Research progress on pathological clinical features and CT diagnosis of gastric signet ring cell carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Lingying ,  LU Chunyan

Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

LU Chunyan, Email: luchunyan@wchscu.cn

Keywords：

Gastric signet ring cell carcinoma; classification; metastasis; prognosis; tomography/X-ray comput

DOI：

10.7507/1007-9424.202201003

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the pathological, clinical features and research progress of CT diagnosis of signet ring cell carcinoma of the stomach, in order to help further understanding and early clinical diagnosis and treatment of this disease. Method The literatures related to pathological classification, clinical manifestations, metastasis patterns, prognosis and CT features of gastric signet ring cell carcinoma were searched and reviewed. Results Gastric signet ring cell carcinoma often had no special clinical symptoms and signs in the early stage, and often entered the advanced stage when symptoms such as gastric ulcer appeared. Gastric signet ring cell carcinoma is more prone to peritoneal and ascites metastases than other types of gastric cancer. The more specific metastases include diffuse infiltration along the bile duct and portal vein to the hepatic hilar area and extension to the Glisson sheath. Compared with other types of gastric cancer, there is no prognostic advantage. even worse. CT showed that the lesions were mostly located in the middle and lower 1/3 of the stomach, with a diffuse infiltrating gross appearance, obvious thickening and enhancement of the gastric wall, and delayed enhancement, especially in the low-enhanced area. The emerging dual-energy/spectral CT has shown good application prospects for the diagnosis of gastric cancer. Conclusions The pathological clinical features and CT diagnosis of gastric signet ring cell carcinoma have certain characteristics, but there are still many controversies, which are related to the fact that some pathological characteristics or infiltration patterns of gastric signet ring cell carcinoma itself have not been clearly studied, which will be discussed in the future direction of continuing research.

Citation： CHEN Lingying, LU Chunyan. Research progress on pathological clinical features and CT diagnosis of gastric signet ring cell carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(3): 376-381. doi: 10.7507/1007-9424.202201003 Copy

