Expression of long non-coding RNA DSCR8 in gastric cancer and its relationship with clinicopathological parameters and prognosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 HU Xiufeng ¹ , QU Zhifeng ² , WANG Yufeng ¹ , ZHU Xiaojuan ¹

1. Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471000, P. R. China;
2. Department of Cancer Radiotherapy, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471000, P. R. China;

Corresponding?author：

HU Xiufeng, Email: hyh0512x@163.com

Keywords：

gastric cancer; long non-coding RNA Down’s syndrome critical region 8; diagnosis; prognosis

DOI：

10.7507/1007-9424.202101027

Video：

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Objective To investigate the expression level of long non-coding RNA Down’s syndrome critical region 8 (LncRNA DSCR8) in gastric cancer and its clinical significance.Methods Eighty-six patients with gastric cancer who were hospitalized in our hospital from August 2014 to August 2015 were selected as the research object. Real-time quantitative PCR (qRT-PCR) was used to detect the expression level of LncRNA DSCR8 mRNA in gastric cancer tissues and its adjacent tissues. The relationship between the expression level of LncRNA DSCR8 mRNA and clinicopathological features of gastric cancer was analyzed. Kaplan-Meier method was used to analyze the relationship between the expression of LncRNA DSCR8 mRNA and the survival rate of patients, and multivariate Cox proportional hazards regression analysis was used to analyze the prognostic factors of gastric cancer.Results The expression level of LncRNA DSCR8 mRNA in gastric cancer tissues was higher than that in the paracancerous tissues (P<0.001). The expression levels of LncRNA DSCR8 mRNA in patients with poorly differentiated, TNM Ⅲ–Ⅳ and lymph node metastasis were higher than those in patients with well/moderately differentiated, TNM Ⅰ–Ⅱ and no lymph node metastasis (P<0.05). The 1, 3 and 5-year survival rate of patients with low LncRNA DSCR8 mRNA expression (97.62%, 92.86%, 83.33%, respectively) were higher than those of patients with high LncRNA DSCR8 mRNA expression (63.64%, 38.64%, 31.82%, respectively), P<0.05. LncRNA DSCR8 mRNA and TNM stage were independent risk factors of death in patients with gastric cancer (P<0.05).Conclusions LncRNA DSCR8 is associated with the occurrence, development and prognosis of gastric cancer. It may be an important molecular marker of tumor stage and lymph node metastasis in patients with gastric cancer.

Citation： HU Xiufeng, QU Zhifeng, WANG Yufeng, ZHU Xiaojuan. Expression of long non-coding RNA DSCR8 in gastric cancer and its relationship with clinicopathological parameters and prognosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(10): 1314-1319. doi: 10.7507/1007-9424.202101027 Copy

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5.	You Q, Yao Y, Wu J, et al. YY1-induced lncRNA DSCR8 promotes the progression of ovarian cancer via miR-3192-5p/YY1 axis. Biomed Pharmacother, 2020, 129: 110339.
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11.	Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark, 2018, 21(2): 299-306.
12.	Athale UH, Puligandla M, Stevenson KE, et al. Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001. Pediatr Blood Cancer, 2018, 65(10): e27256.
13.	Choi C, Kim T, Chang KT, et al. DSCR1-mediated TET1 splicing regulates miR-124 expression to control adult hippocampal neurogenesis. EMBO J, 2019, 38(14): e101293.
14.	Chen M, Wang JY, Luo YJ, et al. Identify Down syndrome transcriptome associations using integrative analysis of microarray database and correlation-interaction network. Hum Genomics, 2018, 12(1): 2.
15.	Zheng JC, Chang KJ, Jin YX, et al. Arsenic trioxide inhibits the metastasis of small cell lung cancer by blocking calcineurin-nuclear factor of activated t cells (nfat) signaling. Med Sci Monit, 2019, 25: 2228-2237.
16.	Wang Y, Sun L, Wang L, et al. Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/β-catenin signal pathway in hepatocellular carcinoma. Cell Death Dis, 2018, 9(9): 851.
17.	Dong L, Cao X, Luo Y, et al. A positive feedback loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α plays a role in the progression of ovarian cancer. Front Oncol, 2020, 10: 1713.
18.	高梓茗, 徐惠綿. 胃癌精準外科治療的研究新進展. 中華醫學信息導報, 2021, 36(1): 7-8.

