Summary in etiologies, prevention and treatment strategies of recurrent acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

KANG Hongxin , LI Junyi , TANG Wenfu ,  WAN Meihua

Department of Integartive Medicine, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

WAN Meihua, Email: meihuawan@hotmail.com

Keywords：

recurrent acute pancreatitis; etiologies; prevention and treatment strategies; review

DOI：

10.7507/1007-9424.201911007

Video：

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Objective To summarize and analyze the etiologies of recurrent acute pancreatitis (RAP) and then conclude the prevention and treatment strategies.Method Searching relevant literatures of PubMed, CNKI, Wanfang data and other databases in recent years, the etiologies of RAP were analysed and reviewed, then the prevention and treatment strategies were developed.Results The causes of RAP included abnormal function and structure of biliopancreatic duct, metabolic factors, bad living habits, genetic factors and so on. Then based on etiologies of RAP, prevention and treatment strategies of it were summarized.Conclusions With the developments of related researches and clinical diagnosis and treatment technologies, the etiologies of RAP are gradually revealed. It is of great significance to clarify the etiologies of RAP and make prevention and treatment strategies for reducing the recurrence of acute pancreatitis.

Citation： KANG Hongxin, LI Junyi, TANG Wenfu, WAN Meihua. Summary in etiologies, prevention and treatment strategies of recurrent acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 895-900. doi: 10.7507/1007-9424.201911007 Copy