1.	王震, 趙春臨, 孫陽, 等. 基于SEER數據庫的胃印戒細胞癌臨床病理特征及預后分析. 醫學研究生學報, 2019, 32(12): 1301-1307.
2.	Lee JH, Park MS, Kim KW, et al. Advanced gastric carcinoma with signet ring cell carcinoma versus non-signet ring cell carcinoma: differentiation with multidetector CT. J Comput Assist Tomogr, 2006, 30(6): 880-884.
3.	張召珍, 沈俊, 陳潔. 胃印戒細胞癌的內鏡及臨床特點. 中華消化內鏡雜志, 2007, 24(4): 284-286.
4.	Kwon KJ, Shim KN, Song EM, et al. Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach. Gastric Cancer, 2014, 17(1): 43-53.
5.	Taghavi S, Jayarajan SN, Davey A, et al. Prognostic significance of signet ring gastric cancer. J Clin Oncol, 2012, 30(28): 3493-3498.
6.	黃海波, 江生. CT輔助診斷胃癌應用進展. 醫學綜述, 2014, 20(11): 2044-2057.
7.	聶愛英, 梁麗娟, 雷超, 等. 胃印戒細胞癌臨床病理特點的分析. 現代腫瘤醫學, 2017, 25(6): 0914-0917.
8.	徐仲航, 金殷植, 房學東. 胃印戒細胞癌的研究進展. 中華胃腸外科雜志, 2018, 21(10): 1196-1200.
9.	楊琳, 王艷萍, 吳東瑛, 等. 胃印戒細胞癌與黏液腺癌生物學特征及分子病理學機制的比較研究. 世界華人消化雜志, 2002, 10(5): 516-524.
10.	唐磊. 胃癌術后復發、轉移的影像學診斷. 中國實用外科雜志, 2015, 35(10): 1132-1144.
11.	李琦, 朱正綱. 胃癌術后腹膜復發和轉移的早期診斷(文獻綜述). 國外醫學(外科學分冊), 2003, 30(2): 73-76.
12.	崔景利, 梁寒, 鄧靖宇, 等. 胃印戒細胞癌的臨床病理特點和預后分析. 中華腫瘤雜志, 2015, 37(5): 367-370.
13.	Rijken A, Lurvink RJ, Luyer MDP, et al. The burden of peritoneal metastases from gastric cancer: a systematic review on the incidence, Risk Factors and Survival. J Clin Med, 2021, 10(21): 4882. doi: 10.3390/jcm10214882.
14.	張培誼, 鄒賽英, 唐新萍. 胃印戒細胞癌腹水轉移的超微結構特征. 電子顯微學報, 2004, 23(4): 325-325.
15.	Wang Z, Zhang X, Hu J, et al. Predictive factors for lymph node metastasis in early gastric cancer with signet ring cell histology and their impact on the surgical strategy: analysis of single institutional experience. J Surg Res, 2014, 191(1): 130-133.
16.	張文靜, 吳克儉, 譚寧平. 早期胃癌淋巴結轉移的危險因素及預后分析. 中國中西醫結合消化雜志, 2020, 28(5): 331-337.
17.	章志偉, 陳如意, 蔣林華, 等. 早期遠端胃印戒細胞癌淋巴結轉移的危險因素分析及外科手術指征探討. 中國普外基礎與臨床雜志, 2020, 27(3): 315-319.
18.	Jin X, Wu W, Zhao J, et al. Clinical features and risk factors for lymph node metastasis in early signet ring cell gastric cancer. Front Oncol, 2021, 11: 630675. doi: 10.3389/fonc.2021.630675.
19.	張佩范, 袁媛, 吳燁秋. 殘胃癌與殘胃再發癌病理分析. 中國實用外科雜志, 1987, 7(2): 212-214.
20.	郗洪慶, 李佶陽, 李少卿, 等. 胃癌根治術后殘胃癌與胃癌復發的臨床病理學特征比較及預后分析. 中華胃腸外科雜志, 2018, 21(5): 212-213.
21.	張蔭昌, 張佩范, 陳峻青, 等 60例胃癌的形態學及生物學特性的研究. 中華病理學雜志, 1964, 8(4): 243-247.
22.	Lee HH, Song KY, Park CH, et al. Undifferentiated-type gastric adenocarcinoma: prognostic impact of three histological types. World J Surg Oncol, 2012, 10: 254. doi: 10.1186/1477- 7819-10-254.
23.	Hyung WJ, Noh SH, Lee JH, et al. Early gastric carcinoma with signet ring cell histology. B Cancer, 2002, 94(1): 78-83.