1. Yang L, Sun X, Meng X. Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non-neoplastic mucosa. Mol Med Rep, 2018, 18(2): 1271-1278.
2. 曹博, 丁麗華, 衛勃. 環狀RNA在胃癌中的研究進展. 生物技術通訊, 2019, 30(6): 833-839.
3. Liu Z, Zhang T, Zhang J. Re: Transcatheter arterial embolization for gastrointestinal bleeding associated with gastric carcinoma: prognostic factors predicting successful hemostasis and survival. J Vasc Interv Radiol, 2018, 29(5): 747-748.
4. 鄒磊, 頡晚林, 張鑫. LncRNA在胃癌早期診斷中的研究進展. 國際檢驗醫學雜志, 2019, 40(1): 102-107.
5. You Q, Yao Y, Wu J, et al. YY1-induced lncRNA DSCR8 promotes the progression of ovarian cancer via miR-3192-5p/YY1 axis. Biomed Pharmacother, 2020, 129: 110339.
6. 國家衛生健康委員會. 胃癌診療規范(2018年版). 中華消化病與影像雜志(電子版), 2019, 9(3): 118-144.
7. 田春艷, 彭仁, 白婷婷, 等. 阿帕替尼不同起始劑量治療晚期胃癌不良反應及療效觀察. 實用腫瘤雜志, 2018, 33(1): 66-69.
8. Wang S, Han H, Hu Y, et al. MicroRNA-130a-3p suppresses cell migration and invasion by inhibition of TBL1XR1-mediated EMT in human gastric carcinoma. Mol Carcinog, 2018, 57(3): 383-392.
9. Akimoto T, Muto S, Kutsuwada T, et al. Peritoneal dialysis and malignancy: an experience with a patient complicated by gastric carcinoma. Clin Med Insights Case Rep, 2019, 12: 1179547619835176.
10. 毛竹君, 祝利民, 盧艷琳, 等. miRNA通過轉錄因子及EMT相關調控蛋白在胃癌侵襲轉移中的作用機制研究. 癌癥進展, 2019, 17(8): 890-892, 896.
11. Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark, 2018, 21(2): 299-306.
12. Athale UH, Puligandla M, Stevenson KE, et al. Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001. Pediatr Blood Cancer, 2018, 65(10): e27256.
13. Choi C, Kim T, Chang KT, et al. DSCR1-mediated TET1 splicing regulates miR-124 expression to control adult hippocampal neurogenesis. EMBO J, 2019, 38(14): e101293.
14. Chen M, Wang JY, Luo YJ, et al. Identify Down syndrome transcriptome associations using integrative analysis of microarray database and correlation-interaction network. Hum Genomics, 2018, 12(1): 2.
15. Zheng JC, Chang KJ, Jin YX, et al. Arsenic trioxide inhibits the metastasis of small cell lung cancer by blocking calcineurin-nuclear factor of activated t cells (nfat) signaling. Med Sci Monit, 2019, 25: 2228-2237.
16. Wang Y, Sun L, Wang L, et al. Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/β-catenin signal pathway in hepatocellular carcinoma. Cell Death Dis, 2018, 9(9): 851.
17. Dong L, Cao X, Luo Y, et al. A positive feedback loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α plays a role in the progression of ovarian cancer. Front Oncol, 2020, 10: 1713.
18. 高梓茗, 徐惠綿. 胃癌精準外科治療的研究新進展. 中華醫學信息導報, 2021, 36(1): 7-8.

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Expression of long non-coding RNA DSCR8 in gastric cancer and its relationship with clinicopathological parameters and prognosis

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