1.	Garg PK, Singh VP. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology, 2019, 156(7): 2008-2023.
2.	彭莉, 彭燕, 蒲垠全, 等. 671 例復發性急性胰腺炎臨床特點及危險因素分析. 實用醫學雜志, 2019, 35(18): 2924-2928.
3.	Sankaran SJ, Xiao AY, Wu LM, et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology, 2015, 149(6): 1490-1500.
4.	班猛猛, 史煉鋼, 王東, 等. 復發性急性胰腺炎危險因素研究進展. 大連醫科大學學報, 2018, 27(2): 171-175, 180.
5.	季鈞淘, 張菂, 辛磊, 等. 復發性急性胰腺炎診斷與治療研究進展. 中華胰腺病雜志, 2016, 16(3): 203-205.
6.	高艷景, 李延青, 黃柳業, 等. 山東省 157 例復發性急性胰腺炎病因和復發特征分析. 山東大學學報(醫學版), 2005, 43(7): 605-608.
7.	溫彥麗, 郝婷婷, 戴光榮, 等. 急性復發性胰腺炎 288 例病因分析. 陜西醫學雜志, 2015, 44(1): 68-70.
8.	那賓. 復發性急性胰腺炎病因學分析. 武漢: 華中科技大學, 2012: 3-10.
9.	何希平, 胡康, 劉洙秀. 復發性胰腺炎的病因與治療. 吉林醫學, 2014, 35(20): 4520.
10.	陳灝珠, 林果為, 王吉耀. 實用內科學. 第 14 版. 北京:人民衛生出版社, 2014: 2015-2057.
11.	畢旭東, 付曉光, 唐樹相, 等. 急性胰腺炎反復發作病因的臨床研究. 錦州醫學院學報, 2003, 24(6): 12-13.
12.	張肇達, 嚴律南, 劉續寶. 急性胰腺炎. 北京: 人民衛生出版社, 2006: 54-55.
13.	曾慶煜, 汪麗燕. Oddi 括約肌功能障礙研究新進展. 世界最新醫學信息文摘, 2019, 19(99): 100-102.
14.	Afghani E, Lo SK, Covington PS, et al. Sphincter of Oddi function and risk factors for dysfunction. Front Nutr, 2017, 4(1): 1-9.
15.	Brawman-Mintzer O, Durkalski V, Wu Q, et al. Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. Am J Gastroenterol, 2014, 109(3): 436-442.
16.	Sonoda Y, Kawamoto M, Woods CN, et al. Sphincter of Oddi function in the Australian brush-tailed possum is inhibited by intragastric ethanol. Neurogastroenterol Motil, 2007, 19(5): 401-10.
17.	Mousavi S, Toussy J, Zahmatkesh M. Opium addiction as a new risk factor of sphincter of Oddi dysfunction. Med Sci Monit, 2007, 13(11): CR528-CR531.
18.	Fernandes SR, Correia LA, Antunes T, et al. Intraductal papillary mucinous neoplasm presenting with recurrent pancreatitis: a report of a painful 3-decade-long history. BMJ Case Rep, 2016, 2016. pii: bcr2016214640.
19.	Bolado F, Tarifa A, Zazpe C, et al. Acute recurrent pancreatitis secondary to hepatocellular carcinoma invading the biliary tree. Pancreatology, 2015, 15(2): 191-193.
20.	Tadic M, Cabrijan Z, Stoos-Veic T, et al. Lymphangioma as a rare cause of acute recurrent pancreatitis. Endoscopy, 2014, 46 Suppl 1 UCTN: E598-E599.
21.	Asimakopoulou NI, Papakonstantinou PE, Lasithiotakis KG, et al. Recurrent episodes of acute pancreatitis due to duodenal gangliocytic paraganglioma: report of a case. JOP, 2014, 15(2): 201-205.
22.	Patel YA, Dhalla S, Olson MT, et al. Pancreatic metastasis from a solitary fibrous tumor of the kidney: a rare cause of acute recurrent pancreatitis. Pancreatology, 2013, 13(6): 631-633.
23.	吳長安, 陳麗娜. 高脂血癥性急性胰腺炎的臨床特點分析. 臨床醫學, 2019, 39(6): 7-9.
24.	丁巖冰, 路國濤, 藍宇, 等. 高脂血癥性急性胰腺炎 130 例. 世界華人消化雜志, 2013, 21(3): 266-271.
25.	杜奕奇, 陳其奎, 李宏宇, 等. 中國急性胰腺炎診治指南(2019 年, 沈陽). 臨床肝膽病雜志, 2019, 35(12): 2706-2711.
26.	李左軍, 張曄. 高脂血癥與胰腺炎關系及治療. 疾病監測與控制, 2017, 11(1): 69-70.
27.	劉東, 付文廣, 李秋. 高脂血癥性急性胰腺炎發病機制研究進展. 現代醫藥衛生, 2015, 31(23): 3585-3588.
28.	牛蕾, 葛春. 急性復發性胰腺炎與高脂血癥的互為因果關系及臨床特點. 世界華人消化雜志, 2016, 24(30): 4205-4210.
