 劉健博, 等. 數據庫研究第八部分: 結直腸癌術后風險與并發癥. 中國普外基礎與臨床雜志, 2021, 28(3): 369-375.
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7.	汪曉東, 李立. 數據庫建設第一部分: 個人數據的標簽與結構化. 中國普外基礎與臨床雜志, 2019, 26(3): 335-342.
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10.	Yu S, Tang Y. Effects of comprehensive care on psychological emotions, postoperative rehabilitation and complications of colorectal cancer patients after colostomy. Am J Transl Res, 2021, 13(6): 6889-6896.
11.	Okugawa Y, Toiyama Y, Yamamoto A, et al. Lymphocyte-C-reactive protein ratio as promising new marker for predicting surgical and oncological outcomes in colorectal cancer. Ann Surg, 2020, 272(2): 342-351.
12.	鄭華, 舒斌, 段光友, 等. 腹部手術后鎮痛藥需求量的影響因素. 臨床外科雜志, 2014, 22(6): 397-400.
13.	卓恩挺, 陳雪蓮, 王連臣, 等. 腹腔鏡結直腸癌手術術后并發癥的臨床分析及預防策略. 山西醫科大學學報, 2013, 44(8): 635-637.
14.	Quiroga-Centeno AC, Jerez-Torra KA, Martin-Mojica PA, et al. Risk factors for prolonged postoperative ileus in colorectal surgery: a systematic review and meta-analysis. World J Surg, 2020, 44(5): 1612-1626.
15.	廖新華, 張磊, 許延發, 等. 結、直腸癌患者術后并發癥的影響因素分析. 西安交通大學學報 (醫學版), 2010, 31(3): 348-350.
16.	Basdanis G, Papadopoulos VN, Michalopoulos A, et al. Colorectal cancer in patients over 70 years of age: determinants of outcome. Tech Coloproctol, 2004, 8 Suppl 1: s112-s115.
17.	康志勇. 結直腸癌術后吻合口漏的相關危險因素分析. 延邊大學, 2021.
18.	康劍霞. 術后早期炎性梗阻的治療體會 (附40例報告). 華北煤炭醫學院學報, 2007, 9(5): 687-688.
19.	王勇, 張巖. 開腹手術后早期炎性腸梗阻的診斷與綜合治療. 醫學與哲學, 2013, 34(8): 32-33.

1. 姚宏偉, 李心翔, 崔龍, 等. 中國結直腸癌手術病例登記數據庫2019年度報告: 一項全國性登記研究. 中國實用外科雜志, 2020, 40(1): 106-110, 116.
2. 汪曉東, 孟鑫宇, 劉健博, 等. 數據庫研究第八部分: 結直腸癌術后風險與并發癥. 中國普外基礎與臨床雜志, 2021, 28(3): 369-375.
3. 江龍龍, 楊鳴. 結直腸癌患者手術并發癥情況和影響因素分析. 現代中西醫結合雜志, 2014, 23(15): 1659-1661.
4. 鄢霆. 青年結直腸癌與老年結直腸癌的臨床對比分析. 福建醫科大學, 2017.
5. Kim YW, Kim IY. Factors associated with postoperative complications and 1-year mortality after surgery for colorectal cancer in octogenarians and nonagenarians. Clin Interv Aging, 2016, 11: 689-697.
6. Wydra J, Kruszewski W, Jasiński W, et al. Is age a risk factor of postoperative complications in colorectal cancer? Pol Przegl Chir, 2013, 85（9）: 491-495.
7. 汪曉東, 李立. 數據庫建設第一部分: 個人數據的標簽與結構化. 中國普外基礎與臨床雜志, 2019, 26(3): 335-342.
8. 汪曉東, 劉健博, 孟鑫宇, 等. 數據庫建設第八部分: 結直腸癌手術反應及圍術期并發癥的標簽與結構化. 中國普外基礎與臨床雜志, 2021, 28(4): 508-511.
9. Hu M, Yu Y, Wu Z, et al. The clinical study of fast-track rehabilitation nursing in the perioperative period of therapeutic laparoscopy of colon cancer patients. J Pak Med Assoc, 2020, 70(9): 24-30.
10. Yu S, Tang Y. Effects of comprehensive care on psychological emotions, postoperative rehabilitation and complications of colorectal cancer patients after colostomy. Am J Transl Res, 2021, 13(6): 6889-6896.
11. Okugawa Y, Toiyama Y, Yamamoto A, et al. Lymphocyte-C-reactive protein ratio as promising new marker for predicting surgical and oncological outcomes in colorectal cancer. Ann Surg, 2020, 272(2): 342-351.
12. 鄭華, 舒斌, 段光友, 等. 腹部手術后鎮痛藥需求量的影響因素. 臨床外科雜志, 2014, 22(6): 397-400.
13. 卓恩挺, 陳雪蓮, 王連臣, 等. 腹腔鏡結直腸癌手術術后并發癥的臨床分析及預防策略. 山西醫科大學學報, 2013, 44(8): 635-637.
14. Quiroga-Centeno AC, Jerez-Torra KA, Martin-Mojica PA, et al. Risk factors for prolonged postoperative ileus in colorectal surgery: a systematic review and meta-analysis. World J Surg, 2020, 44(5): 1612-1626.
15. 廖新華, 張磊, 許延發, 等. 結、直腸癌患者術后并發癥的影響因素分析. 西安交通大學學報 (醫學版), 2010, 31(3): 348-350.
16. Basdanis G, Papadopoulos VN, Michalopoulos A, et al. Colorectal cancer in patients over 70 years of age: determinants of outcome. Tech Coloproctol, 2004, 8 Suppl 1: s112-s115.
17. 康志勇. 結直腸癌術后吻合口漏的相關危險因素分析. 延邊大學, 2021.
18. 康劍霞. 術后早期炎性梗阻的治療體會 (附40例報告). 華北煤炭醫學院學報, 2007, 9(5): 687-688.
19. 王勇, 張巖. 開腹手術后早期炎性腸梗阻的診斷與綜合治療. 醫學與哲學, 2013, 34(8): 32-33.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship between age and surgical trauma reaction and postoperative complications inpatients with colorectal cancer: a real-world data study based on DACCA

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