Risk factors of posthepatectomy liver failure for hepatobiliary malignancies: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHUANG Hongyu ,  KONG Xianbing

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China;

Corresponding?author：

KONG Xianbing, Email: 425995290@qq.com

Keywords：

hepatectomy; liver failure; risk factors; meta-analysis

DOI：

10.7507/1007-9424.202007049

Video：

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Objective To systematically evaluate the risk factors for posthepatectomy liver failure (PHLF) of hepatobiliary malignancies in order to provide evidence-based medical basis for preventing and reducing PHLF.Methods The case-control studies on the risk factors of PHLF for hepatobiliary malignancy were searched in PubMed, CNKI, etc. domestic and foreign databases from January 2011 to March 2020. The quality evaluation of the literatures was performed by using the Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.3.Results A total of 43 studies were included, involving 13 075 patients after hepatectomy, of which 1 943 (14.86%) had PHLF. Meta-analysis results showed that the male, liver cirrhosis, portal hypertension, hepatectomy range ≥3 segments, vascular tumor thrombus, intraoperative blood transfusion, tumor number ≥2, Child-Pugh grade ≥B, less platelet count, lower albumin, higher total bilirubin, higer indocyanine green retention rate at 15 minutes, longer hepatic hilar occlusion time, longer operation time, more intraoperative blood loss, bigger maximum tumor diameter, smaller residual liver volume, and higer MELD score were the risk factors for the occurrence of PHLF (P<0.05).Conclusions According to the risk factors of PHLF, the basic condition, liver function, and residual liver volume should be fully evaluated before operation. The operation should be accurate anatomy, adequate hemostasis, timely treatment of intraoperative complications. After operation, the fluid infusion, anti-infection, correction of coagulation dysfunction, and protection of liver function should be strengthened. So incidence of PHLF might be reduced minimally.

Citation： ZHUANG Hongyu, KONG Xianbing. Risk factors of posthepatectomy liver failure for hepatobiliary malignancies: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(4): 477-487. doi: 10.7507/1007-9424.202007049 Copy