29.	Ward JB, Petersen OH, Jenkins SA, et al. Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis. Lancet, 1995, 346(8981): 1016-1019.
30.	陳偉, 姜琦, 周國雄. 高脂血癥性急性胰腺炎微循環障礙研究進展. 中國血液流變學雜志, 2014, 24(1): 182-185.
31.	Takeyama Y. Long-term prognosis of acute pancreatitis in Japan. Clin Gastroenterol Hepatol, 2009, 7(11 Suppl): S15-S17.
32.	李文婷, 黨彤. 復發性急性胰腺炎病因的研究進展. 胃腸病學, 2018, 23(6): 378-381.
33.	Nikkola J, R?ty S, Laukkarinen J, et al. Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol, 2013, 48(4): 483-486.
34.	Sadr-Azodi O, Andrén-Sandberg ?, Orsini N, et al. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study. Gut, 2012, 61(2): 262-267.
35.	Martínez-Barona S, Ribes-Koninckx C. Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. Rev Esp Enferm Dig, 2017, 109(6): 478-479.
36.	Avanthi US, Bale G, Aslam M, et al. PRSS1 (R122H) mutation in an Indian family with low penetrance is associated with pancreatitis phenotype. Indian J Gastroenterol, 2018, 37(1): 67-69.
37.	Németh BC, Sahin-Tóth M. Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol, 2014, 306(6): G466-G473.
38.	Lee YJ, Kim KM, Choi JH, et al. High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr, 2011, 52(4): 478-481.
39.	Aoun E, Muddana V, Papachristou GI, et al. SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. Am J Gastroenterol, 2010, 105(2): 446-451.
40.	Liu X, Tu M, Dai X, et al. PRSS1 and SPINK1 Mutations in Alcoholic and Idiopathic Chronic Pancreatitis. J Nanosci Nanotechnol, 2017, 17(4): 2358-2362.
41.	Woods GN, Saitman A, Gao H, et al. A young woman with recurrent gestational hypercalcemia and acute pancreatitis caused by CYP24A1 deficiency. J Bone Miner Res, 2016, 31(10): 1841-1844.
42.	徐銘益, 王興鵬, 吳愷. 高脂血癥性急性胰腺炎脂蛋白脂酶基因多態性研究. 中華消化雜志, 2008, 28(9): 600-603.
43.	朱世峰, 李娟, 趙先林, 等. 熟大黃調控酒精性胰腺炎性損傷記憶的表觀遺傳機制研究. 第十二次全國中西醫結合實驗醫學專業委員會暨第七次湖南省中西醫結合神經科專業委員會學術年會, 長沙, 2015: 42-44.
44.	尚海濤, 李忠廉. 自身免疫性胰腺炎的診斷. 天津醫藥, 2019, 47(7): 771-776.
45.	Kaurich T. Drug-induced acute pancreatitis. Proc (Bayl Univ Med Cent), 2008, 21(1): 77-81.
46.	何文華, 呂農華. 藥物性胰腺炎. 臨床內科雜志, 2012, 29(2): 79-81.
47.	鄭本波, 劉山, 陽勇. 復發性急性胰腺炎的臨床特點及其常見病因分析. 中國普外基礎與臨床雜志, 2012, 19(10): 1102-1104.
48.	劉山, 鄭本波, 何永林. 早期血漿置換聯合連續血液濾過治療高血脂性重癥急性胰腺炎的效果觀察. 中國現代醫學雜志, 2009, 19(21): 3323-3325.
49.	Uhl W, Warshaw A, Imrie C, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology, 2002, 2(6): 565-573.
50.	李軍祥, 陳誩, 唐文富. 急性胰腺炎中西醫結合診療共識意見(2017 年). 中國中西醫結合消化雜志, 2017, 25(12): 901-909.
51.	Puri R, Choudhary NS, Sud R. Recurrent acute pancreatitis secondary to pancreatic neuroendocrine tumor: role of endoscopic ultrasound. Trop Gastroenterol, 2014, 35(3): 202-203.
52.	Evans WB, Draganov P. Is empiric cholecystectomy a reasonable treatment option for idiopathic acute pancreatitis. Nat Clin Pract Gastroenterol Hepatol, 2006, 3(7): 356-357.
53.	劉臻. 基于“治未病”思想探討膿毒癥的防治思路. 河南中醫, 2019, 39(9): 1319-1322.
54.	游真, 車德亞. 加味蒿芩清膽湯治療復發性急性胰腺炎臨床分析. 四川中醫, 2017, 35(3): 138-140.
55.	蘇振政, 李小蘭, 林海. 疏肝利膽法預防急性膽源性胰腺炎復發 64 例. 中國中西醫結合消化雜志, 2013, 21(12): 659.

