Analysis of clinical symptoms of digestive system in patients with COVID-19_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIANG Tao ,  MAI Gang , WANG Qiaoli , SONG Xiongfeng , WU Zhixuan , WANG Zhicong

COVID-19 Treatment Team, Peoples’ Hospital of Deyang City, Deyang, Sichuan 618000, R. P. China;

Corresponding?author：

MAI Gang, Email: maigang68@hotmail.com

Keywords：

COVID-19; SARS-Cov-2 nucleic acid; digestive tract symptom; liver function; feces

DOI：

10.7507/1007-9424.202002061

Video：

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Objective To investigate whether novel coronavirus pneumonia (COVID-19) patients complicated with digestive tract symptoms and its influence on digestive system related biochemical indexes.Methods Sixteen novel coronavirus pneumonia patients in our hospital were observed, and their epidemiological data, clinical manifestations and clinical laboratory indicators were analyzed statistically.Results The age of the patients ranged from 5 to 75 years old, and the median age was 46.0 years old. Most of them were male (9 cases, 56.25%), the occurrence of COVID-19 appeared in family aggregation (12 cases, 75.00%). Sixt patients (37.50%) were complicated with basic diseases. The initial symptom involving digestive system accounting for 18.75% (3 cases) of all participants. The main manifestation of a diarrhea in 2 (12.5%) and melena in 1 (6.25%) patients, respectively. Five patients (31.25%) had symptoms of digestive system during the course of the disease, the main symptoms were diarrhea in 3 (18.75%), melena in 1 (6.25%) and loss of appetitein in 5 (31.25%) patients, respectively. The SARS-Cov-2 nucleic acid in the feces of the patients were negative in all patients. In 50.00% of the patients, the SARS-Cov-2 nucleic acid in the feces were negative, but the throat swab/sputum nucleic acid were still positive at the same time or later. Two patients (12.50%) had elevated ALT and 1 patient (6.25%) had elevated AST at the time of admission.Conclusions Patients with COVID-19 will show symptoms of digestive tract.

Citation： LIANG Tao, MAI Gang, WANG Qiaoli, SONG Xiongfeng, WU Zhixuan, WANG Zhicong. Analysis of clinical symptoms of digestive system in patients with COVID-19. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 785-789. doi: 10.7507/1007-9424.202002061 Copy

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1. 楊小玲, 萬娟, 任秋平, 等. 新型冠狀病毒感染肺炎疫情下肝移植受者住院及居家防控策略. 中國普外基礎與臨床雜志, 2020, 27(4): 393-395.
2. 呂濤, 楊家印, 嚴律南, 等. 新型冠狀病毒性肺炎疫情時期器官移植調整策略及體會. 中國普外基礎與臨床雜志, 2020, 27(3): 261-264.
3. 國家衛生健康委辦公廳, 國家中醫藥管理局辦公室. 新型冠狀病毒感染的肺炎診療方案(試行第五版). 國衛辦醫涵[2020] 103號. 2020-02-04. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml.
4. Yeo C, Kaushal S, Yeo D, et al. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol, 2020, 5(4): 335-337.
5. 王文辰, 夏彥明, 朱建飛, 等. 血管緊張素轉換酶 2 在人類高致病性冠狀病毒肺炎中作用的研究進展. 中國胸心血管外科臨床雜雜, 2020, 27(5): 588-596.
6. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, 395(10223): 497-506.
7. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 2020, 395(10223): 507-513.
8. Hashimoto T, Perlot T, Rehman A, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature, 2012, 487(7408): 477-481.
9. 劉川, 江自成, 邵初曉, 等. 新型冠狀病毒肺炎與肝功能損傷的關系初探: 一項多中心研究. 中華肝臟病雜志, 2020, 28(2): 148-152.
10. Qi F, Qian S, Zhang S, et al. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. Biochem Biophys Res Commun, 2020, 526(1): 135-140.
11. 李萍, 趙四林, 陳煜楓, 等. 2 例新型冠狀病毒肺炎糞便 SARS-CoV-2 核酸陽性臨床啟示. 國際檢驗醫學雜志, 2020, 41(4): 385-388.
12. Gao QY, Chen YX, Fang JY, et al. 2019 novel coronavirus infection and gastrointestinal tract. J Dig Dis, 2020, 21(3): 125-126.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of clinical symptoms of digestive system in patients with COVID-19

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