1.	Sultana A, Brooke-Smith M, Ullah S, et al. Prospective evaluation of the International Study Group for liver surgery definition of post hepatectomy liver failure after liver resection: an international multicentre study. HPB (Oxford), 2018, 20(5): 462-469.
2.	Kauffmann R, Fong Y. Post-hepatectomy liver failure. Hepatobiliary Surg Nutr, 2014, 3(5): 238-246.
3.	Wells GA, Shea B, O’Connell D, et al. NewCastle-Ottawa Quallty Assessment Scale—case control studies. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
4.	Kong FH, Miao XY, Zou H, et al. End-stage liver disease score and future liver remnant volume predict post-hepatectomy liver failure in hepatocellular carcinoma. World J Clin Cases, 2019, 7(22): 3734-3741.
5.	Yamamoto G, Taura K, Ikai I, et al. ALPlat criterion for the resection of hepatocellular carcinoma based on a predictive model of posthepatectomy liver failure. Surgery, 2020, 167(2): 410-416.
6.	Wang H, Li L, Bo W, et al. Immediate postoperative fibrosis-4 predicts postoperative liver failure for patients with hepatocellular carcinoma undergoing curative surgery. Dig Liver Dis, 2018, 50(1): 61-67.
7.	Nitta H, Kitano Y, Miyata T, et al. Validation of functional assessment for liver resection considering venous occlusive area after extended hepatectomy. J Gastrointest Surg, 2020, 24(7): 1510-1519.
8.	Jo HS, Kim DS, Jung SW, et al. Clinical significance of post-hepatectomy hepatic failure in patients with liver metastases from colorectal cancer. Ann Hepatobiliary Pancreat Surg, 2018, 22(2): 93-100.
9.	Nakamura I, Iimuro Y, Hai S, et al. Impaired value of ^99mTc-GSA scintigraphy as an independent risk factor for posthepatectomy liver failure in patients with hepatocellular carcinoma. Eur Surg Res, 2018, 59(1-2): 12-22.
10.	Lei JW, Ji XY, Hong JF, et al. Prediction of posthepatectomy liver failure using transient elastography in patients with hepatitis B related hepatocellular carcinoma. BMC Gastroenterol, 2017, 17(1): 171.
11.	Navarro JG, Yang SJ, Kang I, et al. What are the most important predictive factors for clinically relevant posthepatectomy liver failure after right hepatectomy for hepatocellular carcinoma? Ann Surg Treat Res, 2020, 98(2): 62-71.
12.	Fukushima K, Fukumoto T, Kuramitsu K, et al. Assessment of ISGLS definition of posthepatectomy liver failure and its effect on outcome in patients with hepatocellular carcinoma. J Gastrointest Surg, 2014, 18(4): 729-736.
13.	Iguchi K, Hatano E, Yamanaka K, et al. The impact of posthepatectomy liver failure on the recurrence of hepatocellular carcinoma. World J Surg, 2014, 38(1): 150-158.
14.	Olthof PB, Wiggers JK, Groot Koerkamp B, et al. Postoperative liver failure risk score: identifying patients with resectable perihilar cholangiocarcinoma who can benefit from portal vein embolization. J Am Coll Surg, 2017, 225(3): 387-394.
15.	Mai RY, Ye JZ, Long ZR, et al. Preoperative aspartate aminotransferase-to-platelet-ratio index as a predictor of posthepatectomy liver failure for resectable hepatocellular carcinoma. Cancer Manag Res, 2019, 11: 1401-1414.
16.	Zhou SJ, Zhang EL, Liang BY, et al. Morphologic severity of cirrhosis determines the extent of liver resection in patients with hepatocellular carcinoma and Child-Pugh grade A cirrhosis. J Surg Res, 2016, 200(2): 444-451.
