Clinical analysis of clinicopathologic factors affecting perineural invasion of pancreatic carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WU Guangbo , FAN Qiang ,  LUO Meng

Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201999, P. R. China;

Corresponding?author：

LUO Meng, Email: luotysy@sina.com

Keywords：

pancreatic carcinoma; perineural invasion; clinicopathological factor

DOI：

10.7507/1007-9424.202007044

Video：

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Objective To explore the correlation between multiple clinicopathologic factors and perineural invasion in patients with pancreatic carcinoma.Methods The clinical data of 90 patients with pancreatic carcinoma in the Department of General Surgery of Shanghai Ninth People’s Hospital of Shanghai JiaoTong University School of Medicine from January 2012 to January 2020 were retrospectively collected. We collected clinical data such as patient medical records, surgical records, nursing records, examination reports, pathological reports, and studied the parameters that affect the occurrence of perineural invasion in patients with pancreatic carcinoma.Results Among 90 patients with pancreatic carcinoma, 47 cases had perineural invasion and 43 cases had no perineural invasion. The univariate analysis results showed that perineural invasion was associated with abdominal pain and low back pain, levels of fasting blood glucose, glycosylated hemoglobin, CA19-9, carcinoembryonic antigen (CEA), and bilirubin, as well as tumor location, TNM stage, differentiation degree, lymph node metastasis, vascular cancer thrombus, peripheral invasion, and expression of p53 (P<0.05). Binary logistic regression analysis showed that abdominal or lower back pain, increased fasting blood glucose, tumor with invasion of surrounding tissues, and p53-positive expression were the independent risk factors for perineural invasion of pancreatic carcinoma (P<0.05).Conclusion Patients with pancreatic carcinoma have abdominal or lower back pain, elevated fasting blood glucose before surgery, tumor with surrounding tissue invasion, and p53-positive expression are independent risk factors for perineural invasion, which should be paid attention to.

Citation： WU Guangbo, FAN Qiang, LUO Meng. Clinical analysis of clinicopathologic factors affecting perineural invasion of pancreatic carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(4): 452-456. doi: 10.7507/1007-9424.202007044 Copy