1. Garg PK, Singh VP. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology, 2019, 156(7): 2008-2023.
2. 彭莉, 彭燕, 蒲垠全, 等. 671 例復發性急性胰腺炎臨床特點及危險因素分析. 實用醫學雜志, 2019, 35(18): 2924-2928.
3. Sankaran SJ, Xiao AY, Wu LM, et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology, 2015, 149(6): 1490-1500.
4. 班猛猛, 史煉鋼, 王東, 等. 復發性急性胰腺炎危險因素研究進展. 大連醫科大學學報, 2018, 27(2): 171-175, 180.
5. 季鈞淘, 張菂, 辛磊, 等. 復發性急性胰腺炎診斷與治療研究進展. 中華胰腺病雜志, 2016, 16(3): 203-205.
6. 高艷景, 李延青, 黃柳業, 等. 山東省 157 例復發性急性胰腺炎病因和復發特征分析. 山東大學學報(醫學版), 2005, 43(7): 605-608.
7. 溫彥麗, 郝婷婷, 戴光榮, 等. 急性復發性胰腺炎 288 例病因分析. 陜西醫學雜志, 2015, 44(1): 68-70.
8. 那賓. 復發性急性胰腺炎病因學分析. 武漢: 華中科技大學, 2012: 3-10.
9. 何希平, 胡康, 劉洙秀. 復發性胰腺炎的病因與治療. 吉林醫學, 2014, 35(20): 4520.
10. 陳灝珠, 林果為, 王吉耀. 實用內科學. 第 14 版. 北京:人民衛生出版社, 2014: 2015-2057.
11. 畢旭東, 付曉光, 唐樹相, 等. 急性胰腺炎反復發作病因的臨床研究. 錦州醫學院學報, 2003, 24(6): 12-13.
12. 張肇達, 嚴律南, 劉續寶. 急性胰腺炎. 北京: 人民衛生出版社, 2006: 54-55.
13. 曾慶煜, 汪麗燕. Oddi 括約肌功能障礙研究新進展. 世界最新醫學信息文摘, 2019, 19(99): 100-102.
14. Afghani E, Lo SK, Covington PS, et al. Sphincter of Oddi function and risk factors for dysfunction. Front Nutr, 2017, 4(1): 1-9.
15. Brawman-Mintzer O, Durkalski V, Wu Q, et al. Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. Am J Gastroenterol, 2014, 109(3): 436-442.
16. Sonoda Y, Kawamoto M, Woods CN, et al. Sphincter of Oddi function in the Australian brush-tailed possum is inhibited by intragastric ethanol. Neurogastroenterol Motil, 2007, 19(5): 401-10.
17. Mousavi S, Toussy J, Zahmatkesh M. Opium addiction as a new risk factor of sphincter of Oddi dysfunction. Med Sci Monit, 2007, 13(11): CR528-CR531.
18. Fernandes SR, Correia LA, Antunes T, et al. Intraductal papillary mucinous neoplasm presenting with recurrent pancreatitis: a report of a painful 3-decade-long history. BMJ Case Rep, 2016, 2016. pii: bcr2016214640.
19. Bolado F, Tarifa A, Zazpe C, et al. Acute recurrent pancreatitis secondary to hepatocellular carcinoma invading the biliary tree. Pancreatology, 2015, 15(2): 191-193.
20. Tadic M, Cabrijan Z, Stoos-Veic T, et al. Lymphangioma as a rare cause of acute recurrent pancreatitis. Endoscopy, 2014, 46 Suppl 1 UCTN: E598-E599.
21. Asimakopoulou NI, Papakonstantinou PE, Lasithiotakis KG, et al. Recurrent episodes of acute pancreatitis due to duodenal gangliocytic paraganglioma: report of a case. JOP, 2014, 15(2): 201-205.
22. Patel YA, Dhalla S, Olson MT, et al. Pancreatic metastasis from a solitary fibrous tumor of the kidney: a rare cause of acute recurrent pancreatitis. Pancreatology, 2013, 13(6): 631-633.
23. 吳長安, 陳麗娜. 高脂血癥性急性胰腺炎的臨床特點分析. 臨床醫學, 2019, 39(6): 7-9.
24. 丁巖冰, 路國濤, 藍宇, 等. 高脂血癥性急性胰腺炎 130 例. 世界華人消化雜志, 2013, 21(3): 266-271.
25. 杜奕奇, 陳其奎, 李宏宇, 等. 中國急性胰腺炎診治指南(2019 年, 沈陽). 臨床肝膽病雜志, 2019, 35(12): 2706-2711.
26. 李左軍, 張曄. 高脂血癥與胰腺炎關系及治療. 疾病監測與控制, 2017, 11(1): 69-70.
27. 劉東, 付文廣, 李秋. 高脂血癥性急性胰腺炎發病機制研究進展. 現代醫藥衛生, 2015, 31(23): 3585-3588.
28. 牛蕾, 葛春. 急性復發性胰腺炎與高脂血癥的互為因果關系及臨床特點. 世界華人消化雜志, 2016, 24(30): 4205-4210.
29. Ward JB, Petersen OH, Jenkins SA, et al. Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis. Lancet, 1995, 346(8981): 1016-1019.