17.	Chapelle T, Op de Beeck B, Driessen A, et al. Estimation of the future remnant liver function is a better tool to predict post-hepatectomy liver failure than platelet-based liver scores. Eur J Surg Oncol, 2017, 43(12): 2277-2284.
18.	Nishio T, Taura K, Koyama Y, et al. Prediction of posthepatectomy liver failure based on liver stiffness measurement in patients with hepatocellular carcinoma. Surgery, 2016, 159(2): 399-408.
19.	Peng W, Li J, Zhang X, et al. A novel model for predicting posthepatectomy liver failure in patients with hepatocellular carcinoma. PLoS One, 2019, 14(7): e0219219.
20.	Chen X, Zhai J, Cai X, et al. Severity of portal hypertension and prediction of postoperative liver failure after liver resection in patients with Child-Pugh grade A cirrhosis. Br J Surg, 2012, 99(12): 1701-1710.
21.	Lin XJ, Yang J, Chen XB, et al. The critical value of remnant liver volume-to-body weight ratio to estimate posthepatectomy liver failure in cirrhotic patients. J Surg Res, 2014, 188(2): 489-495.
22.	Shen Y, Zhou C, Zhu G, et al. Liver stiffness assessed by shear wave elastography predicts postoperative liver failure in patients with hepatocellular carcinoma. J Gastrointest Surg, 2017, 21(9): 1471-1479.
23.	Miyazaki Y, Kokudo T, Amikura K, et al. Albumin-indocyanine green evaluation grading system predicts post-hepatectomy liver failure for biliary tract cancer. Dig Surg, 2019, 36(1): 13-19.
24.	Tomimaru Y, Eguchi H, Gotoh K, et al. Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test. J Surg Oncol, 2016, 113(5): 565-569.
25.	Jin YJ, Lee SH, Cho SG, et al. Prediction of postoperative liver failure using gadoxetic acid-enhanced magnetic resonance imaging in patients with hepatocellular carcinoma. J Gastroenterol Hepatol, 2016, 31(7): 1349-1356.
26.	劉朔琿, 嚴俊, 張奇煜, 等. 白蛋白-膽紅素評分聯合標準化殘肝體積比對肝細胞癌患者肝切除術后肝功能衰竭的預測價值. 中國普外基礎與臨床雜志, 2019, 26(5): 545-550.
27.	劉朝輝, 杜振雙, 林建泉, 等. 原發性肝癌肝切除術后發生肝功能衰竭的圍術期影響因素分析. 肝膽外科雜志, 2016, 24(5): 375-377.
28.	崔宏, 高琴琴, 王效益, 等. 肝細胞癌合并肝硬化患者肝切除術后標準殘肝體積評估. 中國現代普通外科進展, 2019, 22(4): 296-299.
29.	張毅, 張杰峰, 張艷林, 等. 聯合半肝切除的肝門部膽管癌根治術后發生急性肝衰竭的危險因素分析. 臨床肝膽病雜志, 2016, 32(10): 1936-1938.
30.	徐逸昕, 金雷, 陸維軍, 等. 原發性肝癌切除術后肝功能衰竭的臨床分析. 常州實用醫學, 2013, 29(4): 217-219.
31.	曾勇超, 戴朝六, 卜獻民, 等. ALBI 評分與 Child-Pugh 評分對肝癌肝切除術后肝衰竭預測的比較. 中華普通外科雜志, 2019, 34(8): 649-651.
32.	曾柏強, 吳祥, 冉義洪, 等. 大范圍肝切除術后肝衰竭危險因素分析. 中華肝臟外科手術學電子雜志, 2018, 7(2): 143-146.
33.	李昊, 張宏偉, 唐強, 等. 吲哚菁綠試驗與白蛋白-膽紅素評分對肝切除術后肝功能衰竭的預測作用. 中華實用診斷與治療雜志, 2019, 33(11): 1069-1072.
34.	柳己海, 鄭小林, 鄭直, 等. 原發性肝癌肝切除術后患者發生肝功能衰竭的圍術期危險因素分析. 中國全科醫學, 2013, 16(17): 2036-2038.
35.	江勇, 湯建軍, 遠博. 大肝癌術后肝衰竭的防治. 醫學研究雜志, 2011, 40(1): 77-79.
36.	熊邦文, 侯琨. 原發性肝癌肝切除后發生肝功能衰竭的圍術期相關危險因素. 中國當代醫藥, 2013, 20(25): 12-13, 16.
37.	蘇瑛, 龔昭. 肝癌伴膽管癌栓患者術后發生肝功能衰竭的影響因素研究. 實用癌癥雜志, 2014, 29(2): 233-236.
38.	薄飛, 王燕, 杜建文. 白蛋白-膽紅素評分、吲哚箐綠 15 min 清除率與肝癌肝切除后發生肝衰的關系. 中國普通外科雜志, 2020, 29(1): 115-119.
39.	許顯志, 劉進忠, 李志鋒, 等. 原發性肝癌肝切除術后發生肝功能衰竭的影響因素分析. 現代儀器與醫療, 2017, 23(4): 31-33.
40.	譚蔚鋒, 羅祥基, 張蜀豫, 等. 肝癌伴膽管癌栓術后肝功能衰竭的危險因素分析. 中華消化外科雜志, 2013, 12(3): 217-221.
41.	鄧香萍, 毛曉雪, 趙斌, 等. 原發性肝癌切除后患者血小板計數的恢復情況及臨床意義. 中西醫結合肝病雜志, 2018, 28(3): 173-175.
42.	金昌國, 楊滔, 董家鴻. 肝門部膽管癌大范圍肝切除術前膽道引流作用的臨床研究. 軍事醫學, 2013, 37(7): 529-534.
43.	陳緒濤, 翟健, 張一軍, 等. Child-Pugh A 級肝細胞癌患者術后肝功能衰竭發生的危險因素分析. 肝膽外科雜志, 2012, 20(3): 170-173.
44.	韓秀國, 馬寬生, 夏鋒, 等. 肝硬化肝癌和無肝硬化肝癌患者圍術期肝衰竭和死亡的相關因素分析. 中華消化外科雜志, 2016, 15(6): 605-614.
45.	高娟, 陳琳. 原發性肝癌肝切除患者肝功能衰竭圍術期相關危險因素分析. 健康導報 (醫學版), 2015, 20(7): 49.