1.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin, 2019, 69(1): 7-34.
2.	Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol, 2016, 22(44): 9694-9705.
3.	Jutric Z, Melstrom LG. New treatment options and management considerations in borderline resectable pancreatic cancer. Oncology (Williston Park), 2017, 31(6): 443-452.
4.	李仁濤, 李強. 胰十二指腸切除術中胰腸吻合的優化研究以及胰腺癌術后復發轉移模式的多參數臨床研究. 天津醫科大學, 2019.
5.	Dunn M, Morgan MB, Beer TW. Perineural invasion: identification, significance, and a standardized definition. Dermatol Surg, 2009, 35(2): 214-221.
6.	Sakuta M. One hundred books which built up neurology (35)—Cruveilhier J “Anatomie Pathologique du Corps Humain” (1829-1842). Brain Nerve, 2009, 61(11): 1354-1355.
7.	Liebig C, Ayala G, Wilks JA, et al. Perineural invasion in cancer: a review of the literature. Cancer, 2009, 115(15): 3379-3391.
8.	Chen SH, Zhang BY, Zhou B, et al. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. Am J Cancer Res, 2019, 9(1): 1-21.
9.	Yang YH, Liu JB, Gui Y, et al. Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer. World J Gastroenterol, 2017, 23(40): 7232-7241.
10.	Chen JW, Bhandari M, Astill DS, et al. Predicting patient survival after pancreaticoduodenectomy for malignancy: histopathological criteria based on perineural infiltration and lymphovascular invasion. HPB (Oxford), 2010, 12(2): 101-108.
11.	Chatterjee D, Katz MH, Rashid A, et al. Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. Am J Surg Pathol, 2012, 36(3): 409-417.
12.	Deshmukh SD, Willmann JK, Jeffrey RB. Pathways of extrapancreatic perineural invasion by pancreatic adenocarcinoma: evaluation with 3D volume-rendered MDCT imaging. AJR Am J Roentgenol, 2010, 194(3): 668-674.
13.	Makino I, Kitagawa H, Ohta T, et al. Nerve plexus invasion in pancreatic cancer: spread patterns on histopathologic and embryological analyses. Pancreas, 2008, 37(4): 358-365.
14.	Kawarada Y. New classification of pancreatic carcinoma–Japan Pancreas Society. Nihon Shokakibyo Gakkai Zasshi, 2003, 100(8): 974-980.
15.	Wang X, Zhang H, Wang T, et al. The concept and controversy of retroperitoneal nerve dissection in pancreatic head carcinoma (Review). Int J Oncol, 2015, 47(6): 2017-2027.
16.	中國抗癌協會胰腺癌專業委員會. 胰腺癌綜合診治指南(2018 版). 中華外科雜志, 2018, 56(7): 481-494.
17.	Chun YS, Pawlik TM, Vauthey JN. 8th Edition of the AJCC Cancer Staging Manual: Pancreas and Hepatobiliary Cancers. Ann Surg Oncol, 2018, 25(4): 845-847.
18.	中華醫學會糖尿病學分會. 中國 2 型糖尿病防治指南(2017 年版). 中華糖尿病雜志, 2018, 10(1): 4-67.
19.	Demir IE, Ceyhan GO, Liebl F, et al. Neural invasion in pancreatic cancer: the past, present and future. Cancers (Basel), 2010, 2(3): 1513-1527.
20.	楊延輝, 張玉祥, 桂洋, 等. 胰腺癌與細胞自噬、神經浸潤的關系. 臨床肝膽病雜志, 2018, 34(11): 2475-2479.
21.	Danigo A, Magy L, Demiot C. TRPV1 in neuropathic pain: from animal models to therapeutical prospects. Med Sci (Paris), 2013, 29(6-7): 597-606.
22.	Gasparini G, Pellegatta M, Crippa S, et al. nerves and pancreatic cancer: new insights into a dangerous relationship. Cancers (Basel), 2019, 11(7): 893.
23.	Rahn S, Zimmermann V, Viol F, et al. Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells. Cancer Lett, 2018, 415: 129-150.
24.	Lin QJ, Yang F, Jin C, et al. Current status and progress of pancreatic cancer in China. World J Gastroenterol, 2015, 21(26): 7988-8003.
25.	Ryu TY, Park J, Scherer PE. Hyperglycemia as a risk factor for cancer progression. Diabetes Metab J, 2014, 38(5): 330-336.
26.	Yang J, Li X, Yang R, et al. Susceptibility-weighted imaging manifestations in the brain of Wilson’s disease patients. PLoS One, 2015, 10(4): e0125100.
27.	Kazama S, Watanabe T. Diagnosis of colorectal cancer by measurement of tumor markers. Nihon Rinsho, 2014, 72(1): 71-76.
28.	Goh SK, Gold G, Christophi C, et al. Serum carbohydrate antigen 19-9 in pancreatic adenocarcinoma: a mini review for surgeons. ANZ J Surg, 2017, 87(12): 987-992.
29.	Shimada K, Nara S, Esaki M, et al. Intrapancreatic nerve invasion as a predictor for recurrence after pancreaticoduodenectomy in patients with invasive ductal carcinoma of the pancreas. Pancreas, 2011, 40(3): 464-468.
30.	Mirza A, McGuirk M, Hockenberry TN, et al. Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene, 2002, 21(17): 2613-2622.
31.	Rosenfeldt MT, O’Prey J, Morton JP, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature, 2013, 504(7479): 296-300.
32.	陳汝福, 周泉波. 胰頭癌行根治性胰十二指腸切除術神經清掃指征與技巧. 中國實用外科雜志, 2016, 36(8): 847-850.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin, 2019, 69(1): 7-34.
2. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol, 2016, 22(44): 9694-9705.
3. Jutric Z, Melstrom LG. New treatment options and management considerations in borderline resectable pancreatic cancer. Oncology (Williston Park), 2017, 31(6): 443-452.
4. 李仁濤, 李強. 胰十二指腸切除術中胰腸吻合的優化研究以及胰腺癌術后復發轉移模式的多參數臨床研究. 天津醫科大學, 2019.
5. Dunn M, Morgan MB, Beer TW. Perineural invasion: identification, significance, and a standardized definition. Dermatol Surg, 2009, 35(2): 214-221.
6. Sakuta M. One hundred books which built up neurology (35)—Cruveilhier J “Anatomie Pathologique du Corps Humain” (1829-1842). Brain Nerve, 2009, 61(11): 1354-1355.
7. Liebig C, Ayala G, Wilks JA, et al. Perineural invasion in cancer: a review of the literature. Cancer, 2009, 115(15): 3379-3391.
8. Chen SH, Zhang BY, Zhou B, et al. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. Am J Cancer Res, 2019, 9(1): 1-21.
9. Yang YH, Liu JB, Gui Y, et al. Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer. World J Gastroenterol, 2017, 23(40): 7232-7241.
10. Chen JW, Bhandari M, Astill DS, et al. Predicting patient survival after pancreaticoduodenectomy for malignancy: histopathological criteria based on perineural infiltration and lymphovascular invasion. HPB (Oxford), 2010, 12(2): 101-108.
11. Chatterjee D, Katz MH, Rashid A, et al. Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. Am J Surg Pathol, 2012, 36(3): 409-417.
12. Deshmukh SD, Willmann JK, Jeffrey RB. Pathways of extrapancreatic perineural invasion by pancreatic adenocarcinoma: evaluation with 3D volume-rendered MDCT imaging. AJR Am J Roentgenol, 2010, 194(3): 668-674.
13. Makino I, Kitagawa H, Ohta T, et al. Nerve plexus invasion in pancreatic cancer: spread patterns on histopathologic and embryological analyses. Pancreas, 2008, 37(4): 358-365.
14. Kawarada Y. New classification of pancreatic carcinoma–Japan Pancreas Society. Nihon Shokakibyo Gakkai Zasshi, 2003, 100(8): 974-980.
15. Wang X, Zhang H, Wang T, et al. The concept and controversy of retroperitoneal nerve dissection in pancreatic head carcinoma (Review). Int J Oncol, 2015, 47(6): 2017-2027.
16. 中國抗癌協會胰腺癌專業委員會. 胰腺癌綜合診治指南(2018 版). 中華外科雜志, 2018, 56(7): 481-494.
17. Chun YS, Pawlik TM, Vauthey JN. 8th Edition of the AJCC Cancer Staging Manual: Pancreas and Hepatobiliary Cancers. Ann Surg Oncol, 2018, 25(4): 845-847.
18. 中華醫學會糖尿病學分會. 中國 2 型糖尿病防治指南(2017 年版). 中華糖尿病雜志, 2018, 10(1): 4-67.
19. Demir IE, Ceyhan GO, Liebl F, et al. Neural invasion in pancreatic cancer: the past, present and future. Cancers (Basel), 2010, 2(3): 1513-1527.
20. 楊延輝, 張玉祥, 桂洋, 等. 胰腺癌與細胞自噬、神經浸潤的關系. 臨床肝膽病雜志, 2018, 34(11): 2475-2479.
21. Danigo A, Magy L, Demiot C. TRPV1 in neuropathic pain: from animal models to therapeutical prospects. Med Sci (Paris), 2013, 29(6-7): 597-606.
22. Gasparini G, Pellegatta M, Crippa S, et al. nerves and pancreatic cancer: new insights into a dangerous relationship. Cancers (Basel), 2019, 11(7): 893.
23. Rahn S, Zimmermann V, Viol F, et al. Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells. Cancer Lett, 2018, 415: 129-150.
24. Lin QJ, Yang F, Jin C, et al. Current status and progress of pancreatic cancer in China. World J Gastroenterol, 2015, 21(26): 7988-8003.
25. Ryu TY, Park J, Scherer PE. Hyperglycemia as a risk factor for cancer progression. Diabetes Metab J, 2014, 38(5): 330-336.
26. Yang J, Li X, Yang R, et al. Susceptibility-weighted imaging manifestations in the brain of Wilson’s disease patients. PLoS One, 2015, 10(4): e0125100.
27. Kazama S, Watanabe T. Diagnosis of colorectal cancer by measurement of tumor markers. Nihon Rinsho, 2014, 72(1): 71-76.
28. Goh SK, Gold G, Christophi C, et al. Serum carbohydrate antigen 19-9 in pancreatic adenocarcinoma: a mini review for surgeons. ANZ J Surg, 2017, 87(12): 987-992.
29. Shimada K, Nara S, Esaki M, et al. Intrapancreatic nerve invasion as a predictor for recurrence after pancreaticoduodenectomy in patients with invasive ductal carcinoma of the pancreas. Pancreas, 2011, 40(3): 464-468.
30. Mirza A, McGuirk M, Hockenberry TN, et al. Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene, 2002, 21(17): 2613-2622.
31. Rosenfeldt MT, O’Prey J, Morton JP, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature, 2013, 504(7479): 296-300.
32. 陳汝福, 周泉波. 胰頭癌行根治性胰十二指腸切除術神經清掃指征與技巧. 中國實用外科雜志, 2016, 36(8): 847-850.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical analysis of clinicopathologic factors affecting perineural invasion of pancreatic carcinoma

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