24.	Zhao S, Lv L, Zheng K, et al. Prognosis and biological behavior of gastric signet-ring cell carcinoma better or worse: a meta-analysis. Front Oncol, 2021, 11: 603070. doi: 10.3389/fonc.2021.603070.
25.	Ha TK, An JY, Youn HK, et al. Indication for endoscopic mucosal resection in early signet ring cell gastric cancer. Ann Surg Oncol, 2008, 15(2): 508-513.
26.	石曉燕, 王潤潔, 劉超英. 胃印戒細胞癌臨床病理特征研究. 腫瘤防治研究, 2012, 39(7): 826-828.
27.	Li C, Kim S, Lai JF, et al. Advanced gastric carcinoma with signet ring cell histology. Oncology, 2007, 72(1-2): 64-68.
28.	Piessen G, Messager M, Leteurtre E, et al. Signet ring cell histology is an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral clinical presentation. Ann Surg, 2009, 250(6): 878-887.
29.	趙剛, 詹文華, 彭俊生, 等. 進展期胃印戒細胞癌患者的臨床病理特點與預后. 中華普通外科雜志, 2006, 21(4): 251-253.
30.	Liu K, Wan J, Bei Y, et al. Prognostic impact of different histological types on gastric adenocarcinoma: a surveillance, epidemiology, and end results database analysis. Pathol Oncol Res, 2017, 23(4): 881-887.
31.	Zhang C, Liu R, Zhang WH, et al. Difference between signet ring cell gastric cancers and non-signet ring cell gastric cancers: a systematic review and meta-analysis. Front Oncol, 2021, 11: 618477. doi: 10.3389/fonc.2021.618477.
32.	詹文華. 增強胃印戒細胞癌特征及其診治要點的意識. 消化腫瘤雜志(電子版), 2013, 5(1): 5-7.
33.	周金金, 關文華, 強軍, 等. 胃印戒細胞癌的增強CT診斷與鑒別診斷. 臨床放射學雜志, 2018, 37(6): 972-975.
34.	Park MS, Yu JS, Kim MJ, et al. Mucinous versus nonmucinous gastric carcinoma: differentiation with helical CT. Radiology, 2002, 223(2): 540-546.
35.	鄒茹欣, 周洋, 巴志昌, 等. 進展期胃癌64排螺旋CT三期增強影像強化特點與組織學分型相關性的研究. 實用腫瘤學雜志, 2013, 27(6): 549-553.
36.	Chen J, Cai R, Ren G, et al. Differences in clinicopathological characteristics and computed tomography findings between signet ring cell carcinoma and nonsignet ring cell carcinoma in early and advanced gastric cancer. Cancer Med, 2018, 7(4): 1160-1169.
37.	朱建兵, 陳光強, 李勇, 等. 胃印戒細胞癌的多排螺旋CT強化模式及分期初步研究. 實用放射學雜志, 2013, 29(7): 1094-1097.
38.	朱建兵, 陳光強, 李勇, 等. 64排螺旋CT對胃印戒細胞癌淋巴結轉移的診斷價值. 航空航天醫學雜志, 2012, 23(2): 129-130.
39.	沈丹萍. 胃印戒細胞癌的增強CT診斷與鑒別診斷. 養生保健指南, 2020, 37: 269.
40.	鄒賽英, 唐新萍, 張培誼. 胃印戒細胞癌血管形成及超微結構特征與浸潤轉移的關系. 電子顯微學報, 2002, 21(6): 900-902.
41.	喬英, 李健丁, 張瑞平, 等. CT三期增強掃描對胃癌淋巴結轉移的診斷價值. 放射學實踐, 2006, 21(5): 507-510.
42.	孫國鵬. CT能譜成像在術前評估胃癌患者病理類型的臨床價值. 中國現代藥物應用, 2020, 14(6): 54-56.
43.	董杰, 劉松, 潘梁, 等. CT能譜成像定量評估胃癌分化程度的應用價值. 東南大學學報(醫學版), 2018, 37(3): 489-493.
44.	Pan Z, Pang L, Ding B, et al. Gastric cancer staging with dual energy spectral CT imaging. PLoS One, 2013, 8(2): e53651. doi: 10.1371/journal.pone.0053651.