46.	龔文鋒, 陸戰, 張志遠, 等. 標準殘肝體積預測肝癌合并肝硬化患者半肝切除術后肝功能衰竭的臨床研究. 中國腫瘤臨床, 2018, 45(5): 232-236.
47.	Balzan S, Belghiti J, Farges O, et al. The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg, 2005, 242(6): 824-828.
48.	Rahbari NN, Garden OJ, Padbury R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery, 2011, 149(5): 713-724.
49.	Bernal W, Lee WM, Wendon J, et al. Acute liver failure: A curable disease by 2024? J Hepatol, 2015, 62(1 Suppl): S112-S120.
50.	Yokoyama Y, Schwacha MG, Samy TS, et al. Gender dimorphism in immune responses following trauma and hemorrhage. Immunol Res, 2002, 26(1-3): 63-76.
51.	Rezvani R, Smith J, Lapointe m, et al. Complement receptors C5aR and C5L2 are associated with metabolic profile, sex hormones, and liver enzymes in obese women pre- and postbariatric surgery. J Obes, 2014, 2014: 383102.
52.	Langella S, Russolillo N, Forchino F, et al. Impact of obesity on postoperative outcome of hepatic resection for colorectal metastases. Surgery, 2015, 158(6): 1521-1529.
53.	Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): E359-E386.
54.	Omata M, Cheng AL, Kokudo N, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int, 2017, 11(4): 317-370.
55.	陳述海, 董冰子, 馮玉杰, 等. 肝部分切除術后影響肝再生的臨床病理學因素研究進展. 肝膽胰外科雜志, 2019, 31(7): 444-449.
56.	張東欣, 姜珊, 董家鴻. 大范圍肝切除術后肝功能衰竭的研究進展. 中國現代普通外科進展, 2015, 18(4): 295-299.
57.	Lisman T, Porte RJ. Mechanisms of platelet-mediated liver regeneration. Blood, 2016, 128(5): 625-629.
58.	Kurokawa T, Ohkohchi N. Platelets in liver disease, cancer and regeneration. World J Gastroenterol, 2017, 23(18): 3228-3239.
59.	Chen JS, Huang JQ, Chen XL, et al. Risk factors associated with intraoperative major blood loss during resection of hepatocellular carcinoma. Hepatogastroenterology, 2015, 62(140): 790-793.
60.	Chapelle T, Op de Beeck B, Roeyen G, et al. Measuring future liver remnant function prior to hepatectomy may guide the indication for portal vein occlusion and avoid posthepatectomy liver failure: a prospective interventional study. HPB (Oxford), 2017, 19(2): 108-117.
61.	Yokoyama Y, Ebata T, Igami T, et al. The predictive value of indocyanine green clearance in future liver remnant for posthepatectomy liver failure following hepatectomy with extrahepatic bile duct resection. World J Surg, 2016, 40(6): 1440-1447.
62.	Tanaka S, Iimuro Y, Hirano T, et al. Prediction of postoperative hepatic failure after liver resection for hepatocellular carcinoma: significance of the aspartate aminotransferase-to-platelet ratio index. Hepatogastroenterology, 2014, 61(131): 755-761.
63.	Bennett S, Baker LK, Martel G, et al. The impact of perioperative red blood cell transfusions in patients undergoing liver resection: a systematic review. HPB (Oxford), 2017, 19(4): 321-330.
64.	Shen Y, Wu SD, Wu L, et al. The prognostic role of liver stiffness in patients with chronic liver disease: a systematic review and dose-response meta-analysis. Hepatol Int, 2019, 13(5): 560-572.
65.	Chebib FT, Harmon A, Irazabal Mira MV, et al. Outcomes and durability of hepatic reduction after combined partial hepatectomy and cyst fenestration for massive polycystic liver disease. J Am Coll Surg, 2016, 223(1): 118-126.
66.	Zheng Y, Yang H, He L, et al. Reassessment of different criteria for diagnosing post-hepatectomy liver failure: a single-center study of 1 683 hepatectomy. Oncotarget, 2017, 8(51): 89269-89277.