30. 陳偉, 姜琦, 周國雄. 高脂血癥性急性胰腺炎微循環障礙研究進展. 中國血液流變學雜志, 2014, 24(1): 182-185.
31. Takeyama Y. Long-term prognosis of acute pancreatitis in Japan. Clin Gastroenterol Hepatol, 2009, 7(11 Suppl): S15-S17.
32. 李文婷, 黨彤. 復發性急性胰腺炎病因的研究進展. 胃腸病學, 2018, 23(6): 378-381.
33. Nikkola J, R?ty S, Laukkarinen J, et al. Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol, 2013, 48(4): 483-486.
34. Sadr-Azodi O, Andrén-Sandberg ?, Orsini N, et al. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study. Gut, 2012, 61(2): 262-267.
35. Martínez-Barona S, Ribes-Koninckx C. Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. Rev Esp Enferm Dig, 2017, 109(6): 478-479.
36. Avanthi US, Bale G, Aslam M, et al. PRSS1 (R122H) mutation in an Indian family with low penetrance is associated with pancreatitis phenotype. Indian J Gastroenterol, 2018, 37(1): 67-69.
37. Németh BC, Sahin-Tóth M. Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol, 2014, 306(6): G466-G473.
38. Lee YJ, Kim KM, Choi JH, et al. High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr, 2011, 52(4): 478-481.
39. Aoun E, Muddana V, Papachristou GI, et al. SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. Am J Gastroenterol, 2010, 105(2): 446-451.
40. Liu X, Tu M, Dai X, et al. PRSS1 and SPINK1 Mutations in Alcoholic and Idiopathic Chronic Pancreatitis. J Nanosci Nanotechnol, 2017, 17(4): 2358-2362.
41. Woods GN, Saitman A, Gao H, et al. A young woman with recurrent gestational hypercalcemia and acute pancreatitis caused by CYP24A1 deficiency. J Bone Miner Res, 2016, 31(10): 1841-1844.
42. 徐銘益, 王興鵬, 吳愷. 高脂血癥性急性胰腺炎脂蛋白脂酶基因多態性研究. 中華消化雜志, 2008, 28(9): 600-603.
43. 朱世峰, 李娟, 趙先林, 等. 熟大黃調控酒精性胰腺炎性損傷記憶的表觀遺傳機制研究. 第十二次全國中西醫結合實驗醫學專業委員會暨第七次湖南省中西醫結合神經科專業委員會學術年會, 長沙, 2015: 42-44.
44. 尚海濤, 李忠廉. 自身免疫性胰腺炎的診斷. 天津醫藥, 2019, 47(7): 771-776.
45. Kaurich T. Drug-induced acute pancreatitis. Proc (Bayl Univ Med Cent), 2008, 21(1): 77-81.
46. 何文華, 呂農華. 藥物性胰腺炎. 臨床內科雜志, 2012, 29(2): 79-81.
47. 鄭本波, 劉山, 陽勇. 復發性急性胰腺炎的臨床特點及其常見病因分析. 中國普外基礎與臨床雜志, 2012, 19(10): 1102-1104.
48. 劉山, 鄭本波, 何永林. 早期血漿置換聯合連續血液濾過治療高血脂性重癥急性胰腺炎的效果觀察. 中國現代醫學雜志, 2009, 19(21): 3323-3325.
49. Uhl W, Warshaw A, Imrie C, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology, 2002, 2(6): 565-573.
50. 李軍祥, 陳誩, 唐文富. 急性胰腺炎中西醫結合診療共識意見(2017 年). 中國中西醫結合消化雜志, 2017, 25(12): 901-909.
51. Puri R, Choudhary NS, Sud R. Recurrent acute pancreatitis secondary to pancreatic neuroendocrine tumor: role of endoscopic ultrasound. Trop Gastroenterol, 2014, 35(3): 202-203.
52. Evans WB, Draganov P. Is empiric cholecystectomy a reasonable treatment option for idiopathic acute pancreatitis. Nat Clin Pract Gastroenterol Hepatol, 2006, 3(7): 356-357.
53. 劉臻. 基于“治未病”思想探討膿毒癥的防治思路. 河南中醫, 2019, 39(9): 1319-1322.
54. 游真, 車德亞. 加味蒿芩清膽湯治療復發性急性胰腺炎臨床分析. 四川中醫, 2017, 35(3): 138-140.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Summary in etiologies, prevention and treatment strategies of recurrent acute pancreatitis

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