1. 王震, 趙春臨, 孫陽, 等. 基于SEER數據庫的胃印戒細胞癌臨床病理特征及預后分析. 醫學研究生學報, 2019, 32(12): 1301-1307.
2. Lee JH, Park MS, Kim KW, et al. Advanced gastric carcinoma with signet ring cell carcinoma versus non-signet ring cell carcinoma: differentiation with multidetector CT. J Comput Assist Tomogr, 2006, 30(6): 880-884.
3. 張召珍, 沈俊, 陳潔. 胃印戒細胞癌的內鏡及臨床特點. 中華消化內鏡雜志, 2007, 24(4): 284-286.
4. Kwon KJ, Shim KN, Song EM, et al. Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach. Gastric Cancer, 2014, 17(1): 43-53.
5. Taghavi S, Jayarajan SN, Davey A, et al. Prognostic significance of signet ring gastric cancer. J Clin Oncol, 2012, 30(28): 3493-3498.
6. 黃海波, 江生. CT輔助診斷胃癌應用進展. 醫學綜述, 2014, 20(11): 2044-2057.
7. 聶愛英, 梁麗娟, 雷超, 等. 胃印戒細胞癌臨床病理特點的分析. 現代腫瘤醫學, 2017, 25(6): 0914-0917.
8. 徐仲航, 金殷植, 房學東. 胃印戒細胞癌的研究進展. 中華胃腸外科雜志, 2018, 21(10): 1196-1200.
9. 楊琳, 王艷萍, 吳東瑛, 等. 胃印戒細胞癌與黏液腺癌生物學特征及分子病理學機制的比較研究. 世界華人消化雜志, 2002, 10(5): 516-524.
10. 唐磊. 胃癌術后復發、轉移的影像學診斷. 中國實用外科雜志, 2015, 35(10): 1132-1144.
11. 李琦, 朱正綱. 胃癌術后腹膜復發和轉移的早期診斷(文獻綜述). 國外醫學(外科學分冊), 2003, 30(2): 73-76.
12. 崔景利, 梁寒, 鄧靖宇, 等. 胃印戒細胞癌的臨床病理特點和預后分析. 中華腫瘤雜志, 2015, 37(5): 367-370.
13. Rijken A, Lurvink RJ, Luyer MDP, et al. The burden of peritoneal metastases from gastric cancer: a systematic review on the incidence, Risk Factors and Survival. J Clin Med, 2021, 10(21): 4882. doi: 10.3390/jcm10214882.
14. 張培誼, 鄒賽英, 唐新萍. 胃印戒細胞癌腹水轉移的超微結構特征. 電子顯微學報, 2004, 23(4): 325-325.
15. Wang Z, Zhang X, Hu J, et al. Predictive factors for lymph node metastasis in early gastric cancer with signet ring cell histology and their impact on the surgical strategy: analysis of single institutional experience. J Surg Res, 2014, 191(1): 130-133.
16. 張文靜, 吳克儉, 譚寧平. 早期胃癌淋巴結轉移的危險因素及預后分析. 中國中西醫結合消化雜志, 2020, 28(5): 331-337.
17. 章志偉, 陳如意, 蔣林華, 等. 早期遠端胃印戒細胞癌淋巴結轉移的危險因素分析及外科手術指征探討. 中國普外基礎與臨床雜志, 2020, 27(3): 315-319.
18. Jin X, Wu W, Zhao J, et al. Clinical features and risk factors for lymph node metastasis in early signet ring cell gastric cancer. Front Oncol, 2021, 11: 630675. doi: 10.3389/fonc.2021.630675.
19. 張佩范, 袁媛, 吳燁秋. 殘胃癌與殘胃再發癌病理分析. 中國實用外科雜志, 1987, 7(2): 212-214.
20. 郗洪慶, 李佶陽, 李少卿, 等. 胃癌根治術后殘胃癌與胃癌復發的臨床病理學特征比較及預后分析. 中華胃腸外科雜志, 2018, 21(5): 212-213.
21. 張蔭昌, 張佩范, 陳峻青, 等 60例胃癌的形態學及生物學特性的研究. 中華病理學雜志, 1964, 8(4): 243-247.
22. Lee HH, Song KY, Park CH, et al. Undifferentiated-type gastric adenocarcinoma: prognostic impact of three histological types. World J Surg Oncol, 2012, 10: 254. doi: 10.1186/1477- 7819-10-254.
23. Hyung WJ, Noh SH, Lee JH, et al. Early gastric carcinoma with signet ring cell histology. B Cancer, 2002, 94(1): 78-83.
24. Zhao S, Lv L, Zheng K, et al. Prognosis and biological behavior of gastric signet-ring cell carcinoma better or worse: a meta-analysis. Front Oncol, 2021, 11: 603070. doi: 10.3389/fonc.2021.603070.