1. Sultana A, Brooke-Smith M, Ullah S, et al. Prospective evaluation of the International Study Group for liver surgery definition of post hepatectomy liver failure after liver resection: an international multicentre study. HPB (Oxford), 2018, 20(5): 462-469.
2. Kauffmann R, Fong Y. Post-hepatectomy liver failure. Hepatobiliary Surg Nutr, 2014, 3(5): 238-246.
3. Wells GA, Shea B, O’Connell D, et al. NewCastle-Ottawa Quallty Assessment Scale—case control studies. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
4. Kong FH, Miao XY, Zou H, et al. End-stage liver disease score and future liver remnant volume predict post-hepatectomy liver failure in hepatocellular carcinoma. World J Clin Cases, 2019, 7(22): 3734-3741.
5. Yamamoto G, Taura K, Ikai I, et al. ALPlat criterion for the resection of hepatocellular carcinoma based on a predictive model of posthepatectomy liver failure. Surgery, 2020, 167(2): 410-416.
6. Wang H, Li L, Bo W, et al. Immediate postoperative fibrosis-4 predicts postoperative liver failure for patients with hepatocellular carcinoma undergoing curative surgery. Dig Liver Dis, 2018, 50(1): 61-67.
7. Nitta H, Kitano Y, Miyata T, et al. Validation of functional assessment for liver resection considering venous occlusive area after extended hepatectomy. J Gastrointest Surg, 2020, 24(7): 1510-1519.
8. Jo HS, Kim DS, Jung SW, et al. Clinical significance of post-hepatectomy hepatic failure in patients with liver metastases from colorectal cancer. Ann Hepatobiliary Pancreat Surg, 2018, 22(2): 93-100.
9. Nakamura I, Iimuro Y, Hai S, et al. Impaired value of ^99mTc-GSA scintigraphy as an independent risk factor for posthepatectomy liver failure in patients with hepatocellular carcinoma. Eur Surg Res, 2018, 59(1-2): 12-22.
10. Lei JW, Ji XY, Hong JF, et al. Prediction of posthepatectomy liver failure using transient elastography in patients with hepatitis B related hepatocellular carcinoma. BMC Gastroenterol, 2017, 17(1): 171.
11. Navarro JG, Yang SJ, Kang I, et al. What are the most important predictive factors for clinically relevant posthepatectomy liver failure after right hepatectomy for hepatocellular carcinoma? Ann Surg Treat Res, 2020, 98(2): 62-71.
12. Fukushima K, Fukumoto T, Kuramitsu K, et al. Assessment of ISGLS definition of posthepatectomy liver failure and its effect on outcome in patients with hepatocellular carcinoma. J Gastrointest Surg, 2014, 18(4): 729-736.
13. Iguchi K, Hatano E, Yamanaka K, et al. The impact of posthepatectomy liver failure on the recurrence of hepatocellular carcinoma. World J Surg, 2014, 38(1): 150-158.
14. Olthof PB, Wiggers JK, Groot Koerkamp B, et al. Postoperative liver failure risk score: identifying patients with resectable perihilar cholangiocarcinoma who can benefit from portal vein embolization. J Am Coll Surg, 2017, 225(3): 387-394.
15. Mai RY, Ye JZ, Long ZR, et al. Preoperative aspartate aminotransferase-to-platelet-ratio index as a predictor of posthepatectomy liver failure for resectable hepatocellular carcinoma. Cancer Manag Res, 2019, 11: 1401-1414.
16. Zhou SJ, Zhang EL, Liang BY, et al. Morphologic severity of cirrhosis determines the extent of liver resection in patients with hepatocellular carcinoma and Child-Pugh grade A cirrhosis. J Surg Res, 2016, 200(2): 444-451.
17. Chapelle T, Op de Beeck B, Driessen A, et al. Estimation of the future remnant liver function is a better tool to predict post-hepatectomy liver failure than platelet-based liver scores. Eur J Surg Oncol, 2017, 43(12): 2277-2284.
18. Nishio T, Taura K, Koyama Y, et al. Prediction of posthepatectomy liver failure based on liver stiffness measurement in patients with hepatocellular carcinoma. Surgery, 2016, 159(2): 399-408.
19. Peng W, Li J, Zhang X, et al. A novel model for predicting posthepatectomy liver failure in patients with hepatocellular carcinoma. PLoS One, 2019, 14(7): e0219219.
20. Chen X, Zhai J, Cai X, et al. Severity of portal hypertension and prediction of postoperative liver failure after liver resection in patients with Child-Pugh grade A cirrhosis. Br J Surg, 2012, 99(12): 1701-1710.
21. Lin XJ, Yang J, Chen XB, et al. The critical value of remnant liver volume-to-body weight ratio to estimate posthepatectomy liver failure in cirrhotic patients. J Surg Res, 2014, 188(2): 489-495.
22. Shen Y, Zhou C, Zhu G, et al. Liver stiffness assessed by shear wave elastography predicts postoperative liver failure in patients with hepatocellular carcinoma. J Gastrointest Surg, 2017, 21(9): 1471-1479.
23. Miyazaki Y, Kokudo T, Amikura K, et al. Albumin-indocyanine green evaluation grading system predicts post-hepatectomy liver failure for biliary tract cancer. Dig Surg, 2019, 36(1): 13-19.
24. Tomimaru Y, Eguchi H, Gotoh K, et al. Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test. J Surg Oncol, 2016, 113(5): 565-569.
25. Jin YJ, Lee SH, Cho SG, et al. Prediction of postoperative liver failure using gadoxetic acid-enhanced magnetic resonance imaging in patients with hepatocellular carcinoma. J Gastroenterol Hepatol, 2016, 31(7): 1349-1356.
26. 劉朔琿, 嚴俊, 張奇煜, 等. 白蛋白-膽紅素評分聯合標準化殘肝體積比對肝細胞癌患者肝切除術后肝功能衰竭的預測價值. 中國普外基礎與臨床雜志, 2019, 26(5): 545-550.
27. 劉朝輝, 杜振雙, 林建泉, 等. 原發性肝癌肝切除術后發生肝功能衰竭的圍術期影響因素分析. 肝膽外科雜志, 2016, 24(5): 375-377.
28. 崔宏, 高琴琴, 王效益, 等. 肝細胞癌合并肝硬化患者肝切除術后標準殘肝體積評估. 中國現代普通外科進展, 2019, 22(4): 296-299.
29. 張毅, 張杰峰, 張艷林, 等. 聯合半肝切除的肝門部膽管癌根治術后發生急性肝衰竭的危險因素分析. 臨床肝膽病雜志, 2016, 32(10): 1936-1938.
30. 徐逸昕, 金雷, 陸維軍, 等. 原發性肝癌切除術后肝功能衰竭的臨床分析. 常州實用醫學, 2013, 29(4): 217-219.
31. 曾勇超, 戴朝六, 卜獻民, 等. ALBI 評分與 Child-Pugh 評分對肝癌肝切除術后肝衰竭預測的比較. 中華普通外科雜志, 2019, 34(8): 649-651.
32. 曾柏強, 吳祥, 冉義洪, 等. 大范圍肝切除術后肝衰竭危險因素分析. 中華肝臟外科手術學電子雜志, 2018, 7(2): 143-146.
33. 李昊, 張宏偉, 唐強, 等. 吲哚菁綠試驗與白蛋白-膽紅素評分對肝切除術后肝功能衰竭的預測作用. 中華實用診斷與治療雜志, 2019, 33(11): 1069-1072.
34. 柳己海, 鄭小林, 鄭直, 等. 原發性肝癌肝切除術后患者發生肝功能衰竭的圍術期危險因素分析. 中國全科醫學, 2013, 16(17): 2036-2038.
35. 江勇, 湯建軍, 遠博. 大肝癌術后肝衰竭的防治. 醫學研究雜志, 2011, 40(1): 77-79.
36. 熊邦文, 侯琨. 原發性肝癌肝切除后發生肝功能衰竭的圍術期相關危險因素. 中國當代醫藥, 2013, 20(25): 12-13, 16.
37. 蘇瑛, 龔昭. 肝癌伴膽管癌栓患者術后發生肝功能衰竭的影響因素研究. 實用癌癥雜志, 2014, 29(2): 233-236.
38. 薄飛, 王燕, 杜建文. 白蛋白-膽紅素評分、吲哚箐綠 15 min 清除率與肝癌肝切除后發生肝衰的關系. 中國普通外科雜志, 2020, 29(1): 115-119.
39. 許顯志, 劉進忠, 李志鋒, 等. 原發性肝癌肝切除術后發生肝功能衰竭的影響因素分析. 現代儀器與醫療, 2017, 23(4): 31-33.
40. 譚蔚鋒, 羅祥基, 張蜀豫, 等. 肝癌伴膽管癌栓術后肝功能衰竭的危險因素分析. 中華消化外科雜志, 2013, 12(3): 217-221.
41. 鄧香萍, 毛曉雪, 趙斌, 等. 原發性肝癌切除后患者血小板計數的恢復情況及臨床意義. 中西醫結合肝病雜志, 2018, 28(3): 173-175.
42. 金昌國, 楊滔, 董家鴻. 肝門部膽管癌大范圍肝切除術前膽道引流作用的臨床研究. 軍事醫學, 2013, 37(7): 529-534.
43. 陳緒濤, 翟健, 張一軍, 等. Child-Pugh A 級肝細胞癌患者術后肝功能衰竭發生的危險因素分析. 肝膽外科雜志, 2012, 20(3): 170-173.
44. 韓秀國, 馬寬生, 夏鋒, 等. 肝硬化肝癌和無肝硬化肝癌患者圍術期肝衰竭和死亡的相關因素分析. 中華消化外科雜志, 2016, 15(6): 605-614.
45. 高娟, 陳琳. 原發性肝癌肝切除患者肝功能衰竭圍術期相關危險因素分析. 健康導報 (醫學版), 2015, 20(7): 49.
46. 龔文鋒, 陸戰, 張志遠, 等. 標準殘肝體積預測肝癌合并肝硬化患者半肝切除術后肝功能衰竭的臨床研究. 中國腫瘤臨床, 2018, 45(5): 232-236.