25. Ha TK, An JY, Youn HK, et al. Indication for endoscopic mucosal resection in early signet ring cell gastric cancer. Ann Surg Oncol, 2008, 15(2): 508-513.
26. 石曉燕, 王潤潔, 劉超英. 胃印戒細胞癌臨床病理特征研究. 腫瘤防治研究, 2012, 39(7): 826-828.
27. Li C, Kim S, Lai JF, et al. Advanced gastric carcinoma with signet ring cell histology. Oncology, 2007, 72(1-2): 64-68.
28. Piessen G, Messager M, Leteurtre E, et al. Signet ring cell histology is an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral clinical presentation. Ann Surg, 2009, 250(6): 878-887.
29. 趙剛, 詹文華, 彭俊生, 等. 進展期胃印戒細胞癌患者的臨床病理特點與預后. 中華普通外科雜志, 2006, 21(4): 251-253.
30. Liu K, Wan J, Bei Y, et al. Prognostic impact of different histological types on gastric adenocarcinoma: a surveillance, epidemiology, and end results database analysis. Pathol Oncol Res, 2017, 23(4): 881-887.
31. Zhang C, Liu R, Zhang WH, et al. Difference between signet ring cell gastric cancers and non-signet ring cell gastric cancers: a systematic review and meta-analysis. Front Oncol, 2021, 11: 618477. doi: 10.3389/fonc.2021.618477.
32. 詹文華. 增強胃印戒細胞癌特征及其診治要點的意識. 消化腫瘤雜志(電子版), 2013, 5(1): 5-7.
33. 周金金, 關文華, 強軍, 等. 胃印戒細胞癌的增強CT診斷與鑒別診斷. 臨床放射學雜志, 2018, 37(6): 972-975.
34. Park MS, Yu JS, Kim MJ, et al. Mucinous versus nonmucinous gastric carcinoma: differentiation with helical CT. Radiology, 2002, 223(2): 540-546.
35. 鄒茹欣, 周洋, 巴志昌, 等. 進展期胃癌64排螺旋CT三期增強影像強化特點與組織學分型相關性的研究. 實用腫瘤學雜志, 2013, 27(6): 549-553.
36. Chen J, Cai R, Ren G, et al. Differences in clinicopathological characteristics and computed tomography findings between signet ring cell carcinoma and nonsignet ring cell carcinoma in early and advanced gastric cancer. Cancer Med, 2018, 7(4): 1160-1169.
37. 朱建兵, 陳光強, 李勇, 等. 胃印戒細胞癌的多排螺旋CT強化模式及分期初步研究. 實用放射學雜志, 2013, 29(7): 1094-1097.
38. 朱建兵, 陳光強, 李勇, 等. 64排螺旋CT對胃印戒細胞癌淋巴結轉移的診斷價值. 航空航天醫學雜志, 2012, 23(2): 129-130.
39. 沈丹萍. 胃印戒細胞癌的增強CT診斷與鑒別診斷. 養生保健指南, 2020, 37: 269.
40. 鄒賽英, 唐新萍, 張培誼. 胃印戒細胞癌血管形成及超微結構特征與浸潤轉移的關系. 電子顯微學報, 2002, 21(6): 900-902.
41. 喬英, 李健丁, 張瑞平, 等. CT三期增強掃描對胃癌淋巴結轉移的診斷價值. 放射學實踐, 2006, 21(5): 507-510.
42. 孫國鵬. CT能譜成像在術前評估胃癌患者病理類型的臨床價值. 中國現代藥物應用, 2020, 14(6): 54-56.
43. 董杰, 劉松, 潘梁, 等. CT能譜成像定量評估胃癌分化程度的應用價值. 東南大學學報(醫學版), 2018, 37(3): 489-493.
44. Pan Z, Pang L, Ding B, et al. Gastric cancer staging with dual energy spectral CT imaging. PLoS One, 2013, 8(2): e53651. doi: 10.1371/journal.pone.0053651.

Previous Article
雙原發性胃癌和腎癌并對側腎輸尿管結石1例報道
Next Article
Evaluation of 3D printing technology before transcatheter aortic valve replacement surgery

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress on pathological clinical features and CT diagnosis of gastric signet ring cell carcinoma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content