47. Balzan S, Belghiti J, Farges O, et al. The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg, 2005, 242(6): 824-828.
48. Rahbari NN, Garden OJ, Padbury R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery, 2011, 149(5): 713-724.
49. Bernal W, Lee WM, Wendon J, et al. Acute liver failure: A curable disease by 2024? J Hepatol, 2015, 62(1 Suppl): S112-S120.
50. Yokoyama Y, Schwacha MG, Samy TS, et al. Gender dimorphism in immune responses following trauma and hemorrhage. Immunol Res, 2002, 26(1-3): 63-76.
51. Rezvani R, Smith J, Lapointe m, et al. Complement receptors C5aR and C5L2 are associated with metabolic profile, sex hormones, and liver enzymes in obese women pre- and postbariatric surgery. J Obes, 2014, 2014: 383102.
52. Langella S, Russolillo N, Forchino F, et al. Impact of obesity on postoperative outcome of hepatic resection for colorectal metastases. Surgery, 2015, 158(6): 1521-1529.
53. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): E359-E386.
54. Omata M, Cheng AL, Kokudo N, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int, 2017, 11(4): 317-370.
55. 陳述海, 董冰子, 馮玉杰, 等. 肝部分切除術后影響肝再生的臨床病理學因素研究進展. 肝膽胰外科雜志, 2019, 31(7): 444-449.
56. 張東欣, 姜珊, 董家鴻. 大范圍肝切除術后肝功能衰竭的研究進展. 中國現代普通外科進展, 2015, 18(4): 295-299.
57. Lisman T, Porte RJ. Mechanisms of platelet-mediated liver regeneration. Blood, 2016, 128(5): 625-629.
58. Kurokawa T, Ohkohchi N. Platelets in liver disease, cancer and regeneration. World J Gastroenterol, 2017, 23(18): 3228-3239.
59. Chen JS, Huang JQ, Chen XL, et al. Risk factors associated with intraoperative major blood loss during resection of hepatocellular carcinoma. Hepatogastroenterology, 2015, 62(140): 790-793.
60. Chapelle T, Op de Beeck B, Roeyen G, et al. Measuring future liver remnant function prior to hepatectomy may guide the indication for portal vein occlusion and avoid posthepatectomy liver failure: a prospective interventional study. HPB (Oxford), 2017, 19(2): 108-117.
61. Yokoyama Y, Ebata T, Igami T, et al. The predictive value of indocyanine green clearance in future liver remnant for posthepatectomy liver failure following hepatectomy with extrahepatic bile duct resection. World J Surg, 2016, 40(6): 1440-1447.
62. Tanaka S, Iimuro Y, Hirano T, et al. Prediction of postoperative hepatic failure after liver resection for hepatocellular carcinoma: significance of the aspartate aminotransferase-to-platelet ratio index. Hepatogastroenterology, 2014, 61(131): 755-761.
63. Bennett S, Baker LK, Martel G, et al. The impact of perioperative red blood cell transfusions in patients undergoing liver resection: a systematic review. HPB (Oxford), 2017, 19(4): 321-330.
64. Shen Y, Wu SD, Wu L, et al. The prognostic role of liver stiffness in patients with chronic liver disease: a systematic review and dose-response meta-analysis. Hepatol Int, 2019, 13(5): 560-572.
65. Chebib FT, Harmon A, Irazabal Mira MV, et al. Outcomes and durability of hepatic reduction after combined partial hepatectomy and cyst fenestration for massive polycystic liver disease. J Am Coll Surg, 2016, 223(1): 118-126.
66. Zheng Y, Yang H, He L, et al. Reassessment of different criteria for diagnosing post-hepatectomy liver failure: a single-center study of 1 683 hepatectomy. Oncotarget, 2017, 8(51): 89269-89277.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Risk factors of posthepatectomy liver failure for hepatobiliary malignancies: a meta-analysis

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